Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach

European Journal of Medicinal Chemistry

Volumn 76, Issue , 2014, Pages 531-538

  Wang, Jun ^a   Zhan, Peng ^a   Li, Zhenyu ^a   Liu, Huiqing ^a   De Clercq, Erik ^b   Pannecouque, Christophe ^b   Liu, Xinyong ^a  

^a SHANDONG UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Bioactivity; Drug design; HIV 1; NNRTIs; Organic synthesis; Pyridine; Reverse transcriptase

Indexed keywords

3,5 DIMETHYL 4 [5 NITRO 2 (4 NITROPHENYLAMINO)PYRIDIN 4 YLOXY]BENZONITRILE; 3,5 DIMETHYL 4 [5 NITRO 2 (4 TOLYLAMINO)PYRIDIN 4 YLOXY]BENZONITRILE; 4 [2 (4 CYANOPHENYLAMINO) 5 NITROPYRIDIN 4 YLOXY] 3,5 DIMETHYLBENZONITRILE; 4 [4 (2,4 DIBROMO 6 FLUOROPHENYLAMINO) 5 NITROPYRIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (2,6 DIBROMO 4 METHYLPHENOXY) 5 NITROPYRIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (2,6 DIBROMO 4 METHYLPHENYLAMINO) 5 NITROPYRIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (2,6 DICHLORO 4 NITROPHENOXY) 5 NITROPYRIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (2,6 DICHLOROPHENOXY) 5 NITROPYRIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (2,6 DIMETHOXYPHENOXY) 5 NITROPYRIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (2,6 DIMETHYLPHENOXY) 5 NITROPYRIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (2,6 DIMETHYLPHENYLAMINO) 5 NITROPYRIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (4 BROMO 2,6 DIMETHYLPHENOXY) 5 NITROPYRIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (4 CHLORO 2,6 DIMETHYLPHENOXY) 5 NITROPYRIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (MESITYLAMINO) 5 NITROPYRIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (MESITYLOXY) 5 NITROPYRIDIN 2 YLAMINO]BENZONITRILE; 4 [5 NITRO 4 (2,4,6 TRIBROMOPHENOXY)PYRIDIN 2 YLAMINO]BENZONITRILE; 4 [5 NITRO 4 (2,4,6 TRICHLOROPHENOXY)PYRIDIN 2 YLAMINO]BENZONITRILE; 4 [5 NITRO 4 (2,4,6 TRIFLUOROPHENOXY)PYRIDIN 2 YLAMINO]BENZONITRILE; DELAVIRDINE; EFAVIRENZ; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE; REVERSE TRANSCRIPTASE, HUMAN IMMUNODEFICIENCY VIRUS 1; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION ASSAY; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; SIMULATION; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; WILD TYPE; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; MICROBIAL SENSITIVITY TEST; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY;

CELL LINE; DRUG DISCOVERY; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PYRIDINES; REVERSE TRANSCRIPTASE INHIBITORS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84898476448     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.02.047     Document Type: Article

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