메뉴 건너뛰기




Volumn 89, Issue 5, 2014, Pages 470-479

Hepcidin-dependent and hepcidin-independent regulation of erythropoiesis in a mouse model of anemia of chronic inflammation

Author keywords

[No Author keywords available]

Indexed keywords

BROMETHOL; HEMOGLOBIN; HEPCIDIN; INTERLEUKIN 6; TURPENTINE;

EID: 84898438674     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.23670     Document Type: Article
Times cited : (31)

References (53)
  • 1
    • 84898403805 scopus 로고
    • Anemia WSGoID. Iron Deficiency Anemia Report of a Study group. Switzerland: World Health Organization technical report series; .
    • Anemia WSGoID. Iron Deficiency Anemia Report of a Study group. Switzerland: World Health Organization technical report series; 1959.
    • (1959)
  • 3
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002;110:1037-1044.
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 4
    • 13844307889 scopus 로고    scopus 로고
    • Regulation of hepcidin transcription by interleukin-1 and interleukin-6
    • Proc Natl Acad Sci USA ;:-.
    • Lee P, Peng H, Gelbart T, et al. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci USA 2005;102:1906-1910.
    • (2005) , vol.102 , pp. 1906-1910
    • Lee, P.1    Peng, H.2    Gelbart, T.3
  • 5
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004;113:1271-1276.
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3
  • 6
    • 54949147441 scopus 로고    scopus 로고
    • Immunoassay for human serum hepcidin
    • Ganz T, Olbina G, Girelli D, et al. Immunoassay for human serum hepcidin. Blood 2008;112:4292-4297.
    • (2008) Blood , vol.112 , pp. 4292-4297
    • Ganz, T.1    Olbina, G.2    Girelli, D.3
  • 7
    • 77951745552 scopus 로고    scopus 로고
    • Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia
    • Sasu BJ, Cooke KS, Arvedson TL, et al. Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia. Blood 2010;115:3616-3624.
    • (2010) Blood , vol.115 , pp. 3616-3624
    • Sasu, B.J.1    Cooke, K.S.2    Arvedson, T.L.3
  • 8
    • 79955980950 scopus 로고    scopus 로고
    • Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation
    • Steinbicker AU, Sachidanandan C, Vonner AJ, et al. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood 2011;117:4915-4923.
    • (2011) Blood , vol.117 , pp. 4915-4923
    • Steinbicker, A.U.1    Sachidanandan, C.2    Vonner, A.J.3
  • 9
    • 80052647221 scopus 로고    scopus 로고
    • Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats
    • Theurl I, Schroll A, Sonnweber T, et al. Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood 2011;118:4977-4984.
    • (2011) Blood , vol.118 , pp. 4977-4984
    • Theurl, I.1    Schroll, A.2    Sonnweber, T.3
  • 10
    • 84877930663 scopus 로고    scopus 로고
    • The effects of the anti-hepcidin Spiegelmer NOX H94 on inflammation-induced anemia in cynomolgus monkeys
    • Schwoebel F, van Eijk LT, Zboralski D, et al. The effects of the anti-hepcidin Spiegelmer NOX H94 on inflammation-induced anemia in cynomolgus monkeys. Blood 2013;121:2311-2315.
    • (2013) Blood , vol.121 , pp. 2311-2315
    • Schwoebel, F.1    van Eijk, L.T.2    Zboralski, D.3
  • 11
    • 0037007064 scopus 로고    scopus 로고
    • Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
    • Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 2002;99:4596-4601.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 4596-4601
    • Nicolas, G.1    Bennoun, M.2    Porteu, A.3
  • 12
    • 34247366783 scopus 로고    scopus 로고
    • Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation
    • Roy CN, Mak HH, Akpan I, et al. Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Blood 2007;109:4038-4044.
    • (2007) Blood , vol.109 , pp. 4038-4044
    • Roy, C.N.1    Mak, H.H.2    Akpan, I.3
  • 13
    • 44449177930 scopus 로고    scopus 로고
    • The serine protease TMPRSS6 is required to sense iron deficiency
    • Du X, She E, Gelbart T, et al. The serine protease TMPRSS6 is required to sense iron deficiency. Science 2008;320:1088-1092.
