메뉴 건너뛰기




Volumn 6, Issue 3, 2014, Pages 228-236

Insulin therapy improves islet functions by restoring pancreatic vasculature in high-fat diet-fed streptozotocin-diabetic rats

Author keywords

Insulin treatment; Microcirculation; Type 2 diabetes; cell recovery

Indexed keywords

CD31 ANTIGEN; CHOLESTEROL; GLUCOSE; INSULIN; ISOPHANE INSULIN; TRIACYLGLYCEROL; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; VASCULOTROPIN A;

EID: 84898599918     PISSN: 17530393     EISSN: 17530407     Source Type: Journal    
DOI: 10.1111/1753-0407.12095     Document Type: Article
Times cited : (7)

References (50)
  • 1
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group
    • Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA. 1999; 281: 2005-2012.
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3    Holman, R.R.4
  • 2
    • 0041828484 scopus 로고    scopus 로고
    • Inflammatory mediators and islet beta-cell failure: A link between type 1 and type 2 diabetes
    • Donath MY, Storling J, Maedler K, Mandrup-Poulsen T. Inflammatory mediators and islet beta-cell failure: A link between type 1 and type 2 diabetes. J Mol Med (Berl). 2003; 81: 455-470.
    • (2003) J Mol Med (Berl) , vol.81 , pp. 455-470
    • Donath, M.Y.1    Storling, J.2    Maedler, K.3    Mandrup-Poulsen, T.4
  • 3
    • 43549108142 scopus 로고    scopus 로고
    • Glucolipotoxicity: Fuel excess and beta-cell dysfunction
    • Poitout V, Robertson R. Glucolipotoxicity: Fuel excess and beta-cell dysfunction. Endocr Rev. 2008; 29: 351-366.
    • (2008) Endocr Rev , vol.29 , pp. 351-366
    • Poitout, V.1    Robertson, R.2
  • 4
    • 0142087597 scopus 로고    scopus 로고
    • Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: The Epidemiology of Diabetes Interventions and Complications (EDIC) study
    • Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: The Epidemiology of Diabetes Interventions and Complications (EDIC) study. JAMA. 2003; 290: 2159-2167.
    • (2003) JAMA , vol.290 , pp. 2159-2167
  • 5
    • 77956394914 scopus 로고    scopus 로고
    • DCCT and EDIC studies in type 1 diabetes: Lessons for diabetic neuropathy regarding metabolic memory and natural history
    • Pop-Busui R, Herman WH, Feldman EL etal. DCCT and EDIC studies in type 1 diabetes: Lessons for diabetic neuropathy regarding metabolic memory and natural history. Curr Diab Rep. 2010; 10: 276-282.
    • (2010) Curr Diab Rep , vol.10 , pp. 276-282
    • Pop-Busui, R.1    Herman, W.H.2    Feldman, E.L.3
  • 6
    • 79551593128 scopus 로고    scopus 로고
    • Progression of carotid artery intima-media thickness during 12 years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study
    • Polak JF, Backlund JY, Cleary PA etal. Progression of carotid artery intima-media thickness during 12 years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. Diabetes. 2011; 60: 607-613.
    • (2011) Diabetes , vol.60 , pp. 607-613
    • Polak, J.F.1    Backlund, J.Y.2    Cleary, P.A.3
  • 7
    • 7444234167 scopus 로고    scopus 로고
    • Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function
    • Li Y, Xu W, Liao Z etal. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function. Diabetes Care. 2004; 27: 2597-2602.
    • (2004) Diabetes Care , vol.27 , pp. 2597-2602
    • Li, Y.1    Xu, W.2    Liao, Z.3
  • 8
    • 43849105857 scopus 로고    scopus 로고
    • Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: A multicentre randomised parallel-group trial
    • Weng J, Li Y, Xu W etal. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: A multicentre randomised parallel-group trial. Lancet. 2008; 371: 1753-1760.
    • (2008) Lancet , vol.371 , pp. 1753-1760
    • Weng, J.1    Li, Y.2    Xu, W.3
  • 9
    • 34249682591 scopus 로고    scopus 로고
    • beta-cell failure in diabetes and preservation by clinical treatment
    • Wajchenberg BL. beta-cell failure in diabetes and preservation by clinical treatment. Endocr Rev. 2007; 28: 187-218.
