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Volumn 28, Issue 4, 2014, Pages 603-610

In vitro inhibition of human CYP1A2, CYP2D6, and CYP3A4 by six herbs commonly used in pregnancy

Author keywords

CYP inhibition; cytochrome P450; herb drug interactions; herbal product; in vitro; pregnancy

Indexed keywords

ALCOHOL; CRANBERRY EXTRACT; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; EQUISETUM EXTRACT; FOENICULUM VULGARE EXTRACT; GINGER EXTRACT; PLANT EXTRACT; RASPBERRY EXTRACT; SAMBUCUS NIGRA EXTRACT; UNCLASSIFIED DRUG;

EID: 84897969999     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5037     Document Type: Article
Times cited : (38)

References (46)
  • 1
    • 0345490845 scopus 로고    scopus 로고
    • Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450
    • Busby WF, Jr., Ackermann JM, Crespi CL. 1999. Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450. Drug Metab Dispos 27: 246-249.
    • (1999) Drug Metab Dispos , vol.27 , pp. 246-249
    • Busby Jr., W.F.1    Ackermann, J.M.2    Crespi, C.L.3
  • 2
    • 84861878245 scopus 로고    scopus 로고
    • Herb-drug interactions and mechanistic and clinical considerations
    • Chen XW, Sneed KB, Pan SY, et al. 2012. Herb-drug interactions and mechanistic and clinical considerations. Curr Drug Metab 13: 640-651.
    • (2012) Curr Drug Metab , vol.13 , pp. 640-651
    • Chen, X.W.1    Sneed, K.B.2    Pan, S.Y.3
  • 4
    • 84872318668 scopus 로고    scopus 로고
    • Herb remedies during pregnancy: A systematic review of controlled clinical trials
    • Dante G, Pedrielli G, Annessi E, Facchinetti F. 2012. Herb remedies during pregnancy: a systematic review of controlled clinical trials. J Matern Fetal Neonatal Med 26: 306-312.
    • (2012) J Matern Fetal Neonatal Med , vol.26 , pp. 306-312
    • Dante, G.1    Pedrielli, G.2    Annessi, E.3    Facchinetti, F.4
  • 5
    • 58549088199 scopus 로고    scopus 로고
    • Drug-drug interactions mediated through P-glycoprotein: Clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug
    • Fenner KS, Troutman MD, Kempshall S, et al. 2009. Drug-drug interactions mediated through P-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug. Clin Pharmacol Ther 85: 173-181.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 173-181
    • Fenner, K.S.1    Troutman, M.D.2    Kempshall, S.3
  • 6
    • 0003484310 scopus 로고    scopus 로고
    • Food and Drug Administration, U.S. Department of Health and Human Services. Accessed March 2013 from
    • Food and Drug Administration, U.S. Department of Health and Human Services. 2001. Guidance for industry: bioanalytical method validation. Accessed March 2013 from http://www.fda.gov/downloads/Drugs/ GuidanceComplianceRegulatoryInformation/Guidances/ UCM070107.pdf.
    • (2001) Guidance for Industry: Bioanalytical Method Validation
  • 7
    • 0037911509 scopus 로고    scopus 로고
    • In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products
    • Foster BC, Vandenhoek S, Hana J, et al. 2003. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 10: 334-342.
    • (2003) Phytomedicine , vol.10 , pp. 334-342
    • Foster, B.C.1    Vandenhoek, S.2    Hana, J.3
  • 8
    • 0142212294 scopus 로고    scopus 로고
    • Variations in product choices of frequently purchased herbs: Caveat emptor
    • Garrard J, Harms S, Eberly LE, Matiak A. 2003. Variations in product choices of frequently purchased herbs: caveat emptor. Arch Intern Med 163: 2290-2295.
    • (2003) Arch Intern Med , vol.163 , pp. 2290-2295
    • Garrard, J.1    Harms, S.2    Eberly, L.E.3    Matiak, A.4
  • 9
    • 0038743344 scopus 로고    scopus 로고
    • Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population
    • Glover DD, Amonkar M, Rybeck BF, Tracy TS. 2003. Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population. Am J Obstet Gynecol 188: 1039-1045.
    • (2003) Am J Obstet Gynecol , vol.188 , pp. 1039-1045
    • Glover, D.D.1    Amonkar, M.2    Rybeck, B.F.3    Tracy, T.S.4
  • 10
    • 0031696409 scopus 로고    scopus 로고
    • The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin
