Programmed translational frameshifting

Microbiological Reviews

Volumn 60, Issue 1, 1996, Pages 103-134

  Farabaugh, Philip J ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; FRAMESHIFT MUTATION; NONHUMAN; RETROPOSON; REVIEW; RIBOSOME; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE;

ESCHERICHIA COLI; EUKARYOTA; HUMULUS; SACCHAROMYCES CEREVISIAE;

EID: 0029870925     PISSN: 01460749     EISSN: None     Source Type: Journal    
DOI: 10.1128/mmbr.60.1.103-134.1996     Document Type: Review

References (230)

1. Atkins, J. F., and R. F. Gesteland. 1995. Discontinuous triplet decoding with or without re-pairing by peptidyl-tRNA, p. 471-490. In D. Söll and U. L. RajBhandary (ed.), tRNA: structure, biosynthesis and function. American Society for Microbiology, Washington, D.C.
2. Atkins, J., R. Gesteland, B. Reid, and C. Anderson. 1979. Normal tRNAs promote ribosomal frameshifting. Cell 18:1119-1131.
3. Atkins, J. F., D. Elseviers, and L. Gorini. 1972. Low activity of β-galactosidase in frameshift mutants of Escherichia coli. Proc. Natl. Acad. Sci. USA 69:1192-1195.
4. Atkins, J. F., J. B. Lewis, C. W. Anderson, and R. F. Gesteland. 1975. Enhanced differential synthesis of proteins in a mammalian cell-free system by addition of polyamines. J. Biol. Chem. 250:5688-5695.
5. Ayer, D., and M. Yarns. 1986. The context effect does not require a fourth base pair. Science 231:393-395.
6. Balasundaram, D., J. D. Dinman, C. W. Tabor, and H. Tabor. 1994. SPE1 and SPE2: two essential genes in the biosynthesis of polyamines that modulate +1 ribosomal frameshifting in Saccharomyces cerevisiae. J. Bacteriol. 176:7126-7128.
7. Balasundaram, D., J. D. Dinman, R. B. Wickner, C. W. Tabor, and H. Tabor. 1994. Spermidine deficiency increases +1 ribosomal frameshifting efficiency and inhibits Ty1 retrotransposition in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 91:172-176.
8. Baughman, G., and M. Nomura. 1983. Localization of the target site for translational regulation of the L11 operon and direct evidence for translational coupling in Escherichia coli. Cell 34:979-988.
9. Belcourt, M. F., and P. J. Farabaugh. 1990. Ribosomal frameshifting in the yeast retrotransposon Ty: tRNAs induce slippage on a 7 nucleotide minimal site. Cell 62:339-352.
10. Benhar, I., and K. H. Engelberg. 1993. Frameshifting in the expression of the E. coli trpR gene occurs by the bypassing of a segment of its coding sequence. Cell 72:121-130.
11. Benhar, L, and H. Engelberg-Kulka. 1991. A procedure for amino acid sequencing in internal regions of proteins. Gene 103:79-82.
12. Benhar, I., C. Miller, and H. Engelberg-Kulka. 1992. Frameshifting in the expression of the Escherichia coli trpR gene. Mol. Microbiol. 6:2777-2784.
13. Beremand, M. N., and T. Blumenthal. 1979. Overlapping genes in RNA phage: a new protein implicated in lysis. Cell 18:257-266.
14. Berkhout, B., B. F. Schmidt, A. van Strein, J. van Boom, J. van Westrenen, and J. van Duin. 1987. Lysis gene of bacteriophage MS2 is activated by translation termination at the overlapping coat gene. J. Mol. Biol. 195:517-524.
15. Blinkowa, A. L., and J. R. Walker. 1990. Programmed ribosomal frameshifting generates the Escherichia coli DNA polymerase III γ subunit from within the τ subunit reading frame. Nucleic Acids Res. 18:1725-1729.
16. Böck, A., K. Forchhammer, J. Heider, and C. Baron. 1991. Selenoprotein synthesis: an expansion of the genetic code. Trends Biochem. Sci. 16:463-467.
17. Boeke, J. D., and S. B. Sandmeyer. 1991. Yeast transposable elements, p. 193-261. In E. W. Jones, J. R. Pringle and J. R. Broach (ed.), The molecular biology of the yeast Saccharomyces, vol. 1. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N. Y.
18. Bossi, L. 1983. Context effects: translation of UAG codon by suppressor tRNA is affected by the sequence following UAG in the message. J. Mol. Biol. 164:73-87.
19. Bossi, L., and D. M. Smith. 1984. Suppressor sufJ: a novel type of tRNA mutant that induces translational frameshifting. Proc. Natl. Acad. Sci. USA 81:6105-6109.
20. Brault, V., and W. A. Miller. 1992. Translational frameshifting mediated by a viral sequence in plant cells. Proc. Natl. Acad. Sci. USA 89:2262-2266.
21. Brierley, L., M. Broursnell, M. Birns, B. Bilmoria, V. Block, T. Brown, and S. Inglis. 1987. An efficient ribosomal frame-shifting signal in the polymerase-encoding region of the coronavirus IBV. EMBO J. 6:3779-3785.
22. Brierley, I., P. Digard, and S. C. Inglis. 1989. Characterization of an efficient coronavirus ribosomal frameshifting signal: requirement for an RNA pseudoknot. Cell 57:537-547.
23. Brierley, I., A. J. Jenner, and S. C. Inglis. 1992. Mutational analysis of the "slippery-sequence" component of a coronavirus ribosomal frameshifting signal. J. Mol. Biol. 227:463-479.
24. Brierley, I., N. J. Rolley, A. J. Jenner, and S. C, Inglis. 1991. Mutational analysis of the RNA pseudoknot component of a coronavirus ribosomal frameshifting signal. J. Mol. Biol. 220:889-902.
25. Brinkmann, U., R. E. Mattes, and P. Buckel. 1989. High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product. Gene 85:109-114.
26. Brown, C. M., P. A. Stockwell, C. N. A. Trotman, and W. P. Tate. 1990. Sequence analysis suggests that tetra-nucleotides signal the termination of protein synthesis in eukaryotes. Nucleic Acids Res. 18:6339-6345.
27. Bruce, A. G., J. F. Atkins, and R. F. Gesteland. 1986. tRNA anticodon replacement experiments show that ribosomal frameshifting can be caused by doublet decoding. Proc. Natl, Acad. Sci. USA 83:5062-5066.
