메뉴 건너뛰기




Volumn 9, Issue 3, 2014, Pages

Reduced b lymphoid kinase (BLK) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; B LYMPHOID KINASE; FC RECEPTOR; IMMUNOGLOBULIN; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

EID: 84898623237     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092054     Document Type: Article
Times cited : (34)

References (102)
  • 1
    • 34447099218 scopus 로고    scopus 로고
    • Systemic Lupus Erythematosus: Multiple Immunological Phenotypes in a Complex Genetic Disease
    • DOI 10.1016/S0065-2776(06)92001-X, PII S006527760692001X
    • Fairhurst AM, Wandstrat AE, Wakeland EK (2006) Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease. Adv Immunol 92: 1-69 (Pubitemid 44828118)
    • (2006) Advances in Immunology , vol.92 , pp. 1-69
    • Fairhurst, A.1    Wandstrat, A.E.2    Wakeland, E.K.3
  • 2
    • 33745145869 scopus 로고    scopus 로고
    • Autoimmunity in systemic lupus erythematosus: Integrating genes and biology
    • DOI 10.1016/j.smim.2006.03.011, PII S1044532306000480
    • Krishnan S, Chowdhury B, Tsokos GC (2006) Autoimmunity in systemic lupus erythematosus: Integrating genes and biology. Sem Immunol 18: 230-243 (Pubitemid 43903286)
    • (2006) Seminars in Immunology , vol.18 , Issue.4 , pp. 230-243
    • Krishnan, S.1    Chowdhury, B.2    Tsokos, G.C.3
  • 3
    • 77953552267 scopus 로고    scopus 로고
    • Genetics of SLE: Evidence from mouse models
    • Morel L (2010) Genetics of SLE: evidence from mouse models. Nat Rev Rheumatol 6: 348-357
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 348-357
    • Morel, L.1
  • 6
    • 70350629871 scopus 로고    scopus 로고
    • Genome-wide association study in a chinese han population identifies nine new susceptibility loci for systemic lupus erythematosus
    • Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ,et al.. (2009) Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat. Genet41: 1234-1237
    • (2009) Nat. Genet , vol.41 , pp. 1234-1237
    • Han, J.W.1    Zheng, H.F.2    Cui, Y.3    Sun, L.D.4    Ye, D.Q.5
  • 7
    • 67249160760 scopus 로고    scopus 로고
    • Replication of recently identified systemic lupus erythematosus genetic associations: A case-control study
    • Suarez-Gestal M, Calaza M, Endreffy E, Pullmann R, Ordi-Ros J,et al.. (2009) Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study. Arthritis Res Ther 11: R69
    • (2009) Arthritis Res Ther , vol.11
    • Suarez-Gestal, M.1    Calaza, M.2    Endreffy, E.3    Pullmann, R.4    Ordi-Ros, J.5
  • 8
    • 80155130254 scopus 로고    scopus 로고
    • Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study
    • Sanchez E, Comeau ME, Freedman BI, Kelly JA, Kaufman KM, Langefeld CD,et al.. (2011) Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis Rheum 63: 3493-3501
    • (2011) Arthritis Rheum , vol.63 , pp. 3493-3501
    • Sanchez, E.1    Comeau, M.E.2    Freedman, B.I.3    Kelly, J.A.4    Kaufman, K.M.5    Langefeld, C.D.6
  • 9
    • 79960825735 scopus 로고    scopus 로고
    • Cumulative association of eight susceptibility genes with systemic lupus erythematosus in a Japanese female population
    • Koga M, Kawasaki A, Ito I, Furuya T, Ohashi J,et al.. (2011) Cumulative association of eight susceptibility genes with systemic lupus erythematosus in a Japanese female population. J Hum Genet 56: 503-507
    • (2011) J Hum Genet , vol.56 , pp. 503-507
    • Koga, M.1    Kawasaki, A.2    Ito, I.3    Furuya, T.4    Ohashi, J.5
  • 10
    • 84855179152 scopus 로고    scopus 로고
    • Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population
    • Järvinen TM, Hellquist A, Zucchelli M, Koskenmies S, Panelius J,et al.. (2012) Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population. Rheumatology 51: 87-92
    • (2012) Rheumatology , vol.51 , pp. 87-92
    • Järvinen, T.M.1    Hellquist, A.2    Zucchelli, M.3    Koskenmies, S.4    Panelius, J.5
  • 11
    • 77958094467 scopus 로고    scopus 로고
    • The association of the blk gene with sle was replicated in chinese han
    • Zhang Z, Zhu KJ, Zu Q, Zhang XJ, Sun LD,et al.. (2010) The association of the BLK gene with SLE was replicated in Chinese Han. Arch Dermatol Res 302: 619-624
    • (2010) Arch Dermatol Res , vol.302 , pp. 619-624
    • Zhang, Z.1    Zhu, K.J.2    Zu, Q.3    Zhang, X.J.4    Sun, L.D.5
  • 12
    • 84862570806 scopus 로고    scopus 로고
    • Fine mapping and conditional analysis identify a new mutation in the autoimmune susceptibility gene BLK that leads to reduced half-life of the Blk protein
