Red grape berry-cultured cells reduce blood pressure in rats with metabolic-like syndrome

European Journal of Nutrition

Volumn 53, Issue 3, 2014, Pages 973-980

  Leibowitz, A ^a,b   Faltin, Z ^c   Perl, A ^c   Eshdat, Y ^c   Hagay, Y ^d   Peleg, E ^a,b   Grossman, E ^a,b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c VOLCANI CENTER   (Israel)

^d Fruitura Bioscience   (Israel)

Author keywords

Blood pressure; Endothelial NO synthase; Endothelin 1; Metabolic syndrome; Rats; Red grape cultured cell

Indexed keywords

ADIPONECTIN; ANTIHYPERTENSIVE AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; FRUCTOSE; INSULIN; POLYPHENOL; RESVERATROL; TRIACYLGLYCEROL; ANTILIPEMIC AGENT; NOS3 PROTEIN, HUMAN; PIGMENT; PLANT EXTRACT; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BERRY; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; CELL CULTURE; CONTROLLED STUDY; GRAPE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MALE; METABOLIC DISORDER; METABOLIC PARAMETERS; NONHUMAN; PLANT CELL; RAT; RED GRAPE BERRY; SIGNAL TRANSDUCTION; SODIUM EXCRETION; TRIACYLGLYCEROL BLOOD LEVEL; UMBILICAL VEIN ENDOTHELIAL CELL; VASODILATATION; VITAMIN SUPPLEMENTATION; WESTERN BLOTTING; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DIET SUPPLEMENTATION; DIET THERAPY; ENZYMOLOGY; FRUIT; HYPERINSULINISM; HYPERTENSION; HYPERTRIGLYCERIDEMIA; METABOLIC SYNDROME X; METABOLISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; VITIS;

RATTUS; VITACEAE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CELLS, CULTURED; DIETARY SUPPLEMENTS; ENDOTHELIN-1; FRUIT; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPERINSULINISM; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPOLIPIDEMIC AGENTS; MALE; METABOLIC SYNDROME X; NITRIC OXIDE SYNTHASE TYPE III; PIGMENTS, BIOLOGICAL; PLANT EXTRACTS; RATS, SPRAGUE-DAWLEY; VASODILATOR AGENTS; VITIS;

EID: 84898835569     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-013-0601-z     Document Type: Article

References (39)

