Biochemical studies with DNA polymerase β and DNA polymerase β-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance

DNA Repair

Volumn 7, Issue 11, 2008, Pages 1882-1892

  Lopes, Débora de Oliveira ^a   Schamber Reis, Bruno Luiz Fonseca ^a   Regis da Silva, Carlos Gustavo ^a   Rajão, Matheus Andrade ^a   DaRocha, Wanderson Duarte ^a   Macedo, Andréa Mara ^a   Franco, Glória Regina ^a   Nardelli, Sheila Cristina ^b   Schenkman, Sérgio ^b   Hoffmann, Jean Sébastien ^c   Cazaux, Christophe ^c   Pena, Sérgio Danilo Junho ^a   Teixeira, Santuza Maria Ribeiro ^a   Machado, Carlos Renato ^a  

^a UFMG   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

Author keywords

DNA polymerase ; DNA repair; Mitochondria; Primer extension assay; Translesion synthesis; Trypanosoma cruzi

Indexed keywords

DEOXYRIBOSE; DNA DIRECTED DNA POLYMERASE BETA; MITOCHONDRIAL DNA; PHENYLALANINE; TYROSINE;

ARTICLE; BASE MISPAIRING; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; KINETOPLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS; TRYPANOSOMA CRUZI;

AMINO ACID SEQUENCE; ANIMALS; BIOCHEMISTRY; CLONING, MOLECULAR; DNA POLYMERASE BETA; DNA PRIMERS; DNA, MITOCHONDRIAL; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; P21-ACTIVATED KINASES; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRYPANOSOMA CRUZI;

MAMMALIA; TRYPANOSOMA CRUZI; TRYPANOSOMATIDAE;

EID: 53149149396     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2008.07.018     Document Type: Article

References (24)

1. Idriss H.T., Al-Assar O., and Wilson S.H. DNA polymerase beta. Int. J. Biochem. Cell. Biol. 34 (2002) 321-324
2. Garcia-Diaz M., Bebenek K., Gao G., Pedersen L.C., London R.E., and Kunkel T.A. Structure-function studies of DNA polymerase lambda. DNA Repair (Amst.) 4 (2005) 1358-1367
3. Krutiakov V.M. Eukaryotic error prone DNA polymerases: suggested roles in replication, repair and mutagenesis. Mol. Biol. (Mosk.) 40 (2006) 3-11
4. Kunkel T.A., Pavlov Y.I., and Bebenek K. Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. DNA Repair (Amst.) 2 (2003) 135-149
5. Matsuda T., Vande Berg B.J., Bebenek K., Osheroff W.P., Wilson S.H., and Kunkel T.A. The base substitution fidelity of DNA polymerase beta-dependent single nucleotide base excision repair. J. Biol. Chem. 278 (2003) 25947-25951
6. Prasad R., Batra V.K., Yang X.P., Krahn J.M., Pedersen L.C., Beard W.A., and Wilson S.H. Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism. DNA Repair (Amst.) 4 (2005) 1347-1357
7. Wood R.D., and Shivji M.K. Which DNA polymerases are used for DNA-repair in eukaryotes?. Carcinogenesis 18 (1997) 605-610
8. Torri A.F., Kunkel T.A., and Englund P.T. A beta-like DNA polymerase from the mitochondrion of the trypanosomatid Crithidia fasciculata. J. Biol. Chem. 269 (1994) 8165-8171
9. Taladriz S., Hanke T., Ramiro M.J., Garcia-Diaz M., Garcia De Lacoba M., Blanco L., and Larraga V. Nuclear DNA polymerase beta from Leishmania infantum. Cloning, molecular analysis and developmental regulation. Nucleic Acids Res. 29 (2001) 3822-3834
10. Klingbeil M.M., Motyka S.A., and Englund P.T. Multiple mitochondrial DNA polymerases in Trypanosoma brucei. Mol. Cell 10 (2002) 175-186
11. Saxowsky T.T., Choudhary G., Klingbeil M.M., and Englund P.T. Trypanosoma brucei has two distinct mitochondrial DNA polymerase beta enzymes. J. Biol. Chem. 278 (2003) 49095-49101
12. Katoh K., Kuma K., Toh H., and Miyata T. MAFFT version 5: improvement in accuracy of multiple sequence alignment. Nucleic Acids Res. 33 (2005) 511-518
13. Camargo E.P. Growth and differentiation in Trypanosoma Cruzi. I. Origin of metacyclic trypanosomes in liquid media. Rev. Inst. Med. Trop. Sao Paulo 12 (1964) 93-100
14. Teixeira S.M., and daRocha W.D. Control of gene expression and genetic manipulation in the Trypanosomatidae. Genet. Mol. Res. 2 (2003) 148-158
15. Lopes D.O., Regis-da-Silva C.G., Machado-Silva A., Macedo A.M., Franco G.R., Hoffmann J.S., Cazaux C., Pena S.D., Teixeira S.M., and Machado C.R. Analysis of DNA polymerase activity in vitro using non-radioactive primer extension assay in an automated DNA sequencer. Genet. Mol. Res. 6 (2007) 150-155
16. Sawaya M.R., Pelletier H., Kumar A., Wilson S.H., and Kraut J. Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism. Science 264 (1994) 1930-1935
17. Pelletier H., Sawaya M.R., Kumar A., Wilson S.H., and Kraut J. Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP. Science 264 (1994) 1891-1903
18. Wong D., and Demple B. Modulation of the 5′-deoxyribose-5-phosphate lyase and DNA synthesis activities of mammalian DNA polymerase beta by apurinic/apyrimidinic endonuclease 1. J. Biol. Chem. 279 (2004) 25268-25275
19. Solari A., Tharaud D., Repetto Y., Aldunate J., Morello A., and Litvak S. In vitro and in vivo studies of Trypanosoma cruzi DNA polymerase. Biochem. Int. 7 (1983) 147-157
20. Rojas C., Venegas J., Litvak S., and Solari A. Two DNA polymerases from Trypanosoma cruzi: biochemical characterization and effects of inhibitors. Comp. Biochem. Physiol. C 101 (1992) 27-33
21. Venegas J., and Solari A. Purification and characterization of a beta-like DNA polymerase from Trypanosoma cruzi. Mol. Biochem. Parasitol. 73 (1995) 53-62
22. Venegas J., Salas J., Gonzalez C., Zulantay I., Diaz E., Gajardo M., Sanchez G., and Solari A. Isolation and partial characterization of three DNA polymerases from Trypanosoma cruzi. Comp. Biochem. Physiol. B: Biochem. Mol. Biol. 127 (2000) 11-19
23. Tabor S., and Richardson C.C. A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 6339-6343
24. Fan J., and Wilson III D.M. Protein-protein interactions and posttranslational modifications in mammalian base excision repair. Free Radic. Biol. Med. 38 (2005) 1121-1138