Functional and molecular expression of the proton-coupled oligopeptide transporters in spleen and macrophages from mouse and human

Molecular Pharmaceutics

Volumn 10, Issue 4, 2013, Pages 1409-1416

  Sun, Dongli ^a   Wang, Yuqing ^a   Tan, Fuqing ^b   Fang, Danbo ^b   Hu, Yongjun ^c   Smith, David E ^c   Jiang, Huidi ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

expression; function; NOD; PepT2; POTs; spleen

Indexed keywords

ALANINE; CARNOSINE; DIAMINOPIMELIC ACID; GLYCYLSARCOSINE; HISTIDINE; LYSINE; MESSENGER RNA; MURAMYL DIPEPTIDE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; PEPTIDE TRANSPORTER 1; PEPTIDE TRANSPORTER 2; PEPTIDOMIMETIC AGENT; PROTEIN; PROTEIN PHT1; PROTEIN PHT2; TRANEXAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; INNATE IMMUNITY; KINETICS; LYMPHOCYTE; MACROPHAGE; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALS; CELL LINE, TUMOR; DIPEPTIDES; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; INFLAMMATION; KINETICS; LYMPHOCYTES; MACROPHAGES; MICE; MICE, INBRED ICR; OLIGOPEPTIDES; PEPTIDOMIMETICS; RABBITS; REAL-TIME POLYMERASE CHAIN REACTION; SPECIES SPECIFICITY; SPLEEN; SYMPORTERS;

EID: 84875783127     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300700p     Document Type: Article

References (26)

