Alpha-tocotrienol is the most abundant tocotrienol isomer circulated in plasma and lipoproteins after postprandial tocotrienol-rich vitamin E supplementation

Nutrition Journal

Volumn 11, Issue 1, 2012, Pages

  Fairus, Syed ^a   Nor, Rosnah M ^a   Cheng, Hwee M ^b   Sundram, Kalyana ^c  

^a MALAYSIAN PALM OIL BOARD   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

^c Malaysian Palm Oil Council (MPOC)   (Malaysia)

Author keywords

Postprandial plasma lipoproteins; Tocopherols; Tocotrienols; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; DRUG DERIVATIVE; PALM OIL; TOCOPHEROL; TOCOTRIENOL, ALPHA; VEGETABLE OIL;

ADULT; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; DRUG ABSORPTION; DRUG CAPSULE; DRUG METABOLISM; FEMALE; HUMAN; HUMAN EXPERIMENT; ISOMER; MALE; NORMAL HUMAN; PLASMA; POSTPRANDIAL STATE; SINGLE DRUG DOSE; VITAMIN SUPPLEMENTATION; BLOOD; DIET SUPPLEMENTATION;

ADULT; DIETARY SUPPLEMENTS; FEMALE; HUMANS; LIPOPROTEINS; LIPOPROTEINS, HDL; MALE; PLANT OILS; POSTPRANDIAL PERIOD; TOCOPHEROLS; TOCOTRIENOLS; VITAMIN E;

EID: 84855766685     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-11-5     Document Type: Article

References (46)