    • Delgado-Vega AM, Dozmorov MG, Quiro s MB, Wu YY, Martnez-Garca B,et al.. (2012) Fine mapping and conditional analysis identify a new mutation in the autoimmune susceptibility gene BLK that leads to reduced half-life of the Blk protein. Ann Rheum Dis 71: 1219-1226
    • (2012) Ann Rheum Dis , vol.71 , pp. 1219-1226
    • Delgado-Vega, A.M.1    Dozmorov, M.G.2    Quiros, M.B.3    Wu, Y.Y.4    Martnez-Garca, B.5
  • 13
    • 84865071401 scopus 로고    scopus 로고
    • The autoimmunity-Associated BLK haplotype exhibits cisregulatory effects on mRNA and protein expression that are prominently observed in B cells early in development
    • Simpfendorfer KR, Olsson LM, Manjarrez Orduno N, Khalili H, Simeone AM,et al.. (2012) The autoimmunity-Associated BLK haplotype exhibits cisregulatory effects on mRNA and protein expression that are prominently observed in B cells early in development. Hum Mol Genet 21: 3918-3925
    • (2012) Hum Mol Genet , vol.21 , pp. 3918-3925
    • Simpfendorfer, K.R.1    Olsson, L.M.2    Manjarrez Orduno, N.3    Khalili, H.4    Simeone, A.M.5
  • 14
    • 0025095192 scopus 로고
    • Specific expression of a tyrosine kinase gene, blk
    • B lymphoid cells
    • Dymecki SM, Niederhuber JE, Desiderio SV (1990) Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science 247: 332-336
    • (1990) Science , vol.247 , pp. 332-336
    • Dymecki, S.M.1    Niederhuber, J.E.2    Desiderio, S.V.3
  • 17
    • 84863715658 scopus 로고    scopus 로고
    • Blkhaploinsufficiency impairs the development, but enhances the functional responses, of mz b cells
    • Samuelson EM, Laird RM, Maue AC, Rochford R, Hayes SM (2012) Blkhaploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells. Immunol Cell Biol 90: 620-629
    • (2012) Immunol Cell Biol , vol.90 , pp. 620-629
    • Samuelson, E.M.1    Laird, R.M.2    Maue, A.C.3    Rochford, R.4    Hayes, S.M.5
  • 18
  • 19
    • 33646198040 scopus 로고    scopus 로고
    • B cell immunobiology in disease: Evolving concepts from the clinic
    • Martin F, Chan AC (2006) B cell immunobiology in disease: evolving concepts from the clinic. Ann Rev Immunol 24: 467-496
    • (2006) Ann Rev Immunol , vol.24 , pp. 467-496
    • Martin, F.1    Chan, A.C.2
  • 20
    • 0028797601 scopus 로고
    • Molecular cloning, characterization, and chromosomal localization of human lymphoid tyrosine kinase related to murine Blk
    • Islam KB, Rabbani H, Larsson C, Sanders R, Smith CIE (1995) Molecular cloning, characterization, and chromosomal localization of human lymphoid tyrosine kinase related to murine Blk. J Immunol 154: 1265-1272
    • (1995) J Immunol , vol.154 , pp. 1265-1272
    • Islam, K.B.1    Rabbani, H.2    Larsson, C.3    Sanders, R.4    Cie, S.5
  • 21
    • 35649000957 scopus 로고    scopus 로고
    • BDCA2/FceR1c complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells
    • Cao W, Zhang L, Rosen DR, Bover L, Watanabe G,et al.. (2007) BDCA2/FceR1c complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. PLoS Biol 5: e248
    • (2007) PLoS Biol , vol.5
    • Cao, W.1    Zhang, L.2    Rosen, D.R.3    Bover, L.4    Watanabe, G.5
  • 22
    • 70149104834 scopus 로고    scopus 로고
    • Mutations at the BLK locus linked to maturity onset diabetes of the young and b-cell dysfunction
    • Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J,et al.. (2009) Mutations at the BLK locus linked to maturity onset diabetes of the young and b-cell dysfunction. Proc Natl Acad Sci USA 106: 14460-14465
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14460-14465
    • Borowiec, M.1    Liew, C.W.2    Thompson, R.3    Boonyasrisawat, W.4    Hu, J.5
  • 23
    • 78650633915 scopus 로고    scopus 로고
    • Unexpected role for the b cell-specific src family kinase b lymphoid kinase in the development of il-17-producing cd t cells
    • Laird RM, Laky K, Hayes SM (2010) Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing cd T cells. J Immunol 185: 6518-6527
    • (2010) J Immunol , vol.185 , pp. 6518-6527
    • Laird, R.M.1    Laky, K.2    Hayes, S.M.3
  • 25
    • 0021173447 scopus 로고
    • Induction of various autoantibodies by mutant gene lpr in several strains of mice
    • Izui S, Kelley VE, Masuda K, Yoshida H, Roths JB,et al.. (1984)Induction of various autoantibodies by mutant gene lpr in several strains of mice. J Immunol 133: 227-233 (Pubitemid 14077907)
    • (1984) Journal of Immunology , vol.133 , Issue.1 , pp. 227-233
    • Izui, S.1    Kelley, V.E.2    Masuda, K.3
  • 27
    • 84877327999 scopus 로고    scopus 로고
