메뉴 건너뛰기




Volumn 7, Issue 9, 2012, Pages

The Dual Orexin/Hypocretin Receptor Antagonist, Almorexant, in the Ventral Tegmental Area Attenuates Ethanol Self-Administration

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALMOREXANT; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A; SUCROSE;

EID: 84866678830     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044726     Document Type: Article
Times cited : (59)

References (60)
  • 1
  • 2
    • 20244380014 scopus 로고    scopus 로고
    • Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, et al. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 573-585.
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1    Amemiya, A.2    Ishii, M.3    Matsuzaki, I.4    Chemelli, R.M.5
  • 3
    • 0033588184 scopus 로고    scopus 로고
    • Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    • Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, et al. (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98: 437-451.
    • (1999) Cell , vol.98 , pp. 437-451
    • Chemelli, R.M.1    Willie, J.T.2    Sinton, C.M.3    Elmquist, J.K.4    Scammell, T.5
  • 4
    • 0033529520 scopus 로고    scopus 로고
    • The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    • Lin L, Faraco J, Li R, Kadotani H, Rogers W, et al. (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98: 365-376.
    • (1999) Cell , vol.98 , pp. 365-376
    • Lin, L.1    Faraco, J.2    Li, R.3    Kadotani, H.4    Rogers, W.5
  • 5
    • 0032402181 scopus 로고    scopus 로고
    • Neurons containing hypocretin (orexin) project to multiple neuronal systems
    • Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, et al. (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18: 9996-10015.
    • (1998) J Neurosci , vol.18 , pp. 9996-10015
    • Peyron, C.1    Tighe, D.K.2    van den Pol, A.N.3    de Lecea, L.4    Heller, H.C.5
  • 6
    • 0037052657 scopus 로고    scopus 로고
    • Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area
    • Fadel J, Deutch AY, (2002) Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience 111: 379-387.
    • (2002) Neuroscience , vol.111 , pp. 379-387
    • Fadel, J.1    Deutch, A.Y.2
  • 7
    • 0034704445 scopus 로고    scopus 로고
    • A selective orexin-1 receptor antagonist reduces food consumption in male and female rats
    • Haynes AC, Jackson B, Chapman H, Tadayyon M, Johns A, et al. (2000) A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul Pept 96: 45-51.
    • (2000) Regul Pept , vol.96 , pp. 45-51
    • Haynes, A.C.1    Jackson, B.2    Chapman, H.3    Tadayyon, M.4    Johns, A.5
  • 10
    • 0037659189 scopus 로고    scopus 로고
    • Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal
    • Georgescu D, Zachariou V, Barrot M, Mieda M, Willie JT, et al. (2003) Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J Neurosci 23: 3106-3111.
    • (2003) J Neurosci , vol.23 , pp. 3106-3111
    • Georgescu, D.1    Zachariou, V.2    Barrot, M.3    Mieda, M.4    Willie, J.T.5
  • 11
    • 32344453801 scopus 로고    scopus 로고
    • Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine
    • Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, et al. (2006) Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci 26: 398-405.
    • (2006) J Neurosci , vol.26 , pp. 398-405
    • Narita, M.1    Nagumo, Y.2    Hashimoto, S.3    Narita, M.4    Khotib, J.5
  • 12
    • 32344446144 scopus 로고    scopus 로고
    • Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine
    • Borgland SL, Taha SA, Sarti F, Fields HL, Bonci A, (2006) Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron 49: 589-601.
    • (2006) Neuron , vol.49 , pp. 589-601
    • Borgland, S.L.1    Taha, S.A.2    Sarti, F.3    Fields, H.L.4    Bonci, A.5
  • 13
    • 37349004777 scopus 로고    scopus 로고
    • Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse
    • Dayas CV, McGranahan TM, Martin-Fardon R, Weiss F, (2008) Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse. Biol Psychiatry 63: 152-157.
    • (2008) Biol Psychiatry , vol.63 , pp. 152-157
    • Dayas, C.V.1    McGranahan, T.M.2    Martin-Fardon, R.3    Weiss, F.4
  • 14
    • 46149118191 scopus 로고    scopus 로고
    • Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats
    • Richards JK, Simms JA, Steensland P, Taha SA, Borgland SL, et al. (2008) Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats. Psychopharmacology (Berl) 199: 109-117.
