Wld S prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca 2+ buffering

Current Biology

Volumn 22, Issue 7, 2012, Pages 596-600

  Avery, Michelle A ^a   Rooney, Timothy M ^a   Pandya, Jignesh D ^c   Wishart, Thomas M ^b   Gillingwater, Thomas H ^b   Geddes, James W ^c   Sullivan, Patrick G ^c   Freeman, Marc R ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUS; WALLERIA;

CALCIUM; GREEN FLUORESCENT PROTEIN; NERVE PROTEIN; NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE; WLD PROTEIN, MOUSE;

ANIMAL; ARTICLE; BRAIN; DISEASE MODEL; DROSOPHILA MELANOGASTER; ENZYMOLOGY; GENETICS; METABOLISM; MITOCHONDRION; MOUSE; NERVE DEGENERATION; NERVE FIBER; NERVE FIBER TRANSECTION; PATHOLOGY; POLYMERASE CHAIN REACTION; TRANSGENIC ANIMAL; WESTERN BLOTTING;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AXONS; AXOTOMY; BLOTTING, WESTERN; BRAIN; CALCIUM; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; GREEN FLUORESCENT PROTEINS; MICE; MITOCHONDRIA; NERVE TISSUE PROTEINS; NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE; POLYMERASE CHAIN REACTION; WALLERIAN DEGENERATION;

EID: 84859592010     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2012.02.043     Document Type: Article

References (30)