    • Cd T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a listeria model of infection independently of cd28 stimulation
    • Laird RM, Wolf BJ, Princiotta MF, Hayes SM (2013) cd T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a listeria model of infection independently of CD28 stimulation. PLoS One 8: e63178
    • (2013) PLoS One , vol.8
    • Laird, R.M.1    Wolf, B.J.2    Princiotta, M.F.3    Hayes, S.M.4
  • 29
    • 26244435934 scopus 로고    scopus 로고
    • Th1 cytokines in the pathogenesis of lupus nephritis: The role of IL-18
    • DOI 10.1016/j.autrev.2005.04.009, PII S1568997205000613
    • Calvani N, Tucci M, Richards HB, Tartaglia P, Silvestris F (2005) Th1 cytokines in the pathogenesis of lupus nephritis: the role of IL-18. Autoimmun Rev 4: 542-548 (Pubitemid 41415767)
    • (2005) Autoimmunity Reviews , vol.4 , Issue.8 , pp. 542-548
    • Calvani, N.1    Tucci, M.2    Richards, H.B.3    Tartaglia, P.4    Silvestris, F.5
  • 30
    • 84861694711 scopus 로고    scopus 로고
    • Follicular helper t cells in immunity and systemic autoimmunity
    • Craft JE. (2012) Follicular helper T cells in immunity and systemic autoimmunity. Nat Rev Rheumat 8: 337-347
    • (2012) Nat Rev Rheumat , vol.8 , pp. 337-347
    • Craft, J.E.1
  • 31
    • 75749122606 scopus 로고    scopus 로고
    • Autoantibody-dependent and autoantibodyindependent roles for B cells in systemic lupus erythematosus: Past, present, and future
    • Jacob N, Stohl W (2010) Autoantibody-dependent and autoantibodyindependent roles for B cells in systemic lupus erythematosus: past, present, and future. Autoimmunity 43: 84-97
    • (2010) Autoimmunity , vol.43 , pp. 84-97
    • Jacob, N.1    Stohl, W.2
  • 32
    • 48749085127 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases
    • Gillet M, Cao W, Liu YJ (2008) Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol. 8: 594-606
    • (2008) Nat Rev Immunol , vol.8 , pp. 594-606
    • Gillet, M.1    Cao, W.2    Liu, Y.J.3
  • 33
    • 84856429832 scopus 로고    scopus 로고
    • Development and function of interleukin 17- producing cd T cells
    • Korn T, Petermann F (2012) Development and function of interleukin 17- producing cd T cells. Ann NY Acad Sci 1247: 34-45
    • (2012) Ann NY Acad Sci , vol.1247 , pp. 34-45
    • Korn, T.1    Petermann, F.2
  • 34
    • 79960362531 scopus 로고    scopus 로고
    • CD3 + CD42CD82 T cells: Saviours or villains of the immune response
    • D9Acquisto F
    • D9Acquisto F, Crompton T (2011) CD3 + CD42CD82 T cells: saviours or villains of the immune response. Biochem Pharmacol 82: 333-340
    • (2011) Biochem Pharmacol , vol.82 , pp. 333-340
    • Crompton, T.1
  • 35
    • 77953196382 scopus 로고    scopus 로고
    • Cutting Edge IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice
    • Kyttaris VC, Zhang Z, Kuchroo VK, Oukka M, Tsokos GC (2010) Cutting Edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J Immunol 184: 4605-4609
    • (2010) J Immunol , vol.184 , pp. 4605-4609
    • Kyttaris, V.C.1    Zhang, Z.2    Kuchroo, V.K.3    Oukka, M.4    Tsokos, G.C.5
  • 37
    • 59949091981 scopus 로고    scopus 로고
    • Renal disease in systemic lupus erythematosus with emphasis on classification of lupus glomerulonephritis: Advances and implications
    • Seshan SV, Jennette JC (2009) Renal disease in systemic lupus erythematosus with emphasis on classification of lupus glomerulonephritis: advances and implications. Arch Pathol Lab Med 133: 233-248
    • (2009) Arch Pathol Lab Med , vol.133 , pp. 233-248
    • Seshan, S.V.1    Jennette, J.C.2
  • 38
    • 84864402220 scopus 로고    scopus 로고
    • Lupus-related podocytopathy could it be a new entity within the spectrum of lupus nephritis
    • Gutierrez S, Petiti JP, De Paul AL, Torres AI, Mukdsi JH (2012) Lupus-related podocytopathy. Could it be a new entity within the spectrum of lupus nephritis Nefrologia 32: 245-246
    • (2012) Nefrologia , vol.32 , pp. 245-246
    • Gutierrez, S.1    Petiti, J.P.2    De Paul, A.L.3    Torres, A.I.4    Mukdsi, J.H.5
  • 39
    • 80052527646 scopus 로고    scopus 로고
    • Defining the molecular character of the developing and adult kidney podocyte
    • Brunskill EW, Georgas K, Rumbaue B, Little MH, Potter SS (2011) Defining the molecular character of the developing and adult kidney podocyte. PloS One 6(9): e24640
    • (2011) PloS One , vol.6 , Issue.9
    • Brunskill, E.W.1    Georgas, K.2    Rumbaue, B.3    Little, M.H.4    Potter, S.S.5
  • 40
    • 84965054173 scopus 로고    scopus 로고
