메뉴 건너뛰기




Volumn 16, Issue , 2013, Pages

Non-nucleoside reverse transcriptase inhibitors: A review on pharmacokinetics, pharmacodynamics, safety and tolerability

Author keywords

Delavirdine; Efavirenz; Etravirine; Human immunodeficiency virus; Nevirapine; Next generation non nucleoside reverse transcriptase inhibitors; Non nucleoside reverse transcriptase inhibitors; Rilpivirine

Indexed keywords

ANTIVIRUS AGENT; BILR 355BS; CALANOLIDE A; DELAVIRDINE; DORAVIRINE; EFAVIRENZ; EFAVIRENZ PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; EMTRICITABINE PLUS RILPIVIRINE PLUS TENOFOVIR DISOPROXIL; ETRAVIRINE; FOSDEVIRINE; LERSIVIRINE; MILR 355BS; MK 496; MK 4965; MK 618; MK 6186; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RDEA 806; RILPIVIRINE; UNCLASSIFIED DRUG;

EID: 84891550941     PISSN: None     EISSN: 17582652     Source Type: Journal    
DOI: 10.7448/IAS.16.1.18567     Document Type: Review
Times cited : (177)

References (125)
  • 2
    • 11144236109 scopus 로고    scopus 로고
    • Similar adherence rates favor different virologic outcomes for patients treated with nonnucleoside analogues or protease inhibitors
    • Maggiolo F, Ravasio L, Ripamonti D, Gregis G, Quinzan G, Arici C, et al. Similar adherence rates favor different virologic outcomes for patients treated with nonnucleoside analogues or protease inhibitors. Clin Infect Dis. 2005;40(1):158-63.
    • (2005) Clin Infect Dis , vol.40 , Issue.1 , pp. 158-163
    • Maggiolo, F.1    Ravasio, L.2    Ripamonti, D.3    Gregis, G.4    Quinzan, G.5    Arici, C.6
  • 3
    • 84878319894 scopus 로고    scopus 로고
    • Resistance at virological failure using boosted protease inhibitors versus nonnucleoside reverse transcriptase inhibitors as first-line antiretroviral therapy - Implications for sustained efficacy of ART in resource-limited settings
    • Hill A, McBride A, Sawyer AW, Clumeck N, Gupta RK. Resistance at virological failure using boosted protease inhibitors versus nonnucleoside reverse transcriptase inhibitors as first-line antiretroviral therapy - implications for sustained efficacy of ART in resource-limited settings. J Infect Dis. 2013;207(Suppl 2):S78-84.
    • (2013) J Infect Dis , vol.207 , Issue.SUPPL. 2
    • Hill, A.1    McBride, A.2    Sawyer, A.W.3    Clumeck, N.4    Gupta, R.K.5
  • 4
    • 84862119215 scopus 로고    scopus 로고
    • HIV-1 antiretroviral resistance: Scientific principles and clinical applications
    • Tang MW, Shafer RW. HIV-1 antiretroviral resistance: scientific principles and clinical applications. Drugs. 2012;72(9):e1-25.
    • (2012) Drugs , vol.72 , Issue.9
    • Tang, M.W.1    Shafer, R.W.2
  • 5
    • 0036268538 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 2
    • Reeves JD, Doms RW. Human immunodeficiency virus type 2. J Gen Virol. 2002;83(Pt 6):1253-65.
    • (2002) J Gen Virol , vol.83 , Issue.PART 6 , pp. 1253-1265
    • Reeves, J.D.1    Doms, R.W.2
  • 6
    • 0028102110 scopus 로고
    • Reduced rate of disease development after HIV-2 infection as compared to HIV-1
    • Marlink R, Kanki P, Thior I, Travers K, Eisen G, Siby T, et al. Reduced rate of disease development after HIV-2 infection as compared to HIV-1. Science. 1994;265:1587-90.
    • (1994) Science , vol.265 , pp. 1587-1590
    • Marlink, R.1    Kanki, P.2    Thior, I.3    Travers, K.4    Eisen, G.5    Siby, T.6
  • 8
    • 73549087233 scopus 로고    scopus 로고
    • Pharmacokinetics and drug-drug interactions of antiretrovirals: An update
    • Dickinson L, Khoo S, Back D. Pharmacokinetics and drug-drug interactions of antiretrovirals: an update. Antiviral Res. 2010;85(1):176-89.
    • (2010) Antiviral Res , vol.85 , Issue.1 , pp. 176-189
    • Dickinson, L.1    Khoo, S.2    Back, D.3
  • 9
    • 0035195146 scopus 로고    scopus 로고
    • The role of nevirapine in the treatment of HIV-1 disease
    • Podzamczer D, Fumero E. The role of nevirapine in the treatment of HIV-1 disease. Expert Opin Pharmacother. 2001;2(12):2065-78.
    • (2001) Expert Opin Pharmacother , vol.2 , Issue.12 , pp. 2065-2078
    • Podzamczer, D.1    Fumero, E.2
  • 11
    • 0025875711 scopus 로고
    • Highly potent and selective inhibition of human immunodeficiency virus type 1 by a novel series of 6-substituted acyclouridine derivatives
    • Baba M, De Clercq E, Tanaka H, Ubasawa M, Takashima H, Sekiya K, et al. Highly potent and selective inhibition of human immunodeficiency virus type 1 by a novel series of 6-substituted acyclouridine derivatives. Mol Pharmacol. 1991;39(6):805-10.
    • (1991) Mol Pharmacol , vol.39 , Issue.6 , pp. 805-810
    • Baba, M.1    De Clercq, E.2    Tanaka, H.3    Ubasawa, M.4    Takashima, H.5    Sekiya, K.6
  • 12
    • 0028029961 scopus 로고
    • New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2′,3′-dideoxynucleoside analogs
    • Pauwels R, Andries K, Debyser Z, Kukla MJ, Schols D, Breslin HJ, et al. New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2′,3′-dideoxynucleoside analogs. Antimicrob Agents Chemother. 1994;38(12):2863-70.
    • (1994) Antimicrob Agents Chemother , vol.38 , Issue.12 , pp. 2863-2870
    • Pauwels, R.1    Andries, K.2    Debyser, Z.3    Kukla, M.J.4    Schols, D.5    Breslin, H.J.6
  • 14
    • 0032770872 scopus 로고    scopus 로고
    • Disposition and biotransformation of the antiretroviral drug nevirapine in humans
    • Riska P, Lamson M, MacGregor T, Sabo J, Hattox S, Pav J, et al. Disposition and biotransformation of the antiretroviral drug nevirapine in humans. Drug Metab Dispos. 1999;27(8):895-901.