28. Burke, D. 1988. Ph.D. thesis. Washington University, St. Louis.
29. Cavicchioli, R., P. D. East, and K. Watson. 1991. endAFS, a novel family E endoglucanase gene from Fibrobacter succinogenes AR1. J. Bacteriol. 173: 3265-3268.
30. Chamorro, M., N. Parkin, and H. E. Varmus. 1992. An RNA pseudoknot and an optimal heptameric shift site are required for highly efficient ribosomal frameshifting on a retroviral messenger RNA. Proc. Natl. Acad. Sci. USA 89:713-717.
31. Chandler, M., and O. Fayet. 1993. Translational frameshifting in the control of transposition in bacteria. Mol. Microbiol. 7:497-503.
32. Chen, X., M. Chamorro, S. I. Lee, L. X. Shen, J. V. Hines, I. Tinoco, Jr., and H. E. Varmus. 1995. Structural and functional studies of retroviral RNA pseudoknots involved in ribosomal frameshifting: nucleotides at the junction of the two stems are important for efficient ribosomal frameshifting. EMBO J. 14:842-852.
33. Chu, F. K., G. F. Maley, F. Maley, and M. Belfort. 1984. Intervening sequence in the thymidylate synthase gene of bacteriophage T4. Proc. Natl. Acad. Sci. USA 81:3049-3053.
34. Clare, J., and P. J. Farabaugh. 1985. Nucleotide sequence of a yeast Ty element: evidence for an unusual mechanism of gene expression. Proc. Natl. Acad. Sci. USA 82:2829-2833.
35. Clare, J. J., M. Belcourt, and P. J. Farabaugh. 1988. Efficient translational frameshifting occurs within a conserved sequence of the overlap between the two genes of a yeast Ty1 transposon. Proc. Natl. Acad. Sci. USA 85:6816-6820.
36. Coffin, J. 1984. Structure of the retroviral genome, p. 261-368. in R. Weiss, N. Teich, H. Varmus, and J. Coffin (ed.). RNA tumor viruses: molecular biology of tumor viruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
37. Coffin, J. 1985. Structure of the retroviral genome, p. 17-73. In R. Weiss, N. Teich, H. Varmus, and J. Coffin (ed.). RNA tumor viruses: molecular biology of tumor viruses. Supplements and appendixes. Cold Spring Harbor Laboratory Press. Cold Spring Harbor. N.Y.
38. Condron, B. G., J. F. Atkins, and R. F. Gesteland. 1991. Frameshifting in gene 10 of baeteriophage T7. J. Bacteriol. 173:6998-7003.
39. Condron, B. G., R. F. Gesteland, and J. F. Atkins. 1991. An analysis of sequences stimulating frameshifting in the decoding of gene 10 of bacteriophage T7. Nucleic Acids Res, 19:5607-5612.
40. Craigen, W. J., and C. T. Caskey. 1986. Expression of peptide chain release factor 2 requires high-efficiency frameshift. Nature (London) 322:273-275.
41. Craigen, W. J., R. G. Cook, W. P. Tate, and C. T. Caskey. 1985. Bacterial peptide chain release factors: conserved primary structure and possible frameshift regulation of release factor 2. Proc. Natl. Acad. Sci. USA 82: 3616-3620.
42. Cui, Y., K. W. Hagan, S. Zhang, and S. W. Peltz. 1995. Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Genes Dev. 9:423-436.
43. Curran, J., and M. Yams. 1987. Reading frame selection and transfer RNA anticodon loop stacking. Science 238:1545-1550.
44. Curran, J., and M. Yarus. 1988. Use of tRNA suppressors to probe regulation of Escherichia coli release factor 2. J. Mol. Biol. 203:75-83.
45. Curran, J. F. 1993. Analysis of effects of tRNA:message stability on frameshift frequency at the Escherichia coli RF2 programmed frameshift site. Nucleic Acids Res. 21:1837-1843.
46. Curran, J. F., and M. Yarus. 1989. Rales of aminoacyl-tRNA selection at 29 sense codons in vivo. J. Mol. Biol. 209:65-77.
47. Danilevskaya, O., F. Slot, M. Pavlova, and M. L. Pardue. 1994. Structure of the Drosophila HeT-A transposon: a retrotransposon-like element forming telomeres. Chromosoma 103:215-224.
48. Dayhuff, T., J. Atkins, and R. Gesteland. 1986. Characterization of ribosomal frameshift events by protein sequence analysis. J. Biol. Chem. 261: 7491-7500.
49. den Boon, J. A., E. J. Snijder, E. D. Chirnside, A. A. de Vries, M. C. Horzinek, and W. J. Spaan. 1991. Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily. J. Virol. 65:2910-2920.
50. Denison, M. R., P. W. Zoltick, J. L. Leibowitz, C. J. Pachuk, and S. R. Weiss. 1991. Identification of polypeptides encoded in open reading frame 1b of the putative polymerase gene of the murine coronavirus mouse hepatitis virus A59. J. Virol. 65:3076-3082.
51. Dinman, J. 1995. Personal communication.
52. Dinman, J. D., T. Icho, and R. B. Wickner. 1991. A - 1 ribosomal frameshift in a double-stranded RNA virus of yeast forms a gag-pol fusion protein. Proc. Natl. Acad. Sci. USA 88:174-178.
53. Dinman, J. D., and R. B. Wickner. 1992. Ribosomal frameshifting efficiency and gag/gag-pol ratio are critical for yeast M, double-stranded RNA virus propagation. J. Virol. 66:3669-3676.
54. Dinman, J. D., and R. B. Wickner. 1994. Translational maintenance of frame: mutants of Saccharomyces cerevisiae with altered - 1 ribosomal frameshifting efficiencies. Genetics 136:75-86.
55. Dinman, J. D., and R. B. Wickner. 1995. 5S rRNA is involved in fidelity of translational reading frame. Genetics 141:95-105.
56. Donly, B. C., C. D. Edgar, F. M. Adamski, and W. P. Tate. 1990. Frameshift autoregulation in the gene for Escherichia coli release factor 2: partly functional mutants result in frameshift enhancement. Nucleic Acids Res. 18:6517-6522.
57. Dunn, J. J., and F. W. Studier. 1983. Complete nucleotide sequence of bacteriophage T7 DNA and the locations of T7 genetic elements. J. Mol. Biol. 166:477-535.