    • (2007) Endocr Rev , vol.28 , pp. 187-218
    • Wajchenberg, B.L.1
  • 10
    • 44649165790 scopus 로고    scopus 로고
    • Effects of beta-cell rest on beta-cell function: A review of clinical and preclinical data
    • Brown RJ, Rother KI. Effects of beta-cell rest on beta-cell function: A review of clinical and preclinical data. Pediatr Diabetes. 2008; 9(3 Pt 2): 14-22.
    • (2008) Pediatr Diabetes , vol.9 , Issue.3 PART 2 , pp. 14-22
    • Brown, R.J.1    Rother, K.I.2
  • 11
    • 9644260562 scopus 로고    scopus 로고
    • Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus
    • Kubota N, Terauchi Y, Tobe K etal. Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest. 2004; 114: 917-927.
    • (2004) J Clin Invest , vol.114 , pp. 917-927
    • Kubota, N.1    Terauchi, Y.2    Tobe, K.3
  • 12
  • 13
    • 56149118396 scopus 로고    scopus 로고
    • Acute modulation of toll-like receptors by insulin
    • Ghanim H, Mohanty P, Deopurkar R etal. Acute modulation of toll-like receptors by insulin. Diabetes Care. 2008; 31: 1827-1831.
    • (2008) Diabetes Care , vol.31 , pp. 1827-1831
    • Ghanim, H.1    Mohanty, P.2    Deopurkar, R.3
  • 15
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    • Thorel F, Nepote V, Avril I etal. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature. 2010; 464: 1149-1154.
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1    Nepote, V.2    Avril, I.3
  • 16
    • 85004667998 scopus 로고
    • Morphology and physiology of areas of langerhans in some vertebrates
    • Dewitt LM. Morphology and physiology of areas of langerhans in some vertebrates. J Exp Med. 1906; 8: 193-239.
    • (1906) J Exp Med , vol.8 , pp. 193-239
    • Dewitt, L.M.1
  • 17
    • 0035913986 scopus 로고    scopus 로고
    • Induction of pancreatic differentiation by signals from blood vessels
    • Lammert E, Cleaver O, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science. 2001; 294: 564-567.
    • (2001) Science , vol.294 , pp. 564-567
    • Lammert, E.1    Cleaver, O.2    Melton, D.3
  • 18
    • 0020759617 scopus 로고
    • Insulin binding to microvascular endothelium of intact heart: A kinetic and morphometric analysis
    • Bar RS, DeRose A, Sandra A, Peacock ML, Owen WG. Insulin binding to microvascular endothelium of intact heart: A kinetic and morphometric analysis. Am J Physiol. 1983; 244: E447-452.
    • (1983) Am J Physiol , vol.244
    • Bar, R.S.1    DeRose, A.2    Sandra, A.3    Peacock, M.L.4    Owen, W.G.5
  • 19
    • 0033950472 scopus 로고    scopus 로고
    • Effect of insulin on human aortic endothelial nitric oxide synthase
    • Aljada A, Dandona P. Effect of insulin on human aortic endothelial nitric oxide synthase. Metabolism. 2000; 49: 147-150.
    • (2000) Metabolism , vol.49 , pp. 147-150
    • Aljada, A.1    Dandona, P.2
  • 20
    • 0034456622 scopus 로고    scopus 로고
    • Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide
    • Aljada A, Saadeh R, Assian E, Ghanim H, Dandona P. Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. J Clin Endocrinol Metab. 2000; 85: 2572-2575.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2572-2575
    • Aljada, A.1    Saadeh, R.2    Assian, E.3    Ghanim, H.4    Dandona, P.5
  • 21
    • 0033761823 scopus 로고    scopus 로고
    • A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat
    • Reed MJ, Meszaros K, Entes LJ etal. A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat. Metabolism. 2000; 49: 1390-1394.
