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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 18, 2013, Pages 5209-5212

Extension into the entrance channel of HIV-1 reverse transcriptase - Crystallography and enhanced solubility

(9) Bollini, Mariela a Frey, Kathleen M b Cisneros, José A a Spasov, Krasimir A b Das, Kalyan c Bauman, Joseph D c Arnold, Eddy c Anderson, Karen S b Jorgensen, William L a

a YALE UNIVERSITY (United States)

b YALE UNIVERSITY SCHOOL OF MEDICINE (United States)

c RUTGERS UNIVERSITY (United States)

Author keywords

Anti HIV agent; Crystal structures; Drug solubility; NNRTI

Indexed keywords

ANILINYLPYRIMIDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DAPIVIRINE; EFAVIRENZ; MORPHOLINOETHOXY ANALOG; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RILPIVIRINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRIAZENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL GROWTH; CHANNEL GATING; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SOLUBILITY; HUMAN; HUMAN CELL; LIQUID; MASS SPECTROMETRY; PERFORMANCE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENT; CRYSTAL STRUCTURES; DRUG SOLUBILITY; NNRTI;

ANTI-HIV AGENTS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HIV REVERSE TRANSCRIPTASE; HIV-1; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84882708603 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.06.093 Document Type: Article

Times cited : (33)

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