Neuroprotective effect of melatonin against kainic acid-induced oxidative injury in hippocampal slice culture of rats

International Journal of Molecular Sciences

Volumn 15, Issue 4, 2014, Pages 5940-5951

  Kim, Hyung A ^a   Lee, Kyung Hee ^b   Lee, Bae Hwan ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Dongseo University   (South Korea)

Author keywords

Antioxidant; Kainic acid; Melatonin; Neuroprotection; Organotypic hippocampal slice culture; Reactive oxygen species

Indexed keywords

CASPASE 3; KAINIC ACID; LIPOXYGENASE; MELATONIN; NEUROPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; ANTIOXIDANT; ARACHIDONATE 5 LIPOXYGENASE;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; FLUORESCENCE; HIPPOCAMPUS; NERVE CELL NECROSIS; NERVE INJURY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; STAINING; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL DEATH; CYTOLOGY; DRUG EFFECTS; METABOLISM; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY;

ANIMALS; ANTIOXIDANTS; ARACHIDONATE 5-LIPOXYGENASE; CASPASE 3; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; KAINIC ACID; MELATONIN; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84898651982     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15045940     Document Type: Article

References (34)

1. Floyd, R.A.; Carney, J.M. Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann. Neurol. 1992, 32, 22-27.
2. Floyd, R.A. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc. Soc. Exp. Biol. Med. 1999, 222, 236-245.
3. Liang, L.P.; Ho, Y.S.; Patel, M. Mitochondrial superoxide production in kainate-induced hippocampal damage. Neuroscience 2000, 101, 563-570.
4. Alvira, D.; Tajes, M.; Verdaguer, E. Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinsons disease. J. Pineal Res. 2006, 40, 251-258.
5. Mayo, J.C.; Sainz, R.M.; Tan, D.X.; Antolín, I.; Rodríguez, C.; Reiter, R.J. Melatonin and Parkinson's disease. Endocrine 2005, 27, 169-178.
6. Srinivasan, V.; Pandi-Perumal, S.R.; Maestroni, G.J.; Esquifino, A.I.; Hardeland, R.; Cardinali, D.P. Role of melatonin in neurodegenerative diseases. Neurotox. Res. 2005, 7, 293-318.
7. Antolin, I.; Rodriquez, C.; Sainz, R.M.; Mayo, J.C.; Aria, H.; Kotter, M. Neurohormone melatonin prevents cell damage: Effect on gene expression for antioxidant enzymes. FASEB J. 1996, 10, 882-890.
8. Hashimoto, S.; Minami, N.; Takakura, R. Low oxygen tension during in vitro maturation is beneficial for supporting the subsequent development of bovine cumulus-oocyte complexes. Mol. Reprod. Dev. 2000, 57, 353-360.
9. Costa, E.J.; Lopes, R.H.; Lamy-Freund, M.T. Permeability of pure lipid bilayers to melatonin. J. Pineal Res. 1995, 19, 123-126.
10. Ekmekcioglu, C. Melatonin receptors in humans: Biological role and clinical relevance. Biomed. Pharmacother. 2006, 60, 97-108.
11. Hung, M.W.; Tipoe, G.L.; Poon, A.M.; Reiter, R.J.; Fung, M.L. Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia. J. Pineal Res. 2008, 44, 214-221.
12. Cheung, R.T.; Tipoe, G.L.; Tam, S.; Ma, E.S.; Zou, L.Y.; Chan, P.S. Preclinical evaluation of pharmacokinetics and safety of melatonin in propylene glycol for intravenous administration. J. Pineal Res. 2006, 41, 337-343.
13. Cheung, R.T. The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. J. Pineal Res. 2003, 34, 153-160.
14. Hardeland, R. Antioxidative protection by melatonin: Multiplicity of mechanisms from radical detoxification to radical avoidance. Endocrine 2005, 27, 119-130.
15. Reiter, R.J. Oxidative damage in the central nervous system: Protection by melatonin. Prog. Neurobiol. 1998, 56, 359-384.
