The beneficial effect of Radix Dipsaci total saponins on bone metabolism in vitro and in vivo and the possible mechanisms of action

Osteoporosis International

Volumn 23, Issue 11, 2012, Pages 2649-2660

  Niu, Y B ^a   Li, Y H ^b   Kong, X H ^a   Zhang, R ^c   Sun, Y ^c   Li, Q ^c   Li, C ^c   Liu, L ^c   Wang, J ^d   Mei, Q B ^a,c  

^a NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

^b No 422 Hospital of PLA   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Osteoblast; Osteoclast; Osteoporosis; Ovariectomy; Radix Dipsaci total saponins

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OSTEOPROTEGERIN; SAPONIN DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; BONE MASS; BONE METABOLISM; BONE STRENGTH; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; DRUG MECHANISM; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MEDICINAL PLANT; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RADIX DIPSACI; RAT; TRABECULAR BONE; TURNOVER TIME;

ANIMALS; BODY WEIGHT; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; BONE MORPHOGENETIC PROTEIN 2; CALCIUM; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DIPSACACEAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; ESTRADIOL; FEMALE; FEMUR; ORGAN SIZE; OSTEOBLASTS; OSTEOCLASTS; OSTEOPOROSIS; OSTEOPROTEGERIN; OVARIECTOMY; PHOSPHORUS; RANK LIGAND; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; TOMOGRAPHY, X-RAY COMPUTED; UP-REGULATION; UTERUS;

EID: 84868194462     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-012-1932-y     Document Type: Article

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