Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 12, 2010, Pages 1977-1982

  Kimura, Yuka ^a   Ito, Hideyuki ^a   Hatano, Tsutomu ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Cytochrome P450; Drug interaction; Lignan; Spice

Indexed keywords

1 (2,6 DIHYDROXYPHENYL) 9 3,4 DIHYDROXYPHENYLNONAN 1 ONE; 1 ACETOXY 2 (4 ALLYL 2,6 DIMETHOXYPHENOXY) 1 (3,4 DIMETHOXYPHENYL)PROPANE; 1 ACETOXY 2 (4 ALLYL 2,6 DIMETHOXYPHENOXY) 1 (4 HYDROXY 3 METHOXYPHENYL)PROPANE; 2 (4 ALLYL 2,6 DIMETHOXYPHENOXY) 1 (4 HYDROXY 3 METHOXYPHENYL)PROPAN 1 OL; 2,3 DIMETHOXY 5 (1 PROPENYL)PHENOL; 5 HYDROXYEUGENOL; 7,8 DIHYDRO 7 (3,4 METHYLENEDIOXYPHENYL) 3' METHOXY 8 METHYL 1' PROPENYLBENZOFURAN; 7,8 DIHYDRO 7 (4 HYDROXY 3 METHOXYPHENYL) 3' METHOXY 8 METHYL 1' PROPENYLBENZOFURAN; 7,8 DIHYDRO 7 (4 HYDROXY 3,5 DIMETHOXYPHENYL) 3' METHOXY 8 METHYL 1' PROPENYLBENZOFURAN; 7,8 DIHYDRO 7 (5 METHOXY 3,4 METHYLENEDIOXYPHENYL) 3' METHOXY 8 METHYL 1' PROPENYLBENZOFURAN; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; ELEMICIN; EUGENOL; METHOXYEUGENOL; METHYLEUGENOL; MYRISTICIN; PIPERINE; SAFROLE; TURMERIC; UNCLASSIFIED DRUG;

ARTICLE; BLACK PEPPER; CHEMICAL STRUCTURE; CINNAMON; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; FOOD DRUG INTERACTION; GINGER; HERB DRUG INTERACTION; IC 50; IN VITRO STUDY; NUTMEG; PEPPER; SAGE; SPICE; STRUCTURE ANALYSIS;

ANIMALS; ANTI-INFECTIVE AGENTS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; FURANS; HERB-DRUG INTERACTIONS; HUMANS; INSECTS; MICROSOMES; MYRISTICA FRAGRANS; PHENOLS; PLANT EXTRACTS; SEEDS; SPICES; SULFAPHENAZOLE;

EID: 78751550662     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.1977     Document Type: Article

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