메뉴 건너뛰기




Volumn 5, Issue , 2014, Pages

Propionyl-L-carnitine is efficacious in ulcerative colitis through its action on the immune function and microvasculature

Author keywords

[No Author keywords available]

Indexed keywords

AMINOSALICYLIC ACID; CARNITINE; EMERIAMINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; NITRIC OXIDE; PLACEBO; PROPIONIC ACID; PROPIONYLCARNITINE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; 5 ACETAMIDOSALICYLIC ACID; LEVO AMINOCARNITINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; UNCLASSIFIED DRUG;

EID: 84898838006     PISSN: None     EISSN: 2155384X     Source Type: Journal    
DOI: 10.1038/ctg.2014.4     Document Type: Article
Times cited : (33)

References (45)
  • 1
    • 80455140368 scopus 로고    scopus 로고
    • Ulcerative colitis
    • Danese S, Fiocchi C. Ulcerative Colitis. N Engl J Med 2011; 365: 1713-1725.
    • (2011) N Engl J Med , vol.365 , pp. 1713-1725
    • Danese, S.1    Fiocchi, C.2
  • 2
    • 2442563304 scopus 로고    scopus 로고
    • Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences
    • Loftus EV. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 2004; 126: 1504-1517.
    • (2004) Gastroenterology , vol.126 , pp. 1504-1517
    • Loftus, E.V.1
  • 3
    • 79955551587 scopus 로고    scopus 로고
    • Regulation of homeostasis and inflammation in the intestine
    • MacDonald TT, Monteleone I, Fantini MC et al. Regulation of homeostasis and inflammation in the intestine. Gastroenterology 2011; 140: 1768-1775.
    • (2011) Gastroenterology , vol.140 , pp. 1768-1775
    • MacDonald, T.T.1    Monteleone, I.2    Fantini, M.C.3
  • 4
    • 0032576359 scopus 로고    scopus 로고
    • Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease
    • Binion DG, West GA, Volk EE et al. Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease. Lancet 1998; 352: 1742-1746.
    • (1998) Lancet , vol.352 , pp. 1742-1746
    • Binion, D.G.1    West, G.A.2    Volk, E.E.3
  • 5
    • 0032993527 scopus 로고    scopus 로고
    • Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis
    • Ishiguro Y. Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis. J Gastroenterol 1999; 34: 66-74.
    • (1999) J Gastroenterol , vol.34 , pp. 66-74
    • Ishiguro, Y.1
  • 6
    • 33749016804 scopus 로고    scopus 로고
    • The intestinal microvasculature as a therapeutic target in inflammatory bowel disease
    • Hatoum OA. The intestinal microvasculature as a therapeutic target in inflammatory bowel disease. Ann N Y Acad Sci 2006; 1072: 78-97.
    • (2006) Ann N y Acad Sci , vol.1072 , pp. 78-97
    • Hatoum, O.A.1
  • 7
    • 0018855591 scopus 로고
    • The colonic epithelium in ulcerative colitis: An energy-deficiency disease?
    • Roediger WE. The colonic epithelium in ulcerative colitis: an energy-deficiency disease? Lancet 1980; 2: 712-715.
    • (1980) Lancet , vol.2 , pp. 712-715
    • Roediger, W.E.1
  • 8
    • 0027965190 scopus 로고
    • Ileal and colonic epithelial metabolism in quiescent ulcerative colitis
    • Chapman MA, Grahn MF. Ileal and colonic epithelial metabolism in quiescent ulcerative colitis. Gut 1994; 35: 1152-1153.
    • (1994) Gut , vol.35 , pp. 1152-1153
    • Chapman, M.A.1    Grahn, M.F.2
  • 9
    • 0021024932 scopus 로고
    • Carnitine metabolism and function
    • Bremer J. Carnitine metabolism and function. Physiol Rev 1983; 63: 1420-1479.
    • (1983) Physiol Rev , vol.63 , pp. 1420-1479
    • Bremer, J.1
  • 10
    • 0028957711 scopus 로고
    • Myocyte performance during evolution of myocardial infarction in rats: Effects of propionyl-L-carnitine
    • Li P, Park C, Micheletti R et al. Myocyte performance during evolution of myocardial infarction in rats: effects of propionyl-L-carnitine. Am J Physiol 1995; 268: 1702-1713.
    • (1995) Am J Physiol , vol.268 , pp. 1702-1713
    • Li, P.1    Park, C.2    Micheletti, R.3
  • 11
    • 0033938076 scopus 로고    scopus 로고
    • L -propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector
    • Vanella A, Russo A, Acquaviva R et al. L -propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. Cell Biol Toxicol 2000; 16: 99-104.
    • (2000) Cell Biol Toxicol , vol.16 , pp. 99-104
    • Vanella, A.1    Russo, A.2    Acquaviva, R.3
  • 12
    • 0035942767 scopus 로고    scopus 로고