1. Vidavalur R, Otani H, Singal PK, Maulik N (2006) Significance of wine and resveratrol in cardiovascular disease: French paradox revisited. Exp Clin Cardiol 11:217-225
2. Leifert WR, Abeywardena MY (2008) Cardioprotective actions of grape polyphenols. Nutr Res 28:729-737
3. Rahman I, Biswas SK, Kirkham PA (2006) Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 72:1439-1452
4. Schini-Kerth VB, Auger C, Kim JH, Etienne-Selloum N, Chataigneau T (2010) Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF. Pflugers Arch 459:853-862
5. Corder R, Douthwaite JA, Lees DM, Khan NQ, Viseu Dos Santos AC, Wood EG, Carrier MJ (2001) Endothelin-1 synthesis reduced by red wine. Nature 414:863-864
6. Madeira SV, Auger C, Anselm E, Chataigneau M, Chataigneau T, Soares de Moura R, Schini-Kerth VB (2009) eNOS activation induced by a polyphenol-rich grape skin extract in porcine coronary arteries. J Vasc Res 46:406-416
7. de Lange DW, Verhoef S, Gorter G, Kraaijenhagen RJ, van de Wiel A, Akkerman JW (2007) Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox. Alcohol Clin Exp Res 31:1308-1314
8. de Lange DW, Scholman WL, Kraaijenhagen RJ, Akkerman JW, van de Wiel A (2004) Alcohol and polyphenolic grape extract inhibit platelet adhesion in flowing blood. Eur J Clin Invest 34:818-824
9. Bhatt SR, Lokhandwala MF, Banday AA (2011) Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats. Eur J Pharmacol 667:258-264
10. Soares De Moura R, Costa Viana FS, Souza MA, Kovary K, Guedes DC, Oliveira EP, Rubenich LM, Carvalho LC, Oliveira RM, Tano T, Gusmao Correia ML (2002) Antihypertensive, vasodilator and antioxidant effects of a vinifera grape skin extract. J Pharm Pharmacol 54:1515-1520
11. Chacon MR, Ceperuelo-Mallafre V, Maymo-Masip E, Mateo-Sanz JM, Arola L, Guitierrez C, Fernandez-Real JM, Ardevol A, Simon I, Vendrell J (2009) Grape-seed procyanidins modulate inflammation on human differentiated adipocytes in vitro. Cytokine 47:137-142
12. Dolinsky VW, Dyck JR (2011) Calorie restriction and resveratrol in cardiovascular health and disease. Biochim Biophys Acta 1812:1477-1489
13. Oron-Herman M, Kamari Y, Grossman E, Yeger G, Peleg E, Shabtay Z, Shamiss A, Sharabi Y (2008) Metabolic syndrome comparison of the two commonly used animal models. Am J Hypertens 21:1018-1022
14. Sharabi Y, Oron-Herman M, Kamari Y, Avni I, Peleg E, Shabtay Z, Grossman E, Shamiss A (2007) Effect of PPAR-gamma agonist on adiponectin levels in the metabolic syndrome: lessons from the high fructose fed rat model. Am J Hypertens 20:206-210
15. Delbosc S, Paizanis E, Magous R, Araiz C, Dimo T, Cristol JP, Cros G, Azay J (2005) Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance, the fructose-fed rat. Atherosclerosis 179:43-49
16. Bagul PK, Middela H, Matapally S, Padiya R, Bastia T, Madhusudana K, Reddy BR, Chakravarty S, Banerjee SK (2012) Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacol Res 66:260-268
17. Kojima H, Sakurai K, Kikuchi K, Kawahara S, Kirino Y, Nagoshi H, Hirata Y, Nagano T (1998) Development of a fluorescent indicator for nitric oxide based on the fluorescein chromophore. Chem Pharm Bull (Tokyo) 46:373-375
18. Page B, Page M, Noel C (1993) A new fluorometric assay for cytotoxicity measurements in vitro. Int J Oncol 3:473-476
19. Hazebrouck S, Camoin L, Faltin Z, Strosberg AD, Eshdat Y (2000) Substituting selenocysteine for catalytic cysteine 41 enhances enzymatic activity of plant phospholipid hydroperoxide glutathione peroxidase expressed in Escherichia coli. J Biol Chem 275:28715-28721
20. Wallerath T, Deckert G, Ternes T, Anderson H, Li H, Witte K, Forstermann U (2002) Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-1658
21. Mulvihill EE, Huff MW (2010) Antiatherogenic properties of flavonoids: implications for cardiovascular health. Can J Cardiol 26(Suppl A):17A-21A
22. Aubin MC, Lajoie C, Clement R, Gosselin H, Calderone A, Perrault LP (2008) Female rats fed a high-fat diet were associated with vascular dysfunction and cardiac fibrosis in the absence of overt obesity and hyperlipidemia: therapeutic potential of resveratrol. J Pharmacol Exp Ther 325:961-968
23. Chander V, Chopra K (2006) Possible role of nitric oxide in the protective effect of resveratrol in 5/6th nephrectomized rats. J Surg Res 133:129-135
24. Inanaga K, Ichiki T, Matsuura H, Miyazaki R, Hashimoto T, Takeda K, Sunagawa K (2009) Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis. Hypertens Res 32:466-471
25. Miatello R, Vazquez M, Renna N, Cruzado M, Zumino AP, Risler N (2005) Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats. Am J Hypertens 18:864-870
26. Rivera L, Moron R, Zarzuelo A, Galisteo M (2009) Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem Pharmacol 77:1053-1063
27. Thandapilly SJ, Wojciechowski P, Behbahani J, Louis XL, Yu L, Juric D, Kopilas MA, Anderson HD, Netticadan T (2010) Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the SHR without lowering blood pressure. Am J Hypertens 23:192-196
28. Robich MP, Chu LM, Chaudray M, Nezafat R, Han Y, Clements RT, Laham RJ, Manning WJ, Coady MA, Sellke FW (2010) Anti-angiogenic effect of high-dose resveratrol in a swine model of metabolic syndrome. Surgery 148:453-462
29. Wallerath T, Poleo D, Li H, Forstermann U (2003) Red wine increases the expression of human endothelial nitric oxide synthase: a mechanism that may contribute to its beneficial cardiovascular effects. J Am Coll Cardiol 41:471-478
30. Mikstacka R, Rimando AM, Ignatowicz E (2010) Antioxidant effect of trans-resveratrol, pterostilbene, quercetin and their combinations in human erythrocytes in vitro. Plant Foods Hum Nutr 65:57-63
31. Kamari Y, Grossman E, Oron-Herman M, Peleg E, Shabtay Z, Shamiss A, Sharabi Y (2007) Metabolic stress with a high carbohydrate diet increases adiponectin levels. Horm Metab Res 39:384-388
32. Kamari Y, Harari A, Shaish A, Peleg E, Sharabi Y, Harats D, Grossman E (2008) Effect of telmisartan, angiotensin II receptor antagonist, on metabolic profile in fructose-induced hypertensive, hyperinsulinemic, hyperlipidemic rats. Hypertens Res 31:135-140
33. Grossman E (2008) Does increased oxidative stress cause hypertension? Diabetes Care 31(Suppl 2):S185-S189
34. Akpaffiong MJ, Taylor AA (1998) Antihypertensive and vasodilator actions of antioxidants in spontaneously hypertensive rats. Am J Hypertens 11:1450-1460
35. Virdis A, Neves MF, Amiri F, Touyz RM, Schiffrin EL (2004) Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice. J Hypertens 22:535-542
36. Vitseva O, Varghese S, Chakrabarti S, Folts JD, Freedman JE (2005) Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. J Cardiovasc Pharmacol 46:445-451
37. Yamakoshi J, Kataoka S, Koga T, Ariga T (1999) Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149
38. Leikert JF, Rathel TR, Wohlfart P, Cheynier V, Vollmar AM, Dirsch VM (2002) Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells. Circulation 106:1614-1617
39. Nicholson SK, Tucker GA, Brameld JM (2008) Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc Nutr Soc 67:42-47