Endogenous myeloperoxidase is a mediator of joint inflammation and damage in experimental arthritis

Arthritis and Rheumatology

Volumn 66, Issue 4, 2014, Pages 907-917

  Odobasic, Dragana ^a   Yang, Yuan ^a   Muljadi, Ruth C M ^a   O'Sullivan, Kim M ^a   Kao, Wenping ^a   Smith, Malcolm ^b   Morand, Eric F ^a   Holdsworth, Stephen R ^a  

^a MONASH UNIVERSITY   (Australia)

^b REPATRIATION GENERAL HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; MYELOPEROXIDASE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; EXPERIMENTAL ARTHRITIS; FIBROBLAST; IMMUNE RESPONSE; JOINT BIOPSY; KNOCKOUT MOUSE; LYMPHOID ORGAN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN CELL;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; DISEASE PROGRESSION; INFLAMMATION; JOINTS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEROXIDASE; SYNOVIAL MEMBRANE;

EID: 84898658937     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38299     Document Type: Article

References (46)

1. Kinne RW, Brauer R, Stuhlmuller B, Palombo-Kinne E, Burmester GR,. Macrophages in rheumatoid arthritis. Arthritis Res 2000; 2: 189-202.
2. Pillinger M, Abramson S,. The neutrophil in rheumatoid arthritis. Rheum Dis Clin North Am 1995; 21: 691-714.
3. Skapenko A, Leipe J, Lipsky P, Schulze-Koops H,. The role of the T cell in autoimmune inflammation. Arthritis Res Ther 2005; 7: S4-14.
4. Weyand C, Seyler T, Goronzy J,. B cells in rheumatoid synovitis. Arthritis Res Ther 2005; 7: S9-12.
5. Allen J, Wong H, Costa G, Bienkowski M, Wahl S,. Suppression of monocyte function and differential upregulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis. J Immunol 1993; 151: 4344-51.
6. Mauri C, Chu CQ, Woodrow D, Mori L, Londei M,. Treatment of a newly established transgenic model of chronic arthritis with nondepleting anti-CD4 monoclonal antibody. J Immunol 1997; 159: 5032-41.
7. Svensson L, Jirholt J, Holmdahl R, Jansson L,. B cell-deficient mice do not develop type II collagen-induced arthritis (CIA). Clin Exp Immunol 1998; 111: 521-6.
8. Kraan MC, de Koster BM, Elferink JG, Post WJ, Breedveld FC, Tak PP,. Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients. Arthritis Rheum 2000; 43: 1488-95.
9. Paleolog EM, Hunt M, Elliott MJ, Feldmann M, Maini RN, Woody JN,. Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor α antibody in rheumatoid arthritis. Arthritis Rheum 1996; 39: 1082-91.
10. Eyles JL, Hickey MJ, Norman MU, Croker BA, Roberts AW, Drake SF, et al. A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis. Blood 2008; 112: 5193-201.
11. Wipke BT, Allen PM,. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol 2001; 167: 1601-8.
12. Klebanoff SJ,. Myeloperoxidase: friend and foe. J Leukoc Biol 2005; 77: 598-625.
13. Davies MJ, Hawkins CL, Pattison DI, Rees MD,. Mammalian heme peroxidases: from molecular mechanisms to health implications. Antioxid Redox Signal 2008; 10: 1199-234.
14. Askari AT, Brennan ML, Zhou X, Drinko J, Morehead A, Thomas JD, et al. Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction. J Exp Med 2003; 197: 615-24.
15. Haegens A, Heeringa P, van Suylen RJ, Steele C, Aratani Y, O'Donoghue RJ, et al. Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production. J Immunol 2009; 182: 7990-6.
16. Odobasic D, Kitching AR, Semple TJ, Holdsworth SR,. Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis. J Am Soc Nephrol 2007; 18: 760-70.
17. Brennan M, Gaur A, Pahuja A, Lusis AJ, Reynolds WF,. Mice lacking myeloperoxidase are more susceptible to experimental autoimmune encephalomyelitis. J Neuroimmunol 2001; 112: 97-105.
18. Odobasic D, Kitching AR, Yang Y, O'Sullivan KM, Muljadi RC, Edgtton KL, et al. Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function. Blood 2013; 121: 4195-204.
19. Edwards S, Hughes V, Barlow J, Bucknall R,. Immunological detection of myeloperoxidase in synovial fluid from patients with rheumatoid arthritis. Biochem J 1988; 250: 81-5.
20. Stamp LK, Khalilova I, Tarr JM, Senthilmohan R, Turner R, Haigh RC, et al. Myeloperoxidase and oxidative stress in rheumatoid arthritis. Rheumatology (Oxford) 2012; 51: 1796-803.
21. Rocha FA, Leite AK, Pompeu MM, Cunha TM, Verri WA Jr, Soares FM, et al. Protective effect of an extract from Ascaris suum in experimental arthritis models. Infect Immun 2008; 76: 2736-45.
