Anti-oxidant effect of ascorbic and dehydroascorbic acids in hippocampal slice culture

Biochemical and Biophysical Research Communications

Volumn 366, Issue 1, 2008, Pages 8-14

  Kim, Eun Jin ^a   Won, Ran ^a   Sohn, Jin Hun ^b   Chung, Myung Ae ^c   Nam, Taick Sang ^a   Lee, Hye Jung ^d   Lee, Bae Hwan ^a  

^a Yonsei University   (South Korea)

^b Chungnam National University   (South Korea)

^c Electronics and Telecommunications Research Institute (ETRI)   (South Korea)

^d Kyung Hee University   (South Korea)

Author keywords

Anti oxidants; Ascorbic acid; Dehydroascorbic acid; Kainic acid; Organotypic hippocampal slice culture; Reactive oxygen species

Indexed keywords

ASCORBIC ACID; DEHYDROASCORBIC ACID; KAINIC ACID; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN REGION; BRAIN SLICE; CELL DEATH; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE RESPONSE; HIPPOCAMPUS; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; DEHYDROASCORBIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 37349014104     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.11.050     Document Type: Article

References (36)

1. Choi D.W. Ionic dependence of glutamate neurotoxicity. J. Neurosci. 7 (1987) 369-379
2. Mattson M.P., LaFerla F.M., Chan S.L., Leissring M.A., Shepel P.N., and Geiger J.D. Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 23 (2000) 222-229
3. 3H]kainic acid binding sites in rat CNS as determined by autoradiography. Brain Res. 252 (1987) 91-100
4. Tanaka T., Tanaka S., Fujita T., Takano K., Fukuda H., Sako K., and Yonemasu Y. Experimental complex partial seizures induced by a microinjection of kainic acid into limbic structures. Prog. Neurobiol. 38 (1992) 317-334
5. Bruce A.J., and Baudry M. Oxygen free radicals in rat limbic structures after kainate-induced seizures. Free Radic. Biol. Med. 18 (1995) 993-1002
6. Ferany J.W., Zaczek R., and Coyle J.T. Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors. Nature 298 (1982) 757-759
7. Coyle J.T., and Puttfarcken P. Oxidative stress, glutamate and neurodegenerative disorders. Science 262 (1993) 689-695
8. Lafon-Cazal M., Pietri S., Culcasi M., and Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature 364 (1993) 535-537
9. Vajda F.J. Neuroprotection and neurodegenerative disease. J. Clin. Neurosci. 9 (2002) 4-8
10. Nichols D.G., and Budd S.L. Neuronal excitotoxicity: the role of mitochondria. BioFactors 8 (1998) 287-299
11. Liu W., Liu R., Chun J.T., Bi R., Hoe W., Schreiber S.S., and Baudry M. Kainate excitotoxicity in organotypic hippocampal slice cultures: evidence for multiple apoptotic pathways. Brain Res. 916 (2001) 239-248
12. Liang L.P., Ho Y.S., and Patel M. Mitochondrial superoxide production in kainate-induced hippocampal damage. Neuroscience 2000101 (2000) 563-570
13. Dutrait N., Culcasi M., Cazevieille C., Pietri S., Tordo P., Bonne C., and Muller A. Calcium-dependent free radical generation in cultured retinal neurons injured by kainite. Neurosci. Lett. 198 (1995) 13-16
14. Rice M.E. Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci. 23 (2000) 209-216
15. MacGregor D.G., Higgins M.J., Jones P.A., Maxwell W.L., Watson M.W., Graham D.I., and Stone T.W. Ascorbate attenuates the systemic kainate-induced neurotoxicity in the rat hippocampus. Brain Res. 727 (1996) 133-144
16. Majewska M.D., Bell J.A., and London E.D. Regulation of NMDA receptor by redox phenomena: inhibitory role of ascorbate. Brain Res. 537 (1990) 328-332
17. Stamford J.A., Isaac D., Hicks C.A., Ward M.A., Osborne D.J., and O'Neill M.J. Ascorbic acid is neuroprotective against global ischemia in striatum but not hippocampus: histological and voltammetric data. Brain Res. 835 (1999) 229-240
18. Carr A., and Frei B. Dose vitamin C act as a pro-oxidant under physiological condition?. FASEB J. 13 (1999) 1007-1024
19. Song J.H., Shin S.H., and Ross G.M. Oxidative stress induced by ascorbate causes neuronal damage in an in vitro system. Brain Res. 895 (2001) 66-72
20. Song J.H., Shin S.H., Wang W., and Ross G.M. Involvement of oxidative stress in ascorbate-induced proapoptotic death PC12 cells. Exp. Neurol. 169 (2001) 425-437
21. Puskas F., Gergely Jr. P., Banki K., and Perl A. Stimulation of pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C. FASEB J. 14 (2000) 1352-1361
22. Vera J.C., Rivas C.I., Fischbarg J., and Golde D.W. Mammalian facilitative and hexose transporters mediate the transport of dehydroascorbic acid. Nature 364 (1993) 79-82
23. Meister A. Glutathione-ascorbic acid antioxidant system in animals. J. Biol. Chem. 269 (1994) 9397-9400
24. Wilson J.X., Peters C.E., Sitar S.M., Daoust P., and Gelb A.W. Glutamate stimulates ascorbate transport by astrocyte. Brain Res. 858 (2000) 61-66
25. Bémeur C., Ste-Marie L., Desjardins P., Vachon L., Butterworth R.F., Hazell A.S., and Montgomery J. Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat. Neurochem. Int. 46 (2005) 399-407
26. Sagun K.C., Cárcamo J.M., and Golde D.W. Vitamin C enter mitochondria via facilitative glucose transporter 1 (Glu1) and confers mitochondrial protection against oxidative injury. FASEB J. 19 (2005) 1657-1667
27. Kim E.J., Park Y.G., Baik E.J., Jung S.J., Won R., Nahm T.S., and Lee B.H. Dehydroascorbic acid prevents oxidative cell death through a glutathione pathway in primary astrocytes. J. Neurosci. Res. 79 (2005) 670-679
28. Caeser M., and Aertsen A. Morphological organization of rat hippocampal slice cultures. J. Comp. Neurol. 307 (1991) 87-106
29. Gähwiler B.H., Capogna M., Debanne D., McKinney R.A., and Thompson S.M. Organotypic slice cultures: a technique has come of age. Trends Neurosci. 20 (1997) 471-477
30. Stoppini L., Buchs P.A., and Muller D. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 37 (1991) 173-182
31. Casaccia-Bonnefil P., Benedikz E., Rai R., and Bergold P.J. Excitatory and inhibitory pathways modulate kainate excitotoxicity in hippocampal slice cultures. Neurosci. Lett. 154 (1993) 5-8
32. Routbort M.J., Bausch S.B., and McNamara J.O. Seizures, cell death, and mossy fiber sprouting in kainic acid-treated organotypic hippocampal cultures. Neurosci. 94 (1999) 755-765
33. Nadler J.V., and Cuthbertson J.C. Kainic acid neurotoxicity toward hippocampal formation: dependence on specific excitatory pathways. Brain Res. 195 (1980) 47-56
34. Puttfarcken P.S., Getz R.L., and Coyle J.T. Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells. Brain Res. 624 (1993) 223-232
35. Grunewald R.A. Ascorbic acid in the brain. Brain Res. Rev. 18 (1993) 123-133
36. Hediger A. New view at C. Nat. Med. 8 (2002) 445-446