Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets: A case study using terahertz pulsed imaging

International Journal of Pharmaceutics

Volumn 382, Issue 1-2, 2009, Pages 151-159

  Ho, Louise ^a,b,c   Cuppok, Yvonne ^d   Muschert, Susanne ^d   Gordon, Keith C ^a   Pepper, Michael ^b,c   Shen, Yaochun ^e   Siepmann, Florence ^d   Siepmann, Juergen ^d   Taday, Philip F ^c   Rades, Thomas ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c TERAVIEW LTD   (United Kingdom)

^d UNIV LILLE   (France)

^e UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Coating; Controlled release; Dissolution; Image analysis; Pellets; Unit operations

Indexed keywords

COPOLYMER; ETHYLENE GLYCOL VINYL ALCOHOL COPOLYMER; POLYVINYL ACETATE; THEOPHYLLINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG PELLET; DRUG SOLUBILITY; ELECTRIC FIELD; FILM COATING; IN VITRO STUDY; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; TERAHERTZ SPECTROSCOPY; THICKNESS;

CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG COMPOUNDING; KINETICS; MODELS, CHEMICAL; POLYVINYLS; SOLUBILITY; SURFACE PROPERTIES; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TERAHERTZ IMAGING; THEOPHYLLINE;

EID: 70350347479     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.08.025     Document Type: Article

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