58. Eleouet, J. F., D. Rasschaert, P. Lambert, L. Levy, P. Vende, and H. Laude. 1995. Complete sequence (20 kilobases) of the polyprotein-encoding gene 1 of transmissible gastroenteritis virus. Virology 206:817-822.
59. Escoubas, J., M. Prere, O. Fayet, I. Salvignol, D. Galas, D. Zerbib, and M. Chandler. 1991. Translational control of transposition activity of the bacterial insertion sequence IS1. EMBO J. 10:705-712.
60. Falk, H., N. Mador, R. Udi, A. Panel, and A. Honigman. 1993. Two cis-acting signals control ribosomal frameshift between human T-cell leukemia virus type II gag and pro genes. J. Virol. 67:6273-6277.
61. Farabaugh, P. 1995. Post-transcriptional regulation of transposition by Ty retrotransposons of Saccharomyces cerevisiae. J. Biol. Chem. 270:10361-10364.
62. Farabaugh, P. J., H. Zhao, and A. Vimaladithan. 1993. A novel programed frameshift expresses the POL3 gene of retrotransposon Ty3 of yeast: frameshifting without tRNA slippage. Cell 74:93-103.
63. Fayet, O., M.-F. Prere, P. Polard, J. Atkins, and M. Chandler. 1994. Personal communication.
64. Flower, A. M., and C. S. McHenry. 1990. The gamma subunit of DNA polymerase III holoenzyme of Escherichia coli is produced by ribosomal frameshifting. Proc. Natl. Acad. Sci. USA 87:3713-3717.
65. Fong, W. F., J. S. Heller, and E. S. Canellakis. 1976. The appearance of an ornithine decarboxylase inhibitory protein upon the addition of putrescine to cell cultures. Biochim. Biophys. Acta 428:456-465.
66. Gafner, J., E. M. De Robertis, and P. Philippsen. 1983. δ sequences in the 5′ non-coding region of yeast tRNA genes. EMBO J. 2:583-591.
67. Gallant, J., and D. Foley, 1980. On the causes and prevention of mistranslation, p. 615-638. In O. Chambliss, G. Craven, R. Davies, J. Davis, J. Kahan, and M. Nomura (ed.), Ribosomes: structure, function and genetics. University Park Press, Baltimore.
68. Gallant, J. A., and D. Lindsley. 1992. Leftward ribosome frameshifting at a hungry codon. J. Mol. Biol. 223:31-40.
69. Gesteland, R., R. Weiss, and J. Atkins. 1992. Recoding: reprogrammed genetic decoding. Science 257:1640-1641.
70. Gnirke, A., U. Geigenmüller, H.-J. Rheinberger, and K. H. Nierhaus. 1989. The allosteric 3-site model of the ribosomal elongation cycle: analysis with a heteropolymeric mRNA. J. Biol. Chem. 264:7291-7301.
71. Godeny, E. K., L. Chen, S. N. Kumar, S. L. Methven, E. V. Koonin, and M. A. Brinton. 1993. Complete genomic sequence and phylogenetic analysis of the lactate dehydrogenase-elevating virus (LDV). Virology 194:585-596.
72. Gott, J. M., D. A. Shub, and M. Belfort. 1986. Multiple self-splicing introns in bacteriophage T4: evidence from autocatalytic GTP labeling of RNA in vitro. Cell 47:81-87.
73. Grindley, N., and C. Joyce. 1981. Analysis of the structure and function of the kanamycin-resistance transposon Tn903. Cold Spring Harbor Symp. Quant. Biol. 45:125-133.
74. Grosjean, H., S. DeHenau, and D. M. Crothers. 1978. On the physical basis for the ambiguity in genetic coding interactions. Proc. Natl. Acad. Sci. USA 75:610-614.
75. He, F., and A. Jacobson, 1995. Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev. 9:437-454.
76. Heller, J. S., W. F. Fong, and E. S. Canellakis. 1976. Induction of a protein inhibitor to ornithine decarboxylase by the end products of its reaction. Proc. Natl. Acad. Sci. USA 73:1858-1862.
77. Herbst, K., L. Nichols, R. Gesteland, and R. Weiss. 1994. A mutation in ribosomal protein L9 affects ribosomal hopping during translation of gene 60 from bacteriophage T4. Proc. Natl. Acad. Sci. USA 91:12525-12529.
78. Herold, J., and S. G. Siddell. 1993. An 'elaborated' pseudoknot is required for high frequency frameshifting during translation of HCV 229E polymerase mRNA. Nucleic Acids Res. 21:5838-5842.
79. Hinnebusch, A. G., and S. W. Liebman. 1991. Protein synthesis and translational control in Saccharomyces cerevisiae, p. 627-735. In J. R. Broach, J. R. Pringle, and E. W. Jones (ed.), The molecular biology of the yeast Saccharomyces, vol. 1. Genome dynamics, protein synthesis, and energetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
80. Hopfield, J. 1974. Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. Proc. Natl. Acad. Sci. USA 71:4135-4139.
81. Horsfield, J. A., D. N. Wilson, S. A. Mannering, F. M. Adamski, and W. P. Tate. 1995. Prokaryotic ribosomes recode the HIV-1 gag-pol - 1 frameshift sequence by an E/P site post-translocation simultaneous slippage mechanism. Nucleic Acids Res. 23:1487-1494.
82. Hryniewicz, M., and R. Vonder Haar. 1983. Polyamines enhance readthrough of the UGA termination codon in a mammalian messenger RNA. Mol. Gen. Genet. 190:336-343.
83. Huang, W. M., S.-Z. Ao, S. Casjens, R. Orlandi, R. Zeikus, R. Weiss, D. Winge, and M. Fang. 1988. A persistent untranslated sequence within bacteriophage T4 DNA topoisomerase gene 60. Science 239:1005-1012.
84. Hughes, D., J. F. Atkins, and S. Thompson. 1987. Mutants of elongation factor Tu promote ribosomal frameshifting and nonsense readthrough. EMBO J. 6:4235-4239.
85. Hui, A., and H. de Boer. 1987. Specialized ribosome system: preferential translation of a single mRNA species by a subpopulation of mutated ribosomes in Escherichia coli. Proc. Natl. Acad. Sci. USA 84:4762-4766.
86. Hyun, N. S., T. D. Copeland, M. Hatanaka, and S. Oroszlan. 1993. Characterization of ribosomal frameshifting for expression of pol gene products of human T-cell leukemia virus type I. J. Virol. 67:196-203.