    • FAK-Src signaling is important to renal collecting duct morphogenesis: Discovery using a hierarchical screening technique
    • Tai G, Hohenstein P, Davies JA (2013) FAK-Src signaling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique. Biol. Open 2: 416-423
    • (2013) Biol. Open , vol.2 , pp. 416-423
    • Tai, G.1    Hohenstein, P.2    Davies, J.A.3
  • 41
    • 0032972830 scopus 로고    scopus 로고
    • Urinary protein excretion and serum tumor necrosis factor in diabetic patients with advanced renal failure: Effects of pentoxifylline administration
    • Navarro JF, Mora C, Rivero A, Gallego E, Chahin J,et al.. (1999) Urinary protein excretion and serum tumor necrosis factor in diabetic patients with advanced renal failure: effects of pentoxifylline administration. Am J Kidney Dis 33: 458-463 (Pubitemid 29107022)
    • (1999) American Journal of Kidney Diseases , vol.33 , Issue.3 , pp. 458-463
    • Navarro, J.F.1    Mora, C.2    Rivero, A.3    Gallego, E.4    Chahin, J.5    Macia, M.6    Mendez, M.L.7    Garcia, J.8
  • 42
    • 0035002214 scopus 로고    scopus 로고
    • Suppression of experimental systemic lupus erythematosus (SLE) in mice via TNF inhibition by an anti-TNFα monoclonal antibody and by pentoxiphylline
    • DOI 10.1191/096120301675275538
    • Segal R, Dayan M, Zinger H, Mozes E (2001) Suppression of experimental systemic lupus erythematosus (SLE) in mice via TNF inhibition by an anti- TNFa monoclonal antibody and by pentoxiphylline. Lupus 10: 23-31 (Pubitemid 32416685)
    • (2001) Lupus , vol.10 , Issue.1 , pp. 23-31
    • Segal, R.1    Dayan, M.2    Zinger, H.3    Mozes, E.4
  • 43
    • 0032769336 scopus 로고    scopus 로고
    • The central and multiple roles of B cells in lupus pathogenesis
    • DOI 10.1111/j.1600-065X.1999.tb01310.x
    • Chan OT, Madaio MP, Schlomchik MJ (1999) The central and multiple roles of B cells in lupus pathogenesis. Immunol Rev 169: 107-121 (Pubitemid 29338727)
    • (1999) Immunological Reviews , vol.169 , pp. 107-121
    • Chan, O.T.M.1    Madaio, M.P.2    Shlomchik, M.J.3
  • 44
    • 45449099469 scopus 로고    scopus 로고
    • Cytokine-producing b lymphocytes - Key regulators of immunity
    • Lund FE (2008) Cytokine-producing B lymphocytes - key regulators of immunity. Curr Opin Immunol 20: 332-338
    • (2008) Curr Opin Immunol , vol.20 , pp. 332-338
    • Lund, F.E.1
  • 45
    • 84863803849 scopus 로고    scopus 로고
    • B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6- producing B cells
    • Barr TA, Shen P, Brown S, Lampropoulou V, Roch T,et al.. (2012) B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6- producing B cells. J Exp Med 209: 1001-1010
    • (2012) J Exp Med , vol.209 , pp. 1001-1010
    • Barr, T.A.1    Shen, P.2    Brown, S.3    Lampropoulou, V.4    Roch, T.5
  • 46
    • 45949106108 scopus 로고    scopus 로고
    • Downregulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses
    • Watanabe M, Takagi Y, Kotani M, Hara Y, Inamine A,et al.. (2008) Downregulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses. J Immunol 180: 5222-5234
    • (2008) J Immunol , vol.180 , pp. 5222-5234
    • Watanabe, M.1    Takagi, Y.2    Kotani, M.3    Hara, Y.4    Inamine, A.5
  • 47
    • 79961233459 scopus 로고    scopus 로고
    • Noncanonical NF-kB regulates inducible costimulatory (ICOS) ligand expression and T follicular heler cell development
    • Hu H, Wu X, Jin W, Chang M, Cheng X,et al.(2011) Noncanonical NF-kB regulates inducible costimulatory (ICOS) ligand expression and T follicular heler cell development. Proc Natl Acad Sci USA 108: 12827-12832
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 12827-12832
    • Hu, H.1    Wu, X.2    Jin, W.3    Chang, M.4    Cheng, X.5
  • 49
    • 5644273872 scopus 로고    scopus 로고
    • Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus
    • DOI 10.1002/art.20519
    • Hutloff A, Büchner K, Reiter K, Baelde HJ, Odendahl M,et al.. (2004) Involvement of inducible costimulatory in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus. Arthritis Rheum 50: 3211-3220 (Pubitemid 39371998)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.10 , pp. 3211-3220
    • Hutloff, A.1    Buchner, K.2    Reiter, K.3    Baelde, H.J.4    Odendahl, M.5    Jacobi, A.6    Dorner, T.7    Kroczek, R.A.8
  • 50
    • 0033590502 scopus 로고    scopus 로고
    • ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
    • Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R,et al.. (1999) ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397: 263-266
    • (1999) Nature , vol.397 , pp. 263-266