    • Medical treatment of peripheral arterial disease and claudication
    • Hiatt WR. Medical treatment of peripheral arterial disease and claudication. N Engl J Med 2001; 344: 1608-1621.
    • (2001) N Engl J Med , vol.344 , pp. 1608-1621
    • Hiatt, W.R.1
  • 13
    • 32044464510 scopus 로고    scopus 로고
    • Medical treatment of peripheral arterial disease
    • Hankey GJ, Norman PE, Eikelboom JW. Medical treatment of peripheral arterial disease. JAMA 2006; 295: 547-553.
    • (2006) JAMA , vol.295 , pp. 547-553
    • Hankey, G.J.1    Norman, P.E.2    Eikelboom, J.W.3
  • 14
    • 4444329422 scopus 로고    scopus 로고
    • Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: What is the clinical significance?
    • Touyz RM. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension 2004; 44: 248-252.
    • (2004) Hypertension , vol.44 , pp. 248-252
    • Touyz, R.M.1
  • 15
    • 77649148275 scopus 로고    scopus 로고
    • Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPHoxidase 4-mediated superoxide production
    • Stasi MA, Scioli MG, Arcuri G et al. Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPHoxidase 4-mediated superoxide production. Arterioscler Thromb Vasc Biol 2010; 30: 426-435.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 426-435
    • Stasi, M.A.1    Scioli, M.G.2    Arcuri, G.3
  • 16
    • 34347230266 scopus 로고    scopus 로고
    • Oxidative-stress-mediated arterial dysfunction in patients with peripheral arterial disease
    • Loffredo L, Marcoccia A, Pignatelli P et al. Oxidative-stress-mediated arterial dysfunction in patients with peripheral arterial disease. Eur Heart J 2007; 28: 608-612.
    • (2007) Eur Heart J , vol.28 , pp. 608-612
    • Loffredo, L.1    Marcoccia, A.2    Pignatelli, P.3
  • 17
    • 31144471584 scopus 로고    scopus 로고
    • Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis
    • Bene J, Komlósi K, Havasi V et al. Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis. World J Gastroenterol 2006; 12: 110-113.
    • (2006) World J Gastroenterol , vol.12 , pp. 110-113
    • Bene, J.1    Komlósi, K.2    Havasi, V.3
  • 18
    • 0141763537 scopus 로고    scopus 로고
    • Effects of propionyl-L-carnitine topical irrigation in distal ulcerative colitis: A preliminary report
    • Gasbarrini G, Mingrone G, Giancaterini A et al. Effects of propionyl-L-carnitine topical irrigation in distal ulcerative colitis: a preliminary report. Hepatogastroenterology 2003; 50: 1385-1389.
    • (2003) Hepatogastroenterology , vol.50 , pp. 1385-1389
    • Gasbarrini, G.1    Mingrone, G.2    Giancaterini, A.3
  • 19
    • 80053940411 scopus 로고    scopus 로고
    • Randomised clinical trial: The efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment
    • Mikhailova TL, Sishkova E, Poniewierka E et al. Randomised clinical trial: the efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment. Aliment Pharmacol Ther 2011; 34: 1088-1097.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 1088-1097
    • Mikhailova, T.L.1    Sishkova, E.2    Poniewierka, E.3
  • 20
    • 0036149016 scopus 로고    scopus 로고
    • Propionyl-L-carnitine reduces intimal hyperplasia after injury in normocholesterolemic rabbit carotid artery by modulating proliferation and caspase 3-dependent apoptosis of vascular smooth muscle cells
    • Orlandi A, Marcellini M, Pesce D et al. Propionyl-L-carnitine reduces intimal hyperplasia after injury in normocholesterolemic rabbit carotid artery by modulating proliferation and caspase 3-dependent apoptosis of vascular smooth muscle cells. Atherosclerosis 2002; 160: 81-89.
    • (2002) Atherosclerosis , vol.160 , pp. 81-89
    • Orlandi, A.1    Marcellini, M.2    Pesce, D.3
  • 21
    • 84865370005 scopus 로고    scopus 로고
    • Age-related increase of stem marker expression influences vascular smooth muscle cell properties
    • Ferlosio A, Arcuri G, Doldo E et al. Age-related increase of stem marker expression influences vascular smooth muscle cell properties. Atherosclerosis 2012; 224: 51-57.
    • (2012) Atherosclerosis , vol.224 , pp. 51-57
    • Ferlosio, A.1    Arcuri, G.2    Doldo, E.3
  • 22
    • 84896755505 scopus 로고    scopus 로고
    • Sortilin expression is essential for pronerve growth factor-induced apoptosis of rat vascular smooth muscle cells
