Uptake mechanism and endosomal fate of drug-phospholipid lipid nanoparticles in subcutaneous and in situ hepatoma

Journal of Biomedical Nanotechnology

Volumn 10, Issue 6, 2014, Pages 993-1003

  Wang, Qi ^a,b   Liu, Peifeng ^b   Gong, Tao ^a   Sun, Xun ^a   Duan, Yourong ^b   Zhang, Zhirong ^a  

^a SICHUAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Cellular uptake; DPLNs; In vivo fate; Tumor model

Indexed keywords

CELL CULTURE; CELLS; PHOSPHOLIPIDS; TUMORS;

CELLULAR UPTAKE; CONFOCAL LASER SCANNING MICROSCOPY; DPLNS; HUMAN HEPATOMA CELL LINES; IN-VIVO; NANOSTRUCTURED LIPID CARRIERS; SOLID LIPID NANOPARTICLES; TUMOR MODELS;

NANOPARTICLES;

CHLORPROMAZINE; CYTOCHALASIN D; DRUG CARRIER; DRUG PHOSPHOLIPID LIPID NANOPARTICLE; FILIPIN; NANOCARRIER; NANOSTRUCTURED LIPID CARRIER; SODIUM AZIDE; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL FATE; CELL STRAIN HEPG2; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DELAYED DRUG RELEASE; DRUG DISTRIBUTION; DRUG UPTAKE; ENDOCYTOSIS; ENDOSOME; FLOW CYTOMETRY; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LIVER CELL CARCINOMA; LIVER TOXICITY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; PINOCYTOSIS; SUBCUTANEOUS HEPATOMA; ZETA POTENTIAL;

ANIMALS; CAMPTOTHECIN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DIFFUSION; ENDOSOMES; LIPOSOMES; MALE; MICE; MICE, INBRED C57BL; NANOCAPSULES; ORGAN SPECIFICITY; PHOSPHOLIPIDS; TISSUE DISTRIBUTION;

EID: 84898473475     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2014.1776     Document Type: Article

References (36)