    • (1999) Drug Metab Dispos , vol.27 , Issue.8 , pp. 895-901
    • Riska, P.1    Lamson, M.2    MacGregor, T.3    Sabo, J.4    Hattox, S.5    Pav, J.6
  • 16
    • 84891517848 scopus 로고    scopus 로고
    • cited 2012 Sep 20. Available from
    • Food and Drug Administration. Viramune® (nevirapine) prescribing information [Internet]. 2005 [cited 2012 Sep 20]. Available from: http://www.accessdata.fda.gov/drugsatfda-docs/label/2005/20636s025,20933s014lbl. pdf.
    • (2005) Viramune® (Nevirapine) Prescribing Information [Internet]
  • 17
    • 72949120322 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Company cited 2012 Jul 30. Available from
    • Bristol-Myers Squibb Company. Sustiva® prescribing information [Internet]. 2009 [cited 2012 Jul 30]. Available from: http://dailymed.nlm.nih. gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=10348#section-4.1.
    • (2009) Sustiva® Prescribing Information [Internet]
  • 21
    • 0034527006 scopus 로고    scopus 로고
    • Delavirdine: A review of its use in HIV infection
    • Scott LJ, Perry CM. Delavirdine: a review of its use in HIV infection. Drugs. 2000;60(6):1411-44.
    • (2000) Drugs , vol.60 , Issue.6 , pp. 1411-1444
    • Scott, L.J.1    Perry, C.M.2
  • 23
    • 63649118501 scopus 로고    scopus 로고
    • Etravirine, a next-generation nonnucleoside reverse-transcriptase inhibitor
    • Johnson LB, Saravolatz LD. Etravirine, a next-generation nonnucleoside reverse-transcriptase inhibitor. Clin Infect Dis. 2009;48(8):1123-8.
    • (2009) Clin Infect Dis , vol.48 , Issue.8 , pp. 1123-1128
    • Johnson, L.B.1    Saravolatz, L.D.2
  • 25
    • 26744433521 scopus 로고
    • Preformulation studies of nevirapine, a reverse transcriptase inhibitor
    • Hawi A, Bell G. Preformulation studies of nevirapine, a reverse transcriptase inhibitor. Pharm Res. 1994;11:S236.
    • (1994) Pharm Res , vol.11
    • Hawi, A.1    Bell, G.2
  • 27
    • 0034115801 scopus 로고    scopus 로고
    • The steady-state pharmacokinetics of nevirapine during once daily and twice daily dosing in HIV-1-infected individuals
    • van Heeswijk RP, Veldkamp AI, Mulder JW, Meenhorst PL, Wit FW, Lange JM, et al. The steady-state pharmacokinetics of nevirapine during once daily and twice daily dosing in HIV-1-infected individuals. AIDS. 2000;14(8):F77-82.
    • (2000) AIDS , vol.14 , Issue.8
    • Van Heeswijk, R.P.1    Veldkamp, A.I.2    Mulder, J.W.3    Meenhorst, P.L.4    Wit, F.W.5    Lange, J.M.6
  • 30
    • 0742304500 scopus 로고    scopus 로고
    • Sex differences in nevirapine disposition in HIV-infected patients
    • Regazzi M, Villani P, Seminari E, Ravasi G, Cusato M, Marubbi F, et al. Sex differences in nevirapine disposition in HIV-infected patients. AIDS. 2003;17(16):2399-400.
    • (2003) AIDS , vol.17 , Issue.16 , pp. 2399-2400
    • Regazzi, M.1    Villani, P.2    Seminari, E.3    Ravasi, G.4    Cusato, M.5    Marubbi, F.6
  • 31
    • 49949084478 scopus 로고    scopus 로고
    • Factors influencing efavirenz and nevirapine plasma concentration: Effect of ethnicity, weight and co-medication
    • Stohr W, Back D, Dunn D, Sabin C, Winston A, Gilson R, et al. Factors influencing efavirenz and nevirapine plasma concentration: effect of ethnicity, weight and co-medication. Antivir Ther. 2008;13(5):675-85.
    • (2008) Antivir Ther , vol.13 , Issue.5 , pp. 675-685
    • Stohr, W.1    Back, D.2    Dunn, D.3    Sabin, C.4    Winston, A.5    Gilson, R.6
  • 32
    • 0032727054 scopus 로고    scopus 로고
    • Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450
    • Erickson DA, Mather G, Trager WF, Levy RH, Keirns JJ. Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450. Drug Metab Dispos. 1999;27(12):1488-95.
    • (1999) Drug Metab Dispos , vol.27 , Issue.12 , pp. 1488-1495
    • Erickson, D.A.1    Mather, G.2    Trager, W.F.3    Levy, R.H.4    Keirns, J.J.5
  • 33
    • 46349112103 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adult HIV-1 infection: Recommendations of an International AIDS Society-USA panel
    • Hirsch MS, Gunthard HF, Schapiro JM, Brun-Vezinet F, Clotet B, Hammer SM, et al. Antiretroviral drug resistance testing in adult HIV-1 infection: recommendations of an International AIDS Society-USA panel. Clin Infect Dis. 2008;47(2):266-85.
    • (2008) Clin Infect Dis , vol.47 , Issue.2 , pp. 266-285
    • Hirsch, M.S.1    Gunthard, H.F.2    Schapiro, J.M.3    Brun-Vezinet, F.4    Clotet, B.5    Hammer, S.M.6
  • 34
    • 0027957791 scopus 로고
    • Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy
    • Richman DD, Havlir D, Corbeil J, Looney D, Ignacio C, Spector SA, et al. Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy. J Virol. 1994;68(3):1660-6.
    • (1994) J Virol , vol.68 , Issue.3 , pp. 1660-1666
    • Richman, D.D.1    Havlir, D.2    Corbeil, J.3    Looney, D.4    Ignacio, C.5    Spector, S.A.6
  • 35
    • 48449095358 scopus 로고    scopus 로고
    • Risk for immune-mediated liver reactions by nevirapine revisited
    • Medrano J, Barreiro P, Tuma P, Vispo E, Labarga P, Blanco F, et al. Risk for immune-mediated liver reactions by nevirapine revisited. AIDS Rev. 2008;10(2):110-5.