    • (2000) Metabolism , vol.49 , pp. 1390-1394
    • Reed, M.J.1    Meszaros, K.2    Entes, L.J.3
  • 22
    • 65549167291 scopus 로고    scopus 로고
    • Increased carnitine palmitoyl transferase 1 expression and decreased sterol regulatory element-binding protein 1c expression are associated with reduced intramuscular triglyceride accumulation after insulin therapy in high-fat-diet and streptozotocin-induced diabetic rats
    • Bi Y, Cai M, Liang H etal. Increased carnitine palmitoyl transferase 1 expression and decreased sterol regulatory element-binding protein 1c expression are associated with reduced intramuscular triglyceride accumulation after insulin therapy in high-fat-diet and streptozotocin-induced diabetic rats. Metabolism. 2009; 58: 779-786.
    • (2009) Metabolism , vol.58 , pp. 779-786
    • Bi, Y.1    Cai, M.2    Liang, H.3
  • 23
    • 79751496044 scopus 로고    scopus 로고
    • Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis
    • Xia X, Yan J, Shen Y etal. Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis. PLoS ONE. 2011; 6: e16556.
    • (2011) PLoS ONE , vol.6
    • Xia, X.1    Yan, J.2    Shen, Y.3
  • 24
    • 84871329445 scopus 로고    scopus 로고
    • Effects of exercise on AMPK signaling and downstream components to PI3K in rat with type 2 diabetes
    • Cao S, Li B, Yi X etal. Effects of exercise on AMPK signaling and downstream components to PI3K in rat with type 2 diabetes. PLoS ONE. 2012; 7: e51709.
    • (2012) PLoS ONE , vol.7
    • Cao, S.1    Li, B.2    Yi, X.3
  • 25
    • 84861842716 scopus 로고    scopus 로고
    • Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: Identification of a novel role in improving insulin sensitivity
    • Si Y, Zhao Y, Hao H etal. Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: Identification of a novel role in improving insulin sensitivity. Diabetes. 2012; 61: 1616-1625.
    • (2012) Diabetes , vol.61 , pp. 1616-1625
    • Si, Y.1    Zhao, Y.2    Hao, H.3
  • 26
    • 77649171913 scopus 로고    scopus 로고
    • Changes in islet microvasculature following streptozotocin-induced beta-cell loss and subsequent replacement in the neonatal rat
    • Nicholson JM, Arany EJ, Hill DJ. Changes in islet microvasculature following streptozotocin-induced beta-cell loss and subsequent replacement in the neonatal rat. Exp Biol Med. 2010; 235: 189-198.
    • (2010) Exp Biol Med , vol.235 , pp. 189-198
    • Nicholson, J.M.1    Arany, E.J.2    Hill, D.J.3
  • 27
    • 79952378639 scopus 로고    scopus 로고
    • Glucose and inflammation control islet vascular density and beta-cell function in NOD mice: Control of islet vasculature and vascular endothelial growth factor by glucose
    • Akirav EM, Baquero MT, Opare-Addo LW etal. Glucose and inflammation control islet vascular density and beta-cell function in NOD mice: Control of islet vasculature and vascular endothelial growth factor by glucose. Diabetes. 2011; 60: 876-883.
    • (2011) Diabetes , vol.60 , pp. 876-883
    • Akirav, E.M.1    Baquero, M.T.2    Opare-Addo, L.W.3
  • 28
    • 32944474182 scopus 로고    scopus 로고
    • VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
    • Kamba T, Tam BY, Hashizume H etal. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol. 2006; 290: H560-576.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Kamba, T.1    Tam, B.Y.2    Hashizume, H.3
  • 29
    • 33845540482 scopus 로고    scopus 로고
    • Pancreatic islet production of vascular endothelial growth factor - a is essential for islet vascularization, revascularization, and function
    • Brissova M, Shostak A, Shiota M etal. Pancreatic islet production of vascular endothelial growth factor - a is essential for islet vascularization, revascularization, and function. Diabetes. 2006; 55: 2974-2985.
    • (2006) Diabetes , vol.55 , pp. 2974-2985
    • Brissova, M.1    Shostak, A.2    Shiota, M.3
  • 30
    • 0041523870 scopus 로고    scopus 로고
    • Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients
    • Alvarsson M, Sundkvist G, Lager I etal. Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients. Diabetes Care. 2003; 26: 2231-2237.