    • (2008) Science , vol.320 , pp. 1088-1092
    • Du, X.1    She, E.2    Gelbart, T.3
  • 14
    • 0037111732 scopus 로고    scopus 로고
    • Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
    • Weinstein DA, Roy CN, Fleming MD, et al. Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease. Blood 2002;100:3776-3781.
    • (2002) Blood , vol.100 , pp. 3776-3781
    • Weinstein, D.A.1    Roy, C.N.2    Fleming, M.D.3
  • 15
    • 42649118442 scopus 로고    scopus 로고
    • Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
    • Finberg KE, Heeney MM, Campagna DR, et al. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet 2008;40:569-571.
    • (2008) Nat Genet , vol.40 , pp. 569-571
    • Finberg, K.E.1    Heeney, M.M.2    Campagna, D.R.3
  • 16
    • 0003014286 scopus 로고
    • The anemia of infection. I. Hypoferremia, hypercupremia, and alterations in porphyrin metabolism in patients
    • Cartwright GE, Lauritsen MA, Jones PJ, et al. The anemia of infection. I. Hypoferremia, hypercupremia, and alterations in porphyrin metabolism in patients. J Clin Invest 1946;25:65-80.
    • (1946) J Clin Invest , vol.25 , pp. 65-80
    • Cartwright, G.E.1    Lauritsen, M.A.2    Jones, P.J.3
  • 17
    • 40649122556 scopus 로고    scopus 로고
    • Anemia in early rheumatoid arthritis is associated with interleukin 6-mediated bone marrow suppression, but has no effect on disease course or mortality
    • Nikolaisen C, Figenschau Y, Nossent JC. Anemia in early rheumatoid arthritis is associated with interleukin 6-mediated bone marrow suppression, but has no effect on disease course or mortality. J Rheumatol 2008;35:380-386.
    • (2008) J Rheumatol , vol.35 , pp. 380-386
    • Nikolaisen, C.1    Figenschau, Y.2    Nossent, J.C.3
  • 18
    • 19544390172 scopus 로고    scopus 로고
    • Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia
    • Ripley BJ, Goncalves B, Isenberg DA, et al. Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia. Ann Rheum Dis 2005;64:849-853.
    • (2005) Ann Rheum Dis , vol.64 , pp. 849-853
    • Ripley, B.J.1    Goncalves, B.2    Isenberg, D.A.3
  • 19
    • 0036068710 scopus 로고    scopus 로고
    • Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: A pilot study
    • Leng S, Chaves P, Koenig K, et al. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: A pilot study. J Am Geriatr Soc 2002;50:1268-1271.
    • (2002) J Am Geriatr Soc , vol.50 , pp. 1268-1271
    • Leng, S.1    Chaves, P.2    Koenig, K.3
  • 20
    • 0030854855 scopus 로고    scopus 로고
    • Globin gene silencing in primary erythroid cultures. An inhibitory role for interleukin-6
    • Ferry AE, Baliga SB, Monteiro C, et al. Globin gene silencing in primary erythroid cultures. An inhibitory role for interleukin-6. J Biol Chem 1997;272:20030-20037.
    • (1997) J Biol Chem , vol.272 , pp. 20030-20037
    • Ferry, A.E.1    Baliga, S.B.2    Monteiro, C.3
  • 21
    • 84891903512 scopus 로고    scopus 로고
    • Interleukin-6 directly impairs the erythroid development of human TF-1 erythroleukemic cells
    • McCranor BJ, Kim MJ, Cruz NM, et al. Interleukin-6 directly impairs the erythroid development of human TF-1 erythroleukemic cells. Blood Cells Mol Dis 2014;52:126-133.
    • (2014) Blood Cells Mol Dis , vol.52 , pp. 126-133
    • McCranor, B.J.1    Kim, M.J.2    Cruz, N.M.3
  • 22
    • 84868536306 scopus 로고    scopus 로고
    • Late stage erythroid precursor production is impaired in mice with chronic inflammation
    • Prince OD, Langdon JM, Layman AJ, et al. Late stage erythroid precursor production is impaired in mice with chronic inflammation. Haematologica 2012;97:1648-1656.
    • (2012) Haematologica , vol.97 , pp. 1648-1656
    • Prince, O.D.1    Langdon, J.M.2    Layman, A.J.3
  • 23
    • 33745752870 scopus 로고    scopus 로고
    • Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis
    • Lesbordes-Brion JC, Viatte L, Bennoun M, et al. Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood 2006;108:1402-1405.