    • Hutloff, A.1    Dittrich, A.M.2    Beier, K.C.3    Eljaschewitsch, B.4    Kraft, R.5
  • 51
    • 3242741987 scopus 로고    scopus 로고
    • ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: Increased ICOS expression enhances the effector function of both Th1 and Th2 cells
    • Wassink L, Vieira PL, Smits HH, Kingsbury GA, Coyle AJ,et al.. (2004) ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells. J Immunol 173: 1779-1786 (Pubitemid 38971610)
    • (2004) Journal of Immunology , vol.173 , Issue.3 , pp. 1779-1786
    • Wassink, L.1    Vieira, P.L.2    Smits, H.H.3    Kingsbury, G.A.4    Coyle, A.J.5    Kapsenberg, M.L.6    Wierenga, E.A.7
  • 52
    • 33646483784 scopus 로고    scopus 로고
    • Inducible costimulator: A modulator of IFN-c production in human tuberculosis
    • Quiroga MF, Pasquinelli V, Martnez GJ, Jurado JO, Zorilla LC,et al.. (2006) Inducible costimulator: a modulator of IFN-c production in human tuberculosis. J Immunol 176: 5965-5974
    • (2006) J Immunol , vol.176 , pp. 5965-5974
    • Quiroga, M.F.1    Pasquinelli, V.2    Martnez, G.J.3    Jurado, J.O.4    Zorilla, L.C.5
  • 53
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC,et al.. (2009) The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 10: 167-175
    • (2009) Nat Immunol , vol.10 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3    Mitsdoerffer, M.4    Ho, I.C.5
  • 54
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ,et al.. (2011) ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 34: 932-946
    • (2011) Immunity , vol.34 , pp. 932-946
    • Choi, Y.S.1    Kageyama, R.2    Eto, D.3    Escobar, T.C.4    Johnston, R.J.5
  • 55
    • 51549115916 scopus 로고    scopus 로고
    • IL-17A produced by cd T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver
    • Hamada S, Umemura M, Shiono T, Tanaka K, Yahagi A,et al.. (2008) IL-17A produced by cd T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver. J Immunol 181: 3456-3463
    • (2008) J Immunol , vol.181 , pp. 3456-3463
    • Hamada, S.1    Umemura, M.2    Shiono, T.3    Tanaka, K.4    Yahagi, A.5
  • 56
    • 84860504571 scopus 로고    scopus 로고
    • TLR tolerance reduces IFN-A production despite plasmacytoid dendritic cell expansion and antinuclear antibodies in NZB bicongenic mice
    • Pau E, Cheung YH, Loh C, Lajoie G, Wither JE (2012) TLR tolerance reduces IFN-A production despite plasmacytoid dendritic cell expansion and antinuclear antibodies in NZB bicongenic mice. PLoS One 7: e36761
    • (2012) PLoS One , vol.7
    • Pau, E.1    Cheung, Y.H.2    Loh, C.3    Lajoie, G.4    Wither, J.E.5
  • 58
    • 84870919913 scopus 로고    scopus 로고
    • Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis
    • Pisitkun P, Ha HL, Wang H, Claudio E, Tivy CC,et al.. (2012) Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis. Immunity 37: 1104-1115
    • (2012) Immunity , vol.37 , pp. 1104-1115
    • Pisitkun, P.1    Ha, H.L.2    Wang, H.3    Claudio, E.4    Tivy, C.C.5
  • 60
    • 81255158784 scopus 로고    scopus 로고
    • IL-17C regulates the innate immune function of epithelial cells in an autocrine manner
    • Ramirez-Carrozzi V, Sambandam A, Luis E, Lin Z, Jeet S,et al.. (2011) IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol 12: 1159-1166
    • (2011) Nat Immunol , vol.12 , pp. 1159-1166
    • Ramirez-Carrozzi, V.1    Sambandam, A.2    Luis, E.3    Lin, Z.4    Jeet, S.5
  • 61
    • 77949895907 scopus 로고    scopus 로고
    • IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections
    • Riol-Blanco L, Lazarevic V, Awasthi A, Mitsdoerffer M, Wilson BS,et al. 2010 IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J Immunol 184. 1710-1720. 2010
    • (2010) J Immunol , vol.184 , pp. 1710-1720
    • Riol-Blanco, L.1    Lazarevic, V.2    Awasthi, A.3    Mitsdoerffer, M.4    Wilson, B.S.5
  • 62
    • 79953164804 scopus 로고    scopus 로고
    • Genetic predisposition to autoimmunity - What have we learned
    • Rai E, Wakeland EK (2011) Genetic predisposition to autoimmunity - what have we learned Semin Immunol 23: 67-83
    • (2011) Semin Immunol , vol.23 , pp. 67-83
    • Rai, E.1    Wakeland, E.K.2
  • 64
    • 0034193039 scopus 로고    scopus 로고
    • IL-6 is required for the development of Th1 cell-mediated murine colitis
    • Yamamoto M, Yoshizaki K, Kishimoto T, Ito H (2000) IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol 164: 4878-4882 (Pubitemid 30238092)
    • (2000) Journal of Immunology , vol.164 , Issue.9 , pp. 4878-4882
    • Yamamoto, M.1    Yoshizaki, K.2    Kishimoto, T.3    Ito, H.4