1. P. Watson, A. T. Jones, and D. J.Stephens, Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells. Adv. Drug Deliver. Rev. 57, 43 (2005).
2. S. D. Conner and S. L. Schmid, Regulated portals of entry into the cell. Nature 422, 37 (2003).
3. I. A. Khalil, K. Kogure, H. Akita, and H. Harashima, Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol. Rev. 58, 32 (2006).
4. C. Lamaze and S. L. Schmid, The emergence of clathrin-independent pinocytic pathways. Curr. Opin. Cell Biol. 7, 573 (1995).
5. T. Izumisawaa, Y. Hattori, M. Date, K. Toma, and Y. Maitani, Cell line-dependent internalization pathways determine DNA transfection efficiency of decaarginine-PEG-lipid. Int. J. Pharm. 404, 264 (2011).
6. J. Khan, A. Alexander, Ajazuddin, S. Saraf, and S. Saraf, Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives. J. Control Release 168, 50 (2013).
7. J. Zhang, Q. Tang, X. Xu, and N. Li, Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery. Int. J. Pharm. 448, 168 (2013).
8. A. A. Ajazuddin, J. Khan, T. K. Giri, D. K. Tripathi, and S. Saraf, Advancement in stimuli triggered in situ gelling delivery for local and systemic route. Expert Opin. Drug Deliv. 9, 1573 (2012).
9. T. A. Al-Hilal, F. Alam, and Y. Byun, Oral drug delivery systems using chemical conjugates or physical complexes. Adv. Drug. Deliver. Rev. 65, 845 (2013).
10. M. Pradhan, D. Singh, and M. R. Singh, Novel colloidal carriers for psoriasis: Current issues, mechanistic insight and novel delivery approaches. J. Control Release 170, 380 (2013).
11. K. Jores, A. Haberland, S. Wartewig, K. Mäder, and W. Mehnert, Solid Lipid Nanoparticles (SLN) and Oil-Loaded SLN Studied by Spectrofluorometry and Raman Spectroscopy. Pharm. Res. 22, 1887 (2005).
12. J. Y. Fang, C. L. Fang, C. H. Liu, and Y. H. Sun, Lipid nanoparticles as vehicles for topical psoralen delivery: Solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). Eur. J. Pharm. Biopharm. 70, 633 (2008).
13. Q. Wang, T. Gong, X. Sun, and Z. R. Zhang, Structural characterization of novel phospholipid lipid nanoparticles for controlled drug delivery. Colloid Surface B. 84, 406 (2011).
14. W. Wei, S. J. Shi, J. Liu, X. Sun, K. Ren, D. Zhao, X. N. Zhang, Z. R. Zhang, and T. Gong, Lipid nanoparticles loaded with 10-hydroxycamptothecin- phospholipid complex developed for the treatment of hepatoma in clinical application. J. Drug Target 18, 557 (2010).
15. G. Catarina, E. Torradob, T. Martinsb, P. Perrira, J. Pedrosa, and M. Gama, Dextrin nanoparticles: Studies on the interaction with murine macrophages and blood clearance. Colloid Surface B 75, 483 (2010).
16. W. Wei, D. Zhao, Z. R. Zhang, and T. Gong, Study on the physicochemical properties of hydroxycamptothecin-phospholipid complex. West China J. Pharm. Sci. 23, 396 (2008).
17. A. Gessner, C. Olbrich, W. Schröder, O. Kayser, and R. H. Müller, The role of plasma proteins in brain targeting: Species dependent protein adsorption patterns on brain-specific lipid drug conjugate (LDC) nanoparticles. Int. J. Pharm. 214, 87 (2001).
18. T. M. Okonogi, A. Radhakrishnan, and H. M. McConnell, Two fatty acids can replace one phospholipid in condensed complexes with cholesterol. Bba-Biomembranes. 1564, 1 (2002).
19. P. F. Liu, H. Z. Wang, Y. G. Li, and Y. R. Duan, Preparation of DHAQ-loaded PLA-PLL-RGD nanoparticles and comparison of antitumor efficacy to hepatoma and breast carcinoma. J. Macromol. Sci. A 46, 1024 (2009).
20. S. F. Lan, B. S. Mroczka, and B. Starly, Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: A study of cell viability, morphology and drug metabolism. Toxicol. In Vitro. 24, 1314 (2010).
21. N. Sharma, Q. He, and R. P. Sharma, Augmented fumonisin B1 toxicity in co-cultures: evidence for crosstalk between macrophages and non-parenchymatous liver epithelial cells involving proinflammatory cytokines. Toxicology 203, 239 (2004).
22. R. Mori, Y. Sakai, and K. Nakazawa, Micropatterned Organoid Culture of Rat Hepatocytes and HepG2 Cells. J. Biosci. Bioeng. 106, 237 (2008).
23. P. F. Liu, L. B. Qin, Q. Wang, Y. Sun, M. J. Zhu, M. Shen, and Y. R. Duan, cRGD-functionalized mPEG-PLGA-PLL nanoparticles for imaging and therapy of breast cancer. Biomaterials 33, 6739 (2012).
24. O. C. Farokhzad, S. Jon, and A. Khademhosseini, Nanoparticleaptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res. 64, 7668 (2004).
25. A. K. Gupta and M. Gupta Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles. Biomaterials 26, 1565 (2005).
26. P. F. Liu, X. L. Qi, Y. Sun, H. Z. Wang, Y. G. Li, and Y. R. Duan, RGD-conjuaged PLA-PLL nanoparticles targeting to Bacp-37 breast cancer xenografts in vivo. J. Nanosci. Nanotechnol. 11, 10760 (2011).
27. X. M. Zhang, X. Sun, J. L. Li, X. Zhang, T. Gong, and Z. R. Zhang, Lipid nanoemulsions loaded with doxorubicin-oleic acid ionic complex: characterization, in vitro and in vivo studies. Pharmazie 66, 1 (2011).
28. S. Pils, T. Schmitter, F. Neske, and C. R. Hauck, Quantification of bacterial invasion into adherent cells by flow cytometry. J. Microbiol. Meth. 65, 301 (2006).
29. H. Y. Nam, S. M. Kwon, H. Chung, S. Y. Lee, S. H. Kwon, H. Jeon, Y. Kim, J. H. Park, J. Kim, S. Her, Y. K. Oh, I. C. Kwon, K. Kim, and S. Y. Jeong, Cellular uptake mechanism and intracellular fate of hydrophobically modified glycol chitosan nanoparticles. J. Control Release 135, 259 (2009).
30. T. Horsburgha, S. U. Martinb, and A. J. Robsonb, The application of flow cytometry to histocompatibility testing. Transpl. Immunol. 8, 3 (2000).
31. H. S. Liu, C. E. Pan, W. Yang, and X. M. Liu, Antitumor and immunomodulatory activity of resveratrol on experimentally implanted tumor of H22 in Balb/c mice. World J. Gastroenterol. 9, 1474 (2003).
32. L. Yu, Z. J. Sun, S. L. Wu, and C. E. Pan, Effect of resveratrol on cell cycle proteins in murine transplantable liver cancer. World J. Gastroenterol. 9, 2341 (2003).
33. P. F. Liu, H. Yu, Y. Sun, M. J. Zhu, and Y. R. Duan, A mPEG-PLGA-b-PLL copolymer carrier for adriamycin and siRNA delivery. Biomaterials 33, 4403 (2012).
34. P. F. Liu, H. B. Wang, Q. Wang, Y. Sun, M. Shen, M. J. Zhu, Z. Y. Wan, and Y. R. Duan, cRGD conjugated mPEG-PLGA-PLL nanoparticles for SGC-7901 gastric cancer cells-targeted delivery of fluorouracil. J. Nanosci. Nanotechnol. 12, 4467 (2012).
35. P. F. Liu, Z. H. Li, M. J. Zhu, Y. G. Li, H. Z. Wang, and Y. R. Duan, Preparation of EGFR monoclonal antibody conjugated nanoparticles and targeting to hepatocellular carcinoma. J. Mater. Sci. Mater. Med. 21, 551 (2010).
36. F. Ahsan, I. P. Rivas, M. A. Khan, and A. Z. T. Suarez, Targeting to macrophages: role of physicochemical properties of particulate carriers - liposomes and microspheres - on the phagocytosis by macrophages. J. Control Release 79, 29 (2002).