22. Lefkowitz D, Gelderman M, Fuhrmann S, Graham S, Starnes J, Lefkowitz S, et al. Neutrophilic myeloperoxidase-macrophage interactions perpetuate chronic inflammation associated with experimental arthritis. Clin Immunol 1999; 91: 145-55.
23. Nguyen HX, Lusis AJ, Tidball JG,. Null mutation of myeloperoxidase in mice prevents mechanical activation of neutrophil lysis of muscle cell membranes in vitro and in vivo. J Physiol 2005; 565: 403-13.
24. Santos LL, Fan H, Hall P, Ngo D, Mackay CR, Fingerle-Rowson G, et al. Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice. Arthritis Rheum 2011; 63: 960-70.
25. b) mice: new insights into an important disease model of rheumatoid arthritis. Eur J Immunol 2000; 30: 1568-75.
26. Ooi JD, Phoon RK, Holdsworth SR, Kitching AR,. IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. J Am Soc Nephrol 2009; 20: 980-9.
27. Yang YH, Ngo D, Jones M, Simpson E, Fritzemeier KH, Morand EF,. Endogenous estrogen regulation of inflammatory arthritis and cytokine expression in male mice, predominantly via estrogen receptor α. Arthritis Rheum 2010; 62: 1017-25.
28. Odobasic D, Leech MT, Xue JR, Holdsworth SR,. Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis. Immunology 2008; 124: 503-13.
29. + T cells exacerbates T cell-dependent inflammation. J Immunol 2013; 190: 997-1007.
30. Nozaki Y, Nikolic-Paterson DJ, Snelgrove SL, Akiba H, Yagita H, Holdsworth SR, et al. Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis. Kidney Int 2012; 81: 844-55.
31. Beaulieu E, Ngo D, Santos L, Yang YH, Smith M, Jorgensen C, et al. Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis. Arthritis Rheum 2010; 62: 2651-61.
32. Lubberts E, Koenders MI, Oppers-Walgreen B, van den Bersselaar L, Coenen-de Roo CJ, Joosten LA, et al. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum 2004; 50: 650-9.
33. Sarkar S, Cooney LA, White P, Dunlop DB, Endres J, Jorns JM, et al. Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-γ and IL-4. Arthritis Res Ther 2009; 11: R158.
34. Vermeire K, Heremans H, Vandeputte M, Huang S, Billiau A, Matthys P,. Accelerated collagen-induced arthritis in IFN-γ receptor-deficient mice. J Immunol 1997; 158: 5507-13.
35. Bartok B, Firestein GS,. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev 2010; 233: 233-55.
36. Ji H, Pettit A, Ohmura K, Ortiz-Lopez A, Duchatelle V, Degott C, et al. Critical roles for interleukin 1 and tumor necrosis factor α in antibody-induced arthritis. J Exp Med 2002; 196: 77-85.
37. Park Y, Kim HS, Ahn JY, Yun D, Cho ML, Hong S, et al. IL-12p35 promotes antibody-induced joint inflammation by activating NKT cells and suppressing TGF-β. J Immunol 2010; 185: 1476-84.
38. Abadie V, Badell E, Douillard P, Ensergueix D, Leenen PJ, Tanguy M, et al. Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes. Blood 2005; 106: 1843-50.
39. Yang CW, Strong BS, Miller MJ, Unanue ER,. Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants. J Immunol 2010; 185: 2927-34.
40. Morgan ME, Sutmuller RP, Witteveen HJ, van Duivenvoorde LM, Zanelli E, Melief CJ, et al. CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum 2003; 48: 1452-60.
41. Pohlers D, Nissler K, Frey O, Simon J, Petrow P, Kinne R, et al. Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen-induced arthritis: influence on T helper cell activation. Clin Exp Immunol 2004; 135: 409-15.
42. Joosten LA, Lubberts E, Durez P, Helsen MM, Jacobs MJ, Goldman M, et al. Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis: protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction. Arthritis Rheum 1997; 40: 249-60.
43. El Kebir D, Jozsef L, Pan W, Filep JG,. Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins and prolongs inflammation. Circ Res 2008; 103: 352-9.
44. Solomon S, Rajasekaran N, Jeisy-Walder E, Snapper SB, Illges H,. A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis. Eur J Immunol 2005; 35: 3064-73.
45. Lefkowitz DL, Mills KC, Moguilevsky N, Bollen A, Vaz A, Lefkowitz SS,. Regulation of macrophage function by human recombinant myeloperoxidase. Immunol Lett 1993; 36: 43-9.
46. Grattendick K, Stuart R, Roberts E, Lincoln J, Lefkowitz SS, Bollen A, et al. Alveolar macrophage activation by myeloperoxidase: a model for exacerbation of lung inflammation. Am J Respir Cell Mol Biol 2002; 26: 716-22.