  • 65
    • 60549105041 scopus 로고    scopus 로고
    • The induction of antibody production by IL-6 is indirectly mediated by il-21 produced by cd4 + t cells
    • Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D,et al.. (2009) The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4 + T cells. J Exp Med 206: 69-78
    • (2009) J Exp Med , vol.206 , pp. 69-78
    • Dienz, O.1    Eaton, S.M.2    Bond, J.P.3    Neveu, W.4    Moquin, D.5
  • 66
    • 77957021670 scopus 로고    scopus 로고
    • Cd T cell enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism
    • Petermann F, Rothhammer V, Claussen MC, Haas JD, Blanco LR,et al.. (2010). cd T cell enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity 33: 351-363
    • (2010) Immunity , vol.33 , pp. 351-363
    • Petermann, F.1    Rothhammer, V.2    Claussen, M.C.3    Haas, J.D.4    Blanco, L.R.5
  • 68
    • 84855323717 scopus 로고    scopus 로고
    • Post-GWAS functional characterization of susceptibility variants for chronic lymphocytic leukemia
    • Sille FCM, Thomas R, Smith MT, Conde L, Skibola CF (2012) Post-GWAS functional characterization of susceptibility variants for chronic lymphocytic leukemia. PLoS One7: e29632
    • (2012) PLoS One , vol.7
    • Fcm, S.1    Thomas, R.2    Smith, M.T.3    Conde, L.4    Skibola, C.F.5
  • 69
    • 38349178776 scopus 로고    scopus 로고
    • Interleukin 17- producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    • Hsu HC, Yang PA, Wang J, Wu Q, Myers R,et al.. (2008) Interleukin 17- producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol 9: 166-175
    • (2008) Nat Immunol , vol.9 , pp. 166-175
    • Hsu, H.C.1    Yang, P.A.2    Wang, J.3    Wu, Q.4    Myers, R.5
  • 70
    • 76749121875 scopus 로고    scopus 로고
    • Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17
    • Blaho VA, Buczyniski MW, Dennis EA, Brown CR (2009) Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17. J Immunol 183: 5644-5653
    • (2009) J Immunol , vol.183 , pp. 5644-5653
    • Blaho, V.A.1    Buczyniski, M.W.2    Dennis, E.A.3    Brown, C.R.4
  • 71
    • 77956273246 scopus 로고    scopus 로고
    • Proinflammatory T helper type 17 cells are effective B-cell helpers
    • Mitsdoerffer M, Lee Y, Jä ger A, Kim HJ, Korn T,et al.. (2010) Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci USA 107: 14292-14297
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14292-14297
    • Mitsdoerffer, M.1    Lee, Y.2    Jager, A.3    Kim Korn, H.J.T.4
  • 73
    • 0034816964 scopus 로고    scopus 로고
    • Delineating the genetic basis of systemic lupus erythematosus
    • DOI 10.1016/S1074-7613(01)00201-1
    • Wakeland EK, Liu K, Graham RR, Behrens TW (2001) Delineating the genetic basis of systemic lupus erythematosus. Immunity 15: 397-408 (Pubitemid 32907387)
    • (2001) Immunity , vol.15 , Issue.3 , pp. 397-408
    • Wakeland, E.K.1    Liu, K.2    Graham, R.R.3    Behrens, T.W.4
  • 74
    • 75349113494 scopus 로고    scopus 로고
    • Association of the C8orf13-BLK region with systemic sclerosis
    • North- American and European populations
    • Gourrh P, Agarwal SK, Martin E, Divecha D, Rueda B,et al.. (2010) Association of the C8orf13-BLK region with systemic sclerosis in North- American and European populations. J Autoimmun 34: 155-162
    • (2010) J Autoimmun , vol.34 , pp. 155-162
    • Gourrh, P.1    Agarwal, S.K.2    Martin, E.3    Divecha, D.4    Rueda, B.5
  • 75
    • 67649880295 scopus 로고    scopus 로고
    • REL, encoding a member of the NF- kB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
    • Gregersen PK, Amos CI, Lee AT, Lu Y, Remmers EF,et al.. (2009) REL, encoding a member of the NF- kB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet 41: 820-823
    • (2009) Nat Genet , vol.41 , pp. 820-823
    • Gregersen, P.K.1    Amos, C.I.2    Lee, A.T.3    Lu, Y.4    Remmers, E.F.5
  • 76
    • 79951513121 scopus 로고    scopus 로고
    • Study of the common genetic background for rheumatoid arthrititis and systemic lupus erythematosus
    • Orozco G, Eyre S, Hinks A, Bowes J, Morgan AW,et al.. (2010) Study of the common genetic background for rheumatoid arthrititis and systemic lupus erythematosus. Ann Rheum Dis 70: 463-468
    • (2010) Ann Rheum Dis , vol.70 , pp. 463-468
    • Orozco, G.1    Eyre, S.2    Hinks, A.3    Bowes, J.4    Morgan, A.W.5
  • 77
    • 79952280367 scopus 로고    scopus 로고
    • Association of ebf1 fam167a(c8orf13)-blk and tnfsf4 gene variants with primary Sjogren's syndrome