    • (2008) Psychopharmacology (Berl) , vol.199 , pp. 109-117
    • Richards, J.K.1    Simms, J.A.2    Steensland, P.3    Taha, S.A.4    Borgland, S.L.5
  • 16
    • 79955591870 scopus 로고    scopus 로고
    • The orexin receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats
    • Jupp B, Krivdic B, Krstew E, Lawrence AJ, (2011) The orexin receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats. Brain Res 1391: 54-59.
    • (2011) Brain Res , vol.1391 , pp. 54-59
    • Jupp, B.1    Krivdic, B.2    Krstew, E.3    Lawrence, A.J.4
  • 17
    • 68149156295 scopus 로고    scopus 로고
    • Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol-preferring Sprague-Dawley rats
    • Moorman DE, Aston-Jones G, (2009) Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol-preferring Sprague-Dawley rats. Alcohol 43: 379-386.
    • (2009) Alcohol , vol.43 , pp. 379-386
    • Moorman, D.E.1    Aston-Jones, G.2
  • 18
    • 79955034382 scopus 로고    scopus 로고
    • Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement
    • Shoblock JR, Welty N, Aluisio L, Fraser I, Motley ST, et al. (2011) Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement. Psychopharmacology (Berl) 215: 191-203.
    • (2011) Psychopharmacology (Berl) , vol.215 , pp. 191-203
    • Shoblock, J.R.1    Welty, N.2    Aluisio, L.3    Fraser, I.4    Motley, S.T.5
  • 19
    • 33746325472 scopus 로고    scopus 로고
    • Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms
    • Heilig M, Egli M, (2006) Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol Ther 111: 855-876.
    • (2006) Pharmacol Ther , vol.111 , pp. 855-876
    • Heilig, M.1    Egli, M.2
  • 20
    • 33646178951 scopus 로고    scopus 로고
    • Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial
    • Anton RF, O'Malley SS, Ciraulo DA, Cisler RA, Couper D, et al. (2006) Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. Jama 295: 2003-2017.
    • (2006) Jama , vol.295 , pp. 2003-2017
    • Anton, R.F.1    O'Malley, S.S.2    Ciraulo, D.A.3    Cisler, R.A.4    Couper, D.5
  • 22
    • 0041383898 scopus 로고    scopus 로고
    • A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    • Oslin DW, Berrettini W, Kranzler HR, Pettinati H, Gelernter J, et al. (2003) A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. Neuropsychopharmacology 28: 1546-1552.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1546-1552
    • Oslin, D.W.1    Berrettini, W.2    Kranzler, H.R.3    Pettinati, H.4    Gelernter, J.5
  • 24
    • 38949103745 scopus 로고    scopus 로고
    • An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study
    • Anton RF, Oroszi G, O'Malley S, Couper D, Swift R, et al. (2008) An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry 65: 135-144.
    • (2008) Arch Gen Psychiatry , vol.65 , pp. 135-144
    • Anton, R.F.1    Oroszi, G.2    O'Malley, S.3    Couper, D.4    Swift, R.5
  • 25
    • 74549127520 scopus 로고    scopus 로고
    • Almorexant, a dual orexin receptor antagonist for the treatment of insomnia
    • Neubauer DN, (2010) Almorexant, a dual orexin receptor antagonist for the treatment of insomnia. Curr Opin Investig Drugs 11: 101-110.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 101-110
    • Neubauer, D.N.1
  • 26
    • 77952419292 scopus 로고    scopus 로고
    • Long-Evans rats acquire operant self-administration of 20% ethanol without sucrose fading
    • Simms JA, Bito-Onon JJ, Chatterjee S, Bartlett SE, (2010) Long-Evans rats acquire operant self-administration of 20% ethanol without sucrose fading. Neuropsychopharmacology 35: 1453-1463.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1453-1463
    • Simms, J.A.1    Bito-Onon, J.J.2    Chatterjee, S.3    Bartlett, S.E.4
  • 28
    • 84857061634 scopus 로고    scopus 로고
    • Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking
    • Simms JA, Haass-Koffler CL, Bito-Onon J, Li R, Bartlett SE, (2012) Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking. Neuropsychopharmacology 37: 906-918.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 906-918
    • Simms, J.A.1    Haass-Koffler, C.L.2    Bito-Onon, J.3    Li, R.4    Bartlett, S.E.5
  • 29
    • 54049129747 scopus 로고    scopus 로고
    • Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition
    • Margolis EB, Mitchell JM, Ishikawa J, Hjelmstad GO, Fields HL, (2008) Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition. J Neurosci 28: 8908-8913.