1. Free radical recycling and intramembrane mobility in the antioxidant properties of -tocopherol and -tocotrienol. Serbinova EA, Kagan V, Han D, Packer L, Free Radic Biol Med 1991 10 263 275 10.1016/0891-5849(91)90033-Y 1649783 (Pubitemid 121003898)
2. Comparative antioxidant activity of tocotrienols and other natural lipid soluble antioxidants in homogenous system, and in rat and human lipoproteins. Suarna C, Hood RL, Dean RT, Stocker R, Biochim Biophys Acta 1993 1166 163 170 8443232 (Pubitemid 23060889)
3. Tocotrienol: a review of its therapeutic potential. Theriault A, Jun-Tzu C, Wang Q, Gapor A, Adeli K, Clin Biochem 1999 32 309 319 10.1016/S0009-9120(99) 00027-2 10480444 (Pubitemid 29416720)
4. Molecular aspects of -tocotrienol antioxidant action and cell signaling. Packer L, Weber SU, Rimbach G, J Nutr 2001 131 Suppl 369 373
5. Role of tocotrienols in the preventive of cardiovascular disease and breast cancer. Sylvester PW, Theriault A, Curr Top Nutraceutical Res 2003 1 121 136
6. Effects on the human serum lipoprotein profile of -glucan, soy protein and isoflavones, plant sterols and stanols, garlic and tocotrienols. Kerckhofts DAJM, Brouns F, Honstra G, Mensink RP, J Nutr 2002 132 2494 2505 12221200 (Pubitemid 35013225)
7. Tocotrienols: constitutional effects in aging and disease. Schaffer S, Müller WE, Eckert GP, J Nutr 2005 135 151 154 15671205 (Pubitemid 40194470)
8. Tocotrienols: vitamin E beyond tocopherols. Sen CK, Khanna S, Roy S, Life Sciences 2006 78 2088 2098 10.1016/j.lfs.2005.12.001 16458936
9. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Mensink RP, van Houwelingen AC, Kromhout D, Honstra G, Am J Clin Nutr 1999 69 213 219 9989682 (Pubitemid 29065541)
10. Studies of LDL oxidation following -, -, or -tocotrienyl acetate supplementation of hypercholesterolemic humans. O'Byrne D, Grundy S, Packer L, Devaraj S, Baldenius K, Hoppe PP, Kramer K, Jialal I, Traber MG, Free Radic Biol Med 2000 29 834 845 10.1016/S0891-5849(00)00371-3 11063909
11. Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. Mustad VA, Smith CA, Ruey PP, Edens NK, DeMichele SJ, Am J Clin Nutr 2002 76 1237 1243 12450888 (Pubitemid 35416557)
12. Daily supplementation of tocotrienol-rich fraction or -tocopherol did not induce immunomodulatory changes in healthy human volunteers. Radhakrishnan AK, Lee AL, Wong PK, Kaur J, Aung H, Nesaretnam K, Br J Nutr 2009 101 810 815 10.1017/S0007114508039998 18702848
13. Difference in the plasma transport and tissue concentration of tocopherols and tocotrienols: observations in humans and hamsters. Hayes KC, Pronczuk A, Liang JS, Proc Soc Exp Biol Med 1993 202 353 359 8437992 (Pubitemid 23073473)
14. Differential serum responses of tocopherols and tocotrienols during vitamin supplementation in hypercholesterolaemic individuals without change in coronary risk factors. Wahlqvist ML, Krivokuca-Bogetic Z, Sam Lo C, Nutr Res 1992 12 Suppl 181 201
15. Novel tocotrienols of rice bran modulate cardiovascular disease risk parameters of hypercholesterolemic humans. Qureshi AA, Bradlow BA, Salser WA, Brace LD, J Nutr Biochem 1997 8 290 298 10.1016/S0955-2863(97)89667-2 (Pubitemid 27305619)
16. Pharmacokinetics and bioavailability of -, - and -tocotrienols under different food status. Yap SP, Yuen KH, Wong JW, J Pharm Pharmacol 2001 53 67 71 11206194 (Pubitemid 32123701)
17. Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations. Yap SP, Yuen KH, Int J Pharm 2004 281 67 78 10.1016/j.ijpharm.2004.05.015 15288344 (Pubitemid 39024264)
18. Dose dependent elevation of plasma tocotrienol level and its effect on arterial compliance, plasma total antioxidant status, and lipid profile in healthy humans supplemented with tocotrienol rich vitamin E. Rasool AHG, Yuen KH, Yusoff K, Wong AR, Rahman ARA, J Nutr Sci Vitaminol 2006 52 473 478 10.3177/jnsv.52.473 17330512 (Pubitemid 46292983)
19. Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of -tocopherol. Fairus S, Nor RM, Cheng HM, Sundram K, Am J Clin Nutr 2006 84 835 842 17023711 (Pubitemid 44715666)
20. Postprandial levels of the natural vitamin E tocotrienol in human circulation. Khosla P, Patel V, Whinter JM, Khanna S, Rakhkovskaya M, Roy S, Sen CK, Antioxid Redox Signal 2006 8 1059 1068 10.1089/ars.2006.8.1059 16771695 (Pubitemid 44036522)
21. Arterial compliance and vitamin E blood levels with a self emulsifying preparation of tocotrienol rich vitamin E. Rasool AHG, Rahman ARA, Yuen KH, Wong AR, Arch Pharm Res 2008 31;1212 1217 10.1007/s12272-001-1291-5 19099237
22. Food and Nutrition Board, Institute of Medicine, Dietary reference intakes for vitamin C, vitamin E, selenium and carotenoids Washington DC: National Academy Press 2000
23. Dietary palmitic acid results in lower serum cholesterol than does a lauric-myristic acid combination in normolipemic humans. Sundram K, Hayes KC, Siru OH, Am J Clin Nutr 1994 59 841 846 8147328 (Pubitemid 24112521)
