Persistence of skin-resident memory T cells within an epidermal niche

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 14, 2014, Pages 5307-5312

  Zaid, Ali ^a   Mackay, Laura K ^a   Rahimpour, Azad ^a   Braun, Asolina ^a   Veldhoen, Marc ^b   Carbone, Francis R ^a   Manton, Jonathan H ^a   Heath, William R ^a   Mueller, Scott N ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Brownian motion; Intravital imaging HSV 1 infection; Langerhans cells

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CD8 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; EPIDERMIS; HUMAN; IMMUNOCOMPETENT CELL; INFECTION; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SIMULATION; SKIN CELL; TISSUE RESIDENT MEMORY T LYMPHOCYTE;

BROWNIAN MOTION; INTRAVITAL IMAGING HSV-1 INFECTION; LANGERHANS CELLS;

ADOPTIVE TRANSFER; ANIMALS; CELL MOVEMENT; FLOW CYTOMETRY; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED C57BL; MICROSCOPY; SKIN; T-LYMPHOCYTES;

EID: 84898037662     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1322292111     Document Type: Article

References (29)

1. Heath WR, Carbone FR (2013) The skin-resident and migratory immune system in steady state and memory: Innate lymphocytes, dendritic cells and T cells. Nat Immunol 14(10):978-985.
2. Mackay LK, et al. (2012) Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation. Proc Natl Acad Sci USA 109(18):7037-7042.
3. Gebhardt T, et al. (2011) Different patterns of peripheral migration by memory CD4+ and CD8+ T cells. Nature 477(7363):216-219.
4. Gebhardt T, et al. (2009) Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat Immunol 10(5):524-530.
5. Mueller SN, Gebhardt T, Carbone FR, Heath WR (2013) Memory T cell subsets, migration patterns, and tissue residence. Annu Rev Immunol 31:137-161.
6. Jiang X, et al. (2012) Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature 483(7388):227-231.
7. Bromley SK, Yan S, Tomura M, Kanagawa O, Luster AD (2013) Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern. J Immunol 190(3):970-976.
8. van Lint A, et al. (2004) Herpes simplex virus-specific CD8+ T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation. J Immunol 172(1):392-397.
9. Mueller SN, Heath W, McLain JD, Carbone FR, Jones CM (2002) Characterization of two TCR transgenic mouse lines specific for herpes simplex virus. Immunol Cell Biol 80(2):156-163.
10. Ariotti S, et al. (2012) Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proc Natl Acad Sci USA 109(48):19739-19744.
11. Chodaczek G, Papanna V, Zal MA, Zal T (2012) Body-barrier surveillance by epidermal γδ TCRs. Nat Immunol 13(3):272-282.
12. Igyártó BZ, Kaplan DH (2013) Antigen presentation by Langerhans cells. Curr Opin Immunol 25(1):115-119.
13. Strid J, Sobolev O, Zafirova B, Polic B, Hayday A (2011) The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy. Science 334(6060):1293-1297.
14. Jameson J, et al. (2002) A role for skin gammadelta T cells in wound repair. Science 296(5568):747-749.
15. Komori HK, et al. (2012) Cutting edge: Dendritic epidermal γδ T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding. J Immunol 188(7):2972-2976.
16. Toulon A, et al. (2009) A role for human skin-resident T cells in wound healing. J Exp Med 206(4):743-750.
17. Unutmaz D, et al. (2000) The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse. J Immunol 165(6):3284-3292.
18. Mackay LK, et al. (2013) The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. Nat Immunol 14(12):1294-1301.
19. De Creus A, et al. (2002) Developmental and functional defects of thymic and epidermal V gamma 3 cells in IL-15-deficient and IFN regulatory factor-1-deficient mice. J Immunol 168(12):6486-6493.
20. Borkowski TA, Letterio JJ, Farr AG, Udey MC (1996) A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: The skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells. J Exp Med 184(6):2417-2422.
21. Schluns KS, Williams K, Ma A, Zheng XX, Lefrançois L (2002) Cutting edge: Requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol 168(10):4827-4831.
22. Li Y, et al. (2011) Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 147(3):629-640.
23. Kadow S, et al. (2011) Aryl hydrocarbon receptor is critical for homeostasis of invariant gammadelta T cells in the murine epidermis. J Immunol 187(6):3104-3110.
24. + T cells. Nat Immunol 14(5):509-513.
25. Puttur FK, et al. (2010) Herpes simplex virus infects skin gamma delta T cells before Langerhans cells and impedes migration of infected Langerhans cells by inducing apoptosis and blocking E-cadherin downregulation. J Immunol 185(1):477-487.
26. Gudjonsson JE, Johnston A, Dyson M, Valdimarsson H, Elder JT (2007) Mouse models of psoriasis. J Invest Dermatol 127(6):1292-1308.
27. Turner DL, et al. (2013) Lung niches for the generation and maintenance of tissueresident memory T cells. Mucosal Immunol, 10.1038/mi.2013.67.
28. Anderson KG, et al. (2012) Cutting edge: Intravascular staining redefines lung CD8 T cell responses. J Immunol 189(6):2702-2706.
29. Kissenpfennig A, et al. (2005) Dynamics and function of Langerhans cells in vivo: Dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22(5):643-654.