87. Icho, T., and R. B. Wickner. 1989. The double-stranded RNA genome of yeast virus L-A encodes its own putative RNA polymerase by fusing two open reading frames. J. Biol. Chem. 264:6716-6723.
88. Igarashi, K., K. Kashiwagi, R. Aoki, M. Kojima, and S. Hirose. 1979. Comparative studies on the increase by polyamines of fidelity of protein synthesis in Escherichia coli and wheat germ cell-free systems. Biochem. Biophys. Res. Commun. 91:440-448.
89. Inglis, S., N. Rolley, and I. Brierley. 1990. The ribosomal frame-shift signal of infectious bronchitis virus, p. 603-610. In J. McCarthy and M. Tuite (ed.), Posttranscriptional control of gene expression. Springer-Verlag KG, Berlin.
90. Jacks, T., H. D. Madhani, F. R. Masiarz, and H. E. Varmus. 1988. Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region. Cell 55:447-458.
91. Jacks, T., M. D. Power, F. R. Masiarz, P. A. Luciw, P. J. Barr, and H. E. Varmus. 1988. Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature (London) 331:280-283.
92. Jacks, T., K. Townsley, H. E. Varmus, and J. Majors. 1987. Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins. Proc. Natl. Acad. Sci. USA 84:4298-4302.
93. Jacks, T., and H. E. Varmus. 1985. Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Science 230:1237-1242.
94. Jacob, W., M. Santer, and A. Dahlberg. 1987. A single base change in the Shine-Dalgarno region of 16S rRNA of Escherichia coli affects translation of many proteins. Proc. Natl. Acad. Sci. USA 84:4757-4761.
95. Jiang, B., S. S. Monroe, E. V. Koonin, S. E. Stine, and R. I. Glass. 1993. RNA sequence of astrovirus: distinctive genomic organization and a putative retrovirus-like ribosomal frameshifting signal that directs the viral replicase synthesis. Proc. Natl. Acad. Sci. USA 90:10539-10543.
96. Jørgenson, F., F. M. Adamski, W. P. Tate, and C. G. Kurland. 1993. Release factor-dependent false stops are infrequent in Escherichia coli. J. Mol. Biol. 230:41-50.
97. Kakegawa, T., E. Sato, S. Hirose, and K. Igarashi. 1986. Polyamine binding sites on Escherichia coli ribosomes. Arch. Biochem. Biophys. 251:413-420.
98. Kane, J. F., B. N. Violand, D. F. Curran, N. R. Staten, K. L. Duffin, and G. Bogosian. 1992. Novel in-frame two codon translational hop during synthesis of bovine placental lactogen in a recombinant strain of Escherichia coli. Nucleic Acids Res. 20:6707-6712.
99. Kastelein, R. A., E. Ramaut, W. Fiers, and J. VanDuin. 1982. Lysis gene expression of RNA phage MS2 depends on a frameshift event during translation of the overlapping coat protein gene. Nature (London) 295:35-41.
100. Kawakami, K., S. Pande, B. Faiola, D. P. Moore, J. D. Boeke, P. J. Farahaugh, J. N. Strathern, Y. Nakamura, and D. J. Garfinkel. 1993. A rare tRNA-Arg(CCU) that regulates Ty1 element ribosomal frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae. Genetics 135:309-320.
101. Kim, K. H., and S. A. Lommel. 1994. Identification and analysis of the site of - 1 ribosomal frameshifting in red clover necrotic mosaic virus. Virology 200:574-582.
102. Kleckner, N., T. Foster, M. Davis, S. Hanley-Way, S. Hailing, V. Lundblad, and K. Takeshita. 1981. Genetic organization of Tn4D and analysis of Tn10-associated excision events. Cold Spring Harbor Symp. Quant. Biol. 45:225-238.
103. Kolor, K., D. Lindsley, and J. A. Gallant. 1993. On the role of the P-site in leftward ribosome frameshifting at a hungry codon. J. Mol. Biol. 230:1-5.
104. Kozak, M. 1992. A consideration of alternative models for the initiation of translation in eukaryotes. Crit. Rev. Biochem. Mol. Biol. 27:385-402.
105. Kropinski, A. M., M. A. Farinha, and I. Jansons. 1994. Nucleotide sequence of the Pseudomonas aeruginosa insertion sequence IS222: another member of the IS3 family. Plasmid 31:222-228.
106. Kuhn, T. S. 1970. The structure of scientific revolutions. University of Chicago Press, Chicago.
107. Kurland, C. G. 1992. Translational accuracy and the fitness of bacteria. Annu. Rev. Genet. 26:29-50.
108. Larsen, B., N. M. Wills, R. F. Gesteland, and J. F. Atkins. 1994. rRNA-mRNA base pairing stimulates a programmed - 1 ribosomal frameshift. J. Bacteriol. 176:6842-6851.
109. Le, S. Y., J. H. Chen, and J. V. Maizel. 1989. Thermodynamic stability and statistical significance of potential stem-loop structures situated at the frameshift sites of retroviruses. Nucleic Acids Res. 17:6143-6152.
110. Lee, S., P. Kanda, R. Kennedy, and J. Walker. 1987. Relation of the Escherichia coli dnaX gene to its two products - the tau and gamma subunits of DNA polymerase III holoenzyme. Nucleic Acids Res. 15:7663-7675.
111. Lee, S., J. Umen, and H. Varmus. 1995. A genetic screen identifies cellular factors involved in retroviral - 1 frameshifting. Proc. Natl. Acad. Sci. USA 92:6587-6591.
112. Levin, M. E., R. W. Hendrix, and S. R. Casjens. 1993. A programmed translational frameshift is required for the synthesis of a bacteriophage lambda tail assembly protein. J. Mol. Biol. 234:124-139.
113. Lill, R., and W. Wintermeyer. 1987. Destabilization of codon-anticodon interaction in the ribosomal exit site. J. Mol. Biol. 196:137-148.
114. Lindsley, D., and J. A. Gallant. 1993. On the directional specificity of ribosome frameshifting at a hungry codon. Proc. Natl. Acad. Sci. USA 90:5469-5473.
115. Liu, L. F., C. C. Liu, and B. M. Alberts. 1979. T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication. Nature (London) 281:456-461.
116. Loftfield, R., E. Eigner, and A. Pastuszyn. 1981. The role of spermine in preventing misacylation by phenylalanyl-tRNA synthetase. J. Biol. Chem. 256:6729-6735.