    • (2006) Blood , vol.108 , pp. 1402-1405
    • Lesbordes-Brion, J.C.1    Viatte, L.2    Bennoun, M.3
  • 24
    • 0028328436 scopus 로고
    • Impaired immune and acute-phase responses in interleukin-6-deficient mice
    • Kopf M, Baumann H, Freer G, et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 1994;368:339-342.
    • (1994) Nature , vol.368 , pp. 339-342
    • Kopf, M.1    Baumann, H.2    Freer, G.3
  • 25
    • 84884954923 scopus 로고    scopus 로고
    • Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age
    • McCranor BJ, Langdon JM, Prince OD, et al. Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age. Haematologica 2013;98:1633-1640.
    • (2013) Haematologica , vol.98 , pp. 1633-1640
    • McCranor, B.J.1    Langdon, J.M.2    Prince, O.D.3
  • 27
    • 33644844649 scopus 로고    scopus 로고
    • Statistical analysis of real-time PCR data
    • Yuan JS, Reed A, Chen F, et al. Statistical analysis of real-time PCR data. BMC Bioinformatics 2006;7:85.
    • (2006) BMC Bioinformatics , vol.7 , pp. 85
    • Yuan, J.S.1    Reed, A.2    Chen, F.3
  • 28
    • 0027984754 scopus 로고
    • Defective inflammatory response in interleukin 6-deficient mice
    • Fattori E, Cappelletti M, Costa P, et al. Defective inflammatory response in interleukin 6-deficient mice. J Exp Med 1994;180:1243-1250.
    • (1994) J Exp Med , vol.180 , pp. 1243-1250
    • Fattori, E.1    Cappelletti, M.2    Costa, P.3
  • 29
    • 0027165260 scopus 로고
    • Cachexia and the acute-phase protein response in inflammation are regulated by interleukin-6
    • Oldenburg HS, Rogy MA, Lazarus DD, et al. Cachexia and the acute-phase protein response in inflammation are regulated by interleukin-6. Eur J Immunol 1993;23:1889-1894.
    • (1993) Eur J Immunol , vol.23 , pp. 1889-1894
    • Oldenburg, H.S.1    Rogy, M.A.2    Lazarus, D.D.3
  • 30
    • 0021686564 scopus 로고
    • Inflammation triggers hypoferremia and de novo synthesis of serum transferrin and ceruloplasmin in mice
    • Beaumier DL, Caldwell MA, Holbein BE. Inflammation triggers hypoferremia and de novo synthesis of serum transferrin and ceruloplasmin in mice. Infect Immun 1984;46:489-494.
    • (1984) Infect Immun , vol.46 , pp. 489-494
    • Beaumier, D.L.1    Caldwell, M.A.2    Holbein, B.E.3
  • 31
    • 0021164733 scopus 로고
    • Increased ferritin synthesis and iron uptake in inflammatory mouse macrophages
    • Birgegard G, Caro J. Increased ferritin synthesis and iron uptake in inflammatory mouse macrophages. Scand J Haematol 1984;33:43-48.
    • (1984) Scand J Haematol , vol.33 , pp. 43-48
    • Birgegard, G.1    Caro, J.2
  • 32
    • 77955005442 scopus 로고    scopus 로고
    • Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice
    • De Domenico I, Zhang TY, Koening CL, et al. Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest 2010;120:2395-2405.
    • (2010) J Clin Invest , vol.120 , pp. 2395-2405
    • De Domenico, I.1    Zhang, T.Y.2    Koening, C.L.3
  • 33
    • 0016240473 scopus 로고
    • Storage iron kinetics. VI. The effect of inflammation on iron exchange in the rat
    • Hershko C, Cook JD, Finch CA. Storage iron kinetics. VI. The effect of inflammation on iron exchange in the rat. Br J Haematol 1974;28:67-75.
    • (1974) Br J Haematol , vol.28 , pp. 67-75
    • Hershko, C.1    Cook, J.D.2    Finch, C.A.3
  • 34
    • 0023876497 scopus 로고
    • Iron metabolism in the erythrophagocytosing Kupffer cell
    • Kondo H, Saito K, Grasso JP, et al. Iron metabolism in the erythrophagocytosing Kupffer cell. Hepatology 1988;8:32-38.
