메뉴 건너뛰기




Volumn 72, Issue 1, 2007, Pages 103-111

Differential intracellular signaling through PAC1 isoforms as a result of alternative splicing in the first extracellular domain and the third intracellular loop

Author keywords

[No Author keywords available]

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; MESSENGER RNA; PROTEIN SUBUNIT;

EID: 34347207562     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.035477     Document Type: Article
Times cited : (35)

References (32)
  • 1
    • 0028883720 scopus 로고
    • Structure of the gene encoding the mouse pituitary adenylate cyclase-activating polypeptide receptor
    • Aino H, Hashimoto H, Ogawa N, Nishino A, Yamamoto K, Nogi H, Nagata S, and Baba A (1995) Structure of the gene encoding the mouse pituitary adenylate cyclase-activating polypeptide receptor. Gene 164:301-304.
    • (1995) Gene , vol.164 , pp. 301-304
    • Aino, H.1    Hashimoto, H.2    Ogawa, N.3    Nishino, A.4    Yamamoto, K.5    Nogi, H.6    Nagata, S.7    Baba, A.8
  • 2
    • 0036286336 scopus 로고    scopus 로고
    • Novel splice variants of type I pituitary adenylate cyclase-activating polypeptide receptor in frog exhibit altered adenylate cyclase stimulation and differential relative abundance
    • Alexandre D, Vaudry H, Grumolato L, Turquier V, Fournier A, Jegou S, and Anouar Y (2002) Novel splice variants of type I pituitary adenylate cyclase-activating polypeptide receptor in frog exhibit altered adenylate cyclase stimulation and differential relative abundance. Endocrinology 143:2680-2692.
    • (2002) Endocrinology , vol.143 , pp. 2680-2692
    • Alexandre, D.1    Vaudry, H.2    Grumolato, L.3    Turquier, V.4    Fournier, A.5    Jegou, S.6    Anouar, Y.7
  • 3
    • 0029146992 scopus 로고
    • The amino-terminal fragment of the adenylate cyclase activating polypeptide (PACAP) receptor functions as a high affinity PACAP binding domain
    • Cao YJ, Gimpl G, and Fahrenholz F (1995) The amino-terminal fragment of the adenylate cyclase activating polypeptide (PACAP) receptor functions as a high affinity PACAP binding domain. Biochem Biophys Res Commun 212:673-680.
    • (1995) Biochem Biophys Res Commun , vol.212 , pp. 673-680
    • Cao, Y.J.1    Gimpl, G.2    Fahrenholz, F.3
  • 4
    • 0035918150 scopus 로고    scopus 로고
    • Novel alternatively spliced exon in the extracellular ligand-binding domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) selectively increases ligand affinity and alters signal transduction coupling during spermatogenesis
    • Daniel PB, Kieffer TJ, Leech CA, and Habener JF (2001) Novel alternatively spliced exon in the extracellular ligand-binding domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) selectively increases ligand affinity and alters signal transduction coupling during spermatogenesis. J Biol Chem 276:12938-12944.
    • (2001) J Biol Chem , vol.276 , pp. 12938-12944
    • Daniel, P.B.1    Kieffer, T.J.2    Leech, C.A.3    Habener, J.F.4
  • 5
    • 0032724068 scopus 로고    scopus 로고
    • N-terminal splice variants of the type I PACAP receptor: Isolation, characterization and ligand binding/selectivity determinants
    • Dautzenberg FM, Mevenkamp G, Wille S, and Hauger RL (1999) N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants. J Neuroendocrinol 11:941-949.
    • (1999) J Neuroendocrinol , vol.11 , pp. 941-949
    • Dautzenberg, F.M.1    Mevenkamp, G.2    Wille, S.3    Hauger, R.L.4
  • 6
    • 0025334274 scopus 로고
    • Characterization and distribution of binding sites for the hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide
    • Gottschall PE, Tatsuno I, Miyata A, and Arimura A (1990) Characterization and distribution of binding sites for the hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide. Endocrinology 127:272-277.
    • (1990) Endocrinology , vol.127 , pp. 272-277
    • Gottschall, P.E.1    Tatsuno, I.2    Miyata, A.3    Arimura, A.4
  • 7
    • 0035716295 scopus 로고    scopus 로고
    • Family-B G-protein-coupled receptors
    • REVIEWS3013.10
    • Harmar AJ (2001) Family-B G-protein-coupled receptors. Genome Biol 2:REVIEWS3013.10.
    • (2001) Genome Biol , vol.2
    • Harmar, A.J.1
  • 8
    • 0030049389 scopus 로고    scopus 로고
    • Two isoforms of the prostaglandin E receptor EP3 subtype different in agonist-independent constitutive activity
    • Hasegawa H, Negishi M, and Ichikawa A (1996) Two isoforms of the prostaglandin E receptor EP3 subtype different in agonist-independent constitutive activity. J Biol Chem 271:1857-1860.
    • (1996) J Biol Chem , vol.271 , pp. 1857-1860
    • Hasegawa, H.1    Negishi, M.2    Ichikawa, A.3
  • 9
    • 0027317350 scopus 로고
    • Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide
    • Hashimoto H, Ishihara T, Shigemoto R, Mori K, and Nagata S (1993) Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron 11:333-342.
    • (1993) Neuron , vol.11 , pp. 333-342
    • Hashimoto, H.1    Ishihara, T.2    Shigemoto, R.3    Mori, K.4    Nagata, S.5
  • 10
    • 0027171713 scopus 로고
    • Molecular cloning and functional expression of rat cDNAs encoding the receptor for pituitary adenylate cyclase activating polypeptide (PACAP)
    • Hosoya M, Onda H, Ogi K, Masuda Y, Miyamoto Y, Ohtaki T, Okazaki H, Arimura A, and Fujino M (1993) Molecular cloning and functional expression of rat cDNAs encoding the receptor for pituitary adenylate cyclase activating polypeptide (PACAP). Biochem Biophys Res Commun 194:133-143.
    • (1993) Biochem Biophys Res Commun , vol.194 , pp. 133-143
    • Hosoya, M.1    Onda, H.2    Ogi, K.3    Masuda, Y.4    Miyamoto, Y.5    Ohtaki, T.6    Okazaki, H.7    Arimura, A.8    Fujino, M.9
  • 11
    • 0026511295 scopus 로고
    • Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide
    • Ishihara T, Shigemoto R, Mori K, Takahashi K, and Nagata S (1992) Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron 8:811-889.
    • (1992) Neuron , vol.8 , pp. 811-889
    • Ishihara, T.1    Shigemoto, R.2    Mori, K.3    Takahashi, K.4    Nagata, S.5
  • 12
    • 0035903152 scopus 로고    scopus 로고
    • C-terminal splice variants of the mouse mu-opioid receptor differ in morphine-induced internalization and receptor resensitization
    • Koch T, Schulz S, Pfeiffer M, Klutzny M, Schroder H, Kahl E, and Hollt V (2001) C-terminal splice variants of the mouse mu-opioid receptor differ in morphine-induced internalization and receptor resensitization. J Biol Chem 276:31408-31414.
    • (2001) J Biol Chem , vol.276 , pp. 31408-31414
    • Koch, T.1    Schulz, S.2    Pfeiffer, M.3    Klutzny, M.4    Schroder, H.5    Kahl, E.6    Hollt, V.7
  • 13
    • 0025812114 scopus 로고
    • Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis
    • Lerner EA, Ribeiro JM, Nelson RJ, and Lerner MR (1991) Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis. J Biol Chem 266:11234-11236.
    • (1991) J Biol Chem , vol.266 , pp. 11234-11236
    • Lerner, E.A.1    Ribeiro, J.M.2    Nelson, R.J.3    Lerner, M.R.4
  • 14
    • 32244433214 scopus 로고    scopus 로고
