Inhibition of firefly luciferase by general anesthetics: Effect on in vitro and in vivo bioluminescence imaging

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Keyaerts, Marleen ^a,b   Remory, Isabel ^a,b   Caveliers, Vicky ^a,b   Breckpot, Karine ^a   Bos, Tomas J ^a   Poelaert, Jan ^a,b   Bossuyt, Axel ^a,b   Lahoutte, Tony ^a,b  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BROMETHOL; DESFLURANE; FIREFLY LUCIFERASE; ISOFLURANE; KETAMINE; LUCIFERIN; MEDETOMIDINE; PENTOBARBITAL; SEVOFLURANE; VOLATILE AGENT; XYLAZINE; ALCOHOL; ANESTHETIC AGENT; CELL EXTRACT; DRUG DERIVATIVE; ENZYME INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOLUMINESCENCE; CELL LYSATE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; GENERAL ANESTHESIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; ANESTHESIA; ANIMAL; AREA UNDER THE CURVE; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; INJECTION; LUMINESCENCE; METABOLISM; METHODOLOGY; NUDE MOUSE; PHOTON; THREE DIMENSIONAL IMAGING; VOLATILIZATION;

ANIMALIA; MUS;

ANESTHESIA; ANESTHETICS, GENERAL; ANIMALS; AREA UNDER CURVE; CELL EXTRACTS; CELL LINE; ENZYME INHIBITORS; ETHANOL; HUMANS; IMAGING, THREE-DIMENSIONAL; INJECTIONS; KETAMINE; LUCIFERASES, FIREFLY; LUMINESCENT MEASUREMENTS; MALE; MEDETOMIDINE; MICE; MICE, NUDE; PENTOBARBITAL; PHOTONS; VOLATILIZATION; XYLAZINE;

EID: 84855573333     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030061     Document Type: Article

References (38)