    • (2008) J Neurosci , vol.28 , pp. 8908-8913
    • Margolis, E.B.1    Mitchell, J.M.2    Ishikawa, J.3    Hjelmstad, G.O.4    Fields, H.L.5
  • 30
    • 42149150944 scopus 로고    scopus 로고
    • Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih
    • Wanat MJ, Hopf FW, Stuber GD, Phillips PE, Bonci A, (2008) Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih. J Physiol 586: 2157-2170.
    • (2008) J Physiol , vol.586 , pp. 2157-2170
    • Wanat, M.J.1    Hopf, F.W.2    Stuber, G.D.3    Phillips, P.E.4    Bonci, A.5
  • 31
    • 77958520936 scopus 로고    scopus 로고
    • Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area
    • Madhavan A, Bonci A, Whistler JL, (2010) Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area. J Neurosci 30: 14029-14035.
    • (2010) J Neurosci , vol.30 , pp. 14029-14035
    • Madhavan, A.1    Bonci, A.2    Whistler, J.L.3
  • 32
    • 0033562876 scopus 로고    scopus 로고
    • Properties and plasticity of excitatory synapses on dopaminergic and GABAergic cells in the ventral tegmental area
    • Bonci A, Malenka RC, (1999) Properties and plasticity of excitatory synapses on dopaminergic and GABAergic cells in the ventral tegmental area. J Neurosci 19: 3723-3730.
    • (1999) J Neurosci , vol.19 , pp. 3723-3730
    • Bonci, A.1    Malenka, R.C.2
  • 33
    • 69549083464 scopus 로고    scopus 로고
    • Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists
    • Malherbe P, Borroni E, Pinard E, Wettstein JG, Knoflach F, (2009) Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists. Mol Pharmacol 76: 618-631.
    • (2009) Mol Pharmacol , vol.76 , pp. 618-631
    • Malherbe, P.1    Borroni, E.2    Pinard, E.3    Wettstein, J.G.4    Knoflach, F.5
  • 34
    • 79951508286 scopus 로고    scopus 로고
    • Differential effects of the dual orexin receptor antagonist almorexant and the GABA(A)-alpha1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat
    • Steiner MA, Lecourt H, Strasser DS, Brisbare-Roch C, Jenck F, (2011) Differential effects of the dual orexin receptor antagonist almorexant and the GABA(A)-alpha1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat. Neuropsychopharmacology 36: 848-856.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 848-856
    • Steiner, M.A.1    Lecourt, H.2    Strasser, D.S.3    Brisbare-Roch, C.4    Jenck, F.5
  • 35
    • 33846979755 scopus 로고    scopus 로고
    • Promotion of sleep by targeting the orexin system in rats, dogs and humans
    • Brisbare-Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, et al. (2007) Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat Med 13: 150-155.
    • (2007) Nat Med , vol.13 , pp. 150-155
    • Brisbare-Roch, C.1    Dingemanse, J.2    Koberstein, R.3    Hoever, P.4    Aissaoui, H.5
  • 37
    • 0027903755 scopus 로고
    • The role of the mesoaccumbens dopamine system in ethanol reinforcement: studies using the techniques of microinjection and voltammetry
    • Samson HH, Hodge CW, (1993) The role of the mesoaccumbens dopamine system in ethanol reinforcement: studies using the techniques of microinjection and voltammetry. Alcohol Alcohol Suppl 2: 469-474.
    • (1993) Alcohol Alcohol , Issue.SUPPL. 2 , pp. 469-474
    • Samson, H.H.1    Hodge, C.W.2
  • 38
    • 4444300234 scopus 로고    scopus 로고
    • The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement
    • Gonzales RA, Job MO, Doyon WM, (2004) The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement. Pharmacol Ther 103: 121-146.