    • Nordmark G, Kristjansdottir G, Theander E, Appel A, Eriksson P,et al.. (2011) Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjogren's syndrome. Genes Immun 12: 100-109
    • (2011) Genes Immun , vol.12 , pp. 100-109
    • Nordmark, G.1    Kristjansdottir, G.2    Theander, E.3    Appel, A.4    Eriksson, P.5
  • 78
    • 84862794716 scopus 로고    scopus 로고
    • A genomewide association study identifies three new risk loci for kawasaki disease
    • Onouchi Y, Ozaki K, Burns JC, Shimizu C, Terai M,et al.. (2012) A genomewide association study identifies three new risk loci for Kawasaki disease. Nat Genet 44: 517-521
    • (2012) Nat Genet , vol.44 , pp. 517-521
    • Onouchi, Y.1    Ozaki, K.2    Burns, J.C.3    Shimizu, C.4    Terai, M.5
  • 79
    • 84862814732 scopus 로고    scopus 로고
    • Two new susceptibility loci for kawasaki disease identified through genome-wide association analysis
    • Lee YC, Kuo HC, Chang JS, Chang LY, Huang LM,et al.. (2012) Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet 44: 522-525
    • (2012) Nat Genet , vol.44 , pp. 522-525
    • Lee, Y.C.1    Kuo, H.C.2    Chang, J.S.3    Chang, L.Y.4    Huang, L.M.5
  • 80
  • 83
    • 38649087353 scopus 로고    scopus 로고
    • Effectiveness of etanercept in bleomycin-induced experimental scleroderma
    • DOI 10.1093/rheumatology/kem344
    • Koca SS, Isik A, Ozercan IH, Usundag B, Evren B,et al.. (2008) Effectiveness of etanercept in bleomycin-induced experimental scleroderma. Rheumatol 47: 172-175 (Pubitemid 351168226)
    • (2008) Rheumatology , vol.47 , Issue.2 , pp. 172-175
    • Koca, S.S.1    Isik, A.2    Ozercan, I.H.3    Ustundag, B.4    Evren, B.5    Metin, K.6
  • 84
    • 60849107595 scopus 로고    scopus 로고
    • A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in bxsb-yaa mice
    • Bubier JA, Sproule TJ, Foreman O, Spolski R, Shaffer DJ,et al.. (2009) A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci USA 106:1518-1523
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1518-1523
    • Bubier, J.A.1    Sproule, T.J.2    Foreman, O.3    Spolski, R.4    Shaffer, D.J.5
  • 85
    • 70349238893 scopus 로고    scopus 로고
    • The role of IL-23/IL-17 axis in lupus nephritis
    • Zhang Z, Kyttaris VC, Tsokos GC (2010) The role of IL-23/IL-17 axis in lupus nephritis. J Immunol 183: 3160-3169
    • (2010) J Immunol , vol.183 , pp. 3160-3169
    • Zhang, Z.1    Kyttaris, V.C.2    Tsokos, G.C.3
  • 86
    • 73649123508 scopus 로고    scopus 로고
    • Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: The IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus
    • Cash H, Relle M, Menke J, Brochhausen C, Jones SA,et al.. (2010) Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: The IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus. J Rheumatol 37: 60-70
    • (2010) J Rheumatol , vol.37 , pp. 60-70
    • Cash, H.1    Relle, M.2    Menke, J.3    Brochhausen, C.4    Jones, S.A.5
  • 87
    • 84856880967 scopus 로고    scopus 로고
    • IL-21 receptor is required for the systemic accumulation of activated b and t lymphocytes in mrl/mpj-faslpr/lpr/j mice
    • Rankin AL, Guay H, Herber D, Bertino SA, Duzanski TA,et al.. (2012) IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Faslpr/lpr/J mice. J Immunol 188: 1656-1667
    • (2012) J Immunol , vol.188 , pp. 1656-1667
    • Rankin, A.L.1    Guay, H.2    Herber, D.3    Bertino, S.A.4    Duzanski, T.A.5
  • 88
    • 84875472079 scopus 로고    scopus 로고
    • Autoreactive Th1 cells activate monocytes to support regional Th17 responses in inflammatory arthritis
    • Simons DM, Oh S, Kropf E, Aitken M, Garcia V,et al.. (2013) Autoreactive Th1 cells activate monocytes to support regional Th17 responses in inflammatory arthritis. J Immunol 190: 3134-3141
    • (2013) J Immunol , vol.190 , pp. 3134-3141
    • Simons, D.M.1    Oh, S.2    Kropf, E.3    Aitken, M.4    Garcia, V.5
  • 89
    • 84855173084 scopus 로고    scopus 로고
    • Inflammatory cytokines in systemic lupus erythematosus
    • doi:10.1155/2011/432595
    • Ohl K, Tenbrock K (2011) Inflammatory cytokines in systemic lupus erythematosus. J Biomed Biotech doi:10.1155/2011/432595
    • J Biomed Biotech , vol.2011
    • Ohl, K.1    Tenbrock, K.2
  • 91
    • 84857039916 scopus 로고    scopus 로고
    • Elevated plasma levels of HMGB1 are associated with disease activity and combined alterations with IFN-A and TNF-A in systemic lupus erythematosus
    • Ma CY, Jiao YL, Zhang J, Yang QR, Zhang ZF,et al.. (2012) Elevated plasma levels of HMGB1 are associated with disease activity and combined alterations with IFN-A and TNF-A in systemic lupus erythematosus. Rheumatol Int 32: 395-402