117. Lovgren, T. N., A. Petersson, and R. B. Lofttield. 1978. The mechanism of aminoacylation of transfer ribonucleic acid. The role of magnesium and spermine in the synthesis of isoleucyl-tRNA. J. Biol. Chem. 253:6702-6710.
118. Lustig. F., P. Elias, T. Axberg, T. Samuelsson, I. Tittawella, and U. Lagerkvist. 1981. Codon reading and translational error: reading of the glutamine and lysine codons during protein synthesis in vitro. J. Biol. Chem 256:2635-2643.
119. Machida, Y., C. Machida, and E. Ohtsubo. 1984. Insertion element IS1 encodes two structural genes required for its transposition. J. Mol. Biol 177:229-245.
120. Madhani, H. D., T. Jacks, and H. E. Varmus. 1988. Signals for the expression of the HIV pol gene by ribosomal frameshifting, p. 119-125. In B. R. Franza, B. R. Cullen, and F. Wong-Staal (ed.), The control of human retrovirus gene expression. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
121. Mäkinen, K., V. Næss, T. Tamm, E. Truve, A. Aaspollu, and M. Saarma. 1995. The pulative replicase of the cocksfoot mottle sobemovirus is translated as a part of the polyprotein by - 1 ribosomal frameshift. Virology 207:566-571.
122. Manch-Citron, J., and J. London. 1994. Expression of the Prevotella loescheii adhesin gene (plaA) is mediated by a programmed frameshifting hop. J. Bacteriol. 176:1944-1948.
123. Marczinke, B., A. J. Bloys, T. D. Brown, M. M. Willcocks, M. J. Carter, and I. Brierley. 1994. The human astrovirus RNA-dependent RNA polymerase coding region is expressed by ribosomal frameshifting. J. Virol. 68:5588-5595.
124. Marczynski, B. 1985. The binding of spermine to polynucleotides and complementary oligonucleotides at near physiological ionic strength. Int. J. Biochem. 17:107-111.
125. Marlor, R. L., S. M. Parkhurst, and V. G. Corces. 1986. The Drosophila melanogaster gypsy transposable element encodes putative gene products homologous to retroviral proteins. Mol. Cell. Biol. 6:1129-1134.
126. Matsufuji, S., R. Kanamoto, Y. Murakami, and S. Hayashi. 1990. Monoclonal antibody studies on the properties and regulation of murine ornithine decarboxylase antizymes. J. Biochem. 107:87-91.
127. Matsufuji, S., T. Matsufuji, Y. Miyazaki, Y. Murakami, J. F. Atkins, R. F. Gesteland, and S, Hayashi. 1995. Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme. Cell 80:51-60.
128. Matsufuji, S., Y. Miyazaki, R. Kanamoto, T. Kameji, Y. Murakami, T. Baby, K. Fujita, T. Ohno, and S. Hayashi. 1990. Analyses of ornithine decarboxylase antizyme mRNA with a cDNA cloned from rat liver. J. Biochem. 108:365-371.
129. Matsushita, O., J. B. Russell, and D. B. Wilson. 1991. A Bacteroides ruminicola 1,4-β-D-endoglucanase is encoded in two reading frames. J. Bacteriol. 173:6919-6926.
130. Maurer, B., H. Bannert, G. Darai, and R. M. Flugel. 1988. Analysis of the primary structure of the long terminal repeat and the gag and pol genes of the human spumaretrovirus. J. Virol. 62:1590-1597.
131. McCann, P., C. Tardif, J. Hornsperger, and P. Böhlen. 1979. Two distinct mechanisms for ornithine decarboxylase regulation by polyamines in rat hepatoma cells. J. Cell. Physiol. 99:183-190.
132. McMurry, L. M., and I. D. Algranati. 1986. Effect of polyamines on translation fidelity in vivo. Eur. J. Biochem. 155:383-390.
133. Menninger, J. 1977. Ribosome editing and the error catastrophe hypothesis of cellular aging. Mech. Ageing Dev. 6:131-142.
134. Meulenberg, J. J., M. M. Hulst, E. J. de Meijer, P. L. Moonen, A. den Besten, E. P. de Kluyver, G. Wensvoort, and R. J. Moormann. 1993. Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV. Virology 192:62-72.
135. Miller, J. H., and A. M. Albertini. 1983. Effects of surrounding sequence on the suppression of nonsense codons. J. Mol. Biol. 164:59-71.
136. Miller, W. A., P. M. Waterhouse, and W. L. Gerlach. 1988. Sequence and organization of barley yellow dwarf virus genomic RNA. Nucleic Acids Res. 16:6097-6111.
137. Mitchell, J., G. Judd, A. Bareyal-Leyser, and S. Ling. 1994. Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells. Biochem. J. 299:19-22.
138. Miyazaki, Y., S. Matsufuji, and S. Hayashi. 1992. Cloning and characterization of a rat gene encoding ornithine decarboxylase antizyme. Gene 113:191-197.
139. Moazed, D., and H. F. Noller. 1989. Intermediate states in the movement of transfer RNA in the ribosome. Nature (London) 342:142-148.
140. Morch, M. D., and C. Benicourt. 1980. Polyamines stimulate suppression of amber termination codons in vitro by normal tRNAs. Eur. J. Biochem. 105:445-451.
141. Morikawa, S., and D. H. L. Bishop. 1992. Identification and analysis of the gag-pol ribosomal frameshift site of feline immunodeficiency virus. Virology 186:389-397.
142. Murakami, Y., S. Matsufuji, T. Kameji, S. Hayashi, K. Igarashi, T. Tamura, K. Tanaka, and A. Ichihara. 1992. Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination. Nature (London) 360:597-599.
143. Murakami, Y., S. Matsufuji, Y. Miyazaki, and S. Hayashi. 1992. Destabilization of ornithine decarboxylase by transfected antizyme gene expression in hepatoma tissue culture cells. J. Biol. Chem. 267:13138-13141.
144. Nam, S. H., T. D. Copeland, M. Hatanaka, and S. Oroszlan. 1993. Characterization of ribosomal frameshifting for expression of pol gene products of human T-cell leukemia virus type I. J. Virol. 67:196-203.
145. Naranda, T., and Z. Kucan. 1989. Effect of spermine on the efficiency and fidelity of the codon-specific binding of tRNA to the ribosomes. Eur. J. Biochem. 182:291-297.