    • (2004) Pharmacol Ther , vol.103 , pp. 121-146
    • Gonzales, R.A.1    Job, M.O.2    Doyon, W.M.3
  • 39
    • 79952117828 scopus 로고    scopus 로고
    • Neuroplastic alterations in the limbic system following cocaine or alcohol exposure
    • Stuber GD, Hopf FW, Tye KM, Chen BT, Bonci A, (2010) Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. Curr Top Behav Neurosci 3: 3-27.
    • (2010) Curr Top Behav Neurosci , vol.3 , pp. 3-27
    • Stuber, G.D.1    Hopf, F.W.2    Tye, K.M.3    Chen, B.T.4    Bonci, A.5
  • 40
    • 0037086840 scopus 로고    scopus 로고
    • Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro
    • Korotkova TM, Eriksson KS, Haas HL, Brown RE, (2002) Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro. Regul Pept 104: 83-89.
    • (2002) Regul Pept , vol.104 , pp. 83-89
    • Korotkova, T.M.1    Eriksson, K.S.2    Haas, H.L.3    Brown, R.E.4
  • 41
    • 0037220974 scopus 로고    scopus 로고
    • Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins
    • Korotkova TM, Sergeeva OA, Eriksson KS, Haas HL, Brown RE, (2003) Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. J Neurosci 23: 7-11.
    • (2003) J Neurosci , vol.23 , pp. 7-11
    • Korotkova, T.M.1    Sergeeva, O.A.2    Eriksson, K.S.3    Haas, H.L.4    Brown, R.E.5
  • 42
    • 53949095820 scopus 로고    scopus 로고
    • Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons
    • Borgland SL, Storm E, Bonci A, (2008) Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons. Eur J Neurosci 28: 1545-1556.
    • (2008) Eur J Neurosci , vol.28 , pp. 1545-1556
    • Borgland, S.L.1    Storm, E.2    Bonci, A.3
  • 43
    • 33845305449 scopus 로고    scopus 로고
    • The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?
    • Margolis EB, Lock H, Hjelmstad GO, Fields HL, (2006) The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons? J Physiol 577: 907-924.
    • (2006) J Physiol , vol.577 , pp. 907-924
    • Margolis, E.B.1    Lock, H.2    Hjelmstad, G.O.3    Fields, H.L.4
  • 45
    • 0035055943 scopus 로고    scopus 로고
    • SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats
    • Rodgers RJ, Halford JC, Nunes de Souza RL, Canto de Souza AL, Piper DC, et al. (2001) SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. Eur J Neurosci 13: 1444-1452.
    • (2001) Eur J Neurosci , vol.13 , pp. 1444-1452
    • Rodgers, R.J.1    Halford, J.C.2    Nunes de Souza, R.L.3    Canto de Souza, A.L.4    Piper, D.C.5
  • 46
    • 70349145473 scopus 로고    scopus 로고
    • Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers
    • Borgland SL, Chang SJ, Bowers MS, Thompson JL, Vittoz N, et al. (2009) Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers. J Neurosci 29: 11215-11225.
    • (2009) J Neurosci , vol.29 , pp. 11215-11225
    • Borgland, S.L.1    Chang, S.J.2    Bowers, M.S.3    Thompson, J.L.4    Vittoz, N.5
  • 48
    • 34547527833 scopus 로고    scopus 로고
    • Orexin axons in the rat ventral tegmental area synapse infrequently onto dopamine and gamma-aminobutyric acid neurons
    • Balcita-Pedicino JJ, Sesack SR, (2007) Orexin axons in the rat ventral tegmental area synapse infrequently onto dopamine and gamma-aminobutyric acid neurons. J Comp Neurol 503: 668-684.
    • (2007) J Comp Neurol , vol.503 , pp. 668-684
    • Balcita-Pedicino, J.J.1    Sesack, S.R.2
  • 49
    • 45449106967 scopus 로고    scopus 로고
    • Strain differences in the expression of dopamine D1 receptors in Wistar-Kyoto (WKY) and Wistar rats
    • Novick A, Yaroslavsky I, Tejani-Butt S, (2008) Strain differences in the expression of dopamine D1 receptors in Wistar-Kyoto (WKY) and Wistar rats. Life Sci 83: 74-78.