    • (1988) Hepatology , vol.8 , pp. 32-38
    • Kondo, H.1    Saito, K.2    Grasso, J.P.3
  • 35
    • 20044366342 scopus 로고    scopus 로고
    • Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload
    • Montosi G, Corradini E, Garuti C, et al. Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload. Hepatology 2005;41:545-552.
    • (2005) Hepatology , vol.41 , pp. 545-552
    • Montosi, G.1    Corradini, E.2    Garuti, C.3
  • 36
    • 0018184822 scopus 로고
    • Effect of inflammation on erythroid precursors (BFU-E and CFU-E) in bone marrow and spleen of mice
    • Reissmann KR, Udupa KB. Effect of inflammation on erythroid precursors (BFU-E and CFU-E) in bone marrow and spleen of mice. J Lab Clin Med 1978;92:22-29.
    • (1978) J Lab Clin Med , vol.92 , pp. 22-29
    • Reissmann, K.R.1    Udupa, K.B.2
  • 37
    • 34250363169 scopus 로고    scopus 로고
    • Changes of gene expression of iron regulatory proteins during turpentine oil-induced acute-phase response in the rat
    • Sheikh N, Dudas J, Ramadori G. Changes of gene expression of iron regulatory proteins during turpentine oil-induced acute-phase response in the rat. Lab Invest 2007;87:713-725.
    • (2007) Lab Invest , vol.87 , pp. 713-725
    • Sheikh, N.1    Dudas, J.2    Ramadori, G.3
  • 38
    • 17844362181 scopus 로고    scopus 로고
    • Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo
    • Lou DQ, Lesbordes JC, Nicolas G, et al. Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo. Hepatology 2005;41:1056-1064.
    • (2005) Hepatology , vol.41 , pp. 1056-1064
    • Lou, D.Q.1    Lesbordes, J.C.2    Nicolas, G.3
  • 39
    • 0001288334 scopus 로고
    • Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro
    • Ishibashi T, Kimura H, Uchida T, et al. Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro. Proc Natl Acad Sci USA 1989;86:5953-5957.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 5953-5957
    • Ishibashi, T.1    Kimura, H.2    Uchida, T.3
  • 40
    • 0027893184 scopus 로고
    • Thrombopoietic effects of interleukin-6 in long-term administration in mice
    • Ishibashi T, Shikama Y, Kimura H, et al. Thrombopoietic effects of interleukin-6 in long-term administration in mice. Exp Hematol 1993;21:640-646.
    • (1993) Exp Hematol , vol.21 , pp. 640-646
    • Ishibashi, T.1    Shikama, Y.2    Kimura, H.3
  • 41
    • 79960681867 scopus 로고    scopus 로고
    • Low hepcidin accounts for the proinflammatory status associated with iron deficiency
    • Pagani A, Nai A, Corna G, et al. Low hepcidin accounts for the proinflammatory status associated with iron deficiency. Blood 2011;118:736-746.
    • (2011) Blood , vol.118 , pp. 736-746
    • Pagani, A.1    Nai, A.2    Corna, G.3
  • 42
    • 0031467102 scopus 로고    scopus 로고
    • Anemia of chronic disorders in systemic autoimmune diseases
    • Bertero MT, Caligaris-Cappio F. Anemia of chronic disorders in systemic autoimmune diseases. Haematologica 1997;82:375-381.
    • (1997) Haematologica , vol.82 , pp. 375-381
    • Bertero, M.T.1    Caligaris-Cappio, F.2
  • 43
    • 0024272980 scopus 로고
    • Mechanism of anaemia in rheumatoid arthritis: Demonstration of raised interleukin 1 beta concentrations in anaemic patients and of interleukin 1 mediated suppression of normal erythropoiesis and proliferation of human erythroleukaemia (HEL) cells in vitro
    • Maury CP, Andersson LC, Teppo AM, et al. Mechanism of anaemia in rheumatoid arthritis: Demonstration of raised interleukin 1 beta concentrations in anaemic patients and of interleukin 1 mediated suppression of normal erythropoiesis and proliferation of human erythroleukaemia (HEL) cells in vitro. Ann Rheum Dis 1988;47:972-978.