    • (2003) Diabetes Care , vol.26 , pp. 2231-2237
    • Alvarsson, M.1    Sundkvist, G.2    Lager, I.3
  • 31
    • 56149118663 scopus 로고    scopus 로고
    • Beneficial effects of insulin on glycemic control and beta-cell function in newly diagnosed type 2 diabetes with severe hyperglycemia after short-term intensive insulin therapy
    • Chen HS, Wu TE, Jap TS, Hsiao LC, Lee SH, Lin HD. Beneficial effects of insulin on glycemic control and beta-cell function in newly diagnosed type 2 diabetes with severe hyperglycemia after short-term intensive insulin therapy. Diabetes Care. 2008; 31: 1927-1932.
    • (2008) Diabetes Care , vol.31 , pp. 1927-1932
    • Chen, H.S.1    Wu, T.E.2    Jap, T.S.3    Hsiao, L.C.4    Lee, S.H.5    Lin, H.D.6
  • 32
    • 84862832942 scopus 로고    scopus 로고
    • Short-term intensive therapy in newly diagnosed type 2 diabetes partially restores both insulin sensitivity and beta-cell function in subjects with long-term remission
    • Hu Y, Li L, Xu Y etal. Short-term intensive therapy in newly diagnosed type 2 diabetes partially restores both insulin sensitivity and beta-cell function in subjects with long-term remission. Diabetes Care. 2011; 34: 1848-1853.
    • (2011) Diabetes Care , vol.34 , pp. 1848-1853
    • Hu, Y.1    Li, L.2    Xu, Y.3
  • 34
    • 0017239486 scopus 로고
    • Improvement in insulin secretion in diabetes after diazoxide
    • Greenwood RH, Mahler RF, Hales CN. Improvement in insulin secretion in diabetes after diazoxide. Lancet. 1976; 1: 444-447.
    • (1976) Lancet , vol.1 , pp. 444-447
    • Greenwood, R.H.1    Mahler, R.F.2    Hales, C.N.3
  • 35
    • 0018092385 scopus 로고
    • Sustained insulin-induced remissions of juvenile diabetes by means of an external artificial pancreas
    • Mirouze J, Selam JL, Pham TC, Mendoza E, Orsetti A. Sustained insulin-induced remissions of juvenile diabetes by means of an external artificial pancreas. Diabetologia. 1978; 14: 223-227.
    • (1978) Diabetologia , vol.14 , pp. 223-227
    • Mirouze, J.1    Selam, J.L.2    Pham, T.C.3    Mendoza, E.4    Orsetti, A.5
  • 36
    • 78649814620 scopus 로고    scopus 로고
    • Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity
    • Ritzel RA, Jayasinghe S, Hansen JB, Sturis J, Langen R, Butler PC. Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity. Regul Pept. 2010; 165: 158-162.
    • (2010) Regul Pept , vol.165 , pp. 158-162
    • Ritzel, R.A.1    Jayasinghe, S.2    Hansen, J.B.3    Sturis, J.4    Langen, R.5    Butler, P.C.6
  • 37
    • 0020570005 scopus 로고
    • Stimulation by glucose of the blood flow to the pancreatic islets of the rat
    • Jansson L, Hellerstrom C. Stimulation by glucose of the blood flow to the pancreatic islets of the rat. Diabetologia. 1983; 25: 45-50.
    • (1983) Diabetologia , vol.25 , pp. 45-50
    • Jansson, L.1    Hellerstrom, C.2
  • 38
    • 33947253406 scopus 로고    scopus 로고
    • Pancreatic islet blood flow during euglycaemic, hyperinsulinaemic clamp in anaesthetized rats
    • Jansson L, Andersson A, Bodin B, Kallskog O. Pancreatic islet blood flow during euglycaemic, hyperinsulinaemic clamp in anaesthetized rats. Acta Physiol. 2007; 189: 319-324.
    • (2007) Acta Physiol , vol.189 , pp. 319-324
    • Jansson, L.1    Andersson, A.2    Bodin, B.3    Kallskog, O.4
  • 39
    • 33845582804 scopus 로고    scopus 로고
    • Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes
    • Li X, Zhang L, Meshinchi S etal. Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes. Diabetes. 2006; 55: 2965-2973.
    • (2006) Diabetes , vol.55 , pp. 2965-2973
    • Li, X.1    Zhang, L.2    Meshinchi, S.3
  • 40
    • 0037665295 scopus 로고    scopus 로고
    • Role of VEGF-A in vascularization of pancreatic islets
    • Lammert E, Gu G, McLaughlin M etal. Role of VEGF-A in vascularization of pancreatic islets. Curr Biol. 2003; 13: 1070-1074.
