Axons degenerate in the absence of mitochondria in C. elegans

Current Biology

Volumn 24, Issue 7, 2014, Pages 760-765

  Rawson, Randi L ^a   Yam, Lung ^b   Weimer, Robby M ^a,d   Bend, Eric G ^a   Hartwieg, Erika ^c   Horvitz, H Robert ^c   Clark, Scott G ^b,e   Jorgensen, Erik M ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d GENENTECH INC   (United States)

^e UNIVERSITY OF NEVADA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS;

CAENORHABDITIS ELEGANS PROTEIN; CALCIUM; NERVE PROTEIN; REACTIVE OXYGEN METABOLITE; RIC-7 PROTEIN, C ELEGANS;

ANIMAL; CAENORHABDITIS ELEGANS; CYTOLOGY; DEGENERATIVE DISEASE; GENETICS; METABOLISM; MITOCHONDRION; MUTATION; NERVE DEGENERATION; NERVE FIBER; NERVE FIBER TRANSECTION; PHYSIOLOGY; ULTRASTRUCTURE;

ANIMALS; AXONS; AXOTOMY; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CALCIUM; MITOCHONDRIA; MUTATION; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; REACTIVE OXYGEN SPECIES;

EID: 84898057928     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2014.02.025     Document Type: Article

References (28)

1. D.A. Patten, M. Germain, M.A. Kelly, and R.S. Slack Reactive oxygen species: stuck in the middle of neurodegeneration J. Alzheimers Dis. 20 Suppl 2 2010 S357 S367
2. D.T.W. Chang, G.L. Rintoul, S. Pandipati, and I.J. Reynolds Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons Neurobiol. Dis. 22 2006 388 400
3. E.A. Schon, and S. Przedborski Mitochondria: the next (neurode)generation Neuron 70 2011 1033 1053
4. S. Alvarez, M. Moldovan, and C. Krarup Acute energy restriction triggers Wallerian degeneration in mouse Exp. Neurol. 212 2008 166 178
5. R. Lucius, and J. Sievers Postnatal retinal ganglion cells in vitro: protection against reactive oxygen species (ROS)-induced axonal degeneration by cocultured astrocytes Brain Res. 743 1996 56 62
6. P.D. Koeberle, and A.K. Ball Nitric oxide synthase inhibition delays axonal degeneration and promotes the survival of axotomized retinal ganglion cells Exp. Neurol. 158 1999 366 381
7. M.K. Shigenaga, T.M. Hagen, and B.N. Ames Oxidative damage and mitochondrial decay in aging Proc. Natl. Acad. Sci. USA 91 1994 10771 10778
8. M.A. Avery, T.M. Rooney, J.D. Pandya, T.M. Wishart, T.H. Gillingwater, J.W. Geddes, P.G. Sullivan, and M.R. Freeman WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering Curr. Biol. 22 2012 596 600
9. S.A. Barrientos, N.W. Martinez, S. Yoo, J.S. Jara, S. Zamorano, C. Hetz, J.L. Twiss, J. Alvarez, and F.A. Court Axonal degeneration is mediated by the mitochondrial permeability transition pore J. Neurosci. 31 2011 966 978
10. L.C. Keller, L. Cheng, C.J. Locke, M. Müller, R.D. Fetter, and G.W. Davis Glial-derived prodegenerative signaling in the Drosophila neuromuscular system Neuron 72 2011 760 775
11. Y. Fang, L. Soares, X. Teng, M. Geary, and N.M. Bonini A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity Curr. Biol. 22 2012 590 595
12. K. Iijima-Ando, M. Sekiya, A. Maruko-Otake, Y. Ohtake, E. Suzuki, B. Lu, and K.M. Iijima Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1 PLoS Genet. 8 2012 e1002918
13. S)-mediated axon protection independent of axonal mitochondria Hum. Mol. Genet. 22 2013 1601 1614
14. Y. Hao, Z. Hu, D. Sieburth, and J.M. Kaplan RIC-7 promotes neuropeptide secretion PLoS Genet. 8 2012 e1002464
15. D.W. Liu, and J.H. Thomas Regulation of a periodic motor program in C. elegans J. Neurosci. 14 1994 1953 1962
16. S.L. McIntire, E. Jorgensen, J. Kaplan, and H.R. Horvitz The GABAergic nervous system of Caenorhabditis elegans Nature 364 1993 337 341
17. Z. Wu, A. Ghosh-Roy, M.F. Yanik, J.Z. Zhang, Y. Jin, and A.D. Chisholm Caenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching Proc. Natl. Acad. Sci. USA 104 2007 15132 15137
18. B. Pinan-Lucarre, C.V. Gabel, C.P. Reina, S.E. Hulme, S.S. Shevkoplyas, R.D. Slone, J. Xue, Y. Qiao, S. Weisberg, K. Roodhouse, and L. Sun et al. The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans PLoS Biol. 10 2012 e1001331
19. D.H. Hall, and E.M. Hedgecock Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans Cell 65 1991 837 847
20. D. Otsuga, B.R. Keegan, E. Brisch, J.W. Thatcher, G.J. Hermann, W. Bleazard, and J.M. Shaw The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeast J. Cell Biol. 143 1998 333 349
21. E. Smirnova, D.L. Shurland, S.N. Ryazantsev, and A.M. van der Bliek A human dynamin-related protein controls the distribution of mitochondria J. Cell Biol. 143 1998 351 358
22. W.Y. Tsang, L.C. Sayles, L.I. Grad, D.B. Pilgrim, and B.D. Lemire Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span J. Biol. Chem. 276 2001 32240 32246
23. N. Ishii, M. Fujii, P.S. Hartman, M. Tsuda, K. Yasuda, N. Senoo-Matsuda, S. Yanase, D. Ayusawa, and K. Suzuki A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes Nature 394 1998 694 697
24. A.L. Misko, Y. Sasaki, E. Tuck, J. Milbrandt, and R.H. Baloh Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration J. Neurosci. 32 2012 4145 4155
25. M.A. Calupca, G.M. Hendricks, J.C. Hardwick, and R.L. Parsons Role of mitochondrial dysfunction in the Ca2+-induced decline of transmitter release at K+-depolarized motor neuron terminals J. Neurophysiol. 81 1999 498 506
26. B.S. Winkler, M.J. Arnold, M.A. Brassell, and D.G. Puro Energy metabolism in human retinal Müller cells Invest. Ophthalmol. Vis. Sci. 41 2000 3183 3190
27. S.B. Tekkök, A.M. Brown, and B.R. Ransom Axon function persists during anoxia in mammalian white matter J. Cereb. Blood Flow Metab. 23 2003 1340 1347
28. U. Fünfschilling, L.M. Supplie, D. Mahad, S. Boretius, A.S. Saab, J. Edgar, B.G. Brinkmann, C.M. Kassmann, I.D. Tzvetanova, W. Möbius, and F. Diaz et al. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity Nature 485 2012 517 521