Multiple sporadic colorectal cancers display a unique methylation phenotype

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Gonzalo, Victoria ^a   Lozano, Juan Jose ^b   Alonso Espinaco, Virginia ^a   Moreira, Leticia ^a   MuñOz, Jenifer ^a   Pellisé, Maria ^a   Castellví Bel, Sergi ^a   Bessa, Xavier ^c   Andreu, Montserrat ^c   Xicola, Rosa M ^d   Llor, Xavier ^d   Ruiz Ponte, Clara ^e   Carracedo, Angel ^e   Jover, Rodrigo ^f   Castells, Antoni ^a   Balaguer, Francesc ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c HOSPITAL DEL MAR   (Spain)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^e UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^f HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BRAF PROTEIN, HUMAN; KRAS PROTEIN, HUMAN; ONCOPROTEIN; RAS PROTEIN;

AGED; ARTICLE; BRAF GENE; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA METHYLATION ASSAY; EPIGENETICS; FEMALE; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; MALE; METHYLATION; MICROARRAY ANALYSIS; MISMATCH REPAIR; ONCOGENE K RAS; PHENOTYPE; TUMOR LOCALIZATION; COLORECTAL TUMOR; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; METABOLISM; MIDDLE AGED; MULTIPLE CANCER; PATHOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEOPLASMS, MULTIPLE PRIMARY; PHENOTYPE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; RAS PROTEINS;

EID: 84898612239     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091033     Document Type: Article

References (42)