    • (2012) Rheumatol Int , vol.32 , pp. 395-402
    • Ma, C.Y.1    Jiao, Y.L.2    Zhang, J.3    Yang, Q.R.4    Zhang, Z.F.5
  • 92
    • 0034856397 scopus 로고    scopus 로고
    • Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis
    • DOI 10.1016/S0923-1811(01)00128-1, PII S0923181101001281
    • Sato SM. Hasegawa M, Takehara K (2001) Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis. J Dermatol Sci 27: 140-146 (Pubitemid 32781022)
    • (2001) Journal of Dermatological Science , vol.27 , Issue.2 , pp. 140-146
    • Sato, S.1    Hasegawa, M.2    Takehara, K.3
  • 93
    • 75649105070 scopus 로고    scopus 로고
    • Plasma cytokine profiles in systemic sclerosis: Association with autoantibody subsets and clinical manifestations
    • Gourh P, Arnett FC, Assassi S, Tan FK, Huang M,et al.. 2009. Plasma cytokine profiles in systemic sclerosis: association with autoantibody subsets and clinical manifestations. Arthritis Res Ther 11: R147
    • (2009) Arthritis Res Ther , vol.11
    • Gourh, P.1    Arnett, F.C.2    Assassi, S.3    Tan, F.K.4    Huang, M.5
  • 94
    • 0026314938 scopus 로고
    • Tumor necrosis factor alpha and interleukin-2 in plasma from rheumatoid arthritis patients in relation to disease activity
    • Espersen GT, Vestergaard M, Ernst E, Grunnet N (1991) Tumor necrosis factor alpha and interleukin-2 in plasma from rheumatoid arthritis patients in relation to disease activity. Clin Rheumatol 10: 374-376
    • (1991) Clin Rheumatol , vol.10 , pp. 374-376
    • Espersen, G.T.1    Vestergaard, M.2    Ernst, E.3    Grunnet, N.4
  • 95
    • 0026758511 scopus 로고
    • Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis, and systemic lupus erythematosus
    • Metsä rinne KP, Nordström DC, Konttinen YT, Teppo AM, Fyhrquist FY (1992) Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Rheumatol Int 12: 93-96
    • (1992) Rheumatol Int , vol.12 , pp. 93-96
    • Rinne Kp, M.1    Nordström, D.C.2    Konttinen, Y.T.3    Teppo, A.M.4    Fyhrquist, F.Y.5
  • 96
    • 34247130945 scopus 로고    scopus 로고
    • Update on cytokines in rheumatoid arthritis
    • DOI 10.1097/BOR.0b013e32805e87f1, PII 0000228120070500000013
    • Brennan F, Beech J (2007) Update on cytokines in rheumatoid arthritis. Curr Opin Rheum 19: 296-301 (Pubitemid 46597470)
    • (2007) Current Opinion in Rheumatology , vol.19 , Issue.3 , pp. 296-301
    • Brennan, F.1    Beech, J.2
  • 97
    • 70349244787 scopus 로고    scopus 로고
    • Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis
    • Katsifis GE, Rekka S, Moutsopoulos NM, Pillemer S, Wahl SM (2009) Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis. Am J Pathol 175: 1167-1177
    • (2009) Am J Pathol , vol.175 , pp. 1167-1177
    • Katsifis, G.E.1    Rekka, S.2    Moutsopoulos, N.M.3    Pillemer, S.4    Wahl, S.M.5
  • 98
    • 84855445128 scopus 로고    scopus 로고
    • Impact of interleukin-21 in the pathogenesis of primary Sjögren's syndrome: Increased serum levels or interleukin-21 and its expression in the labial salivary glands
    • Kang KY, Kim HO, Kwok SK, Ju JH, Park KS,et al.. (2011) Impact of interleukin-21 in the pathogenesis of primary Sjögren's syndrome: increased serum levels or interleukin-21 and its expression in the labial salivary glands. Arth Res Ther 13: R179
    • (2011) Arth Res Ther , vol.13
    • Kang, K.Y.1    Kim, H.O.2    Kwok, S.K.3    Ju, J.H.4    Park, K.S.5
  • 99
    • 84872719070 scopus 로고    scopus 로고
    • Polymorphism in the TNF-A gene promoter at position -1031 is associated with increased circulating levels of TNF-A, myeloperoxidase and nitrotyrosine in primary Sjögren's syndrome
    • Cay HF, Sezer I, Dogan S, Felek R, Aslan M (2012) Polymorphism in the TNF-A gene promoter at position -1031 is associated with increased circulating levels of TNF-A, myeloperoxidase and nitrotyrosine in primary Sjögren's syndrome. Clin Exp Rheumatol 30: 843-849
    • (2012) Clin Exp Rheumatol , vol.30 , pp. 843-849
    • Cay, H.F.1    Sezer, I.2    Dogan, S.3    Felek, R.4    Aslan, M.5
  • 101
    • 77956544810 scopus 로고    scopus 로고
    • The T helper type 17/regulatory T cell imbalance in patients with acute Kawasaki disease
    • Jia S, Li C, Wang G, Yang J, Zu Y (2010) The T helper type 17/regulatory T cell imbalance in patients with acute Kawasaki disease. Clin Exp Med 162: 131-137
    • (2010) Clin Exp Med , vol.162 , pp. 131-137
    • Jia, S.1    Li, C.2    Wang, G.3    Yang, J.4    Zu, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.