    • Gorski J, Jones D, Haehner-Daniels B, Hamman M, O'Mara Jr. E, Hall S. 1998. The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin. Clin Pharmacol Ther 64: 133-143.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 133-143
    • Gorski, J.1    Jones, D.2    Haehner-Daniels, B.3    Hamman, M.4    O'Mara Jr., E.5    Hall, S.6
  • 12
    • 81255134512 scopus 로고    scopus 로고
    • The use of complementary and alternative medicine by pregnant women: A literature review
    • Hall HG, Griffiths DL, McKenna LG. 2011. The use of complementary and alternative medicine by pregnant women: a literature review. Midwifery 27: 817-824.
    • (2011) Midwifery , vol.27 , pp. 817-824
    • Hall, H.G.1    Griffiths, D.L.2    McKenna, L.G.3
  • 13
    • 4043081922 scopus 로고    scopus 로고
    • Medication use during pregnancy: Data from the Avon longitudinal study of parents and children
    • Headley J, Northstone K, Simmons H, Golding J. 2004. Medication use during pregnancy: data from the Avon longitudinal study of parents and children. Eur J Clin Pharmacol 60: 355-361.
    • (2004) Eur J Clin Pharmacol , vol.60 , pp. 355-361
    • Headley, J.1    Northstone, K.2    Simmons, H.3    Golding, J.4
  • 14
    • 33845996201 scopus 로고    scopus 로고
    • The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes
    • Hellum BH, Hu Z, Nilsen OG. 2007. The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes. Basic Clin Pharmacol Toxicol 100: 23-30.
    • (2007) Basic Clin Pharmacol Toxicol , vol.100 , pp. 23-30
    • Hellum, B.H.1    Hu, Z.2    Nilsen, O.G.3
  • 15
    • 34848906016 scopus 로고    scopus 로고
    • The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol
    • Hellum BH, Nilsen OG. 2007. The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol. Basic Clin Pharmacol Toxicol 101: 350-358.
    • (2007) Basic Clin Pharmacol Toxicol , vol.101 , pp. 350-358
    • Hellum, B.H.1    Nilsen, O.G.2
  • 16
    • 42149119034 scopus 로고    scopus 로고
    • Vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products
    • Hellum BH, Nilsen OG. 2008. In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products. Basic Clin Pharmacol Toxicol 102: 466-475.
    • (2008) Basic Clin Pharmacol Toxicol , vol.102 , pp. 466-475
    • Hellum, B.H.1    Nilsen, O.G.2
  • 17
  • 18
    • 0035734306 scopus 로고    scopus 로고
    • Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds
    • Ho PC, Saville DJ, Wanwimolruk S. 2001. Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds. J Pharm Pharm Sci 4: 217-227.
    • (2001) J Pharm Pharm Sci , vol.4 , pp. 217-227
    • Ho, P.C.1    Saville, D.J.2    Wanwimolruk, S.3
  • 19
    • 1942421701 scopus 로고    scopus 로고
    • Pharmacogenetics of cytochrome P450 and its applications in drug therapy: The past, present and future
    • Ingelman-Sundberg M. 2004. Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future. Trends Pharmacol Sci 25: 193-200.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 193-200
    • Ingelman-Sundberg, M.1
  • 20
    • 84865010199 scopus 로고    scopus 로고
    • Interactions between herbs and conventional drugs: Overview of the clinical data
    • Izzo AA. 2012. Interactions between herbs and conventional drugs: overview of the clinical data. Med Princ Pract 21: 404-428.
    • (2012) Med Princ Pract , vol.21 , pp. 404-428
    • Izzo, A.A.1
  • 21
    • 84870377691 scopus 로고    scopus 로고
    • Effects of an aqueous-ethanolic extract of ginger on cytochrome P450 enzyme-mediated drug metabolism
    • Kim IS, Kim SY, Yoo HH. 2012. Effects of an aqueous-ethanolic extract of ginger on cytochrome P450 enzyme-mediated drug metabolism. Pharmazie 67: 1007-1009.
    • (2012) Pharmazie , vol.67 , pp. 1007-1009
    • Kim, I.S.1    Kim, S.Y.2    Yoo, H.H.3
  • 22
    • 78751550662 scopus 로고    scopus 로고
    • Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity
    • Kimura Y, Ito H, Hatano T. 2010. Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity. Biol Pharm Bull 33: 1977-1982.
    • (2010) Biol Pharm Bull , vol.33 , pp. 1977-1982
    • Kimura, Y.1    Ito, H.2    Hatano, T.3
  • 23
    • 34248992947 scopus 로고    scopus 로고
    • Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam-probes of CYP2C9, CYP1A2, and CYP3A4