    • (1988) Ann Rheum Dis , vol.47 , pp. 972-978
    • Maury, C.P.1    Andersson, L.C.2    Teppo, A.M.3
  • 44
    • 84881239640 scopus 로고    scopus 로고
    • Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response
    • Richardson CL, Delehanty LL, Bullock GC, et al. Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response. J Clin Invest 2013;123:3614-3623.
    • (2013) J Clin Invest , vol.123 , pp. 3614-3623
    • Richardson, C.L.1    Delehanty, L.L.2    Bullock, G.C.3
  • 45
    • 80052510705 scopus 로고    scopus 로고
    • Chronic IFN-gamma production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis
    • Libregts SF, Gutierrez L, de Bruin AM, et al. Chronic IFN-gamma production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis. Blood 2011;118:2578-2588.
    • (2011) Blood , vol.118 , pp. 2578-2588
    • Libregts, S.F.1    Gutierrez, L.2    de Bruin, A.M.3
  • 46
    • 33748121115 scopus 로고    scopus 로고
    • Interleukin-6 and chronic inflammation
    • Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res Ther 2006;8 Suppl 2:S3.
    • (2006) Arthritis Res Ther , vol.8 , Issue.SUPPL 2
    • Gabay, C.1
  • 47
    • 33646782974 scopus 로고    scopus 로고
    • Erythroblastic islands: Specialized microenvironmental niches for erythropoiesis
    • Chasis JA. Erythroblastic islands: Specialized microenvironmental niches for erythropoiesis. Curr Opin Hematol 2006;13:137-141.
    • (2006) Curr Opin Hematol , vol.13 , pp. 137-141
    • Chasis, J.A.1
  • 48
    • 84878444005 scopus 로고    scopus 로고
    • CD169(+) macrophages provide a niche promoting erythropoiesis under homeostasis and stress
    • Chow A, Huggins M, Ahmed J, et al. CD169(+) macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med 2013;19:429-436.
    • (2013) Nat Med , vol.19 , pp. 429-436
    • Chow, A.1    Huggins, M.2    Ahmed, J.3
  • 49
    • 84878439561 scopus 로고    scopus 로고
    • Macrophages support pathological erythropoiesis in polycythemia vera and beta-thalassemia
    • Ramos P, Casu C, Gardenghi S, et al. Macrophages support pathological erythropoiesis in polycythemia vera and beta-thalassemia. Nat Med 2013;19:437-445.
    • (2013) Nat Med , vol.19 , pp. 437-445
    • Ramos, P.1    Casu, C.2    Gardenghi, S.3
  • 50
    • 67149084949 scopus 로고    scopus 로고
    • Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: Diagnostic and therapeutic implications
    • Theurl I, Aigner E, Theurl M, et al. Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: Diagnostic and therapeutic implications. Blood 2009;113:5277-5286.
    • (2009) Blood , vol.113 , pp. 5277-5286
    • Theurl, I.1    Aigner, E.2    Theurl, M.3
  • 51
    • 33745526068 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha causes hypoferraemia and reduced intestinal iron absorption in mice
    • Laftah AH, Sharma N, Brookes MJ, et al. Tumour necrosis factor alpha causes hypoferraemia and reduced intestinal iron absorption in mice. Biochem J 2006;397:61-67.
    • (2006) Biochem J , vol.397 , pp. 61-67
    • Laftah, A.H.1    Sharma, N.2    Brookes, M.J.3
  • 52
    • 84861330076 scopus 로고    scopus 로고
    • Effects of acute and chronic inflammation on proteins involved in duodenal iron absorption in mice: A time-course study
    • Sukumaran A, Varghese J, Tamilselvan J, et al. Effects of acute and chronic inflammation on proteins involved in duodenal iron absorption in mice: A time-course study. Br J Nutr 2012;108:1994-2001.
    • (2012) Br J Nutr , vol.108 , pp. 1994-2001
    • Sukumaran, A.1    Varghese, J.2    Tamilselvan, J.3
  • 53
    • 84876539389 scopus 로고    scopus 로고
    • Role of hepcidin in the setting of hypoferremia during acute inflammation
    • Deschemin JC, Vaulont S. Role of hepcidin in the setting of hypoferremia during acute inflammation. PLoS One 2013;8:e61050.
    • (2013) PLoS One , vol.8
    • Deschemin, J.C.1    Vaulont, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.