Endothelial insulin-like growth factor-1 modulates proliferation and phenotype of smooth muscle cells induced by low shear stress

Annals of Biomedical Engineering

Volumn 42, Issue 4, 2014, Pages 776-786

  Wang, Lu ^a   Han, Yue ^a   Shen, Yan ^a   Yan, Zhi Qiang ^a   Zhang, Ping ^a   Yao, Qing Ping ^a   Shen, Bao Rong ^a   Gao, Li Zhi ^a   Qi, Ying Xin ^a   Jiang, Zong Lai ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Endothelial cells; Insulin like growth factor 1; Phenotypic transformation; Proliferation; Shear stress; Vascular smooth muscle cells

Indexed keywords

ENDOTHELIAL CELLS; INSULIN; PHOSPHORYLATION; PHYSIOLOGY;

AKT PHOSPHORYLATION; INSULIN-LIKE GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR 1; PARALLEL-PLATE FLOW CHAMBERS; PHENOTYPIC TRANSFORMATION; PROLIFERATION; SPECIFIC INHIBITORS; VASCULAR SMOOTH MUSCLE CELLS;

SHEAR STRESS;

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SIRTUIN 2; SOMATOMEDIN C;

ARTICLE; CELL PROLIFERATION; NONHUMAN; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; RNA INTERFERENCE; SHEAR STRESS; SMOOTH MUSCLE FIBER;

ANIMALS; AORTA; CELL PROLIFERATION; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; INSULIN-LIKE GROWTH FACTOR I; MYOCYTES, SMOOTH MUSCLE; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, IGF TYPE 1; RNA, MESSENGER; RNA, SMALL INTERFERING; SIRTUIN 2; STRESS, MECHANICAL;

EID: 84898600840     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-013-0957-5     Document Type: Article

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