    • Lilja JJ, Backman JT, Neuvonen PJ. 2007. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam-probes of CYP2C9, CYP1A2, and CYP3A4. Clin Pharmacol Ther 81: 833-839.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 833-839
    • Lilja, J.J.1    Backman, J.T.2    Neuvonen, P.J.3
  • 24
    • 0030982634 scopus 로고    scopus 로고
    • Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression
    • Lown K, Bailey D, Fontana R, et al. 1997. Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression. J Clin Invest 99: 2545-2553.
    • (1997) J Clin Invest , vol.99 , pp. 2545-2553
    • Lown, K.1    Bailey, D.2    Fontana, R.3
  • 25
    • 0034818391 scopus 로고    scopus 로고
    • Use of dietary supplements and natural remedies increased dramatically during the 1990s
    • Messerer M, Johansson SE, Wolk A. 2001. Use of dietary supplements and natural remedies increased dramatically during the 1990s. J Intern Med 250: 160-166.
    • (2001) J Intern Med , vol.250 , pp. 160-166
    • Messerer, M.1    Johansson, S.E.2    Wolk, A.3
  • 26
    • 61449104884 scopus 로고    scopus 로고
    • Identification of a cranberry juice product that inhibits enteric CYP3A-mediated first-pass metabolism in humans
    • Ngo N, Yan Z, Graf TN, et al. 2009. Identification of a cranberry juice product that inhibits enteric CYP3A-mediated first-pass metabolism in humans. Drug Metab Dispos 37: 514-522.
    • (2009) Drug Metab Dispos , vol.37 , pp. 514-522
    • Ngo, N.1    Yan, Z.2    Graf, T.N.3
  • 27
    • 79960147444 scopus 로고    scopus 로고
    • Use of herbal drugs during pregnancy among 600 Norwegian women in relation to concurrent use of conventional drugs and pregnancy outcome
    • Nordeng H, Bayne K, Havnen GC, Paulsen BS. 2011. Use of herbal drugs during pregnancy among 600 Norwegian women in relation to concurrent use of conventional drugs and pregnancy outcome. Complement Ther Clin Pract 17: 147-151.
    • (2011) Complement Ther Clin Pract , vol.17 , pp. 147-151
    • Nordeng, H.1    Bayne, K.2    Havnen, G.C.3    Paulsen, B.S.4
  • 28
    • 2942750271 scopus 로고    scopus 로고
    • Use of herbal drugs in pregnancy: A survey among 400 Norwegian women
    • Nordeng H, Havnen GC. 2004. Use of herbal drugs in pregnancy: a survey among 400 Norwegian women. Pharmacoepidemiol Drug Saf 13: 371-380.
    • (2004) Pharmacoepidemiol Drug Saf , vol.13 , pp. 371-380
    • Nordeng, H.1    Havnen, G.C.2
  • 29
    • 76949084637 scopus 로고    scopus 로고
    • Perception of risk regarding the use of medications and other exposures during pregnancy
    • Nordeng H, Ystrom E, Einarson A. 2010. Perception of risk regarding the use of medications and other exposures during pregnancy. Eur J Clin Pharmacol 66: 207-214.
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 207-214
    • Nordeng, H.1    Ystrom, E.2    Einarson, A.3
  • 30
    • 84878284729 scopus 로고    scopus 로고
    • Predictors of the use of medications before and during pregnancy
    • [in press]. Doi: 10.1007/ s11096-013-9750-7.
    • Odalovic M, Vezmar Kovacevic S, Nordeng H, Ilic K, Sabo A, Tasic L. 2013. Predictors of the use of medications before and during pregnancy. Int J Clin Pharm [in press]. Doi: 10.1007/ s11096-013-9750-7.
    • (2013) Int J Clin Pharm
    • Odalovic, M.1    Vezmar Kovacevic, S.2    Nordeng, H.3    Ilic, K.4    Sabo, A.5    Tasic, L.6
  • 32
    • 84873477369 scopus 로고    scopus 로고
    • Herb-drug interactions: An overview of systematic reviews
    • Posadzki P, Watson L, Ernst E. 2012. Herb-drug interactions: an overview of systematic reviews. Br J Clin Pharmacol 75: 603-618.
    • (2012) Br J Clin Pharmacol , vol.75 , pp. 603-618
    • Posadzki, P.1    Watson, L.2    Ernst, E.3
  • 33
    • 84867849480 scopus 로고    scopus 로고
    • In vitro inhibition of CYP3A4 by the multiherbal commercial product Sambucus force and its main constituents Echinacea purpurea and Sambucus nigra
    • Schroder-Aasen T, Molden G, Nilsen OG. 2012. In vitro inhibition of CYP3A4 by the multiherbal commercial product Sambucus force and its main constituents Echinacea purpurea and Sambucus nigra. Phytother Res 26: 1606-1613.
