Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition

EMBO Molecular Medicine

Volumn 6, Issue 4, 2014, Pages 551-566

  Lakhani, Ronak ^a   Vogel, Kara R ^b   Till, Andreas ^a,c   Liu, Jingjing ^a,c   Burnett, Sarah F ^a   Gibson, K Michael ^b   Subramani, Suresh ^a,c  

^a SECTION OF MOLECULAR BIOLOGY   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c University of California San Diego   (United States)

Author keywords

Autophagy; GABA; MTOR; Rapamycin; SSADH deficiency

Indexed keywords

4 AMINOBUTYRIC ACID; RAPAMYCIN; SUCCINATE SEMIALDEHYDE DEHYDROGENASE; TARGET OF RAPAMYCIN KINASE;

4 AMINOBUTYRIC ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; HUMAN; HUMAN CELL; LIVER MITOCHONDRION; MITOPHAGY; MOUSE; MOUSE MODEL; MOUSE MUTANT; NONHUMAN; OXIDATIVE STRESS; PEROXISOME; PEXOPHAGY; PRIORITY JOURNAL; STARVATION; SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY; YEAST CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOPHAGY; BRAIN; DEFICIENCY; DISORDERS OF AMINO ACID AND PROTEIN METABOLISM; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; LIVER; METABOLISM;

AMINO ACID METABOLISM, INBORN ERRORS; ANIMALS; AUTOPHAGY; BRAIN; GAMMA-AMINOBUTYRIC ACID; HUMANS; LIVER; MICE; MICE, KNOCKOUT; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE; TOR SERINE-THREONINE KINASES;

EID: 84898599469     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201303356     Document Type: Article

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