Off-rate screening (ORS) by surface plasmon resonance. An efficient method to kinetically sample hit to lead chemical space from unpurified reaction products

Journal of Medicinal Chemistry

Volumn 57, Issue 7, 2014, Pages 2845-2850

  Murray, James B ^a   Roughley, Stephen D ^a   Matassova, Natalia ^a   Brough, Paul A ^a  

^a Vernalis PLC   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DISSOCIATION; DRUG DEVELOPMENT; ENVIRONMENTAL TEMPERATURE; LIGAND BINDING; OFF RATE SCREENING; PROTEIN BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIC MIXTURE; REACTION TIME; SCREENING; SURFACE PLASMON RESONANCE;

BIOSENSING TECHNIQUES; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; KINETICS; PHARMACEUTICAL PREPARATIONS; SMALL MOLECULE LIBRARIES; SURFACE PLASMON RESONANCE;

EID: 84898474395     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401848a     Document Type: Article

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