Identification and mechanistic studies of a novel ubiquitin E1 inhibitor

Journal of Biomolecular Screening

Volumn 17, Issue 4, 2012, Pages 421-434

  Ungermannova, Dana ^a   Parker, Seth J ^a   Nasveschuk, Christopher G ^a   Chapnick, Douglas A ^a   Phillips, Andrew J ^a   Kuchta, Robert D ^a   Liu, Xuedong ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

inhibitor; p27kip1; proteolysis; ubiquitin; ubiquitin E1

Indexed keywords

MLN 4924; NSC 624206; PROTEIN INHIBITOR; PROTEIN P27; PYR 41; THIOESTER; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ADENYLATION; ANIMAL CELL; ARTICLE; CELL ASSAY; CONTROLLED STUDY; DRUG SCREENING; DRUG TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; UBIQUITINATION;

ANIMALS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISULFIDES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MICE; PROTEOLYSIS; SMALL MOLECULE LIBRARIES; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITINATION;

EID: 84858978749     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111433843     Document Type: Article

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