    • Characterization of novel splice variants of the PAC1 receptor in human neuroblastoma cells: Consequences for signaling by VIP and PACAP
    • Lutz EM, Ronaldson E, Shaw P, Johnson MS, Holland PJ, and Mitchell R (2006) Characterization of novel splice variants of the PAC1 receptor in human neuroblastoma cells: consequences for signaling by VIP and PACAP. Mol Cell Neurosci 31:193-209.
    • (2006) Mol Cell Neurosci , vol.31 , pp. 193-209
    • Lutz, E.M.1    Ronaldson, E.2    Shaw, P.3    Johnson, M.S.4    Holland, P.J.5    Mitchell, R.6
  • 15
    • 0032844818 scopus 로고    scopus 로고
    • Structure of the human VIPR2 gene for vasoactive intestinal peptide receptortype 2
    • Lutz EM, Shen S, Mackay M, West K, and Harmar AJ (1999) Structure of the human VIPR2 gene for vasoactive intestinal peptide receptortype 2. FEBS Lett 458:197-203.
    • (1999) FEBS Lett , vol.458 , pp. 197-203
    • Lutz, E.M.1    Shen, S.2    Mackay, M.3    West, K.4    Harmar, A.J.5
  • 16
    • 0027332401 scopus 로고
    • The VIP2 receptor: Molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide
    • Lutz EM, Sheward WJ, West KM, Morrow JA, Fink G, and Harmar AJ (1993) The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide. FEBS Lett 334:3-8.
    • (1993) FEBS Lett , vol.334 , pp. 3-8
    • Lutz, E.M.1    Sheward, W.J.2    West, K.M.3    Morrow, J.A.4    Fink, G.5    Harmar, A.J.6
  • 20
    • 0025075727 scopus 로고
    • Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38)
    • Miyata A, Jiang L, Dahl RD, Kitada C, Kubo K, Fujino M, Minamino N, and Arimura A (1990) Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38). Biochem Biophys Res Commun 170:643-648.
    • (1990) Biochem Biophys Res Commun , vol.170 , pp. 643-648
    • Miyata, A.1    Jiang, L.2    Dahl, R.D.3    Kitada, C.4    Kubo, K.5    Fujino, M.6    Minamino, N.7    Arimura, A.8
  • 21
    • 13444303901 scopus 로고    scopus 로고
    • Identification of neuromedin S and its possible role in the mammalian circadian oscillator system
    • Mori K, Miyazato M, Ida T, Murakami N, Serino R, Ueta Y, Kojima M, and Kangawa K (2005) Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J 24:325-335.
    • (2005) EMBO J , vol.24 , pp. 325-335
    • Mori, K.1    Miyazato, M.2    Ida, T.3    Murakami, N.4    Serino, R.5    Ueta, Y.6    Kojima, M.7    Kangawa, K.8
  • 22
    • 0031030207 scopus 로고    scopus 로고
    • Maxadilan, the vasodilator from sand flies, is a specific pituitary adenylate cyclase activating peptide type I receptor agonist
    • Moro O, and Lerner EA (1997) Maxadilan, the vasodilator from sand flies, is a specific pituitary adenylate cyclase activating peptide type I receptor agonist. J Biol Chem 272:966-970.
    • (1997) J Biol Chem , vol.272 , pp. 966-970
    • Moro, O.1    Lerner, E.A.2
  • 23
    • 0033551767 scopus 로고    scopus 로고
    • Functional characterization of structural alterations in the sequence of the vasodilatory peptide maxadilan yields a pituitary adenylate cyclase-activating peptide type 1 receptor-specific antagonist
    • Moro O, Wakita K, Ohnuma M, Denda S, Lerner EA, and Tajima M (1999) Functional characterization of structural alterations in the sequence of the vasodilatory peptide maxadilan yields a pituitary adenylate cyclase-activating peptide type 1 receptor-specific antagonist. J Biol Chem 274:23103-28110.
    • (1999) J Biol Chem , vol.274 , pp. 23103-28110
    • Moro, O.1    Wakita, K.2    Ohnuma, M.3    Denda, S.4    Lerner, E.A.5    Tajima, M.6
  • 24
    • 0027184809 scopus 로고
    • Molecular cloning and expression of a cDNA encoding a receptor for pituitary adenylate cyclase activating polypeptide (PACAP)