    • Campagnolo L, Costanza G, Francesconi A et al. Sortilin expression is essential for pronerve growth factor-induced apoptosis of rat vascular smooth muscle cells. PLoSOne 2014; 9: e84969.
    • (2014) PLoSOne , vol.9
    • Campagnolo, L.1    Costanza, G.2    Francesconi, A.3
  • 23
    • 0030001831 scopus 로고    scopus 로고
    • Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells
    • Haraldsen G, Kvale D, Lien B et al. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J Immunol 1996; 156: 2558-2565.
    • (1996) J Immunol , vol.156 , pp. 2558-2565
    • Haraldsen, G.1    Kvale, D.2    Lien, B.3
  • 24
    • 0034969250 scopus 로고    scopus 로고
    • Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide
    • Corda S, Laplace C, Vicaut E et al. Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide. Am J Respir Cell Mol Biol 2001; 24: 762-768.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 762-768
    • Corda, S.1    Laplace, C.2    Vicaut, E.3
  • 25
    • 10344245047 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor signal transduction in endothelial cells by dimethylaminopurine
    • Marino MW, Dunbar JD, Wu LW et al. Inhibition of tumor necrosis factor signal transduction in endothelial cells by dimethylaminopurine. J Biol Chem 1996; 271: 28624-28629.
    • (1996) J Biol Chem , vol.271 , pp. 28624-28629
    • Marino, M.W.1    Dunbar, J.D.2    Wu, L.W.3
  • 26
    • 79955550194 scopus 로고    scopus 로고
    • Future therapeutic approaches for inflammatory bowel diseases
    • Plevy SE, Targan SR. Future therapeutic approaches for inflammatory bowel diseases. Gastroenterology 2011; 140: 1838-1846.
    • (2011) Gastroenterology , vol.140 , pp. 1838-1846
    • Plevy, S.E.1    Targan, S.R.2
  • 27
    • 33847632044 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Past, present, and future
    • Sands BE. Inflammatory bowel disease: past, present, and future. J Gastroenterol 2007; 42: 16-25.
    • (2007) J Gastroenterol , vol.42 , pp. 16-25
    • Sands, B.E.1
  • 28
    • 0037369649 scopus 로고    scopus 로고
    • Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis
    • Lindsay JO, Ciesielski CJ, Scheinin T et al. Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis. Gut 2003; 52: 363-369.
    • (2003) Gut , vol.52 , pp. 363-369
    • Lindsay, J.O.1    Ciesielski, C.J.2    Scheinin, T.3
  • 29
    • 33646271377 scopus 로고    scopus 로고
    • A phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis
    • van Deventer SJ, Wedel MK, Baker BF et al. A phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis. Aliment Pharmacol Ther 2006; 23: 1415-1425.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1415-1425
    • Van Deventer, S.J.1    Wedel, M.K.2    Baker, B.F.3
  • 30
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000; 87: 840-844.
    • (2000) Circ Res , vol.87 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 31
    • 74049159439 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), arginine, and 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) level in patients with inflammatory bowel diseases
    • Owczarek D, Cibor D, Mach T. Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), arginine, and 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) level in patients with inflammatory bowel diseases. Inflamm Bowel Dis 2010; 16: 52-57.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 52-57
    • Owczarek, D.1    Cibor, D.2    Mach, T.3
  • 32
    • 0025804736 scopus 로고
    • Effect of propionyl-L-carnitine on human endothelial cells
    • Van Hinsbergh VW, Scheffer MA. Effect of propionyl-L-carnitine on human endothelial cells. Cardiovasc Drugs Ther 1991; 5: 97-105.
    • (1991) Cardiovasc Drugs Ther , vol.5 , pp. 97-105
    • Van Hinsbergh, V.W.1    Scheffer, M.A.2
  • 33
    • 28844438030 scopus 로고    scopus 로고
    • Antioxidant effect of L-carnitine and its short chain esters: Relevance for the protection from oxidative stress related cardiovascular damage
    • Calò LA, Pagnin E, Davis PA et al. Antioxidant effect of L-carnitine and its short chain esters: relevance for the protection from oxidative stress related cardiovascular damage. Int J Cardiol 2006; 107: 54-60.
    • (2006) Int J Cardiol , vol.107 , pp. 54-60
    • Calò, L.A.1    Pagnin, E.2    Davis, P.A.3
  • 34
    • 0031913741 scopus 로고    scopus 로고