146. Ninio, J. 1974. A semiquantitative treatment of missense and nonsense suppression in the strA and ram ribosomal mutants of Escherichia coli. Evaluation of some molecular parameters of translation in vitro. J. Mol. Biol. 84:297-313.
147. Oh, S. K., and P. Sarnow. 1993. Gene regulation: translational initiation by internal ribosome binding. Curr. Opin. Genet. Dev. 3:295-300.
148. Olins, P. O., and S. C. Lee. 1993. Recent advances in heterologous gene expression in Escherichia coli. Curr. Opin. Biotechnol. 4:520-525.
149. Oppenheim, D., and C. Yanofsky. 1980. Translational coupling during expression of the tryptophan operon of Escherichia coll. Genetics 95:785-795.
150. Palmer, E., J. M. Wilhelm, and F. Sherman. 1979. Phenotypic suppression of nonsense mutants in yeast by aminoglycoside antibiotics. Nature (London) 277:148-150.
151. Pande, S., A. Vimaladithan, H. Zhao, and P. J. Farabaugh. 1995. Pulling the ribosome out of frame +1 at a programmed frameshift site by cognate binding of aminoacyl-tRNA. Mol. Cell. Biol. 15:298-304.
152. Parker, J. 1989. Errors and alternatives in reading the universal genetic code. Microbiol. Rev. 53:273-298.
153. Parkin, N. T., M. Chamorro, and H. E. Varmus. 1992. Human immunodeficiency virus type 1 gag-pol frameshifting is dependent on downstream mRNA secondary structure: demonstration by expression in vivo. J. Virol. 66:5147-5151.
154. Pedersen, S. 1984. Escherichia coli ribosomes translate in vivo with variable rate. EMBO J. 3:2895-2898.
155. Pedersen, W. T., and J. F. Curran. 1991. Effects of the nucleotide 3′ to an amber codon on ribosomal selection rates of suppressor tRNA and release factor-1. J. Mol. Biol. 219:231-241.
156. Pegg, A. 1986. Recent advances in the biochemistry of polyamines in eukaryotes. Biochem. J. 234:249-262.
157. Peter, K., D. Lindsley, L. Peng, and J. A. Gallant. 1992. Context rules of rightward overlapping reading. New Biol. 4:520-526.
158. Pinto, I., J. G. Na, F. Sherman, and M. Hampsey. 1992. cis- and trans-acting suppressors of a translation initiation defect at the cyc1 locus of Saccharomyces cerevisiae. Genetics 132:97-112.
159. Pleij, C. W., K. Rietveld, and L. Bosch. 1985. A new principle of RNA folding based on pseudoknotting. Nucleic Acids Res. 13:1717-1731.
160. Polard, P., M. F. Prère, M. Chandler, and O. Fayet. 1991. Programmed translational frameshifting and initiation at an AUU codon in gene expression of bacterial insertion sequence IS911. J. Mol. Biol. 222:465-477.
161. Prère, M.-F., M. Chandler, and O. Fayet. 1990. Transposition in Shigella dysenteriae: isolation and analysis of IS911, a new member of the IS3 group of insertion sequences. J. Bacteriol. 172:4090-4099.
162. Priimagi, A. F., L. J. Mizrokhi, and Y. V. Ilyin. 1988. The Drosophila mobile element jockey belongs to LINEs and contains coding sequences homologous to some retroviral proteins. Gene 70:253-262.
163. Prüfer, D., E. Tacke, J. Schmitz, B. Kull, A. Kaufmann, and W. Rohde. 1992. Ribosomal frameshifting in plants: a novel signal directs the - 1 frameshift in the synthesis of the putative viral replicase of potato leafroll luteovirus. EMBO J. 11:1111-1117.
164. Quigley, G. J., and A. Rich. 1976. Structural domains of transfer RNA molecules. Science 194:796-806.
165. Randerath, E., R. C. Gupta, L. L. S. Y. Chia, S. H. Chang, and K. Randerath. 1979. Yeast tRNALEU/UAG. Purification, properties, and determination of the nucleotide sequence by radioactive derivative methods. Eur. J. Biochem. 93:79-94.
166. Rezsohazy, R., B. Hallet, J. Mahillon, and J. Delcour. 1993. IS231V and W from Bacillus thuringiensis subsp. israelensis, two distant members of the IS231 family of insertion sequences. Plasmid 30:141-149.
167. Rheinberger, H.-J., U. Geigenmüller, A. Gnirke, T.-P. Hausner, J. Remme, H. Saruyama, and K. H. Nierhaus. 1990. Allosteric three-site model for the ribosomal elongation cycle, p. 318-330. In W. E. Hill, A. Dahlberg, R. A. Garrett, P. B. Moore, D. Schlessinger, and J. R. Warner (ed.), The ribosome: structure, function, and evolution. American Society for Microbiology, Washington, D.C.
168. Riddle, D., and J. Carbon. 1973. Frameshift suppression: a nucleotide addition in the anticodon of a glycine tRNA. Nature (London) New Biol. 242:230-234.
169. Riyasaty, S., and J. Atkins. 1968. External suppression of a frameshift mutation in Salmonella. J. Mol. Biol. 34:541-557.
170. Rom, E., and C. Kahana. 1994. Polyamines regulate the expression of ornithine decarboxylase antizyme in vitro by inducing ribosomal frameshifting. Proc. Natl. Acad. Sci. USA 91:3959-3963.
171. Rothstein, S., R. Jorgensen, J. Yin, Z. Yong-di, R. Johnson, and W. Reznikoff. 1981. Genetic organization of Tn5. Cold Spring Harbor Symp. Quant. Biol. 45:99-105.
172. '72. Sacerdot, C., G. Fayat, P. Dessen, M. Springer, J. A. Plumbridge, M. Grunberg-Manago, and S, Blanquet. 1982. Sequence of 1.26 kb DNA fragment containing the structural gene for E. coli initiation factor IF-3: presence of an AUU initiator codon. EMBO J. 1:311-315.
173. Saigo, K., W. Kugimiya, Y. Matsuo, S. Inouye, K. Yoshioka, and S, Yuki. 1984. Identification of the coding sequence for a reverse transcriptase-like enzyme in a transposable genetic element in Drosophila melanogaster. Nature (London) 312:659-661.
174. Sandbaken, M. G., and M. R. Culbertson. 1988. Mutations in elongation factor EF-1α affect the frequency of frameshifting and amino acid misincorporation in Saccharomvces cerevisiae. Genetics 120:923-934.