    • (2012) Phytother Res , vol.26 , pp. 1606-1613
    • Schroder-Aasen, T.1    Molden, G.2    Nilsen, O.G.3
  • 34
    • 33745627338 scopus 로고    scopus 로고
    • Variation in concentration and labeling of ginger root dietary supplements
    • Schwertner HA, Rios DC, Pascoe JE. 2006. Variation in concentration and labeling of ginger root dietary supplements. Obstet Gynecol 107: 1337-1343.
    • (2006) Obstet Gynecol , vol.107 , pp. 1337-1343
    • Schwertner, H.A.1    Rios, D.C.2    Pascoe, J.E.3
  • 35
    • 33745726391 scopus 로고    scopus 로고
    • The inhibition of human cytochrome P450 by ethanol extracts of North American botanicals
    • Scott IM, Leduc RI, Burt AJ, Marles RJ, Arnason JT, Foster BC. 2006. The inhibition of human cytochrome P450 by ethanol extracts of North American botanicals. Pharm Biol 44: 315-327.
    • (2006) Pharm Biol , vol.44 , pp. 315-327
    • Scott, I.M.1    Leduc, R.I.2    Burt, A.J.3    Marles, R.J.4    Arnason, J.T.5    Foster, B.C.6
  • 36
    • 77949457681 scopus 로고    scopus 로고
    • Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail
    • Sevior DK, Hokkanen J, Tolonen A, et al. 2010. Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail. Xenobiotica 40: 245-254.
    • (2010) Xenobiotica , vol.40 , pp. 245-254
    • Sevior, D.K.1    Hokkanen, J.2    Tolonen, A.3
  • 37
    • 79960375923 scopus 로고    scopus 로고
    • Health service utilisation by pregnant women over a seven-year period
    • Sibbritt D, Adams J, Lui CW. 2011. Health service utilisation by pregnant women over a seven-year period. Midwifery 27: 474-476.
    • (2011) Midwifery , vol.27 , pp. 474-476
    • Sibbritt, D.1    Adams, J.2    Lui, C.W.3
  • 39
    • 1542348613 scopus 로고    scopus 로고
    • An approach to the in vitro evaluation of potential for cytochrome P450 enzyme inhibition from herbals and other natural remedies
    • Strandell J, Neil A, Carlin G. 2004. An approach to the in vitro evaluation of potential for cytochrome P450 enzyme inhibition from herbals and other natural remedies. Phytomedicine 11: 98-104.
    • (2004) Phytomedicine , vol.11 , pp. 98-104
    • Strandell, J.1    Neil, A.2    Carlin, G.3
  • 40
    • 33646118973 scopus 로고    scopus 로고
    • Mechanismbased inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants
    • Subehan, UT, Iwata H, Kadota S, Tezuka Y. 2006. Mechanismbased inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol 105: 449-455.
    • (2006) J Ethnopharmacol , vol.105 , pp. 449-455
    • Subehan, U.T.1    Iwata, H.2    Kadota, S.3    Tezuka, Y.4
  • 41
    • 38049001985 scopus 로고    scopus 로고
    • Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): Identification and characterization of a mechanismbased inactivator
    • Subehan, ZSF, Kadota S, Tezuka Y. 2007. Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanismbased inactivator. J Agric Food Chem 55: 10162-10167.
    • (2007) J Agric Food Chem , vol.55 , pp. 10162-10167
    • Subehan, Z.S.F.1    Kadota, S.2    Tezuka, Y.3
  • 42
    • 68949103975 scopus 로고    scopus 로고
    • Cytochrome P450-mediated metabolism in the human gut wall
    • Thelen K, Dressman JB. 2009. Cytochrome P450-mediated metabolism in the human gut wall. J Pharm Pharmacol 61: 541-558.
    • (2009) J Pharm Pharmacol , vol.61 , pp. 541-558
    • Thelen, K.1    Dressman, J.B.2
  • 43
    • 13444269471 scopus 로고    scopus 로고
    • Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A activity) during pregnancy
    • Tracy TS, Venkataramanan R, Glover DD, Caritis SN. 2005. Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A activity) during pregnancy. Am J Obstet Gynecol 192: 633-639.
    • (2005) Am J Obstet Gynecol , vol.192 , pp. 633-639
    • Tracy, T.S.1    Venkataramanan, R.2    Glover, D.D.3    Caritis, S.N.4
  • 46
    • 84875211310 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
    • Doi: 10.1016/j.pharmthera.2012.12.007
    • Zanger UM, Schwab M. 2013. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther 138: 103-141 Doi: 10.1016/j.pharmthera.2012.12.007.
    • (2013) Pharmacol Ther , vol.138 , pp. 103-141
    • Zanger, U.M.1    Schwab, M.2


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