    • (2003) Curr Biol , vol.13 , pp. 1070-1074
    • Lammert, E.1    Gu, G.2    McLaughlin, M.3
  • 41
    • 0031000258 scopus 로고    scopus 로고
    • Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor
    • Tilton RG, Kawamura T, Chang KC etal. Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. J Clin Invest. 1997; 99: 2192-2202.
    • (1997) J Clin Invest , vol.99 , pp. 2192-2202
    • Tilton, R.G.1    Kawamura, T.2    Chang, K.C.3
  • 42
    • 0023628856 scopus 로고
    • High glucose prolongs cell-cycle traversal of cultured human endothelial cells
    • Lorenzi M, Nordberg JA, Toledo S. High glucose prolongs cell-cycle traversal of cultured human endothelial cells. Diabetes. 1987; 36: 1261-1267.
    • (1987) Diabetes , vol.36 , pp. 1261-1267
    • Lorenzi, M.1    Nordberg, J.A.2    Toledo, S.3
  • 43
    • 0034612261 scopus 로고    scopus 로고
    • High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal kinase and caspase-3
    • Ho FM, Liu SH, Liau CS, Huang PJ, Lin-Shiau SY. High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal kinase and caspase-3. Circulation. 2000; 101: 2618-2624.
    • (2000) Circulation , vol.101 , pp. 2618-2624
    • Ho, F.M.1    Liu, S.H.2    Liau, C.S.3    Huang, P.J.4    Lin-Shiau, S.Y.5
  • 44
    • 48249091745 scopus 로고    scopus 로고
    • Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators
    • Busik JV, Mohr S, Grant MB. Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators. Diabetes. 2008; 57: 1952-1965.
    • (2008) Diabetes , vol.57 , pp. 1952-1965
    • Busik, J.V.1    Mohr, S.2    Grant, M.B.3
  • 45
    • 79961110359 scopus 로고    scopus 로고
    • High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors
    • Kageyama S, Yokoo H, Tomita K etal. High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors. Cardiovasc Diabetol. 2011; 10: 73.
    • (2011) Cardiovasc Diabetol , vol.10 , pp. 73
    • Kageyama, S.1    Yokoo, H.2    Tomita, K.3
  • 46
    • 0037188926 scopus 로고    scopus 로고
    • Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells
    • Chen J, Brodsky SV, Goligorsky DM etal. Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells. Circ Res. 2002; 90: 1290-1298.
    • (2002) Circ Res , vol.90 , pp. 1290-1298
    • Chen, J.1    Brodsky, S.V.2    Goligorsky, D.M.3
  • 47
    • 0036095269 scopus 로고    scopus 로고
    • Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: Inhibition by the AMP-activated protein kinase activation
    • Ido Y, Carling D, Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: Inhibition by the AMP-activated protein kinase activation. Diabetes. 2002; 51: 159-167.
    • (2002) Diabetes , vol.51 , pp. 159-167
    • Ido, Y.1    Carling, D.2    Ruderman, N.3
  • 48
    • 80053208251 scopus 로고    scopus 로고
    • PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1alpha expression in MCF-7 breast cancer cells
    • Du J, Xu R, Hu Z etal. PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1alpha expression in MCF-7 breast cancer cells. PLoS ONE. 2011; 6: e25213.
    • (2011) PLoS ONE , vol.6
    • Du, J.1    Xu, R.2    Hu, Z.3
  • 49
    • 0036196081 scopus 로고    scopus 로고
    • Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF
    • Poulaki V, Qin W, Joussen AM etal. Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. J Clin Invest. 2002; 109: 805-815.
    • (2002) J Clin Invest , vol.109 , pp. 805-815
    • Poulaki, V.1    Qin, W.2    Joussen, A.M.3
  • 50
    • 0038665339 scopus 로고    scopus 로고
    • The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance
    • Vicent D, Ilany J, Kondo T etal. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest. 2003; 111: 1373-1380.
    • (2003) J Clin Invest , vol.111 , pp. 1373-1380
    • Vicent, D.1    Ilany, J.2    Kondo, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.