24. From analysis of tocotrienols in different sample matrixes by HPLC. Sundram K, Nor RM, Methods in Molecular Biology, Oxidative Stress Biomarkers and Antioxidant Protocols Totowa, New Jersey: Humana Press Inc, Armstrong D, 2002 186 221 232
25. Vitamin E regulatory mechanisms. Traber MG, Annu Rev Nutr 2007 27 347 362 10.1146/annurev.nutr.27.061406.093819 17439363 (Pubitemid 351373361)
26. Preferential incorporation of alpha-tocopherol vs gamma-tocopherol in human lipoproteins. Traber MG, Kayden HJ, Am J Clin Nutr 1989 49 517 526 2923084 (Pubitemid 19107266)
27. Vitamin E to prevent cardiovascular disease: pill or dietary package? Schwenke DC, Curr Opin Lipidol 2007 18 467 469 10.1097/MOL.0b013e32825fea3a 17620864 (Pubitemid 47051925)
28. Lymphatic transport of -, - and -tocotrienols and -tocopherol in rats. Ikeda I, Sasaki E, Sugano M, Int J Vit Nutr Res 1996 66 217 221 (Pubitemid 26369558)
29. Influence of route of administration on the absorption and disposition of -, - and -tocotrienols in rats. Yap SP, Yuen KH, Lim AB, J Pharm Pharmacol 2003 55 53 58 12625867 (Pubitemid 36142081)
30. Affinity for -tocopherol transfer protein as a determinant of the biological activities of vitamin E analogues. Hosomi A, Arita M, Sato Y, Kiyose C, Ueda T, Igarashi O, Arai H, Inoue K, FEBS Letters 1997 409 105 108 10.1016/S0014-5793(97)00499-7 9199513 (Pubitemid 27248576)
31. Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption. Anwar K, Iqbal J, Hussain MM, J Lipid Res 2007 48 2028 2038 10.1194/jlr.M700207-JLR200 17582142 (Pubitemid 47360622)
32. - and -tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine. Lodge JK, Ridllington J, Leonard S, Vaule H, Traber MG, Lipids 2001 36 43 48 10.1007/s11745-001-0666-z 11214728 (Pubitemid 32163621)
33. Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism. Traber MG, Burton GW, Hughes L, Ingold KU, Hidaka H, Malloy M, Kane J, Hyams J, Kayden HJ, J Lipid Res 1992 33 1171 1182 1431596
34. Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. Kayden HJ, Traber MG, J Lipid Res 1993 34 343 358 8468520 (Pubitemid 23095362)
35. Biodiscrimination of -tocopherol stereoisomers in humans after oral administration. Kiyose C, Muramatsu R, Kameyama Y, Ueda T, Igarashi O, Am J Clin Nutr 1997 65 785 789 9062530 (Pubitemid 27111086)
36. The absorption of vitamin E is influenced by the amount of fat in a meal and the food matrix. Jeanes YM, Hall WL, Ellard S, Lee E, Lodge JK, Br J Nutr 2004 92 575 579 10.1079/BJN20041249 15522126 (Pubitemid 39406639)
37. Intestinal absorption of -tocotrienol is mediated by Niemann-Pick C1-Like 1: in situ rat intestinal perfusion studies. Abuasal A, Sylvester PW, Kaddoumi A, Drug Metab Dipos 2010 38 939 945 10.1124/dmd.109.031567
38. Cytochrome P450-dependent metabolism of vitamin E isoforms is a critical determinant of their tissue concentration in rats. Abe C, Uchida T, Ohta M, Ichikawa T, Yamashita K, Ikeda S, Lipids 2007 42 637 645 10.1007/s11745-007- 3064-2 17520307 (Pubitemid 47196032)
39. Vitamin E dose-response studies in humans with use of deuterated RRR - tocopherol. Traber MG, Rader D, Acuff RV, Ramakrishnan R, Brewer HB, Kayden HJ, Am J Clin Nutr 1998 68 847 853 9771861 (Pubitemid 28471067)
40. Postprandial changes in the plasma concentration of - and -tocopherol in human subjects fed a fat-rich meal supplemented with fat-soluble vitamins. Meydani M, Cohn JS, Macauley JB, McNamara JR, Blumberg JB, Schaefer EJ, J Nutr 1989 119 1252 1258 2795239 (Pubitemid 19268003)
41. Postprandial chylomicron and plasma vitamin E responses in healthy older subjects compared with younger ones. Borel P, Mekki N, Boirie Y, Partier A, Grolier P, Alexandre-Gouabau MC, Beaufrere B, Armand M, Lairon D, Azais-Braesco V, Eur J Clin Invest 1997 27 812 821 10.1046/j.1365-2362.1997.1960744.x 9373758 (Pubitemid 27460617)
42. The therapeutic impacts of tocotrienols in type 2 diabetic patients with hyperlipidemia. Baliarsingh S, Beg ZH, Ahmad J, Atherosclerosis 2005 182 367 374 10.1016/j.atherosclerosis.2005.02.020 16159610 (Pubitemid 41267206)
43. 25) of rice bran in hypercholesterolemic humans. Qureshi AA, Sami SA, Salser WA, Atherosclerosis 2002 161 199 207 10.1016/S0021-9150(01) 00619-0 11882333 (Pubitemid 34214837)
44. Response of hypercholesterolemic subjects to administration of tocotrienols. Qureshi AA, Bradlow BA, Brace L, Manganello J, Peterson DM, Pearce BC, Wright JJK, Gapor A, Elson CE, Lipids 1995 30 1171 1177 10.1007/BF02536620 8614309
45. Dose-response impact of various tocotrienols on serum lipid parameters in 5-week-old female chickens. Yu SG, Thomas AM, Gapor A, Tan B, Qureshi N, Qureshi AA, Lipids 2006 41 453 461 10.1007/s11745-006-5119-1 16933790 (Pubitemid 44204869)
46. Palm oil derived natural vitamin E -tocotrienol in brain disease and health. Sen CK, Rink C, Khanna S, J Am Coll Nutr 2010 29 314S 323S 20823491