Glial-derived prodegenerative signaling in the drosophila neuromuscular system

Neuron

Volumn 72, Issue 5, 2011, Pages 760-775

  Keller, Lani C ^a   Cheng, Ling ^a   Locke, Cody J ^a   Müller, Martin ^a   Fetter, Richard D ^a,b   Davis, Graeme W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE; EFFECTOR CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NERVE PROTEIN; PROTEIN BCL 2; PROTEIN DCP 1; PROTEIN DRONC; PROTEIN WENGEN; SPECTRIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; GLIA CELL; INTRACELLULAR SIGNALING; MITOCHONDRIAL MEMBRANE; MOTOR NEURON DISEASE; MUTATIONAL ANALYSIS; NERVE CELL DEGENERATION; NEUROMUSCULAR DISEASE; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASES; DISEASE MODELS, ANIMAL; DROSOPHILA; DROSOPHILA PROTEINS; EXCITATORY POSTSYNAPTIC POTENTIALS; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GREEN FLUORESCENT PROTEINS; MITOCHONDRIA; MOTOR NEURON DISEASE; MUTATION; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROGLIA; NEUROMUSCULAR JUNCTION; PROTO-ONCOGENE PROTEINS; RECEPTORS, TUMOR NECROSIS FACTOR; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 83255194577     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2011.09.031     Document Type: Article

References (49)