    • (2008) Life Sci , vol.83 , pp. 74-78
    • Novick, A.1    Yaroslavsky, I.2    Tejani-Butt, S.3
  • 50
    • 62749115142 scopus 로고    scopus 로고
    • Strain specific synaptic modifications on ventral tegmental area dopamine neurons after ethanol exposure
    • Wanat MJ, Sparta DR, Hopf FW, Bowers MS, Melis M, et al. (2009) Strain specific synaptic modifications on ventral tegmental area dopamine neurons after ethanol exposure. Biol Psychiatry 65: 646-653.
    • (2009) Biol Psychiatry , vol.65 , pp. 646-653
    • Wanat, M.J.1    Sparta, D.R.2    Hopf, F.W.3    Bowers, M.S.4    Melis, M.5
  • 52
    • 30944459667 scopus 로고    scopus 로고
    • Hypocretin/orexin selectively increases dopamine efflux within the prefrontal cortex: involvement of the ventral tegmental area
    • Vittoz NM, Berridge CW, (2006) Hypocretin/orexin selectively increases dopamine efflux within the prefrontal cortex: involvement of the ventral tegmental area. Neuropsychopharmacology 31: 384-395.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 384-395
    • Vittoz, N.M.1    Berridge, C.W.2
  • 53
    • 78449260551 scopus 로고    scopus 로고
    • Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences
    • Moorman DE, Aston-Jones G, (2010) Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences. J Neurosci 30: 15585-15599.
    • (2010) J Neurosci , vol.30 , pp. 15585-15599
    • Moorman, D.E.1    Aston-Jones, G.2
  • 54
    • 79955988304 scopus 로고    scopus 로고
    • Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking
    • James MH, Charnley JL, Levi EM, Jones E, Yeoh JW, et al. (2011) Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking. Int J Neuropsychopharmacol 14: 684-690.
    • (2011) Int J Neuropsychopharmacol , vol.14 , pp. 684-690
    • James, M.H.1    Charnley, J.L.2    Levi, E.M.3    Jones, E.4    Yeoh, J.W.5
  • 55
    • 79957649079 scopus 로고    scopus 로고
    • Similarities in hypothalamic and mesocorticolimbic circuits regulating the overconsumption of food and alcohol
    • Barson JR, Morganstern I, Leibowitz SF, (2011) Similarities in hypothalamic and mesocorticolimbic circuits regulating the overconsumption of food and alcohol. Physiol Behav 104: 128-137.
    • (2011) Physiol Behav , vol.104 , pp. 128-137
    • Barson, J.R.1    Morganstern, I.2    Leibowitz, S.F.3
  • 56
    • 77953710614 scopus 로고    scopus 로고
    • Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity
    • Cason AM, Smith RJ, Tahsili-Fahadan P, Moorman DE, Sartor GC, et al. (2010) Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity. Physiol Behav 100: 419-428.
    • (2010) Physiol Behav , vol.100 , pp. 419-428
    • Cason, A.M.1    Smith, R.J.2    Tahsili-Fahadan, P.3    Moorman, D.E.4    Sartor, G.C.5
  • 57
    • 75149160394 scopus 로고    scopus 로고
    • Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction
    • Aston-Jones G, Smith RJ, Sartor GC, Moorman DE, Massi L, et al. (2010) Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction. Brain Res 1314: 74-90.
    • (2010) Brain Res , vol.1314 , pp. 74-90
    • Aston-Jones, G.1    Smith, R.J.2    Sartor, G.C.3    Moorman, D.E.4    Massi, L.5
  • 58
    • 0042565939 scopus 로고    scopus 로고
    • Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins
    • Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, et al. (2003) Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and-insensitive G-proteins. J Pharmacol Sci 92: 259-266.
    • (2003) J Pharmacol Sci , vol.92 , pp. 259-266
    • Zhu, Y.1    Miwa, Y.2    Yamanaka, A.3    Yada, T.4    Shibahara, M.5
  • 60
    • 0035908282 scopus 로고    scopus 로고
    • Mapping of the mRNAs for the hypocretin/orexin and melanin-concentrating hormone receptors: networks of overlapping peptide systems
    • Kilduff TS, de Lecea L, (2001) Mapping of the mRNAs for the hypocretin/orexin and melanin-concentrating hormone receptors: networks of overlapping peptide systems. J Comp Neurol 435: 1-5.
    • (2001) J Comp Neurol , vol.435 , pp. 1-5
    • Kilduff, T.S.1    de Lecea, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.