The role of ginsenosides in inhibiting ubiquitin activating enzyme (E1) activity

Journal of Functional Foods

Volumn 7, Issue 1, 2014, Pages 462-470

  Chang, Tsui Ling ^a   Huang, Yi Han ^a   Ou, Yi Dan ^a  

^a NATIONAL UNIVERSITY OF TAINAN   (Taiwan)

Author keywords

Ginsenoside; Ubiquitin; Ubiquitin activating enzyme (E1)

Indexed keywords

PANAX GINSENG;

EID: 84898029743     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2014.01.010     Document Type: Article

References (47)

1. Amarowicz R., Pegg R.B. Inhibition of proliferation of human carcinoma cell lines by phenolic compounds from a bearberry-leaf crude extract and its fractions. Journal of Functional Foods 2013, 5(2):660-667.
2. Cai B.X., Jin S.L., Luo D., Lin X.F., Gao J. Ginsenoside Rb1 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Biological and Pharmaceutical Bulletin 2009, 32(5):837-841.
3. Chang T.L., Ding H.Y., Kao Y.W. Role of ginsenoside Rd in inhibiting 26S proteasome activity. Journal of Agriculture and Food Chemistry 2008, 56(24):12011-12015.
4. Chang Y.S., Seo E.K., Gyllenhaal C., Block K.I. Panax ginseng: A role in cancer therapy?. Integrative Cancer Therapies 2003, 2(1):13-33.
5. Chen J.J., Tsu C.A., Gavin J.M., Milhollen M.A., Bruzzese F.J., Mallender W.D., Sintchak M.D., Bump N.J., Yang X., Ma J., Loke H.K., Xu Q., Li P., Bence N.F., Brownell J.E., Dick L.R. Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues. Journal of Biological Chemistry 2011, 286(47):40867-40877.
6. Chen Q., Xie W., Kuhn D.J., Voorhees P.M., Lopez-Girona A., Mendy D., Corral L.G., Krenitsky V.P., Xu W., Moutouh-de Parseval L., Webb D.R., Mercurio F., Nakayama K.I., Nakayama K., Orlowski R.Z. Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy. Blood 2008, 111(9):4690-4699.
7. Ciechanover A., Elias S., Heller H., Ferber S., Hershko A. Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes. Journal of Biological Chemistry 1980, 255(16):7525-7528.
8. Ciechanover A., Schwartz A.L. The ubiquitin system: Pathogenesis of human diseases and drug targeting. Biochimica et Biophysica Acta 2004, 1695(1-3):3-17.
9. Deng G.F., Lin X.F., Xu X.R., Gao L.L., Xie J.F., Li H.B. Antioxidant capacities and total phenolic contents of 56 vegetables. Journal of Functional Foods 2013, 5(1):260-266.
10. Dong H., Bai L.P., Wong V.K., Zhou H., Wang J.R., Liu Y., Jiang Z.H., Liu L. The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives. Molecules 2011, 16(12):10619-10630.
11. Fang S., Weissman A.M. A field guide to ubiquitylation. Cellular and Molecular Life Sciences 2004, 61(13):1546-1561.
12. Gao H.W., Zhang M.M., Liu Y.L., Xu Q.M., Yang S.L. Anticomplement activity of ginsenosides from Panax ginseng. Journal of Functional Foods 2013, 5(1):498-502.
13. Gao Q.G., Chen W.F., Xie J.X., Wong M.S. Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways. Journal of Neurochemistry 2009, 109(5):1338-1347.
14. Haas A.L., Rose I.A. The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis. Journal of Biological Chemistry 1982, 257(17):10329-10337.
15. Haas A.L., Siepmann T.J. Pathways of ubiquitin conjugation. FASEB Journal 1997, 11(14):1257-1268.
16. Haas A.L., Warms J.V., Hershko A., Rose I.A. Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation. Journal of Biological Chemistry 1982, 257(5):2543-2548.
17. Hershko A., Ciechanover A. The ubiquitin system. Annual Review of Biochemistry 1998, 67:425-479.
18. Huibregtse J.M., Scheffner M., Beaudenon S., Howley P.M. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proceedings of the National Academy Sciences of the United States of America 1995, 92(7):2563-2567.
19. Kisselev A.F., Callard A., Goldberg A.L. Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate. Journal of Biological Chemistry 2006, 281(13):8582-8590.
20. Lau W.S., Chan R.Y., Guo D.A., Wong M.S. Ginsenoside Rg1 exerts estrogen-like activities via ligand-independent activation of ERalpha pathway. Journal of Steroid Biochemistry and Molecular Biology 2008, 108(1-2):64-71.
21. Lau W.S., Chen W.F., Chan R.Y., Guo D.A., Wong M.S. Mitogen-activated protein kinase (MAPK) pathway mediates the oestrogen-like activities of ginsenoside Rg1 in human breast cancer (MCF-7) cells. British Journal of Pharmacology 2009, 156(7):1136-1146.
22. Lee I.A., Hyam S.R., Jang S.E., Han M.J., Kim D.H. Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages. Journal of Agriculture and Food Chemistry 2012, 60(38):9595-9602.
23. Lee Y.J., Jin Y.R., Lim W.C., Ji S.M., Cho J.Y., Ban J.J., Lee S.K. Ginsenoside Rc and Re stimulate c-fos expression in MCF-7 human breast carcinoma cells. Archives Pharmacal Research 2003, 26(1):53-57.
24. Leung K.W., Pon Y.L., Wong R.N., Wong A.S. Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells. Journal of Biological Chemistry 2006, 281(47):36280-36288.