1. Aggarwal B.B. Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB. Ann. Rheum. Dis. 2000, 59(Suppl 1):i6-i16.
2. Awasaki T., Tatsumi R., Takahashi K., Arai K., Nakanishi Y., Ueda R., Ito K. Essential role of the apoptotic cell engulfment genes draper and ced-6 in programmed axon pruning during Drosophila metamorphosis. Neuron 2006, 50:855-867.
3. Ayaz D., Leyssen M., Koch M., Yan J., Srahna M., Sheeba V., Fogle K.J., Holmes T.C., Hassan B.A. Axonal injury and regeneration in the adult brain of Drosophila. J. Neurosci. 2008, 28:6010-6021.
4. Babcock D.T., Landry C., Galko M.J. Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae. Curr. Biol. 2009, 19:799-806.
5. Banerjee S., Bhat M.A. Glial ensheathment of peripheral axons in Drosophila. J. Neurosci. Res. 2008, 86:1189-1198.
6. Barbeito L.H., Pehar M., Cassina P., Vargas M.R., Peluffo H., Viera L., Estévez A.G., Beckman J.S. A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. Brain Res. Brain Res. Rev. 2004, 47:263-274.
7. Bettencourt da Cruz A., Schwärzel M., Schulze S., Niyyati M., Heisenberg M., Kretzschmar D. Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila. Mol. Biol. Cell 2005, 16:2433-2442.
8. Chintapalli V.R., Wang J., Dow J.A. Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat. Genet. 2007, 39:715-720.
9. Doumanis J., Dorstyn L., Kumar S. Molecular determinants of the subcellular localization of the Drosophila Bcl-2 homologues DEBCL and BUFFY. Cell Death Differ. 2007, 14:907-915.
10. Eaton B.A., Davis G.W. LIM Kinase1 controls synaptic stability downstream of the type II BMP receptor. Neuron 2005, 47:695-708.
11. Eaton B.A., Fetter R.D., Davis G.W. Dynactin is necessary for synapse stabilization. Neuron 2002, 34:729-741.
12. Fuentes-Medel Y., Logan M.A., Ashley J., Ataman B., Budnik V., Freeman M.R. Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris. PLoS Biol. 2009, 7:e1000184.
13. Gowing G., Dequen F., Soucy G., Julien J.P. Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations. J. Neurosci. 2006, 26:11397-11402.
14. Guo X., Macleod G.T., Wellington A., Hu F., Panchumarthi S., Schoenfield M., Marin L., Charlton M.P., Atwood H.L., Zinsmaier K.E. The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses. Neuron 2005, 47:379-393.
15. Heckscher E.S., Fetter R.D., Marek K.W., Albin S.D., Davis G.W. NF-kappaB, IkappaB, and IRAK control glutamate receptor density at the Drosophila NMJ. Neuron 2007, 55:859-873.
16. Henkel J.S., Beers D.R., Zhao W., Appel S.H. Microglia in ALS: the good, the bad, and the resting. J. Neuroimmune Pharmacol. 2009, 4:389-398.
17. Igaki T., Kanda H., Yamamoto-Goto Y., Kanuka H., Kuranaga E., Aigaki T., Miura M. Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J. 2002, 21:3009-3018.
18. Igaki T., Pastor-Pareja J.C., Aonuma H., Miura M., Xu T. Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev. Cell 2009, 16:458-465.
19. Ikeda Y., Dick K.A., Weatherspoon M.R., Gincel D., Armbrust K.R., Dalton J.C., Stevanin G., Dürr A., Zühlke C., Bürk K., et al. Spectrin mutations cause spinocerebellar ataxia type 5. Nat. Genet. 2006, 38:184-190.
20. Kanda H., Igaki T., Kanuka H., Yagi T., Miura M. Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. J. Biol. Chem. 2002, 277:28372-28375.
21. Kauppila S., Maaty W.S., Chen P., Tomar R.S., Eby M.T., Chapo J., Chew S., Rathore N., Zachariah S., Sinha S.K., et al. Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila. Oncogene 2003, 22:4860-4867.
22. Klaiman G., Champagne N., LeBlanc A.C. Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells. Biochim. Biophys. Acta 2009, 1793:592-601.
23. LaMonte B.H., Wallace K.E., Holloway B.A., Shelly S.S., Ascaño J., Tokito M., Van Winkle T., Howland D.S., Holzbaur E.L. Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. Neuron 2002, 34:715-727.
24. Laundrie B., Peterson J.S., Baum J.S., Chang J.C., Fileppo D., Thompson S.R., McCall K. Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila. Genetics 2003, 165:1881-1888.
25. Lin D.M., Goodman C.S. Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance. Neuron 1994, 13:507-523.
26. Lorenzo D.N., Li M.G., Mische S.E., Armbrust K.R., Ranum L.P., Hays T.S. Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration in Drosophila. J. Cell Biol. 2010, 189:143-158.
27. Martin L.J., Liu Z., Chen K., Price A.C., Pan Y., Swaby J.A., Golden W.C. Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. J. Comp. Neurol. 2007, 500:20-46.
28. Massaro C.M., Pielage J., Davis G.W. Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton. J. Cell Biol. 2009, 187:101-117.
29. McDonald E.R., Chui P.C., Martelli P.F., Dicker D.T., El-Deiry W.S. Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling. J. Biol. Chem. 2001, 276:14939-14945.
30. Menzies F.M., Cookson M.R., Taylor R.W., Turnbull D.M., Chrzanowska-Lightowlers Z.M.A., Dong L., Figlewicz D.A., Shaw P.J. Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis. Brain 2002, 125:1522-1533.
31. Nikolaev A., McLaughlin T., O'Leary D.D., Tessier-Lavigne M. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 2009, 457:981-989.
32. Pielage J., Fetter R.D., Davis G.W. Presynaptic spectrin is essential for synapse stabilization. Curr. Biol. 2005, 15:918-928.
33. Pielage J., Cheng L., Fetter R.D., Carlton P.M., Sedat J.W., Davis G.W. A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion. Neuron 2008, 58:195-209.
34. Pielage J., Bulat V., Zuchero J.B., Fetter R.D., Davis G.W. Hts/Adducin controls synaptic elaboration and elimination. Neuron 2011, 69:1114-1131.
35. Pilling A.D., Horiuchi D., Lively C.M., Saxton W.M. Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Mol. Biol. Cell 2006, 17:2057-2068.
36. Puls I., Jonnakuty C., LaMonte B.H., Holzbaur E.L., Tokito M., Mann E., Floeter M.K., Bidus K., Drayna D., Oh S.J., et al. Mutant dynactin in motor neuron disease. Nat. Genet. 2003, 33:455-456.
37. Qin Y., Cheng C., Wang H., Shao X., Gao Y., Shen A. TNF-alpha as an autocrine mediator and its role in the activation of Schwann cells. Neurochem. Res. 2008, 33:1077-1084.
38. Reyes N.A., Fisher J.K., Austgen K., VandenBerg S., Huang E.J., Oakes S.A. Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis. J. Clin. Invest. 2010, 120:3673-3679.
39. Richardson H., Kumar S. Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods 2002, 265:21-38.
40. Russo G.J., Louie K., Wellington A., Macleod G.T., Hu F., Panchumarthi S., Zinsmaier K.E. Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport. J. Neurosci. 2009, 29:5443-5455.
41. Schoenmann Z., Assa-Kunik E., Tiomny S., Minis A., Haklai-Topper L., Arama E., Yaron A. Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals. J. Neurosci. 2010, 30:6375-6386.
42. Sevrioukov E.A., Burr J., Huang E.W., Assi H.H., Monserrate J.P., Purves D.C., Wu J.N., Song E.J., Brachmann C.B. Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development. Genesis 2007, 45:184-193.
43. Shah S.B., Nolan R., Davis E., Stokin G.B., Niesman I., Canto I., Glabe C., Goldstein L.S. Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiol. Dis. 2009, 36:11-25.
44. Stork T., Engelen D., Krudewig A., Silies M., Bainton R.J., Klämbt C. Organization and function of the blood-brain barrier in Drosophila. J. Neurosci. 2008, 28:587-597.
45. Wang C., Youle R.J. The role of mitochondria in apoptosis. Annu. Rev. Genet. 2009, 43:95-118.
46. Wang X.J., Cao Q., Liu X., Wang K.T., Mi W., Zhang Y., Li L.F., LeBlanc A.C., Su X.D. Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage and self-activation. EMBO Rep. 2010, 11:841-847.
47. Weber U., Paricio N., Mlodzik M. Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development 2000, 127:3619-3629.
48. Xue L., Igaki T., Kuranaga E., Kanda H., Miura M., Xu T. Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Dev. Cell 2007, 13:446-454.
49. Yang C.S., Thomenius M.J., Gan E.C., Tang W., Freel C.D., Merritt T.J., Nutt L.K., Kornbluth S. Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. EMBO J. 2010, 29:3196-3207.