1. Chen HS, Sheen-Chen SM (2000) Synchronous and ''early'' metachronous colorectal adenocarcinoma: analysis of prognosis and current trends. Dis Colon Rectum 43: 1093-1099.
2. Latournerie M, Jooste V, Cottet V, Lepage C, Faivre J, et al. (2008) Epidemiology and prognosis of synchronous colorectal cancers. Br J Surg 95: 1528-1533.
3. Pinol V, Andreu M, Castells A, Paya A, Bessa X, et al. (2004) Synchronous colorectal neoplasms in patients with colorectal ca (Pubitemid 38857072)
4. Nosho K, Kure S, Irahara N, Shima K, Baba Y, et al. (2009) A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. Gastroenterology 137: 1609-1620 e1601-1603.
5. Ogino S, Brahmandam M, Kawasaki T, Kirkner GJ, Loda M, et al. (2006) Epigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis. Mod Pathol 19: 1083-1090. (Pubitemid 44106723)
6. Shen L, Kondo Y, Rosner GL, Xiao L, Hernandez NS, et al. (2005) MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst 97: 1330-1338. (Pubitemid 41487800)
7. Young J, Jass JR (2006) The case for a genetic predisposition to serrated neoplasia in the colorectum: hypothesis and review of the literature. Cancer Epidemiol Biomarkers Prev 15: 1778-1784. (Pubitemid 44664248)
8. Dykes SL, Qui H, Rothenberger DA, Garcia-Aguilar J (2003) Evidence of a preferred molecular pathway in patients with synchronous colorectal cancer. Cancer 98: 48-54. (Pubitemid 36741124)
9. Lawes DA, Pearson T, Sengupta S, Boulos PB (2005) The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers. Br J Cancer 93: 472-477. (Pubitemid 43080023)
10. Pedroni M, Tamassia MG, Percesepe A, Roncucci L, Benatti P, et al. (1999) Microsatellite instability in multiple colorectal tumors. Int J Cancer 81: 1-5. (Pubitemid 29124187)
11. Balaguer F, Castellvi-Bel S, Castells A, Andreu M, Munoz J, et al. (2007) Identification of MYH mutation carriers in colorectal cancer: a multicenter, case-control, population-based study. Clin Gastroenterol Hepatol 5: 379-387. (Pubitemid 46420561)
12. Lynch HT, de la Chapelle A (2003) Hereditary colorectal cancer. N Engl J Med 348: 919-932. (Pubitemid 36298000)
13. Chan AO, Issa JP, Morris JS, Hamilton SR, Rashid A (2002) Concordant CpG island methylation in hyperplastic polyposis. Am J Pathol 160: 529-536. (Pubitemid 34160330)
14. Kamiyama H, Suzuki K, Maeda T, Koizumi K, Miyaki Y, et al. (2012) DNA demethylation in normal colon tissue predicts predisposition to multiple cancers. Oncogene 31: 5029-5037.
15. Minoo P, Baker K, Goswami R, Chong G, Foulkes WD, et al. (2006) Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis. Gut 55: 1467-1474. (Pubitemid 44476793)
16. Giovannucci E, Ogino S (2005) DNA methylation, field effects, and colorectal cancer. J Natl Cancer Inst 97: 1317-1319. (Pubitemid 41487792)
17. Gonzalo V, Lozano JJ, Munoz J, Balaguer F, Pellise M, et al. (2010) Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer. PLoS One 5: e8777.
18. Konishi K, Shen L, Jelinek J, Watanabe Y, Ahmed S, et al. (2009) Concordant DNA methylation in synchronous colorectal carcinomas. Cancer Prev Res (Phila) 2: 814-822.
19. Gonzalo V, Castellvi-Bel S, Balaguer F, Pellise M, Ocana T, et al. (2008) [Epigenetics of cancer]. Gastroenterol Hepatol 31: 37-45.
20. Bardhan K, Liu K (2013) Epigenetics and colorectal cancer pathogenesis. Cancers (Basel) 5: 676-713.
21. Colussi D, Brandi G, Bazzoli F, Ricciardiello L (2013) Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention. Int J Mol Sci 14: 16365-16385.
22. Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, et al. (2003) Induction of tumors in mice by genomic hypomethylation. Science 300: 489-492. (Pubitemid 36444330)
23. Holm TM, Jackson-Grusby L, Brambrink T, Yamada Y, Rideout WM 3rd, et al. (2005) Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell 8: 275-285. (Pubitemid 41443413)
24. Abuli A, Bessa X, Gonzalez JR, Ruiz-Ponte C, Caceres A, et al. (2010) Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype. Gastroenterology 139: 788-796, 796 e781-786.
25. Bibikova M, Le J, Barnes B, Saedinia-Melnyk S, Zhou L, et al. (2009) Genomewide DNA methylation profiling using Infinium(R) assay. Epigenomics 1: 177-200.
26. Gunderson KL (2009) Whole-genome genotyping on bead arrays. Methods Mol Biol 529: 197-213.
27. Hinoue T, Weisenberger DJ, Lange CP, Shen H, Byun HM, et al. (2012) Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res 22: 271-282.
28. Eads CA, Danenberg KD, Kawakami K, Saltz LB, Blake C, et al. (2000) MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res 28: E32.
29. Perez-Carbonell L, Ruiz-Ponte C, Guarinos C, Alenda C, Paya A, et al. (2012) Comparison between universal molecular screening for Lynch syndrome and revised Bethesda guidelines in a large population-based cohort of patients with colorectal cancer. Gut 61: 865-872.
30. Goel A, Xicola RM, Nguyen TP, Doyle BJ, Sohn VR, et al. (2010) Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology 138: 1854-1862.
31. Giraldez MD, Balaguer F, Bujanda L, Cuatrecasas M, Munoz J, et al. (2010) MSH6 and MUTYH deficiency is a frequent event in early-onset colorectal cancer. Clin Cancer Res 16: 5402-5413.
32. Jiao X, Sherman BT, Huang da W, Stephens R, Baseler MW, et al. (2012) DAVID-WS: a stateful web service to facilitate gene/protein list analysis. Bioinformatics 28: 1805-1806.
33. Weisenberger DJ, Siegmund KD, Campan M, Young J, Long TI, et al. (2006) CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 38: 787-793. (Pubitemid 43980599)
34. Yamauchi M, Morikawa T, Kuchiba A, Imamura Y, Qian ZR, et al. (2012) Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 61: 847-854.
35. Zauber P, Huang J, Sabbath-Solitare M, Marotta S (2013) Similarities of molecular genetic changes in synchronous and metachronous colorectal cancers are limited and related to the cancers' proximities to each other. J Mol Diagn 15: 652-660.
36. Ferracin M, Gafa R, Miotto E, Veronese A, Pultrone C, et al. (2008) The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile. J Pathol 214: 594-602. (Pubitemid 351482274)
37. Mullany SA, Moslemi-Kebria M, Rattan R, Khurana A, Clayton A, et al. (2011) Expression and functional significance of HtrA1 loss in endometrial cancer. Clin Cancer Res 17: 427-436.
38. Catalano V, Mellone P, d'Avino A, Shridhar V, Staccioli MP, et al. (2011) HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer. Histopathology 58: 669-678.
39. Lorenzi T, Lorenzi M, Altobelli E, Marzioni D, Mensa E, et al. (2013) HtrA1 in human urothelial bladder cancer: A secreted protein and a potential novel biomarker. Int J Cancer.
40. Zuo X, Peng Z, Wu Y, Moussalli MJ, Yang XL, et al. (2012) Effects of guttargeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice. J Natl Cancer Inst 104: 709-716.
41. Joensuu EI, Abdel-Rahman WM, Ollikainen M, Ruosaari S, Knuutila S, et al. (2008) Epigenetic signatures of familial cancer are characteristic of tumor type and family category. Cancer Res 68: 4597-4605.
42. Kim YH, Petko Z, Dzieciatkowski S, Lin L, Ghiassi M, et al. (2006) CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. Genes Chromosomes Cancer 45: 781-789.