Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages

Immunity

Volumn 40, Issue 4, 2014, Pages 554-568

  Coulombe, François ^a   Jaworska, Joanna ^a   Verway, Mark ^a   Tzelepis, Fanny ^a   Massoud, Amir ^a   Gillard, Joshua ^a   Wong, Gary ^b   Kobinger, Gary ^b   Xing, Zhou ^c   Couture, Christian ^d   Joubert, Philippe ^d   Fritz, Jörg H ^e   Powell, William S ^a   Divangahi, Maziar ^a  

^a MCGILL UNIVERSITY   (Canada)

^b PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

^d LAVAL UNIVERSITY   (Canada)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CXCL1 CHEMOKINE; CXCL9 CHEMOKINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 12P40; INTERLEUKIN 13; LEUKOTRIENE B4; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 5; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 3; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; RAG1 PROTEIN; ISOMERASE; PROSTAGLANDIN E SYNTHASE;

ADAPTIVE IMMUNITY; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; EPITHELIUM CELL; HUMAN; HUMAN CELL; INFLUENZA A (H1N1); INFLUENZA A VIRUS (A/PUERTO RICO/8/1934(H1N1)); INNATE IMMUNITY; INTERFERON INDUCTION; MACROPHAGE; MONOCYTE; MORTALITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS LOAD; VIRUS REPLICATION; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNITY; IMMUNOLOGY; INFLUENZA VIRUS A; KNOCKOUT MOUSE; METABOLISM; MOLECULARLY TARGETED THERAPY; ORTHOMYXOVIRUS INFECTION; PHYSIOLOGY; T LYMPHOCYTE; VIROLOGY;

ANIMALS; ANTIGEN PRESENTATION; APOPTOSIS; CELLS, CULTURED; DINOPROSTONE; GENE EXPRESSION REGULATION; IMMUNITY; INFLUENZA A VIRUS; INTERFERON TYPE I; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR TARGETED THERAPY; ORTHOMYXOVIRIDAE INFECTIONS; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; T-LYMPHOCYTES; VIRUS REPLICATION;

EID: 84898683719     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2014.02.013     Document Type: Article

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