16. Kristensen, B.W.; Noraberg, J.; Zimmer, J. Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures. Brain Res. 2001, 917, 21-44.
17. Kim, E.J.; Won, R.; Sohn, J.-H.; Chung, M.-A.; Nam, T.S.; Lee, H.-J.; Lee, B.H. Anti-oxidant effect of ascorbic and dehydroascorbic acids in hippocampal slice culture. Biochem. Biophys. Res. Commun. 2008, 366, 8-14.
18. Won, R.; Lee, K.H.; Lee, B.H. Coenzyme Q10 protects neurons against neurotoxicity in hippocampal slice culture. Neuroreport 2011, 22, 721-726.
19. Jung, N.Y.; Lee, K.H.; Won, R.; Lee, B.H. Neuroprotective effects of α-tocotrienol on kainic acid-induced neurotoxicity in organotypic hippocampal slice cultures. Int. J. Mol. Sci. 2013, 14, 18256-18268.
20. Zaja-Milatovic, S.; Gupta, R.C.; Aschner, M.; Montine, T.J.; Milatovic, D. Pharmacologic suppression of oxidative damage and dendritic degeneration following kainic acid-induced excitotoxicity in mouse cerebrum. Neurotoxicology 2008, 29, 621-627.
21. Kotler, M.; Rodriquez, C.; Sainz, R.M.; Antolin, I.; Menendez-Pelaez, A. Melatonin increases gene expression for antioxidant enzymes in rat brain cortex. J. Pineal Res. 1998, 24, 83-89.
22. Juliana, B.H.; Rudimar, L.F.; Ana, P.H.; Ricardo, A.C.; Andressa, B.; Maria, M.C. Amyloid-β neurotoxicity in organotypic culture is attenuated by melatonin: Involvement of GSK-3β, tau and neuroinflammation. J. Pineal Res. 2010, 48, 230-238.
23. Chung, S.Y.; Han, S.H. Melatonin attenuates kainic acid-induced hippocampal neurodeneration and oxidative stress through microglial inhibition. J. Pineal Res. 2003, 34, 95-102.
24. Holopainen, I.E.; Jarvela, J.; Lopez-Picon, F.R.; Pelliniemi, L.J.; Kukko-Lukjanov, T.K. Mechanisms of kainate-induced region-specific neuronal death in immature organotypic hippocampal slice cultures. Neurochem. Int. 2004, 45, 1-10.
25. Noraberg, J.; Kristensen, B.W.; Zimmer, J. Markers for neuronal degeneration in organotypic slice cultures. Brain Res. Protoc. 1999, 3, 278-290.
26. Vornov, J.J.; Tasker, R.C.; Coyle, J.T. Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures. Exp. Neurol. 1991, 114, 11-22.
27. Zelko, I.N.; Mariani, T.J.; Folz, R.J. Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic. Biol. Med. 2002, 33, 337-349.
28. Flavia, R.; Laura, P.; Milena, D.N.; Claudia, C.; Sergio, A.; Annalida, B. Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes. Toxicol. Appl. Pharmacol. 2009, 239, 37-45.
29. Werz, O.; Szellas, D.; Steinhilber, D. Reactive oxygen species released from granulocytes stimulate 5-lipoxygenase activity in a B-lymphocytic cell line. Eur. J. Biochem. 2000, 267, 1263-1269.
30. Liu, W.; Liu, R.; Schreiber, S.S.; Baudry, M. Role of polyamine metabolism in kainic acid excitotoxicity in organotypic hippocampal slice cultures. J. Neurochem. 2001, 79, 976-984.
31. Monyer, H.; Hartley, D.M.; Choi, D.W. 21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures. Neuron 1990, 5, 121-126.
32. Ries, W.L.; Key, L.L., Jr.; Rodriguiz, R.M. Nitroblue tetrazolium reduction and bone resorption by osteoclasts in vitro inhibited by a manganese-based superoxide dismutase mimic. J. Bone Miner. Res. 1992, 7, 931-939.
33. Yalcin, A.; Kilinc, E.; Kocturk, S.; Resmi, H.; Sozmen, E.Y. Effect of melatonin cotreatment against kainic acid on coenzyme Q10, lipid peroxidation and Trx mRNA in rat hippocampus. Int. J. Neurosci. 2004, 114, 1085-1097.
34. Stoppini, L.; Buchs, P.A.; Muller, D.A. Simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 1991, 37, 173-182.