    • (2008) AIDS Rev , vol.10 , Issue.2 , pp. 110-115
    • Medrano, J.1    Barreiro, P.2    Tuma, P.3    Vispo, E.4    Labarga, P.5    Blanco, F.6
  • 36
    • 73649143152 scopus 로고    scopus 로고
    • Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared with other antiretrovirals
    • Ouyang DW, Brogly SB, Lu M, Shapiro DE, Hershow RC, French AL, et al. Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared with other antiretrovirals. AIDS. 2010;24(1):109-14.
    • (2010) AIDS , vol.24 , Issue.1 , pp. 109-114
    • Ouyang, D.W.1    Brogly, S.B.2    Lu, M.3    Shapiro, D.E.4    Hershow, R.C.5    French, A.L.6
  • 38
    • 0001988236 scopus 로고    scopus 로고
    • Severe liver toxicity in patients receiving two nucleoside analogues and a non-nucleoside reverse transcriptase inhibitor
    • Sanne I. Severe liver toxicity in patients receiving two nucleoside analogues and a non-nucleoside reverse transcriptase inhibitor. AIDS. 2000;14(Suppl 4):S12.
    • (2000) AIDS , vol.14 , Issue.SUPPL. 4
    • Sanne, I.1
  • 39
    • 34547879291 scopus 로고    scopus 로고
    • Antiretroviral pharmacokinetic profile: A review of sex differences
    • Ofotokun I, Chuck SK, Hitti JE. Antiretroviral pharmacokinetic profile: a review of sex differences. Gend Med. 2007;4(2):106-19.
    • (2007) Gend Med , vol.4 , Issue.2 , pp. 106-119
    • Ofotokun, I.1    Chuck, S.K.2    Hitti, J.E.3
  • 40
    • 12644270207 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of delavirdine in HIV-positive patients: Effect on erythromycin breath test
    • Cheng CL, Smith DE, Carver PL, Cox SR,Watkins PB, Blake DS, et al. Steady-state pharmacokinetics of delavirdine in HIV-positive patients: effect on erythromycin breath test. Clin Pharmacol Ther. 1997;61(5):531-43.
    • (1997) Clin Pharmacol Ther , vol.61 , Issue.5 , pp. 531-543
    • Cheng, C.L.1    Smith, D.E.2    Carver, P.L.3    Cox, S.R.4    Watkins, P.B.5    Blake, D.S.6
  • 41
    • 0031020802 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics of delavirdine mesylate and didanosine in patients with human immunodeficiency virus infection
    • Morse GD, Fischl MA, Shelton MJ, Cox SR, Driver M, DeRemer M, et al. Single-dose pharmacokinetics of delavirdine mesylate and didanosine in patients with human immunodeficiency virus infection. Antimicrob Agents Chemother. 1997;41(1):169-74.
    • (1997) Antimicrob Agents Chemother , vol.41 , Issue.1 , pp. 169-174
    • Morse, G.D.1    Fischl, M.A.2    Shelton, M.J.3    Cox, S.R.4    Driver, M.5    DeRemer, M.6
  • 42
    • 53949089826 scopus 로고    scopus 로고
    • Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies
    • Radi M, Angeli L, Franchi L, Contemori L, Maga G, Samuele A, et al. Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies. Bioorg Med Chem Lett. 2008;18(21):5777-80.
    • (2008) Bioorg Med Chem Lett , vol.18 , Issue.21 , pp. 5777-5780
    • Radi, M.1    Angeli, L.2    Franchi, L.3    Contemori, L.4    Maga, G.5    Samuele, A.6
  • 44
    • 0037266158 scopus 로고    scopus 로고
    • Effect of food on the steady-state pharmacokinetics of delavirdine in patients with HIV infection
    • Morse GD, Fischl MA, Shelton MJ, Cox SR, Thompson L, Della-Coletta AA, et al. Effect of food on the steady-state pharmacokinetics of delavirdine in patients with HIV infection. Clin Drug Invest. 2003;23(4):255-61.
    • (2003) Clin Drug Invest , vol.23 , Issue.4 , pp. 255-261
    • Morse, G.D.1    Fischl, M.A.2    Shelton, M.J.3    Cox, S.R.4    Thompson, L.5    Della-Coletta, A.A.6
  • 45
    • 0031819080 scopus 로고    scopus 로고
    • Metabolism of delavirdine, a human immunodeficiency virus type-1 reverse transcriptase inhibitor, by microsomal cytochrome P450 in humans, rats, and other species: Probable involvement of CYP2D6 and CYP3A
    • Voorman RL, Maio SM, Hauer MJ, Sanders PE, Payne NA, Ackland MJ. Metabolism of delavirdine, a human immunodeficiency virus type-1 reverse transcriptase inhibitor, by microsomal cytochrome P450 in humans, rats, and other species: probable involvement of CYP2D6 and CYP3A. Drug Metab Dispos. 1998;26(7):631-9.
    • (1998) Drug Metab Dispos , vol.26 , Issue.7 , pp. 631-639
    • Voorman, R.L.1    Maio, S.M.2    Hauer, M.J.3    Sanders, P.E.4    Payne, N.A.5    Ackland, M.J.6
  • 46
    • 0031180005 scopus 로고    scopus 로고
    • Delavirdine levels in women
    • Vazquez E. Delavirdine levels in women. Posit Aware. 1997;8(4):14.
    • (1997) Posit Aware , vol.8 , Issue.4 , pp. 14
    • Vazquez, E.1
  • 47
    • 19944426706 scopus 로고    scopus 로고
    • Population pharmacokinetics of delavirdine and N-delavirdine in HIV-infected individuals
    • Smith PF, Dicenzo R, Forrest A, Shelton M, Friedland G, Para M, et al. Population pharmacokinetics of delavirdine and N-delavirdine in HIV-infected individuals. Clin Pharmacokinet. 2005;44(1):99-109.
    • (2005) Clin Pharmacokinet , vol.44 , Issue.1 , pp. 99-109
    • Smith, P.F.1    Dicenzo, R.2    Forrest, A.3    Shelton, M.4    Friedland, G.5    Para, M.6
  • 50
    • 0032437454 scopus 로고    scopus 로고
    • The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection
    • De Clercq E. The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection. Antiviral Res. 1998;38(3):153-79.
    • (1998) Antiviral Res , vol.38 , Issue.3 , pp. 153-179
    • De Clercq, E.1
  • 51
    • 0034002944 scopus 로고    scopus 로고
    • Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260)
    • Demeter LM, Shafer RW, Meehan PM, Holden-Wiltse J, Fischl MA, Freimuth WW, et al. Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260). Antimicrob Agents Chemother. 2000;44(3):794-7.
