Unveiling Benznidazole's mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi

Environmental and Molecular Mutagenesis

Volumn 55, Issue 4, 2014, Pages 309-321

  Rajão, Matheus Andrade ^a   Furtado, Carolina ^a   Alves, Ceres Luciana ^a   Passos Silva, Danielle Gomes ^a   De Moura, Michelle Barbi ^a   Schamber Reis, Bruno Luiz ^a   Kunrath Lima, Marianna ^a   Zuma, Aline Araújo ^b   Vieira da Rocha, João Pedro ^a   Garcia, Juliana Borio Ferreira ^c   Mendes, Isabela Cecília ^a   Pena, Sérgio Danilo Junho ^a   Macedo, Andrea Mara ^a   Franco, Glória Regina ^a   De Souza Pinto, Nadja Cristhina ^c   De Medeiros, Marisa Helena Gennari ^c   Cruz, Angela Kaysel ^c   Motta, Maria Cristina Machado ^b   Teixeira, Santuza Maria Ribeiro ^a   Machado, Carlos Renato ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Benznidazole; DNA repair; Drug resistance; Oxidative stress; Trypanosoma cruzi

Indexed keywords

3 METHYLADENINE; 7 METHYLGUANINE; 8 HYDROXYGUANINE; BACTERIAL PROTEIN; BENZNIDAZOLE; DEOXYRIBONUCLEOPROTEIN; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE BETA; DNA GLYCOSYLASE MUTY; DNA POLYMERASE; MITOCHONDRIAL DNA; MUTT PROTEIN; NUCLEOTIDE PYROPHOSPHATASE; PROTOZOAL DNA; RAD51 PROTEIN; TCOGG1 PROTEIN; TCPOLB PROTEIN; TCPOLH PROTEIN; TCPOLK PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ANTIBIOTIC RESISTANCE; ARTICLE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DNA FRAGMENTATION; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; ELECTRON MICROSCOPY; GENE INACTIVATION; GENE OVEREXPRESSION; HETEROLOGOUS EXPRESSION; MITOCHONDRION SWELLING; NONHUMAN; OXIDATION; PARASITE SURVIVAL; POLYMERIZATION; SURVIVAL RATE; TRANSMISSION ELECTRON MICROSCOPY; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

BENZNIDAZOLE; DNA REPAIR; DRUG RESISTANCE; OXIDATIVE STRESS; TRYPANOSOMA CRUZI;

ANIMALS; CELL SURVIVAL; CHAGAS DISEASE; DNA GLYCOSYLASES; DNA REPAIR; DNA REPAIR ENZYMES; DNA, PROTOZOAN; DRUG RESISTANCE; GUANINE; NITROIMIDAZOLES; PROTOZOAN PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 84898058359     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21839     Document Type: Article

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