Orexin-1 and orexin-2 receptor antagonists reduce ethanol self-administration in high-drinking rodent models

Frontiers in Neuroscience

Volumn , Issue 8 FEB, 2014, Pages

  Anderson, Rachel I ^a,b   Becker, Howard C ^a,b,c   Adams, Benjamin L ^d   Jesudason, Cynthia D ^d   Rorick Kehn, Linda M ^d  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

C57BL 6J mouse; Ethanol consumption; Hypocretins orexins; Operant progressive ratio; P rat

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ALCOHOL; ALMOREXANT; DSB LSN 2424100; N [(1H IMIDAZOL 2 YL)METHYL] N [(1,1' BIPHENYL) 2 YL] 4 FLUOROBENZENESULFONAMIDE; NALTREXONE; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; SUCROSE; UNCLASSIFIED DRUG;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; BINGE DRINKING; CONTROLLED STUDY; DRINKING BEHAVIOR; ENANTIOMER; FEMALE; FLUID INTAKE; MOTIVATION; MOUSE; NONHUMAN;

EID: 84898034367     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2014.00033     Document Type: Article

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