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.3 , pp. 794-797
    • Demeter, L.M.1    Shafer, R.W.2    Meehan, P.M.3    Holden-Wiltse, J.4    Fischl, M.A.5    Freimuth, W.W.6
  • 52
    • 0036115697 scopus 로고    scopus 로고
    • Kinetics and mechanism of hydrolysis of efavirenz
    • Maurin MB, Rowe SM, Blom K, Pierce ME. Kinetics and mechanism of hydrolysis of efavirenz. Pharm Res. 2002;19(4):517-21.
    • (2002) Pharm Res , vol.19 , Issue.4 , pp. 517-521
    • Maurin, M.B.1    Rowe, S.M.2    Blom, K.3    Pierce, M.E.4
  • 53
    • 36849020049 scopus 로고    scopus 로고
    • Investigation of human pharmacoscintigraphic behavior of two tablets and a capsule formulation of a high dose, poorly water soluble/highly permeable drug (efavirenz)
    • Gao JZ, Hussain MA, Motheram R, Gray DA, Benedek IH, Fiske WD, et al. Investigation of human pharmacoscintigraphic behavior of two tablets and a capsule formulation of a high dose, poorly water soluble/highly permeable drug (efavirenz). J Pharm Sci. 2007;96(11):2970-7.
    • (2007) J Pharm Sci , vol.96 , Issue.11 , pp. 2970-2977
    • Gao, J.Z.1    Hussain, M.A.2    Motheram, R.3    Gray, D.A.4    Benedek, I.H.5    Fiske, W.D.6
  • 54
    • 3242728351 scopus 로고    scopus 로고
    • Molecular properties of WHO essential drugs and provisional biopharmaceutical classification
    • Kasim NA, Whitehouse M, Ramachandran C, Bermejo M, Lennernas H, Hussain AS, et al. Molecular properties of WHO essential drugs and provisional biopharmaceutical classification. Mol Pharm. 2004;1(1):85-96.
    • (2004) Mol Pharm , vol.1 , Issue.1 , pp. 85-96
    • Kasim, N.A.1    Whitehouse, M.2    Ramachandran, C.3    Bermejo, M.4    Lennernas, H.5    Hussain, A.S.6
  • 56
    • 33644910426 scopus 로고    scopus 로고
    • Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz: The effect of gender, race, and CYP2B6 polymorphism
    • Burger D, van der Heiden I, la Porte C, van der Ende M, Groeneveld P, Richter C, et al. Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz: the effect of gender, race, and CYP2B6 polymorphism. Br J Clin Pharmacol. 2006;61(2):148-54.
    • (2006) Br J Clin Pharmacol , vol.61 , Issue.2 , pp. 148-154
    • Burger, D.1    Van Der Heiden, I.2    La Porte, C.3    Van Der Ende, M.4    Groeneveld, P.5    Richter, C.6
  • 58
    • 0038002981 scopus 로고    scopus 로고
    • The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: Implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
    • Ward BA, Gorski JC, Jones DR, Hall SD, Flockhart DA, Desta Z. The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J Pharmacol Exp Ther. 2003;306(1):287-300.
    • (2003) J Pharmacol Exp Ther , vol.306 , Issue.1 , pp. 287-300
    • Ward, B.A.1    Gorski, J.C.2    Jones, D.R.3    Hall, S.D.4    Flockhart, D.A.5    Desta, Z.6
  • 59
    • 0033840455 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy
    • Bacheler LT, Anton ED, Kudish P, Baker D, Bunville J, Krakowski K, et al. Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. Antimicrob Agents Chemother. 2000;44(9):2475-84.
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.9 , pp. 2475-2484
    • Bacheler, L.T.1    Anton, E.D.2    Kudish, P.3    Baker, D.4    Bunville, J.5    Krakowski, K.6
  • 60
    • 2342537759 scopus 로고    scopus 로고
    • Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection
    • Gulick RM, Ribaudo HJ, Shikuma CM, Lustgarten S, Squires KE, Meyer WA 3rd, et al. Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection. N Engl J Med. 2004;350(18):1850-61.
    • (2004) N Engl J Med , vol.350 , Issue.18 , pp. 1850-1861
    • Gulick, R.M.1    Ribaudo, H.J.2    Shikuma, C.M.3    Lustgarten, S.4    Squires, K.E.5    Meyer III, W.A.6
  • 62
    • 0035875828 scopus 로고    scopus 로고
    • Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
    • Marzolini C, Telenti A, Decosterd LA, Greub G, Biollaz J, Buclin T. Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. AIDS. 2001;15(1):71-5.
    • (2001) AIDS , vol.15 , Issue.1 , pp. 71-75
    • Marzolini, C.1    Telenti, A.2    Decosterd, L.A.3    Greub, G.4    Biollaz, J.5    Buclin, T.6
  • 63
    • 0031591778 scopus 로고    scopus 로고
    • Guidelines for the use of antiretroviral agents in pediatric HIV infection - HRSA. Request for comments
    • Department of Health and Human Services
    • Department of Health and Human Services. Guidelines for the use of antiretroviral agents in pediatric HIV infection - HRSA. Request for comments. Fed Regist. 1997;62(189):51115-6.
    • (1997) Fed Regist , vol.62 , Issue.189 , pp. 51115-51116
  • 64
    • 67651096095 scopus 로고    scopus 로고
    • Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment
    • Haubrich RH, Riddler SA, DiRienzo AG, Komarow L, Powderly WG, Klingman K, et al. Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment. AIDS. 2009;23(9):1109-18.
    • (2009) AIDS , vol.23 , Issue.9 , pp. 1109-1118
    • Haubrich, R.H.1    Riddler, S.A.2    DiRienzo, A.G.3    Komarow, L.4    Powderly, W.G.5    Klingman, K.6
  • 66
    • 0031742830 scopus 로고    scopus 로고
    • Influence of gender on the pharmacokinetics and pharmacodynamics of drugs
    • Thurmann PA, Hompesch BC. Influence of gender on the pharmacokinetics and pharmacodynamics of drugs. Int J Clin Pharmacol Ther. 1998;36(11):586-90.
    • (1998) Int J Clin Pharmacol Ther , vol.36 , Issue.11 , pp. 586-590
    • Thurmann, P.A.1    Hompesch, B.C.2
  • 67
    • 0037178329 scopus 로고    scopus 로고
    • Female sex but not ethnicity is a strong predictor of non-nucleoside reverse transcriptase inhibitor-induced rash
    • Mazhude C, Jones S, Murad S, Taylor C, Easterbrook P. Female sex but not ethnicity is a strong predictor of non-nucleoside reverse transcriptase inhibitor-induced rash. AIDS. 2002;16(11):1566-8.