1. Rubio-Aliaga, I.; Daniel, H. Peptide transporters and their roles in physiological processes and drug disposition Xenobiotica 2008, 38 (7-8) 1022-1042
2. Brandsch, M.; Knutter, I.; Bosse-Doenecke, E. Pharmaceutical and pharmacological importance of peptide transporters J. Pharm. Pharmacol. 2008, 60 (5) 543-585
3. Smith, D. E.; ClémencÌon, B.; Hediger, M. A. Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications. Mol. Aspects. Med., in press.
4. Jappar, D.; Wu, S. P.; Hu, Y.; Smith, D. E. Significance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: in situ single-pass perfusion studies in wild-type and Pept1 knockout mice Drug. Metab. Dispos. 2010, 38, 1740-1746
5. Shen, H.; Smith, D. E.; Yang, T.; Huang, Y. G.; Schnermann, J. B.; Brosius, F. C., III. Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney Am. J. Physiol. 1999, 276, F658-F665
6. Berger, U. V.; Hediger, M. A. Distribution of peptide transporter PEPT2 mRNA in the rat nervous system Anat. Embryol. 1999, 199 (5) 439-449
7. Shen, H.; Smith, D. E.; Keep, R. F.; Brosius, F. C., III. Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain Mol. Pharmaceutics 2004, 1 (4) 248-256
8. Groneberg, D. A.; Nickolaus, M.; Springer, J.; Doring, F.; Daniel, H.; Fischer, A. Localization of the peptide transporter PEPT2 in the lung-Implications for pulmonary oligopeptide uptake Am. J. Pathol. 2001, 158 (2) 707-714
9. Yamashita, T.; Shimada, S.; Guo, W.; Sato, K.; Kohmura, E.; Hayakawa, T.; Takagi, T.; Tohyama, M. Cloning and functional expression of a brain peptide/histidine transporter J. Biol. Chem. 1997, 272 (15) 10205-10211
10. Sakata, K.; Yamashita, T.; Maeda, M.; Moriyama, Y.; Shimada, S.; Tohyama, M. Cloning of a lymphatic peptide/histidine transporter Biochem. J. 2001, 356 (Pt 1) 53-60
11. Dalmasso, G.; Nguyen, H. T.; Ingersoll, S. A.; Ayyadurai, S.; Laroui, H.; Charania, M. A.; Yan, Y.; Sitaraman, S. V.; Merlin, D. The PepT1-NOD2 signaling pathway aggravates induced colitis in mice Gastroenterology 2011, 141 (4) 1334-1345
12. Dalmasso, G.; Nguyen, H. T.; Charrier-Hisamuddin, L.; Yan, Y.; Laroui, H.; Demoulin, B.; Sitaraman, S. V.; Merlin, D. PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells Am. J. Physiol. Gastrointest. Liver. Physiol. 2010, 299 (3) G687-696
13. Inohara, N.; Nunez, G. NODs: intracellular proteins involved in inflammation and apoptosis Nat. Rev. Immunol. 2003, 3 (5) 371-382
14. Marina-Garcia, N.; Franchi, L.; Kim, Y. G.; Hu, Y.; Smith, D. E.; Boons, G. J.; Nunez, G. Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation J. Immunol. 2009, 182 (7) 4321-4327
15. Mebius, R. E.; Kraal, G. Structure and function of the spleen Nat. Rev. Immunol. 2005, 5 (8) 606-616
16. Döring, F.; Walter, J.; Will, J.; Focking, M.; Boll, M.; Amasheh, S.; Clauss, W.; Daniel, H. Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications J. Clin. Invest. 1998, 101, 2761-2767
17. Herrera-Ruiz, D.; Wang, Q.; Gudmundsson, O. S.; Cook, T. J.; Smith, R. L.; Faria, T. N.; Knipp, G. T. Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 in vitro cell culture model, and multiple human tissues AAPS PharmSci 2001, 3 (1) E9
18. Hu, Y.; Smith, D. E.; Ma, K.; Jappar, D.; Thomas, W.; Hillgren, K. M. Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine Mol. Pharmaceutics 2008, 5 (6) 1122-1130
19. Sun, D.; Tan, F.; Fang, D.; Wang, Y.; Zeng, S.; Jiang, H. Expression of proton-coupled oligopeptide transporter (POTs) in prostate of mice and patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa) Prostate 2013, 73, 287-295
20. Xu, G. J.; Hannappel, E.; Morgan, J.; Hempstead, J.; Horecker, B. L. Synthesis of thymosin beta 4 by peritoneal macrophages and adherent spleen cells Proc Natl. Acad. Sci. U.S.A. 1982, 79 (13) 4006-4009
21. Wenzel, U.; Diehl, D.; Herget, M.; Daniel, H. Endogenous expression of the renal high-affinity H+-peptide cotransporter in LLC-PK1 cells Am. J. Physiol. 1998, 275 (6 Pt 1) C1573-C1579
22. Sasawatari, S.; Okamura, T.; Kasumi, E.; Tanaka-Furuyama, K.; Yanobu-Takanashi, R.; Shirasawa, S.; Kato, N.; Toyama-Sorimachi, N. The Solute Carrier Family 15A4 Regulates TLR9 and NOD1 Functions in the Innate Immune System and Promotes Colitis in Mice Gastroenterology 2011, 140 (5) 1513-1525
23. Moreau, A.; Le Vee, M.; Jouan, E.; Parmentier, Y.; Fardel, O. Drug transporter expression in human macrophages Fundam. Clin. Pharmacol. 2011, 25 (6) 743-752
24. Strober, W.; Murray, P. J.; Kitani, A.; Watanabe, T. Signalling pathways and molecular interactions of NOD1 and NOD2 Nat. Rev. Immunol. 2006, 6 (1) 9-20
25. Vavricka, S. R.; Musch, M. W.; Chang, J. E.; Nakagawa, Y.; Phanvijhitsiri, K.; Waypa, T. S.; Merlin, D.; Schneewind, O.; Chang, E. B. hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells Gastroenterology 2004, 127 (5) 1401-1409
26. Swaan, P. W.; Bensman, T.; Bahadduri, P. M.; Hall, M. W.; Sarkar, A.; Bao, S.; Khantwal, C. M.; Ekins, S.; Knoell, D. L. Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2 Am. J. Respir. Cell Mol. Biol. 2008, 39 (5) 536-542