Effects of propionyl-L-carnitine topical irrigation in distal ulcerative colitis: A preliminary report

Hepato-Gastroenterology

Volumn 50, Issue 53, 2003, Pages 1385-1389

  Gasbarrini, Giovanni ^a,b   Mingrone, G ^a   Giancaterini, A ^a   De Gaetano, A ^a   Scarfone, A ^a   Capristo, E ^a   Calvani, M ^a   Caso, V ^a   Greco, A V ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

Enema; Interleukin 2; Propionyl L carnitine; Tumor necrosis factor ; Ulcerative colitis

Indexed keywords

ENEMA; INTERLEUKIN 2; PROPIONYLCARNITINE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERABILITY; HUMAN; MALE; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BODY COMPOSITION; CARNITINE; COLITIS, ULCERATIVE; FEMALE; HUMANS; INTERLEUKIN-2; IRRIGATION; MALE; MIDDLE AGED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0141763537     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Breuer RI, Soergel KH, Lashner BA, et al: Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo controlled trial. Gut 1997; 40:485-491.
2. Podosky DK: Inflammatory bowel disease (first part). N Engl J Med 1991; 325:928-935.
3. Sachar DB: Budesonide for inflammatory bowel disease it a magic bullet? N Engl J Med 1994; 331:873-874.
4. Belluzzi A, Brignola C, Campieri M, et al: Effect of an enteric coated fish-oil preparation on relapses in Crohn's disease. N Engl J Med 1996; 334:1557-1560.
5. Roediger WEW: The colonic epithelium in ulcerative colitis: an energy-deficiency disease? Lancet 1980; ii:712-715.
6. Cummings JH, Pomare EW, Branch WJ, et al: Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 1987; 28:1221-1227.
7. Cummings JH, Rombeau JL, Sakata T (Eds.). Physiological and clinical aspects of short chain fatty acids. Cambridge: Cambridge University Press, 1995.
8. Scheppach W, Muller JG, Boxberger F, et al: Histological changes in the colonic mucosa following irrigation with short-chain fatty acids. Eur J Gastroenterol Hepatol 1997; 9:163-168.
9. Roediger WEW, Duncan A, Kapaniris O, et al: Reducing sulfur compounds of the colon impair colonocyte nutrition: implications for ulcerative colitis. Gastroenterology 1993; 104:802-809.
10. Gibson GR, Cummings JH, Macfarlane GT: Growth and activities of sulphate-reducing bacteria in gut contents from healthy subjects and patients with ulcerative colitis. FEMS Microbiol Ecol 1991; 86:103-112.
11. Harig JM, Soergel KH, Komorowski RA, et al: Treatment of diversion colitis with short-chain fatty acid irrigation. N Engl J Med 1989; 320:23-28.
12. Tremaine WJ, Sandborn WJ, Phillips SF, et al: Short chain fatty acids (SCFA) enema therapy for treatment-resistant pouchitis following ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC). Gastroenterology 1994; 106:A784.
13. Wischmeyer P, Grotz RL, Pemberton JH, et al: Treatment of pouchitis after ileo-anal anastomosis with glutamine and butyric acid. Gastroenterology 1992; 102:A947.
14. Sutherland LR, Martin F, Greer MR, et al: 5-aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis. Gastroenterology 1987; 92:1894-1898.
15. Tanaka M, Riddell RH, Saito H, et al: Morphologic criteria applicable to biopsy specimens for effective distinction of inflammatory bowel disease from other forms of colitis and of Crohn's disease from ulcerative colitis. Scand J Gastroenterol 1999; 1:55-67.
16. Capristo E, Mingrone G, Addolorato G, et al: Glucose metabolism and insulin sensitivity in inactive inflammatory bowel disease. Aliment Pharmacol Ther 1999; 13:209-217.
17. Yanovski JA, Cutler GB Jr: Glucocorticoid action and the clinical features of Cushing's syndrome. Endocrinol Metab Clin N Am 1994; 23:487-509.
18. Roediger WEW, Heyworth M, Willoghby P, et al: Luminal ions and short fatty acids as markers of functional activity of colon in ulcerative colitis. J Clin Pathol 1982; 35:323-326.
19. Scheppard W, Sommer H, Kirchner T, et al: Effect of butyrate enemas in the colonic mucosa in distal ulcerative colitis. Gastroenterology 1992; 103:51-56.
20. Vernia P, Marcheggiano A, Caprilli R, et al: Short-chain fatty acid topical treatment in distal ulcerative colitis. Aliment Pharmacol Ther 1995; 9:309-313.