    • (2002) AIDS , vol.16 , Issue.11 , pp. 1566-1568
    • Mazhude, C.1    Jones, S.2    Murad, S.3    Taylor, C.4    Easterbrook, P.5
  • 68
    • 9744258219 scopus 로고    scopus 로고
    • Crystallography and the design of anti-AIDS drugs: Conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors
    • Das K, Lewi PJ, Hughes SH, Arnold E. Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors. Prog Biophys Mol Biol. 2005;88(2):209-31.
    • (2005) Prog Biophys Mol Biol , vol.88 , Issue.2 , pp. 209-231
    • Das, K.1    Lewi, P.J.2    Hughes, S.H.3    Arnold, E.4
  • 69
    • 65549107808 scopus 로고    scopus 로고
    • Etravirine: A second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) active against NNRTI-resistant strains of HIV
    • Schiller DS, Youssef-Bessler M. Etravirine: a second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) active against NNRTI-resistant strains of HIV. Clin Ther. 2009;31(4):692-704.
    • (2009) Clin Ther , vol.31 , Issue.4 , pp. 692-704
    • Schiller, D.S.1    Youssef-Bessler, M.2
  • 70
    • 73549115378 scopus 로고    scopus 로고
    • Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989-2009)
    • de Bethune MP. Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: a review of the last 20 years (1989-2009). Antiviral Res. 2010;85(1):75-90.
    • (2010) Antiviral Res , vol.85 , Issue.1 , pp. 75-90
    • De Bethune, M.P.1
  • 73
    • 54749118543 scopus 로고    scopus 로고
    • Effects of different meal compositions and fasted state on the oral bioavailability of etravirine
    • Scholler-Gyure M, Boffito M, Pozniak AL, Leemans R, Kakuda TN, Woodfall B, et al. Effects of different meal compositions and fasted state on the oral bioavailability of etravirine. Pharmacotherapy. 2008;28(10):1215-22.
    • (2008) Pharmacotherapy , vol.28 , Issue.10 , pp. 1215-1222
    • Scholler-Gyure, M.1    Boffito, M.2    Pozniak, A.L.3    Leemans, R.4    Kakuda, T.N.5    Woodfall, B.6
  • 74
    • 84891542543 scopus 로고    scopus 로고
    • cited 2012 Oct 5. Available from
    • Food and Drug Administration. INTELENCE® (etravirine) prescribing information [Internet]. 2011 [cited 2012 Oct 5]. Available from: http://www.accessdata.fda.gov/drugsatfda-docs/label/2011/022187s008lbl.pdf
    • (2011) INTELENCE® (Etravirine) Prescribing Information [Internet]
  • 75
    • 77953436063 scopus 로고    scopus 로고
    • Simplification of antiretroviral therapy with etravirine
    • Martinez E, Nelson M. Simplification of antiretroviral therapy with etravirine. AIDS Rev. 2010;12(1):52-9.
    • (2010) AIDS Rev , vol.12 , Issue.1 , pp. 52-59
    • Martinez, E.1    Nelson, M.2
  • 77
    • 84873847180 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of darunavir and etravirine in HIV-1-infected, treatment-experienced patients in the Gender, Race, and Clinical Experience (GRACE) trial
    • Kakuda T, Sekar V, Vis P, Coate B, Ryan R, Anderson D, et al. Pharmacokinetics and pharmacodynamics of darunavir and etravirine in HIV-1-infected, treatment-experienced patients in the Gender, Race, and Clinical Experience (GRACE) trial. AIDS Res Treat. 2012;2012:186987.
    • (2012) AIDS Res Treat , vol.2012 , pp. 186987
    • Kakuda, T.1    Sekar, V.2    Vis, P.3    Coate, B.4    Ryan, R.5    Anderson, D.6
  • 78
    • 70350331091 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine
    • Xu H, Quan Y, Brenner BG, Bar-Magen T, Oliveira M, Schader SM, et al. Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine. Antimicrob Agents Chemother. 2009;53(11):4667-72.
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.11 , pp. 4667-4672
    • Xu, H.1    Quan, Y.2    Brenner, B.G.3    Bar-Magen, T.4    Oliveira, M.5    Schader, S.M.6
  • 79
    • 2342620790 scopus 로고    scopus 로고
    • Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants
    • Das K, Clark AD Jr, Lewi PJ, Heeres J, De Jonge MR, Koymans LM, et al. Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. J Med Chem. 2004;47(10):2550-60.
    • (2004) J Med Chem , vol.47 , Issue.10 , pp. 2550-2560
    • Das, K.1    Clark Jr., A.D.2    Lewi, P.J.3    Heeres, J.4    De Jonge, M.R.5    Koymans, L.M.6
  • 81
    • 51549087941 scopus 로고    scopus 로고
    • Combating non-nucleoside reverse transcriptase inhibitor resistance with a focus on etravirine (Intelence) for HIV-1 infection
    • Eraikhuemen N, Thornton AM, Branch E, Huynh ST, Farley C. Combating non-nucleoside reverse transcriptase inhibitor resistance with a focus on etravirine (Intelence) for HIV-1 infection. P T. 2008;33(8):445-91.
    • (2008) P T , vol.33 , Issue.8 , pp. 445-491
    • Eraikhuemen, N.1    Thornton, A.M.2    Branch, E.3    Huynh, S.T.4    Farley, C.5
  • 82
    • 34347327010 scopus 로고    scopus 로고
    • Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
    • Madruga JV, Cahn P, Grinsztejn B, Haubrich R, Lalezari J, Mills A, et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet. 2007;370(9581):29-38.
    • (2007) Lancet , vol.370 , Issue.9581 , pp. 29-38
    • Madruga, J.V.1    Cahn, P.2    Grinsztejn, B.3    Haubrich, R.4    Lalezari, J.5    Mills, A.6
  • 83
    • 34347354196 scopus 로고    scopus 로고
    • Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial
    • Lazzarin A, Campbell T, Clotet B, Johnson M, Katlama C, Moll A, et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet. 2007;370(9581):39-48.
    • (2007) Lancet , vol.370 , Issue.9581 , pp. 39-48
    • Lazzarin, A.1    Campbell, T.2    Clotet, B.3    Johnson, M.4    Katlama, C.5    Moll, A.6
  • 84
    • 54849410704 scopus 로고    scopus 로고
    • Adverse cutaneous reactions associated with the newest antiretroviral drugs in patients with human immunodeficiency virus infection
    • Borras-Blasco J, Navarro-Ruiz A, Borras C, Castera E. Adverse cutaneous reactions associated with the newest antiretroviral drugs in patients with human immunodeficiency virus infection. J Antimicrob Chemother. 2008;62(5):879-88.
