Luciferase does not alter metabolism in cancer cells

Metabolomics

Volumn 10, Issue 3, 2014, Pages 354-360

  Johnson, Caroline H ^a   Fisher, Timothy S ^b   Hoang, Linh T ^a   Felding, Brunhilde H ^a   Siuzdak, Gary ^a   O'Brien, Peter J ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b PFIZER INC   (United States)

Author keywords

Bioluminescence imaging; Luciferase; Metabolomics; Reporter gene

Indexed keywords

LONG CHAIN FATTY ACID COENZYME A LIGASE; LUCIFERASE; PHLEOMYCIN; POLYCLONAL ANTIBODY; PUROMYCIN; RETROVIRUS VECTOR;

ARTICLE; BIOLUMINESCENCE; CANCER CELL CULTURE; CELL MANIPULATION; CELL METABOLISM; CELL VIABILITY; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG DETOXIFICATION; EXPRESSION VECTOR; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; LYMPHATIC LEUKEMIA CELL LINE; LYMPHOMA METABOLISM; METABOLOMICS; NEOPLASM; PROTEIN EXPRESSION; REPORTER GENE;

EID: 84898547332     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-014-0622-5     Document Type: Article

References (28)

1. Brutkiewicz, S., Mendonca, M., Stantz, K., Comerford, K., Bigsby, R., Hutchins, G., et al. (2007). The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging. Luminescence, 22, 221-228.
2. Czupryna, J., & Tsourkas, A. (2011). Firefly luciferase and RLuc8 exhibit differential sensitivity to oxidative stress in apoptotic cells. PLoS ONE, 6, e20073.
3. Ellis, J. M., Frahm, J. L., & Li, L. O. (2010). Acyl-coenzyme a synthetases in metabolic control. Current Opinion Lipidol, 21, 212-217.
4. Gatignol, A., Durand, H., & Tiraby, G. (1988). Bleomycin resistance conferred by a drug-binding protein. FEBS Lett, 230, 171-175.
5. Gould, S. G., Keller, G. A., & Subramani, S. (1987). Identification of a peroxisomal targeting signal at the carboxy terminus of firefly luciferase. J Cell Biol, 105, 2921-2923.
6. Greer, L. F, 3rd, & Szalay, A. A. (2002). Imaging of light emission from the expression of luciferases in living cells and organisms: A review. Luminescence, 17, 43-74.
7. Gulick, A. M. (2009). Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase. ACS Chem Biol, 4, 811-827.
8. Guranowski, A., Sillero, M. A. G., & Sillero, A. (1990). Firefly luciferase synthesizes P1, P 4-bis (5′-adenosyl) tetraphosphate (Ap4A) and other dinucleoside polyphosphates. FEBS Lett, 271, 215-218.
9. Ivanisevic, J., Zhu, Z., Plate, L., Tautenhahn, R., Chen, S., O'Brien, P. J., et al. (2013). Toward 'Omic' scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipids and central carbon metabolism. Anal Chem, 85, 6876-6884.
10. Keller, G. A., Gould, S., Deluca, M., & Subramani, S. (1987). Firefly luciferase is targeted to peroxisomes in mammalian cells. Proc Natl Acad Sci USA, 84, 3264-3268.
11. Keyaerts, M., Remory, I., Caveliers, V., Breckpot, K., Bos, T. J., Poelaert, J., et al. (2012). Inhibition of firefly luciferase by general anesthetics: effect on in vitro and in vivo bioluminescence imaging. PLoS ONE, 7, e30061.
12. McElroy, W. D., DeLuca, M., & Travis, J. (1967). Molecular uniformity in biological catalyses. The enzymes concerned with firefly luciferin, amino acid, and fatty acid utilization are compared. Science, 157, 150-160.
13. Milsom, C. C., Lee, C. R., Hackl, C., Man, S., & Kerbel, R. S. (2013). Differential post-surgical metastasis and survival in SCID, NOD-SCID and NOD-SCID-IL-2Rgamma(null) mice with parental and subline variants of human breast cancer: implications for host defense mechanisms regulating metastasis. PLoS ONE, 8, e71270.
14. Oba, Y., Iida, K., & Inouye, S. (2009). Functional conversion of fatty acyl-CoA synthetase to firefly luciferase by site-directed mutagenesis: a key substitution responsible for luminescence activity. FEBS Lett, 583, 2004-2008.
15. Oba, Y., Ojika, M., & Inouye, S. (2003). Firefly luciferase is a bifunctional enzyme: ATP-dependent monooxygenase and a long chain fatty acyl-CoA synthetase. FEBS Lett, 540, 251-254.
16. Oliva-Trastoy, M., Defais, M., & Larminat, F. (2005). Resistance to the antibiotic Zeocin by stable expression of the Sh ble gene does not fully suppress Zeocin-induced DNA cleavage in human cells. Mutagenesis, 20, 111-114.
17. Patti, G. J., Tautenhahn, R., Rinehart, D., Cho, K., Shriver, L. P., Manchester, M., et al. (2013). A view from above: cloud plots to visualize global metabolomic data. Anal Chem, 85, 798-804.
18. Patti, G. J., Tautenhahn, R., & Siuzdak, G. (2012). Meta-analysis of untargeted metabolomic data from multiple profiling experiments. Nat Prot, 7, 508-516.
19. Schipper, M. L., Patel, M. R., & Gambhir, S. S. (2006). Evaluation of firefly luciferase bioluminescence mediated photodynamic toxicity in cancer cells. Mol Imaging Biol, 8, 218-225.
20. Sim, H., Bibee, K., Wickline, S., & Sept, D. (2011). Pharmacokinetic modeling of tumor bioluminescence implicates efflux, and not influx, as the bigger hurdle in cancer drug therapy. Cancer Res, 71, 686-692.
21. Tautenhahn, R., Patti, G. J., Rinehart, D., & Siuzdak, G. (2012). XCMS Online: a web-based platform to process untargeted metabolomic data. Anal Chem, 84, 5035-5039.
22. Theodossiou, T., Hothersall, J. S., Woods, E. A., Okkenhaug, K., Jacobson, J., & MacRobert, A. J. (2003). Firefly luciferin-activated rose bengal: in vitro photodynamic therapy by intracellular chemiluminescence in transgenic NIH 3T3 cells. Cancer Res, 63, 1818-1821.
23. Thorne, N., Shen, M., Lea, W. A., Simeonov, A., Lovell, S., Auld, D. S., et al. (2012). Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter. Chem Bol, 19, 1060-1072.
24. Tiffen, J. C., Bailey, C. G., Ng, C., Rasko, J. E., & Holst, J. (2010). Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo. MolCancer, 9, 299.
25. van Staveren, W. C., Solis, D. Y., Hebrant, A., Detours, V., Dumont, J. E., & Maenhaut, C. (2009). Human cancer cell lines: Experimental models for cancer cells in situ? For cancer stem cells? Biochim et Biophys Acta, 1795, 92-103.
26. Watkins, P. A., & Ellis, J. M. (1822). Peroxisomal acyl-CoA synthetases. Biochim et Biophys Acta, 2012, 1411-1420.
27. Zhang, C. C., Yan, Z., Li, W., Kuszpit, K., Painter, C. L., Zhang, Q., et al. (2012). [(18)F]FLT-PET imaging does not always "light up" proliferating tumor cells. Clin Cancer Res, 18, 1303-1312.
28. Zhu, Z. J., Schultz, A. W., Wang, J., Johnson, C. H., Yannone, S. M., Patti, G. J., et al. (2013). Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database. Nat Prot, 8, 451-460.