Structure-guided design of α-amino acid-derived Pin1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 2, 2010, Pages 586-590

  Potter, Andrew J ^a   Ray, Stuart ^a   Gueritz, Louisa ^a   Nunns, Claire L ^a   Bryant, Christopher J ^a   Scrace, Simon F ^a   Matassova, Natalia ^a   Baker, Lisa ^a   Dokurno, Pawel ^a   Robinson, David A ^a   Surgenor, Allan E ^a   Davis, Ben ^a   Murray, James B ^a   Richardson, Christine M ^a   Moore, Jonathan D ^a  

^a Vernalis PLC   (United Kingdom)

Author keywords

Cancer; Crystal structure; Isomerase; Kinase signaling; NMR; Pin1; Rotamase; Small molecule inhibitor; Surface plasmon resonance

Indexed keywords

2 INDOLECARBOXYLIC ACID; ALPHA AMINO ACID; BENZIMIDAZOLE; BIOLOGICAL MARKER; LIGAND; NAPHTHYL GROUP; PEPTIDYLPROLYL ISOMERASE PIN1;

ARTICLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; MALE;

AMINO ACIDS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; BINDING SITES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; INDOLES; PEPTIDYLPROLYL ISOMERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72549105518     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.090     Document Type: Article

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