175. Schumperli, D., K. McKenney, D. Sobieski, and M. Rosenberg. 1982. Translational coupling at an intercistronic boundary of the Escherichia coli galactose operon. Cell 30:865-871.
176. Sekine, Y., and E. Ohtsubo. 1989. Frameshifting is required for production of the transposase encoded by insertion sequence 1. Proc. Natl. Acad. Sci. USA 86:4609-4613.
177. Sekine, Y., N. Eisaki, and E. Ohtsubo. 1994. Translational control in production of transposase and in transposition of insertion sequence IS3. J. Mol. Biol. 235:1406-1420.
178. Sekine, Y., H. Nagasawa, and E. Ohtsubo. 1992. Identification of the site of translational frameshifting required for production of the transposase encoded by insertion sequence IS1. Mol. Gen. Genet. 235:317-324.
179. Sekine, Y., and E. Ohtsubo. 1992. DNA sequences required for translational frameshifting in production of the transposase encoded by IS1. Mol. Gen. Genet. 235:325-332.
180. Sekiya, T., K. Takeishi, and T. Ukita. 1969. Specificity of yeast glutamic acid transfer RNA for codon recognition. Biochim. Biophys. Acta 182:411-426.
181. Shen, L. X., and I. Tinoco, Jr. 1995. The structure of an RNA pseudoknot that causes efficient frameshifting in mouse mammary tumor virus. J. Mol. Biol. 247:963-978.
182. Shine, J., and L. Dalgarno. 1974. The 3′-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. Proc. Natl. Acad. Sci. USA 71:1342-1346.
183. Shub, D. A., J. M. Gott, M. Q. Xu, B. F. Lang, F. Michel, J. Tomaschewski, J. Pedersen-Lane, and M. Belfort. 1988. Structural conservation among three homologous introns of bacteriophage T4 and the group I introns of eukaryotes. Proc. Natl. Acad. Sci. USA 85:1151-1155.
184. Singh, A., D. Ursic, and J. Davies. 1979. Phenotypic suppression and misreading in Saccharomyces cerevisiae. Nature (London) 277:146-148.
185. Sjoberg, B. M., S. Hahne, C. Z. Mathews, C. K. Mathews, K. N. Rand, and M. J. Gait. 1986. The bacteriophage T4 gene for the small subunit of ribonucleotide reductase contains an intron. EMBO J. 5:2031-2036.
186. Snijder, E. J., J. A. den Boon, P. J. Bredenbeek, M. C. Horzinek, R. Rijnbrand, and W. J. Spaan. 1990. The carboxyl-terminal part of the putative Berne virus polymerase is expressed by ribosomal frameshifting and contains sequence motifs which indicate that toro- and coronaviruses are evolutionarily related. Nucleic Acids Res. 18:4535-4542.
187. Somogyi, P., A. J. Jenner, I. Brierley, and S. C. Inglis. 1993. Ribosomal pausing during translation of an RNA pseudoknot. Mol. Cell. Biol. 13: 6931-6940.
188. Steibl, H. D., and F. M. Lewecke. 1995. IS1222: analysis and distribution of a new insertion sequence in Enterobacter agglomerans 339. Gene 156:37-42.
189. Steinberg, S., A. Misch, and M. Sprinzl. 1993. Compilation of tRNA sequences and sequences of tRNA genes. Nucleic Acids Res. 21:3011-3015.
190. Stetler, G. L., G. J. King, and W. M. Huang. 1979. T4 DNA-delay proteins, required for specific DNA replication, form a complex that has ATP-dependent DNA topoisomerase activity. Proc. Natl. Acad. Sci. USA 76: 3737-3741.
191. Suzuki, T., Y. He, K. Kashiwagi, Y. Murakami, S.-I. Hayashi, and K. Igarashi. 1994. Antizyme protects against abnormal accumulation and toxicity of polyamines in ornithine decarboxylase-overproducing cells. Proc. Natl. Acad. Sci. USA 91:8930-8934.
192. ten Dam, E., I. Brierley, S. Inglis, and C. Pleij. 1994. Identification and analysis of the pseudoknot-containing gag-pro ribosomal frameshift signal of simian retrovirus-1. Nucleic Acids Res. 22:2304-2310.
193. ten Dam, E., C. Pleij, and L. Bosch. 1990. RNA pseudoknots: translational frameshifting and readthrough of viral RNAs. Virus Genes 4:121-136.
194. ten Dam, E., P. Verlaan, and C. Pleij. 1995. Analysis of the role of the pseudoknot component in the SRV-1 gag-pro ribosomal frameshift signal: loop lengths and stability of the stem regions. RNA 1:146-154.
195. Thomas, L. K., D. B. Dix, and R. C. Thompson. 1988. Codon choice and gene expression: synonymous codons differ in their ability to direct aminoacylated-transfer RNA binding to ribosomes in vitro. Proc. Natl. Acad. Sci. USA 85:4242-4246.
196. Thompson, R. 1988. EFTu provides an internal kinetic standard for translational accuracy. Trends Biochem. Sci. 13:91-93.
197. Thompson, R. C., D. B. Dix, and J. F. Eccleston. 1980. Single turnover kinetic studies of guanosine triphosphate hydrolysis and peptide formation in the elongation factor Tu-dependent binding of aminoacyl-tRNA to Escherichia coli ribosomes. J. Biol. Chem. 255:11088-11090.
198. Tokunaga, F., T. Goto, T. Koide, Y. Murakami, S. Hayashi, T. Tamura, K. Tanaka, and A. Ichihara. 1994. ATP- and antizyme-dependent endoproteolysis of ornithine decarboxylase to oligopeptides by the 26 S proteasome. J. Biol. Chem. 269:17382-17385.
199. Tsuchihashi, Z. 1991. Translational frameshifting in the Escherichia coli dnaX gene in vitro. Nucleic Acids Res. 19:2457-2462.
200. Tsuchihashi, Z., and P. O. Brown. 1992. Sequence requirements for efficient translational frameshifting in the Escherichia coli dnaX gene and the role of an unstable interaction between tRNALys and an AAG lysine codon. Genes Dev. 6:511-519.
201. Tsuchihashi, Z., and A. Kornberg. 1990. Translational frameshifting generates the gamma subunit of DNA polymerase III holoenzyme. Proc. Natl. Acad. Sci. USA 87:2516-2520.
