Dissecting the p53-Mdm2 feedback loop in vivo: Uncoupling the role in p53 stability and activity

Oncotarget

Volumn 5, Issue 5, 2014, Pages 1149-1156

  Pant, Vinod ^a   Lozano, Guillermina ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Autoregulation; E3 ligase; Mdm4; MEFs; Mouse model; P2 promoter; P53 degradation

Indexed keywords

PROTEIN MDM2; PROTEIN P53; UBIQUITIN PROTEIN LIGASE E3; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CYCLOHEXIMIDE; DACTINOMYCIN; DOXORUBICIN; LEUPEPTIN; MDM2 PROTEIN, MOUSE; MDM4 PROTEIN, MOUSE; ONCOPROTEIN; UBIQUITIN PROTEIN LIGASE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DEGRADATION KINETICS; ENZYME ACTIVITY; FEEDBACK SYSTEM; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN STABILITY; REGULATORY MECHANISM; ANIMAL; CELL CULTURE; DNA DAMAGE; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; METABOLISM; PHYSIOLOGICAL STRESS; POINT MUTATION; PROMOTER REGION; RADIATION DOSE; RADIATION RESPONSE; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; CYCLOHEXIMIDE; DACTINOMYCIN; DNA DAMAGE; DOXORUBICIN; FEEDBACK, PHYSIOLOGICAL; FIBROBLASTS; GENE EXPRESSION REGULATION; GENOTYPE; LEUPEPTINS; MICE; POINT MUTATION; PROMOTER REGIONS, GENETIC; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RADIATION TOLERANCE; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 84898608024     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1797     Document Type: Article

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