    • (2008) J Antimicrob Chemother , vol.62 , Issue.5 , pp. 879-888
    • Borras-Blasco, J.1    Navarro-Ruiz, A.2    Borras, C.3    Castera, E.4
  • 85
    • 84861915880 scopus 로고    scopus 로고
    • Efficacy and safety outcomes among treatment-experienced women and men treated with etravirine in gender, race and clinical experience
    • Grace Study Group
    • Hodder S, Jayaweera D, Mrus J, Ryan R, Witek J, Grace Study Group. Efficacy and safety outcomes among treatment-experienced women and men treated with etravirine in gender, race and clinical experience. AIDS Res Hum Retroviruses. 2012;28(6):544-51.
    • (2012) AIDS Res Hum Retroviruses , vol.28 , Issue.6 , pp. 544-551
    • Hodder, S.1    Jayaweera, D.2    Mrus, J.3    Ryan, R.4    Witek, J.5
  • 86
    • 20144372481 scopus 로고    scopus 로고
    • In search of a novel anti-HIV drug: Multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1 E)-2-cyanoethenyl]-2, 6-dimethylphenyl] amino]-2-pyrimidinyl] amino] benzonitrile (R278474, rilpivirine)
    • Janssen PAJ, Lewi PJ, Arnold E, Daeyaert F, de Jonge M, Heeres J, et al. In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1 E)-2-cyanoethenyl]-2, 6-dimethylphenyl] amino]-2-pyrimidinyl] amino] benzonitrile (R278474, rilpivirine). J Med Chem. 2005;48(6):1901-9.
    • (2005) J Med Chem , vol.48 , Issue.6 , pp. 1901-1909
    • Janssen, P.A.J.1    Lewi, P.J.2    Arnold, E.3    Daeyaert, F.4    De Jonge, M.5    Heeres, J.6
  • 87
    • 84870734551 scopus 로고    scopus 로고
    • Bioequivalence of the emtricitabine/rilpivirine/tenofovir disoproxil fumarate single tablet regimen
    • Mathias A, Menning M, Wiser L, Wei X, Dave A, Chuck S, et al. Bioequivalence of the emtricitabine/rilpivirine/tenofovir disoproxil fumarate single tablet regimen. J Bioequiv Availab. 2012;4(7):100-5.
    • (2012) J Bioequiv Availab , vol.4 , Issue.7 , pp. 100-105
    • Mathias, A.1    Menning, M.2    Wiser, L.3    Wei, X.4    Dave, A.5    Chuck, S.6
  • 88
    • 84872402317 scopus 로고    scopus 로고
    • Rilpivirine: A new non-nucleoside reverse transcriptase inhibitor
    • Sharma M, Saravolatz LD. Rilpivirine: a new non-nucleoside reverse transcriptase inhibitor. J Antimicrob Chemother. 2013;68(2):250-6.
    • (2013) J Antimicrob Chemother , vol.68 , Issue.2 , pp. 250-256
    • Sharma, M.1    Saravolatz, L.D.2
  • 91
    • 84863190048 scopus 로고    scopus 로고
    • Effect of gender and race on the week 48 findings in treatment-naive, HIV-1-infected patients enrolled in the randomized, phase III trials ECHO and THRIVE
    • Hodder S, Arasteh K, De Wet J, Gathe J, Gold J, Kumar P, et al. Effect of gender and race on the week 48 findings in treatment-naive, HIV-1-infected patients enrolled in the randomized, phase III trials ECHO and THRIVE. HIV Med. 2012;13(7):406-15.
    • (2012) HIV Med , vol.13 , Issue.7 , pp. 406-415
    • Hodder, S.1    Arasteh, K.2    De Wet, J.3    Gathe, J.4    Gold, J.5    Kumar, P.6
  • 92
    • 84891499473 scopus 로고    scopus 로고
    • Tibotec Pharmaceuticals cited 2012 Sep 26. Available from
    • Tibotec Pharmaceuticals. Edurant (rilpivirine) tablets: US prescribing information [Internet]. 2011 [cited 2012 Sep 26]. Available from: http://www.accessdata.fda.gov/drugsatfda-docs/label/2011/202022s000lbl.pdf
    • (2011) Edurant (Rilpivirine) Tablets: US Prescribing Information [Internet]
  • 93
    • 75749118495 scopus 로고    scopus 로고
    • TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1
    • Azijn H, Tirry I, Vingerhoets J, de Bethune MP, Kraus G, Boven K, et al. TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1. Antimicrob Agents Chemother. 2010;54(2):718-27.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.2 , pp. 718-727
    • Azijn, H.1    Tirry, I.2    Vingerhoets, J.3    De Bethune, M.P.4    Kraus, G.5    Boven, K.6
  • 94
    • 73649148381 scopus 로고    scopus 로고
    • Efficacy and safety of TMC278 in antiretroviral-naive HIV-1 patients: Week 96 results of a phase IIb randomized trial
    • Pozniak AL, Morales-Ramirez J, Katabira E, Steyn D, Lupo SH, Santoscoy M, et al. Efficacy and safety of TMC278 in antiretroviral-naive HIV-1 patients: week 96 results of a phase IIb randomized trial. AIDS. 2010;24(1):55-65.
    • (2010) AIDS , vol.24 , Issue.1 , pp. 55-65
    • Pozniak, A.L.1    Morales-Ramirez, J.2    Katabira, E.3    Steyn, D.4    Lupo, S.H.5    Santoscoy, M.6
  • 95
    • 84862777419 scopus 로고    scopus 로고
    • Efficacy and safety of rilpivirine (TMC278) versus efavirenz at 48 weeks in treatment-naive HIV-1-infected patients: Pooled results from the phase 3 double-blind randomized ECHO and THRIVE Trials
    • Cohen CJ, Molina JM, Cahn P, Clotet B, Fourie J, Grinsztejn B, et al. Efficacy and safety of rilpivirine (TMC278) versus efavirenz at 48 weeks in treatment-naive HIV-1-infected patients: pooled results from the phase 3 double-blind randomized ECHO and THRIVE Trials. J Acquir Immune Defic Syndr. 2012;60(1):33-42.
