A frameshifting stimulatory stem loop destabilizes the hybrid state and impedes ribosomal translocation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 15, 2014, Pages 5538-5543

  Kima, Hee Kyung ^a   Liua, Fei ^a   Fei, Jingyi ^b   Bustamante, Carlos ^a,c   Gonzalez Jr , Ruben L ^b   Tinoco Jr , Ignacio ^a  

^a Department of Chemistry ^*  (United States)

^b Howard Hughes Medical Institute   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Mrna Secondary Structure; Programmed Ribosomal Frameshifting; Ribosomal Dynamics; Single Molecule Fret

Indexed keywords

ELONGATION FACTOR G; MESSENGER RNA; PEPTIDYLTRANSFERASE; TRANSFER RNA;

ARTICLE; BACTERIAL GENE; BINDING SITE; BLEACHING; CATALYSIS; CODON; CONFORMATIONAL TRANSITION; DISSOCIATION; ELECTROSPRAY MASS SPECTROMETRY; ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; IN VITRO STUDY; LARGE RIBOSOMAL SUBUNIT; NONHUMAN; PRIORITY JOURNAL; PROGRAMMED 1 RIBOSOMAL FRAMESHIFTING; PROTEIN SECONDARY STRUCTURE; QUANTITATIVE ANALYSIS; RIBOSOMAL FRAMESHIFTING; RIBOSOME; RIBOSOME TRANSLOCATION;

MRNA SECONDARY STRUCTURE; PROGRAMMED RIBOSOMAL FRAMESHIFTING; RIBOSOMAL DYNAMICS; SINGLE-MOLECULE FRET;

BACTERIAL PROTEINS; DNA POLYMERASE III; ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; FRAMESHIFTING, RIBOSOMAL; MODELS, GENETIC; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RIBOSOMES; RNA, MESSENGER;

EID: 84898802217     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1403457111     Document Type: Article

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