    • Morrow JA, Lutz EM, West KM, Fink G, and Harmar AJ (1993), Molecular cloning and expression of a cDNA encoding a receptor for pituitary adenylate cyclase activating polypeptide (PACAP). FEBS Lett 329:99-105.
    • (1993) FEBS Lett , vol.329 , pp. 99-105
    • Morrow, J.A.1    Lutz, E.M.2    West, K.M.3    Fink, G.4    Harmar, A.J.5
  • 25
    • 28444479463 scopus 로고    scopus 로고
    • Diversity and complexity of the mu opioid receptor gene: Alternative pre-mRNA splicing and promoters
    • Pan YX (2005) Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters. DNA Cell Biol 24:736-750.
    • (2005) DNA Cell Biol , vol.24 , pp. 736-750
    • Pan, Y.X.1
  • 26
    • 0029811975 scopus 로고    scopus 로고
    • Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation
    • Pantaloni C, Brabet P, Bilanges B, Dumuis A, Houssami S, Spengler D, Bockaert J, and Journot L (1996) Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation. J Biol Chem 271:22146-22151.
    • (1996) J Biol Chem , vol.271 , pp. 22146-22151
    • Pantaloni, C.1    Brabet, P.2    Bilanges, B.3    Dumuis, A.4    Houssami, S.5    Spengler, D.6    Bockaert, J.7    Journot, L.8
  • 27
    • 0027281138 scopus 로고
    • Molecular cloning and functional expression of the pituitary adenylate cyclase-activating polypeptide type I receptor
    • Pisegna JR, and Wank SA (1993) Molecular cloning and functional expression of the pituitary adenylate cyclase-activating polypeptide type I receptor. Proc Natl Acad Sci U S A 90:6345-6349.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6345-6349
    • Pisegna, J.R.1    Wank, S.A.2
  • 28
    • 0030035113 scopus 로고    scopus 로고
    • Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C
    • Pisegna JR, and Wank SA (1996) Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C. J Biol Chem 271:17267-17274.
    • (1996) J Biol Chem , vol.271 , pp. 17267-17274
    • Pisegna, J.R.1    Wank, S.A.2
  • 30
    • 0038749491 scopus 로고    scopus 로고
    • Expression of the receptor for pituitary adenylate cyclase-activatin polypeptide (PAC1-R) in reactive astrocytes
    • Suzuki R, Arata S, Nakajo S, Ikenaka K, Kikuyama S, and Shioda S (2003) Expression of the receptor for pituitary adenylate cyclase-activatin polypeptide (PAC1-R) in reactive astrocytes. Brain Res Mol Brain Res 115:10-20.
    • (2003) Brain Res Mol Brain Res , vol.115 , pp. 10-20
    • Suzuki, R.1    Arata, S.2    Nakajo, S.3    Ikenaka, K.4    Kikuyama, S.5    Shioda, S.6
  • 31
    • 0025356772 scopus 로고
    • Demonstration of specific binding sites for pituitary adenylate cyclase activating polypeptide (PACAP) in rat astrocytes
    • Tatsuno I, Gottschall PE, Koves K, and Arimura A (1990) Demonstration of specific binding sites for pituitary adenylate cyclase activating polypeptide (PACAP) in rat astrocytes. Biochem Biophys Res Commun 168:1027-1033.
    • (1990) Biochem Biophys Res Commun , vol.168 , pp. 1027-1033
    • Tatsuno, I.1    Gottschall, P.E.2    Koves, K.3    Arimura, A.4
  • 32
    • 0034048147 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide and its receptors: From structure to functions
    • Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, and Vaudry H (2000) Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions. Pharmacol Rev 52:269-324.
    • (2000) Pharmacol Rev , vol.52 , pp. 269-324
    • Vaudry, D.1    Gonzalez, B.J.2    Basille, M.3    Yon, L.4    Fournier, A.5    Vaudry, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.