1. L. Conforti, A. Tarlton, T.G. Mack, W. Mi, E.A. Buckmaster, D. Wagner, V.H. Perry, and M.P. Coleman A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse Proc. Natl. Acad. Sci. USA 97 2000 11377 11382
2. M.P. Coleman, and M.R. Freeman Wallerian degeneration, wld(s), and nmnat Annu. Rev. Neurosci. 33 2010 245 267
3. E.R. Lunn, V.H. Perry, M.C. Brown, H. Rosen, and S. Gordon Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve Eur. J. Neurosci. 1 1989 27 33 (Pubitemid 19142026)
4. V.H. Perry, M.C. Brown, E.R. Lunn, P. Tree, and S. Gordon Evidence that Very Slow Wallerian Degeneration in C57BL/Ola Mice is an Intrinsic Property of the Peripheral Nerve Eur. J. Neurosci. 2 1990 802 808 (Pubitemid 20314475)
5. J.D. Glass, T.M. Brushart, E.B. George, and J.W. Griffin Prolonged survival of transected nerve fibres in C57BL/Ola mice is an intrinsic characteristic of the axon J. Neurocytol. 22 1993 311 321 (Pubitemid 23162784)
6. T.H. Gillingwater, C.A. Ingham, K.E. Parry, A.K. Wright, J.E. Haley, T.M. Wishart, G.W. Arbuthnott, and R.R. Ribchester Delayed synaptic degeneration in the CNS of Wlds mice after cortical lesion Brain 129 2006 1546 1556 (Pubitemid 43999386)
7. T.G. Mack, M. Reiner, B. Beirowski, W. Mi, M. Emanuelli, D. Wagner, D. Thomson, T. Gillingwater, F. Court, and L. Conforti Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene Nat. Neurosci. 4 2001 1199 1206 (Pubitemid 33135625)
8. M.A. Avery, A.E. Sheehan, K.S. Kerr, J. Wang, and M.R. Freeman Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration J. Cell Biol. 184 2009 501 513
9. N. Yahata, S. Yuasa, and T. Araki Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration J. Neurosci. 29 2009 6276 6284
10. E.B. George, J.D. Glass, and J.W. Griffin Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels J. Neurosci. 15 1995 6445 6452
11. M. Yi, D. Weaver, and G. Hajnóczky Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit J. Cell Biol. 167 2004 661 672 (Pubitemid 39565147)
12. X. Wang, and T.L. Schwarz The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility Cell 136 2009 163 174
13. G.J. Russo, K. Louie, A. Wellington, G.T. Macleod, F. Hu, S. Panchumarthi, and K.E. Zinsmaier Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport J. Neurosci. 29 2009 5443 5455
14. V.Y. Ganitkevich The role of mitochondria in cytoplasmic Ca2+ cycling Exp. Physiol. 88 2003 91 97 (Pubitemid 36150062)
15. M.R. Brown, P.G. Sullivan, K.A. Dorenbos, E.A. Modafferi, J.W. Geddes, and O. Steward Nitrogen disruption of synaptoneurosomes: an alternative method to isolate brain mitochondria J. Neurosci. Methods 137 2004 299 303 (Pubitemid 38942894)
16. K.K. Naga, P.G. Sullivan, and J.W. Geddes High cyclophilin D content of synaptic mitochondria results in increased vulnerability to permeability transition J. Neurosci. 27 2007 7469 7475 (Pubitemid 47066566)
17. Y. Sasaki, and J. Milbrandt Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons J. Biol. Chem. 285 2010 41211 41215
18. J. Knöferle, J.C. Koch, T. Ostendorf, U. Michel, V. Planchamp, P. Vutova, L. Tönges, C. Stadelmann, W. Brück, M. Bähr, and P. Lingor Mechanisms of acute axonal degeneration in the optic nerve in vivo Proc. Natl. Acad. Sci. USA 107 2010 6064 6069
19. J. Santo-Domingo, and N. Demaurex Calcium uptake mechanisms of mitochondria Biochim. Biophys. Acta 1797 2010 907 912
20. C. Sievers, N. Platt, V.H. Perry, M.P. Coleman, and L. Conforti Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential Neurosci. Res. 46 2003 161 169 (Pubitemid 36593279)
21. A. Sunio, and G.D. Bittner Cyclosporin A retards the wallerian degeneration of peripheral mammalian axons Exp. Neurol. 146 1997 46 56 (Pubitemid 27319718)
22. S.A. Barrientos, N.W. Martinez, S. Yoo, J.S. Jara, S. Zamorano, C. Hetz, J.L. Twiss, J. Alvarez, and F.A. Court Axonal degeneration is mediated by the mitochondrial permeability transition pore J. Neurosci. 31 2011 966 978
23. J.D. Pandya, J.R. Pauly, and P.G. Sullivan The optimal dosage and window of opportunity to maintain mitochondrial homeostasis following traumatic brain injury using the uncoupler FCCP Exp. Neurol. 218 2009 381 389
24. J.D. Pandya, J.R. Pauly, V.N. Nukala, A.H. Sebastian, K.M. Day, A.S. Korde, W.F. Maragos, E.D. Hall, and P.G. Sullivan Post-Injury Administration of Mitochondrial Uncouplers Increases Tissue Sparing and Improves Behavioral Outcome following Traumatic Brain Injury in Rodents J. Neurotrauma 24 2007 798 811 (Pubitemid 46799272)
25. K. Ikegami, and T. Koike Non-apoptotic neurite degeneration in apoptotic neuronal death: pivotal role of mitochondrial function in neurites Neuroscience 122 2003 617 626 (Pubitemid 37410283)
26. E.A. Schon, and S. Przedborski Mitochondria: the next (neurode)generation Neuron 70 2011 1033 1053
27. K.J. De Vos, A.L. Chapman, M.E. Tennant, C. Manser, E.L. Tudor, K.F. Lau, J. Brownlees, S. Ackerley, P.J. Shaw, and D.M. McLoughlin Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content Hum. Mol. Genet. 16 2007 2720 2728 (Pubitemid 350018514)
28. P. Shi, A.L. Ström, J. Gal, and H. Zhu Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport Biochim. Biophys. Acta 1802 2010 707 716
29. X. Wang, B. Su, L. Zheng, G. Perry, M.A. Smith, and X. Zhu The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease J. Neurochem. 109 Suppl 1 2009 153 159
30. D.T. Chang, G.L. Rintoul, S. Pandipati, and I.J. Reynolds Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons Neurobiol. Dis. 22 2006 388 400