25. Lin C.Y., Hsiao W.C., Wright D.E., Hsu C.L., Lo Y.C., Wang Hsu G.S., Kao C.F. Resveratrol activates the histone H2B ubiquitin ligase, RNF20, in MD A-MB-231 breast cancer cells. Journal of Functional Foods 2013, 5(2):790-800.
26. Mattern M.R., Wu J., Nicholson B. Ubiquitin-based anticancer therapy: Carpet bombing with proteasome inhibitors vs surgical strikes with E1, E2, E3, or DUB inhibitors. Biochimica et Biophysica Acta 2012, 1823(11):2014-2021.
27. Nawrocki S.T., Griffin P., Kelly K.R., Carew J.S. MLN4924: A novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy. Expert Opinion on Investigational Drugs 2012, 21(10):1563-1573.
28. Nussbaum A.K., Dick T.P., Keilholz W., Schirle M., Stevanovic S., Dietz K., Heinemeyer W., Groll M., Wolf D.H., Huber R., Rammensee H.G., Schild H. Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1. Proceedings of the National Academy of Sciences of the United States of America 1998, 95(21):12504-12509.
29. Peng D., Wang H., Qu C., Xie L., Wicks S.M., Xie J. Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics. Chinese Medicine 2012, 7:2.
30. Pickart C.M. Targeting of substrates to the 26S proteasome. FASEB Journal 1997, 11(13):1055-1066.
31. Pokharel Y.R., Kim N.D., Han H.K., Oh W.K., Kang K.W. Increased ubiquitination of multidrug resistance 1 by ginsenoside Rd. Nutrition and Cancer 2010, 62(2):252-259.
32. Roupasa P., Keogh J. The role of edible mushrooms in health: Evaluation of the evidence. Journal of Functional Foods 2012, 4:687-709.
33. Saw C.L., Yang A.Y., Cheng D.C., Boyanapalli S.S., Su Z.Y., Khor T.O., Gao S., Wang J., Jiang Z.H., Kong A.N. Pharmacodynamics of ginsenosides: Antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations. Chemical Research in Toxicology 2012, 25(8):1574-1580.
34. Senanayake S.P.J.N. Green tea extract: Chemistry, antioxidant properties and food applications - A review. Journal of Functional Foods 2013, 5(4):1529-1541.
35. Spataro V., Norbury C., Harris A.L. The ubiquitin-proteasome pathway in cancer. British Journal of Cancer 1998, 77(3):448-455.
36. Tu Y., Chen C., Pan J., Xu J., Zhou Z.G., Wang C.Y. The ubiquitin proteasome pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis. International Journal of Clinical and Experimental Pathology 2012, 5(8):726-738.
37. Ungermannova D., Parker S.J., Nasveschuk C.G., Chapnick D.A., Phillips A.J., Kuchta R.D., Liu X. Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. Journal of Biomolecular Screening 2012, 17(4):421-434.
38. Ungermannova D., Parker S.J., Nasveschuk C.G., Wang W., Quade B., Zhang G., Kuchta R.D., Phillips A.J., Liu X. Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1). PLoS ONE 2012, 7(1):e29208.
39. Wang C.Z., Zhang B., Song W.X., Wang A., Ni M., Luo X., Aung H.H., Xie J.T., Tong R., He T.C., Yuan C.S. Steamed American ginseng berry: Ginsenoside analyses and anticancer activities. Journal of Agriculture and Food Chemistry 2006, 54(26):9936-9942.
40. Wang W., Zhao Y., Rayburn E.R., Hill D.L., Wang H., Zhang R. In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemotherapy and Pharmacology 2007, 59(5):589-601.
41. Wong V.K., Cheung S.S., Li T., Jiang Z.H., Wang J.R., Dong H., Yi X.Q., Zhou H., Liu L. Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NF-kappaB signaling. Journal of Cellular Biochemistry 2010, 111(4):899-910.
42. Xu Q.M., Jia D., Gao H.W., Zhang M.M., He W.J., Pan S.L., Liu Y.L., Li X.R., Cui J.H., Yang S.L. In vitro and in vivo protective effects of gingenosides on acute renal injury induced by cantharidin. Journal of Functional Foods 2013, 5(4):2012-2018.
43. Yamabe N., Kim Y.J., Lee S., Cho E.J., Park S.H., Ham J., Kim H.Y., Kang K.S. Increase in antioxidant and anticancer effects of ginsenoside Re-lysine mixture by Maillard reaction. Food Chemistry 2013, 138(2-3):876-883.
44. Yang Y., Kitagaki J., Dai R.M., Tsai Y.C., Lorick K.L., Ludwig R.L., Pierre S.A., Jensen J.P., Davydov I.V., Oberoi P., Li C.C., Kenten J.H., Beutler J.A., Vousden K.H., Weissman A.M. Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Research 2007, 67(19):9472-9481.
45. Yi X.Q., Li T., Wang J.R., Wong V.K., Luo P., Wong I.Y., Jiang Z.H., Liu L., Zhou H. Total ginsenosides increase coronary perfusion flow in isolated rat hearts through activation of PI3K/Akt-eNOS signaling. Phytomedicine 2010, 17(13):1006-1015.
46. Yoon J.H., Choi Y.J., Cha S.W., Lee S.G. Anti-metastatic effects of ginsenoside Rd via inactivation of MAPK signaling and induction of focal adhesion formation. Phytomedicine 2012, 19(3-4):284-292.
47. Yun T.K., Choi S.Y. Preventive effect of ginseng intake against various human cancers: A case-control study on 1987 pairs. Cancer Epidemiology Biomarkers and Prevention 1995, 4(4):401-408.