Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement

Psychopharmacology

Volumn 215, Issue 1, 2011, Pages 191-203

  Shoblock, James R ^a   Welty, Natalie ^a   Aluisio, Leah ^a   Fraser, Ian ^a   Motley, S Timothy ^a   Morton, Kirsten ^a   Palmer, James ^a   Bonaventure, Pascal ^a   Carruthers, Nicholas I ^a   Lovenberg, Timothy W ^a   Boggs, Jamin ^a   Galici, Ruggero ^a,b  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Alcoholism; Hypocretin; Microdialysis; Orexin receptor type 2; Reward; Self administration

Indexed keywords

1 (2,4 DIBROMOPHENYL) 3 (2,2 DIMETHYL 4 PHENYL 1,3 DIOXAN 5 YL)UREA; 1 (6,8 DIFLUORO 2 METHYL 4 QUINOLINYL) 3 (4 DIMETHYLAMINOPHENYL)UREA; 1 (6,8 DIFLUORO 2 METHYLQUINOLIN 4 YL) 3 [4 (DIMETHYLAMINO)PHENYL]UREA; ALCOHOL; DOPAMINE; DRUGS USED IN THE TREATMENT OF ADDICTION; JNJ 10397049; NALOXONE; OREXIN 2 RECEPTOR; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DRUG SCREENING; DRUG SELF ADMINISTRATION; HYPERACTIVITY; MALE; MOUSE; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; PRIORITY JOURNAL; REINFORCEMENT; TREATMENT RESPONSE;

ALCOHOLISM; ANIMALS; BEHAVIOR, ADDICTIVE; BEHAVIOR, ANIMAL; CONDITIONING, OPERANT; DIOXANES; DISEASE MODELS, ANIMAL; ETHANOL; MALE; MICE; MICE, INBRED DBA; MOTOR ACTIVITY; PHENYLUREA COMPOUNDS; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; REINFORCEMENT (PSYCHOLOGY); REINFORCEMENT SCHEDULE; SELF ADMINISTRATION;

EID: 79955034382     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-2127-x     Document Type: Article

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