    • (2012) J Acquir Immune Defic Syndr , vol.60 , Issue.1 , pp. 33-42
    • Cohen, C.J.1    Molina, J.M.2    Cahn, P.3    Clotet, B.4    Fourie, J.5    Grinsztejn, B.6
  • 97
    • 84891507651 scopus 로고    scopus 로고
    • Efficacy and safety of lersivirine (UK-453,061) vs. Efavirenz in antiretroviral treatment-naïve HIV-1-infected patients: Week 48 primary analysis results from an ongoing, multicentre, randomised, double-blind, phase IIb trial (study A5271015)
    • Abstract TUAB0101
    • Vernazza P, Wang C, Pozniak A, Weil E, Pulik P, Cooper D, et al. editors. Efficacy and safety of lersivirine (UK-453,061) vs. efavirenz in antiretroviral treatment-naïve HIV-1-infected patients: week 48 primary analysis results from an ongoing, multicentre, randomised, double-blind, phase IIb trial (study A5271015). 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 2011 Jul 17-20; Rome, Italy. Abstract TUAB0101.
    • 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 2011 Jul 17-20; Rome, Italy
    • Vernazza, P.1    Wang, C.2    Pozniak, A.3    Weil, E.4    Pulik, P.5    Cooper, D.6
  • 98
    • 84860159987 scopus 로고    scopus 로고
    • Safety and Efficacy of GSK2248761, a next-generation nonnucleoside reverse transcriptase inhibitor, in treatment-naive HIV-1-infected subjects
    • Zala C, Clair MS, Dudas K, Kim J, Lou Y, White S, et al. Safety and Efficacy of GSK2248761, a next-generation nonnucleoside reverse transcriptase inhibitor, in treatment-naive HIV-1-infected subjects. Antimicrob Agents Chemother. 2012;56(5):2570-5.
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.5 , pp. 2570-2575
    • Zala, C.1    Clair, M.S.2    Dudas, K.3    Kim, J.4    Lou, Y.5    White, S.6
  • 99
    • 77955386895 scopus 로고    scopus 로고
    • Phase 2a randomized controlled trial of short-term activity, safety, and pharmacokinetics of a novel nonnucleoside reverse transcriptase inhibitor, RDEA806, in HIV-1-positive, antiretroviral-naive subjects
    • Moyle G, Boffito M, Stoehr A, Rieger A, Shen Z, Manhard K, et al. Phase 2a randomized controlled trial of short-term activity, safety, and pharmacokinetics of a novel nonnucleoside reverse transcriptase inhibitor, RDEA806, in HIV-1-positive, antiretroviral-naive subjects. Antimicrob Agents Chemother. 2010;54(8):3170-8.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.8 , pp. 3170-3178
    • Moyle, G.1    Boffito, M.2    Stoehr, A.3    Rieger, A.4    Shen, Z.5    Manhard, K.6
  • 100
    • 59749105775 scopus 로고    scopus 로고
    • Pharmacokinetics of BILR 355 after multiple oral doses coadministered with a low dose of ritonavir
    • Huang F, Drda K, MacGregor TR, Scherer J, Rowland L, Nguyen T, et al. Pharmacokinetics of BILR 355 after multiple oral doses coadministered with a low dose of ritonavir. Antimicrob Agents Chemother. 2009;53(1):95-103.
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.1 , pp. 95-103
    • Huang, F.1    Drda, K.2    MacGregor, T.R.3    Scherer, J.4    Rowland, L.5    Nguyen, T.6
  • 101
    • 0035037065 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of single doses of (+)-calanolide a, a novel, naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy, human immunodeficiency virus-negative human subjects
    • Creagh T, Ruckle JL, Tolbert DT, Giltner J, Eiznhamer DA, Dutta B, et al. Safety and pharmacokinetics of single doses of (+)-calanolide a, a novel, naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy, human immunodeficiency virus-negative human subjects. Antimicrob Agents Chemother. 2001;45(5):1379-86.
    • (2001) Antimicrob Agents Chemother , vol.45 , Issue.5 , pp. 1379-1386
    • Creagh, T.1    Ruckle, J.L.2    Tolbert, D.T.3    Giltner, J.4    Eiznhamer, D.A.5    Dutta, B.6
  • 104
    • 84891511111 scopus 로고    scopus 로고
    • Clinicaltrials.gov cited 2012 Sep 20. Available from
    • Clinicaltrials.gov. MK6186 in HIV-1 infected patients (MK-6186-007 AM2) [Internet]. 2011 [cited 2012 Sep 20]. Available from: http://clinicaltrials.gov/ ct2/show/NCT01152255?term=MK-6186&rank=1
    • (2011) MK6186 in HIV-1 Infected Patients (MK-6186-007 AM2) [Internet]
  • 106
    • 77951232416 scopus 로고    scopus 로고
    • Lack of a clinically relevant effect of an antacid on the pharmacokinetics of lersivirine
    • Vourvahis M, Banerjee S, LaBadie R, Gore D, Mayer H. Lack of a clinically relevant effect of an antacid on the pharmacokinetics of lersivirine. Antimicrob Agents Chemother. 2010;54(5):2209-11.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.5 , pp. 2209-2211
    • Vourvahis, M.1    Banerjee, S.2    LaBadie, R.3    Gore, D.4    Mayer, H.5
  • 108
    • 77950920638 scopus 로고    scopus 로고
    • Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2- hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers
    • Vourvahis M, Gleave M, Nedderman ANR, Hyland R, Gardner I, Howard MR, et al. Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl) (3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers. Drug Metab Dispos. 2010;38(5):789-800.
    • (2010) Drug Metab Dispos , vol.38 , Issue.5 , pp. 789-800
    • Vourvahis, M.1    Gleave, M.2    Nedderman, A.N.R.3    Hyland, R.4    Gardner, I.5    Howard, M.R.6
  • 109
    • 77950922576 scopus 로고    scopus 로고
    • Activity, pharmacokinetics and safety of lersivirine (UK-453,061), a next-generation nonnucleoside reverse transcriptase inhibitor, during 7-day monotherapy in HIV-1-infected patients
    • Fätkenheuer G, Staszewski S, Plettenburg A, Hackman F, Layton G, McFadyen L, et al. Activity, pharmacokinetics and safety of lersivirine (UK-453,061), a next-generation nonnucleoside reverse transcriptase inhibitor, during 7-day monotherapy in HIV-1-infected patients. AIDS. 2009;23(16):2115.