    • Disruption of intestinal barrier function associated with experimental colitis: Possible role of mast cells
    • Stein J, Ries J, Barrett KE. Disruption of intestinal barrier function associated with experimental colitis: possible role of mast cells. Am J Physiol 1998; 274: G203-G209.
    • (1998) Am J Physiol , vol.274
    • Stein, J.1    Ries, J.2    Barrett, K.E.3
  • 35
    • 77951297553 scopus 로고    scopus 로고
    • Progenitor cell-derived smooth muscle cells in vascular disease
    • Orlandi A, Bennett M. Progenitor cell-derived smooth muscle cells in vascular disease. Biochem Pharmacol 2010; 79: 1706-1713.
    • (2010) Biochem Pharmacol , vol.79 , pp. 1706-1713
    • Orlandi, A.1    Bennett, M.2
  • 36
    • 0029090167 scopus 로고
    • Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity
    • Goossens V, Grooten J, De Vos K et al. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc Natl Acad Sci USA 1995; 92: 8115-8119.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8115-8119
    • Goossens, V.1    Grooten, J.2    De Vos, K.3
  • 37
    • 84861062943 scopus 로고    scopus 로고
    • Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system
    • Lassègue B, San Martín A, Griendling KK et al. Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system. Circ Res 2012; 110: 1364-1390.
    • (2012) Circ Res , vol.110 , pp. 1364-1390
    • Lassègue, B.1    San Martín, A.2    Griendling, K.K.3
  • 38
    • 80052266526 scopus 로고    scopus 로고
    • Cross talk between mitochondria and NADPH oxidases
    • Dikalov S. Cross talk between mitochondria and NADPH oxidases. Free Radic Biol Med 2011; 51: 1289-1301.
    • (2011) Free Radic Biol Med , vol.51 , pp. 1289-1301
    • Dikalov, S.1
  • 39
    • 70349352744 scopus 로고    scopus 로고
    • Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: Roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase
    • Santos CX, Tanaka LY, Wosniak J et al. Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. Antioxid Redox Signal 2009; 11: 2409-2427.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2409-2427
    • Santos, C.X.1    Tanaka, L.Y.2    Wosniak, J.3
  • 40
    • 9144255403 scopus 로고    scopus 로고
    • Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase
    • Ago T, Kitazono T, Ooboshi H et al. Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase. Circulation 2004; 109: 227-233.
    • (2004) Circulation , vol.109 , pp. 227-233
    • Ago, T.1    Kitazono, T.2    Ooboshi, H.3
  • 41
    • 33845405725 scopus 로고    scopus 로고
    • Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules
    • Chen YH, Lin SJ, Chen YL et al. Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules. Cardiovasc Hematol Disord Drug Targets 2006; 6: 279-304.
    • (2006) Cardiovasc Hematol Disord Drug Targets , vol.6 , pp. 279-304
    • Chen, Y.H.1    Lin, S.J.2    Chen, Y.L.3
  • 42
    • 12144271043 scopus 로고    scopus 로고
    • Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells
    • Ogawa H, Binion DG, Heidemann J et al. Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells. Am J Physiol Cell Physiol 2005; 288: C272-C281.
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Ogawa, H.1    Binion, D.G.2    Heidemann, J.3
  • 43
    • 23244435286 scopus 로고    scopus 로고
    • Mechanisms of inducible nitric oxide synthasemediated vascular dysfunction
    • Gunnett CA, Lund DD, McDowell AK et al. Mechanisms of inducible nitric oxide synthasemediated vascular dysfunction. Arterioscler Thromb Vasc Biol 2005; 25: 1617-1622.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1617-1622
    • Gunnett, C.A.1    Lund, D.D.2    McDowell, A.K.3
  • 44
    • 0034105271 scopus 로고    scopus 로고
    • Peroxynitrite and inflammatory bowel disease
    • McCafferty DM. Peroxynitrite and inflammatory bowel disease. Gut 2000; 46: 436-439.
    • (2000) Gut , vol.46 , pp. 436-439
    • McCafferty, D.M.1
  • 45
    • 0032415840 scopus 로고    scopus 로고
    • Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease
    • Dijkstra G, Moshage H, van Dullemen HM et al. Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease. J Pathol 1998; 186: 416-421.
    • (1998) J Pathol , vol.186 , pp. 416-421
    • Dijkstra, G.1    Moshage, H.2    Van Dullemen, H.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.