Crystallographic analysis of NHERF1-PLCβ3 interaction provides structural basis for CXCR2 signaling in pancreatic cancer

Biochemical and Biophysical Research Communications

Volumn 446, Issue 2, 2014, Pages 638-643

  Jiang, Yuanyuan ^a   Wang, Shuo ^a   Holcomb, Joshua ^a   Trescott, Laura ^a   Guan, Xiaoqing ^a   Hou, Yuning ^a   Brunzelle, Joseph ^b   Sirinupong, Nualpun ^c   Li, Chunying ^a   Yang, Zhe ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

^c PRINCE OF SONGKLA UNIVERSITY   (Thailand)

Author keywords

CXCR2; NHERF1; Pancreatic cancer; PLC 3; Scaffold protein; X ray crystallography

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; PDZ PROTEIN; PHOSPHOLIPASE C BETA3; SCAFFOLD PROTEIN; SODIUM HYDROGEN EXCHANGER REGULATORY FACTOR 1; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PANCREAS CANCER; PDZ DOMAIN; PDZ1 DOMAIN; PDZ2 DOMAIN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY;

CXCR2; NHERF1; PANCREATIC CANCER; PLCΒ3; SCAFFOLD PROTEIN; X-RAY CRYSTALLOGRAPHY;

BINDING SITES; CELL LINE, TUMOR; CRYSTALLOGRAPHY; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; PANCREATIC NEOPLASMS; PHOSPHOLIPASE C BETA; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, INTERLEUKIN-8B; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER;

EID: 84897971111     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.03.028     Document Type: Article

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