    • (2009) AIDS , vol.23 , Issue.16 , pp. 2115
    • Fätkenheuer, G.1    Staszewski, S.2    Plettenburg, A.3    Hackman, F.4    Layton, G.5    McFadyen, L.6
  • 110
    • 84872832386 scopus 로고    scopus 로고
    • Efficacy and safety of lersivirine (UK-453,061) versus efavirenz in antiretroviral treatment-naive HIV-1-infected patients: Week 48 primary analysis results from an ongoing, multicenter, randomized, double-blind, phase IIb trial
    • Vernazza P, Wang C, Pozniak A, Weil E, Pulik P, Cooper DA, et al. Efficacy and safety of lersivirine (UK-453,061) versus efavirenz in antiretroviral treatment-naive HIV-1-infected patients: week 48 primary analysis results from an ongoing, multicenter, randomized, double-blind, phase IIb trial. J Acquir Immune Defic Syndr. 2013;62(2):171-9.
    • (2013) J Acquir Immune Defic Syndr , vol.62 , Issue.2 , pp. 171-179
    • Vernazza, P.1    Wang, C.2    Pozniak, A.3    Weil, E.4    Pulik, P.5    Cooper, D.A.6
  • 111
    • 84891515550 scopus 로고    scopus 로고
    • 5 February cited 2013 Jun 4. Available from
    • ViiV Healthcare. Update Status of Lersivirine Development Program [Internet]. 5 February 2013 [cited 2013 Jun 4]. Available from: http://www.viivhealthcare.com/r-and-d/our-pipeline
    • (2013) Update Status of Lersivirine Development Program [Internet]
  • 113
    • 84863759763 scopus 로고    scopus 로고
    • Drug interaction profile for GSK2248761, a next generation non-nucleoside reverse transcriptase inhibitor
    • Piscitelli S, Kim J, Gould E, Lou Y, White S, de Serres M, et al. Drug interaction profile for GSK2248761, a next generation non-nucleoside reverse transcriptase inhibitor. Br J Clin Pharmacol. 2012;74(2):336-45.
    • (2012) Br J Clin Pharmacol , vol.74 , Issue.2 , pp. 336-345
    • Piscitelli, S.1    Kim, J.2    Gould, E.3    Lou, Y.4    White, S.5    De Serres, M.6
  • 114
  • 116
    • 32544442309 scopus 로고    scopus 로고
    • Next-generation HIV-1 non-nucleoside reverse transcriptase inhibitors
    • Boone LR. Next-generation HIV-1 non-nucleoside reverse transcriptase inhibitors. Curr Opin Invest Drugs. 2006;7(2):128-35.
    • (2006) Curr Opin Invest Drugs , vol.7 , Issue.2 , pp. 128-135
    • Boone, L.R.1
  • 117
    • 79958788137 scopus 로고    scopus 로고
    • Coadministration with lopinavir and ritonavir decreases exposure to BILR 355, a nonnucleoside reverse transcriptase inhibitor, in healthy volunteers
    • Huang F, Scholl P, Huang DB, MacGregor TR, Vinisko R, Castles MA, et al. Coadministration with lopinavir and ritonavir decreases exposure to BILR 355, a nonnucleoside reverse transcriptase inhibitor, in healthy volunteers. J Clin Pharmacol. 2011;51(7):1061-70.
    • (2011) J Clin Pharmacol , vol.51 , Issue.7 , pp. 1061-1070
    • Huang, F.1    Scholl, P.2    Huang, D.B.3    MacGregor, T.R.4    Vinisko, R.5    Castles, M.A.6
  • 118
    • 84856352143 scopus 로고    scopus 로고
    • Evaluation of steady-state pharmacokinetic interactions between ritonavir-boosted BILR 355, a non-nucleoside reverse transcriptase inhibitor, and lamivudine/zidovudine in healthy subjects
    • Huang F, Allen L, Huang DB, Moy F, Vinisko R, Nguyen T, et al. Evaluation of steady-state pharmacokinetic interactions between ritonavir-boosted BILR 355, a non-nucleoside reverse transcriptase inhibitor, and lamivudine/zidovudine in healthy subjects. J Clin Pharm Ther. 2012;37(1):81-8.
    • (2012) J Clin Pharm Ther , vol.37 , Issue.1 , pp. 81-88
    • Huang, F.1    Allen, L.2    Huang, D.B.3    Moy, F.4    Vinisko, R.5    Nguyen, T.6
  • 119
    • 79951750503 scopus 로고    scopus 로고
    • Concomitant administration of BILR 355/r with emtricitabine/tenofovir disoproxil fumarate increases exposure to emtricitabine and tenofovir: A randomized, open-label, prospective study
    • Huang F, Scholl P, Huang DB, MacGregor TR, Taub ME, Vinisko R, et al. Concomitant administration of BILR 355/r with emtricitabine/tenofovir disoproxil fumarate increases exposure to emtricitabine and tenofovir: a randomized, open-label, prospective study. Basic Clin Pharmacol Toxicol. 2011;108(3):163-70.
    • (2011) Basic Clin Pharmacol Toxicol , vol.108 , Issue.3 , pp. 163-170
    • Huang, F.1    Scholl, P.2    Huang, D.B.3    MacGregor, T.R.4    Taub, M.E.5    Vinisko, R.6
  • 120
  • 121
    • 57349096037 scopus 로고    scopus 로고
    • Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase
    • Sweeney ZK, Harris SF, Arora SF, Javanbakht H, Li Y, Fretland J, et al. Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase. J Med Chem. 2008;51(23):7449-58.
    • (2008) J Med Chem , vol.51 , Issue.23 , pp. 7449-7458
    • Sweeney, Z.K.1    Harris, S.F.2    Arora, S.F.3    Javanbakht, H.4    Li, Y.5    Fretland, J.6
  • 122
    • 70949096800 scopus 로고    scopus 로고
    • Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses
    • Su DS, Lim JJ, Tinney E, Wan BL, Young MB, Anderson KD, et al. Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses. J Med Chem. 2009;52(22):7163-9.
    • (2009) J Med Chem , vol.52 , Issue.22 , pp. 7163-7169
    • Su, D.S.1    Lim, J.J.2    Tinney, E.3    Wan, B.L.4    Young, M.B.5    Anderson, K.D.6
  • 124
    • 84861179369 scopus 로고    scopus 로고
    • Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor
    • Lu M, Felock PJ, Munshi V, Hrin RC,Wang YJ, Yan Y, et al. Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2012;56(6):3324-35.
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.6 , pp. 3324-3335
    • Lu, M.1    Felock, P.J.2    Munshi, V.3    Hrin, R.C.4    Wang, Y.J.5    Yan, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.