1. Inoue Y, Kiryu S, Izawa K, Watanabe M, Tojo A, et al. (2009) Comparison of subcutaneous and intraperitoneal injection of D-luciferin for in vivo bioluminescence imaging. Eur J Nucl Med Mol Imaging 36: 771-779.
2. Jeon YH, Bae SA, Lee YJ, Lee YL, Lee SW, et al. (2010) Evaluation of the reversal of multidrug resistance by MDR1 ribonucleic acid interference in a human colon cancer model using a renilla luciferase reporter gene and coelenterazine. Mol Imaging 9: 343-350.
3. Keyaerts M, Heneweer C, Gainkam LO, Caveliers V, Beattie BJ, et al. (2011) Plasma protein binding of luciferase substrates influences sensitivity and accuracy of bioluminescence imaging. Mol Imaging Biol 13: 59-66.
4. Keyaerts M, Verschueren J, Bos TJ, Tchouate-Gainkam LO, Peleman C, et al. (2008) Dynamic bioluminescence imaging for quantitative tumour burden assessment using IV or IP administration of D:-luciferin: effect on intensity, time kinetics and repeatability of photon emission. Eur J Nucl Med Mol Imaging 35: 999-1007.
5. Virostko J, Chen Z, Fowler M, Poffenberger G, Powers AC, et al. (2004) Factors influencing quantification of in vivo bioluminescence imaging: application to assessment of pancreatic islet transplants. Mol Imaging 3: 333-342.
6. Zhang Y, Bressler JP, Neal J, Lal B, Bhang HE, et al. (2007) ABCG2/BCRP expression modulates D-Luciferin based bioluminescence imaging. Cancer Res 67: 9389-9397.
7. Ueda I, Kamaya H, Eyring H, (1976) Molecular mechanism of inhibition of firefly luminescence by local-anesthetics. Proceedings of the National Academy of Sciences of the United States of America 73: 481-485.
8. Franks NP, Jenkins A, Conti E, Lieb WR, Brick P, (1998) Structural basis for the inhibition of firefly luciferase by a general anesthetic. Biophys J 75: 2205-2211.
9. Ueda I, Suzuki A, (1998) Is there a specific receptor for anesthetics? Contrary effects of alcohols and fatty acids on phase transition and bioluminescence of firefly luciferase. Biophysical Journal 75: 1052-1057.
10. Franks NP, Lieb WR, (1984) Do general anaesthetics act by competitive binding to specific receptors? Nature 310: 599-601.
11. Franks NP, Lieb WR, (1994) Molecular and cellular mechanisms of general anesthesia. Nature 367: 607-614.
12. Dickinson R, Franks NP, Lieb WR, (1993) Thermodynamics of anesthetic protein interactions- temperature studies on Firefly luciferase. Biophysical Journal 64: 1264-1271.
13. Szarecka A, Xu Y, Tang P, (2007) Dynamics of firefly luciferase inhibition by general anesthetics: Gaussian and anisotropic network analyses. Biophys J 93: 1895-1905.
14. Maddison J, Page S, Church D, (2008) Small Animal Clinical Pharmacology: Elsevier Limited.
15. Cui KM, Xu XY, Zhao H, Wong STC, (2008) A quantitative study of factors affecting in vivo bioluminescence imaging. Luminescence 23: 292-295.
16. Branchini BR, Ablamsky DM, Murtiashaw MH, Uzasci L, Fraga H, et al. (2007) Thermostable red and green light-producing firefly luciferase mutants for bioluminescent reporter applications. Anal Biochem 361: 253-262.
17. Baeyens L, Bonne S, Bos T, Rooman I, Peleman C, et al. (2009) Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro. Gastroenterology 136: 1750-1760 e1713.
18. Merkel G, Eger EI 2nd, (1963) A comparative study of halothane and halopropane anesthesia including method for determining equipotency. Anesthesiology 24: 346-357.
19. Appleton GO, Li Y, Taffet GE, Hartley CJ, Michael LH, et al. (2004) Determinants of cardiac electrophysiological properties in mice. J Interv Card Electrophysiol 11: 5-14.
20. Hart CY, Burnett JC Jr, Redfield MM, (2001) Effects of avertin versus xylazine-ketamine anesthesia on cardiac function in normal mice. Am J Physiol Heart Circ Physiol 281: H1938-1945.
21. Janssen BJ, De Celle T, Debets JJ, Brouns AE, Callahan MF, et al. (2004) Effects of anesthetics on systemic hemodynamics in mice. Am J Physiol Heart Circ Physiol 287: H1618-1624.
22. Schaefer A, Meyer GP, Brand B, Hilfiker-Kleiner D, Drexler H, et al. (2005) Effects of anesthesia on diastolic function in mice assessed by echocardiography. Echocardiography 22: 665-670.
23. Kawahara Y, Tanonaka K, Daicho T, Nawa M, Oikawa R, et al. (2005) Preferable anesthetic conditions for echocardiographic determination of murine cardiac function. J Pharmacol Sci 99: 95-104.
24. Kober F, Iltis I, Cozzone PJ, Bernard M, (2004) Cine-MRI assessment of cardiac function in mice anesthetized with ketamine/xylazine and isoflurane. MAGMA 17: 157-161.
25. Rottman JN, Ni G, Khoo M, Wang Z, Zhang W, et al. (2003) Temporal changes in ventricular function assessed echocardiographically in conscious and anesthetized mice. J Am Soc Echocardiogr 16: 1150-1157.
26. Cali JJ, Niles A, Valley MP, O'Brien MA, Riss TL, et al. (2008) Bioluminescent assays for ADMET. Expert Opin Drug Metab Toxicol 4: 103-120.
27. Vaneycken I, Govaert J, Vincke C, Caveliers V, Lahoutte T, et al. (2010) In vitro analysis and in vivo tumor targeting of a humanized, grafted nanobody in mice using pinhole SPECT/micro-CT. J Nucl Med 51: 1099-1106.
28. Lovell DP, (1986) Variation in pentobarbitone sleeping time in mice. 1. Strain and sex differences. Lab Anim 20: 85-90.
29. Udagawa T, Birsner AE, Wood M, D'Amato RJ, (2007) Chronic suppression of angiogenesis following radiation exposure is independent of hematopoietic reconstitution. Cancer Res 67: 2040-2045.
30. Ueda I, (1965) Effects of diethyl ether and halothane on firefly luciferin bioluminescence. Anesthesiology 26: 603.
31. Leitao JM, Esteves da Silva JC, (2010) Firefly luciferase inhibition. J Photochem Photobiol B 101: 1-8.
32. Lee HT, Emala CW, Joo JD, Kim M, (2007) Isoflurane improves survival and protects against renal and hepatic injury in murine septic peritonitis. Shock 27: 373-379.
33. Sonner JM, Gong D, Eger EI 2nd, (2000) Naturally occurring variability in anesthetic potency among inbred mouse strains. Anesth Analg 91: 720-726.
34. Lee HT, Chen SW, Doetschman TC, Deng C, D'Agati VD, et al. (2008) Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-beta1 pathway. Am J Physiol Renal Physiol 295: F128-136.
35. Liao M, Laster MJ, Eger EI 2nd, Tang M, Sonner JM, (2006) Naloxone does not increase the minimum alveolar anesthetic concentration of sevoflurane in mice. Anesth Analg 102: 1452-1455.
36. Tchouate Gainkam LO, Keyaerts M, Caveliers V, Devoogdt N, Vanhove C, et al. (1304) Correlation Between Epidermal Growth Factor Receptor-Specific Nanobody Uptake and Tumor Burden: A Tool for Noninvasive Monitoring of Tumor Response to Therapy. Mol Imaging Biol DOI 10.1007/s11307-11010-10428-11304.
37. Buitrago S, Martin TE, Tetens-Woodring J, Belicha-Villanueva A, Wilding GE, (2008) Safety and efficacy of various combinations of injectable anesthetics in BALB/c mice. J Am Assoc Lab Anim Sci 47: 11-17.
38. Matsuda Y, Ohsaka K, Yamamoto H, Natsume K, Hirabayashi S, et al. (2007) Comparison of newly developed inhalation anesthesia system and intraperitoneal anesthesia on the hemodynamic state in mice. Biol Pharm Bull 30: 1716-1720.