202. Tu, C., T. H. Tzeng, and J. A. Bruenn. 1992. Ribosomal movement impeded at a pseudoknot required for frameshifting. Proc. Natl. Acad. Sci. USA 89:8636-8640.
203. Türkel, S., and P. Farabaugh. Unpublished data.
204. Turner, D. H., and N. Sugimoto. 1988. RNA structure prediction. Annu. Rev. Biophys. Biophys. Chem. 17:167-192.
205. Tzeng, T.-H., C.-L. Tu, and J. A. Bruenn. 1992. Ribosomal frameshifting requires a pseudoknot in the Saccharomyces cerevisiae double-stranded RNA virus. J. Virol. 66:999-1006.
206. Van Ryk, D., Y. Lee, and R. Nazar. 1990. Efficient expression and utilization of a mutant 5S rRNA in Saccharomyces cerevisiae. J. Biol. Chem. 265:8377-8381.
207. Varenne, S., and C. Lazdunski. 1986. Effect of distribution of unfavourable codons on the maximum rate of gene expression by an heterologous organism. J. Theor. Biol. 120:99-110.
208. Vimaladithan, A., and P. J. Farabaugh. 1994. Special peptidyl-tRNA molecules promote translational frameshifting without slippage. Mol. Cell. Biol. 14:8107-8116.
209. Vögele, K., E. Schwartz, C. Welz, E. Schiltz, and B. Rak. 1991. High-level ribosomal frameshifting directs the synthesis of IS150 gene products. Nucleic Acids Res. 19:4377-4385.
210. Walker, D. C., and T. R. Klaenhammer. 1994. Isolation of a novel IS3 group insertion element and construction of an integration vector for Lactobacillus spp. J. Bacteriol. 176:5330-5340.
211. Wang, A. L., H. M. Yang, K. A. Shen, and C. C. Wang. 1993. Giardiavirus double-stranded RNA genome encodes a capsid polypeptide and a gag-pol-like fusion protein by a translation frameshift. Proc. Natl. Acad. Sci. USA 90:8595-8599.
212. Watanabe, K., N. Hayashi, A. Oyama, K. Nishikawa, T. Ueda, and K. Miura. 1994. Unusual anticodon loop structure found in E. coli lysine tRNA. Nucleic Acids Res. 22:79-87.
213. Weiss, R., D. Dunn, A. Dahlberg, J. Atkins, and R. Gesteland. 1988. Reading frame switch caused by base-pair formation between the 3′ end of 16S rRNA and the mRNA during elongation of protein synthesis in Escherichia coli. EMBO J. 7:1503-1507.
214. Weiss, R., and J. Gallant. 1983. Mechanism of ribosome frameshifting during translation of the genetic code. Nature (London) 302:389-393.
215. Weiss, R., and J. Gallant. 1986. Frameshift suppression in aminoacyl-tRNA limited cells. Genetics 112:727-739.
216. Weiss, R., W. Huang, and D. Dunn. 1990. A nascent peptide is required for ribosomal bypass of the coding gap in bacteriophage T4 gene 60. Cell 62:117-126.
217. Weiss, R. B., D. M. Dunn, J. F. Atkins, and R. F. Gesteland. 1987. Slippery runs, shifty stops, backward steps, and forward hops: -2, -1, +1, +2, +5, and +6 ribosomal frameshifting. Cold Spring Harbor Symp. Quant. Biol. 52:687-693.
218. Weiss, R. B., D. M. Dunn, M. Shuh, J. F. Atkins, and R. F. Gesteland. 1989. E. coli ribosomes re-phase on retroviral frameshift signals at rates ranging from 2 to 50 percent. New Biol. 1:159-169.
219. Weiss, R. B., D. Lindsley, B. Falahee, and J. Gallant. 1988. On the mechanism of ribosomal frameshifting at hungry codons. J. Mol. Biol. 203:403-410.
220. Willcocks, M. M., T. D. Brown, C. R. Madeley, and M. J. Carter. 1994. The complete sequence of a human astrovirus. J. Gen. Virol. 75:1785-1788.
221. Wilson, W., M. Braddock, S. E. Adams, P. Rathjen, S. Kingsman, and A. Kingsman. 1988. HIV expression strategies: ribosomal frameshifting is directed by a short sequence in both mammalian and yeast systems. Cell 55:1159-1169.
222. Wilson, W., M. H. Malim, J. Mellor, A. J. Kingsman. and S. M. Kingsman. 1986. Expression strategies of the yeast retrotransposon Ty: a short sequence directs ribosomal frameshifting. Nucleic Acids Res. 14:7001-7016.
223. Wintermeyer, W., R. Lill, and J. M. Robertson. 1990. Role of the tRNA exit site in ribosomal translocation, p. 348-357. In W. E. Hill, A. Dahlberg, R. A. Garrett, P. B. Moore, D. Schlessinger, and J. R. Warner (ed.). The ribosome: structure, function, and evolution. American Society for Microbiology, Washington, D.C.
224. Wolin, S. L., and P. Walter. 1988. Ribosome pausing and stacking during translation of a eukaryotic mRNA. EMBO J. 7:3559-3569.
225. Wyatt, J. R., J. D. Puglisi, and I. Tinoco, Jr. 1990. RNA pseudoknots. Stability and loop size requirements. J. Mol. Biol. 214:455-470.
226. Xiong, Z., and S. A. Lommel. 1989. The complete nucleotide sequence and genome organization of red clover necrotic mosaic virus RNA-1. Virology 171:543-554.
227. Xu, H., and J. D. Boeke. 1990. Host genes that influence transposition in yeast: the abundance of a rare tRNA regulates Ty1 transposition frequency. Proc. Natl. Acad. Sci. USA 87:8360-8364.
228. Yarns, M., S. W. Cline, P. Wier, L. Breeden, and R. C. Thompson. 1986. Actions of the anticodon arm in translation on the phenotypes of RNA mutants. J. Mol. Biol. 192:235-255.
229. Yelverton, E., D. Lindsley, P. Yamauchi, and J. Gallant. 1994. The function of a ribosomal frameshifting signal from human immunodeficiency virus-1 in Escherichia coli. Mol. Microbiol. 11:303-313.
230. Yokoyama, S., T. Watanabe, K. Murao, H. Ishikura, Z. Yamaizumi, S. Nishimura, and T. Miyazawa. 1985. Molecular mechanism of codon recognition by tRNA species with modified uridine in the first position of the codon. Proc. Natl. Acad. Sci. USA 82:4905-4909.