A new pathway of exogenous fatty acid incorporation proceeds by a classical phosphoryl transfer reaction

Molecular Microbiology

Volumn 92, Issue 2, 2014, Pages 217-221

  Cronan, John E ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; FATTY ACID; FATTY ACID SYNTHASE; GLYCEROPHOSPHATE; LIPID; PHOSPHATIDIC ACID; PHOSPHORYL; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; PHOSPHOTRANSFERASE; PLSX PROTEIN, BACTERIA;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; BLOOD LEVEL; ESCHERICHIA COLI; FATTY ACID ANALYSIS; FATTY ACID SYNTHESIS; FATTY ACID TRANSPORT; HUMAN; IN VITRO STUDY; MOLECULAR DYNAMICS; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; ENZYMOLOGY; METABOLISM;

BACTERIAL PROTEINS; FATTY ACIDS; METABOLIC NETWORKS AND PATHWAYS; PHOSPHOTRANSFERASES; STAPHYLOCOCCUS AUREUS;

EID: 84897965544     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/mmi.12558     Document Type: Article

References (26)

1. Balemans, W., Lounis, N., Gilissen, R., Guillemont, J., Simmen, K., Andries, K., and Koul, A. (2010) Essentiality of FASII pathway for Staphylococcus aureus. Nature 463: E3; discussion E4.
2. Brinster, S., Lamberet, G., Staels, B., Trieu-Cuot, P., Gruss, A., and Poyart, C. (2009) Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens. Nature 458: 83-86.
3. Brown, T.D., Jones-Mortimer, M.C., and Kornberg, H.L. (1977) The enzymic interconversion of acetate and acetyl-coenzyme A in Escherichia coli. J Gen Microbiol 102: 327-336.
4. Campbell, J.W., and Cronan, J.E., Jr (2001) Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery. Annu Rev Microbiol 55: 305-332.
5. Campbell, J.W., Morgan-Kiss, R.M., and Cronan, J.E., Jr (2003) A new Escherichia coli metabolic competency: growth on fatty acids by a novel anaerobic β-oxidation pathway. Mol Microbiol 47: 793-805.
6. Davis, M.S., and Cronan, J.E., Jr (2001) Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein. J Bacteriol 183: 1499-1503.
7. Fey, P.D., Endres, J.L., Yajjala, V.K., Widhelm, T.J., Boissy, R.J., Bose, J.L., and Bayles, K.W. (2013) A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes. mBio 4: e537-e512.
8. Garlid, K.D., Orosz, D.E., Modriansky, M., Vassanelli, S., and Jezek, P. (1996) On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein. J Biol Chem 271: 2615-2620.
9. Heath, R.J., and Rock, C.O. (1996) Inhibition of β-ketoacyl-acyl carrier protein synthase III (FabH) by acyl-acyl carrier protein in Escherichia coli. J Biol Chem 271: 10996-11000.
10. Jiang, Y., Chan, C.H., and Cronan, J.E. (2006) The soluble acyl-acyl carrier protein synthetase of Vibrio harveyi B392 is a member of the medium chain acyl-CoA synthetase family. Biochemistry 45: 10008-10019.
11. Jiang, Y., Morgan-Kiss, R.M., Campbell, J.W., Chan, C.H., and Cronan, J.E. (2010) Expression of Vibrio harveyi acyl-ACP synthetase allows efficient entry of exogenous fatty acids into the Escherichia coli fatty acid and lipid A synthetic pathways. Biochemistry 49: 718-726.
12. Lai, C.Y., and Cronan, J.E. (2003) β-Ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis. J Biol Chem 278: 51494-51503.
13. Lipmann, F., and Tuttle, L.C. (1944) Acetyl phosphate: chemistry, determination, and synthesis. J Biol Chem 153: 571-582.
14. Lu, Y.J., Zhang, Y.M., Grimes, K.D., Qi, J., Lee, R.E., and Rock, C.O. (2006) Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens. Mol Cell 23: 765-772.
15. McDevitt, D., Payne, D.J., Holmes, D.J., and Rosenberg, M. (2002) Novel targets for the future development of antibacterial agents. J Appl Microbiol 92 (Suppl.): 28S-34S.
16. Manandhar, M., and Cronan, J.E. (2013) Proofreading of noncognate acyl adenylates by an acyl-coenzyme A ligase. Chem Biol 20: 1441-1446.
17. Morgan-Kiss, R.M., and Cronan, J.E. (2004) The Escherichia coli fadK (ydiD) gene encodes an anerobically regulated short chain acyl-CoA synthetase. J Biol Chem 279: 37324-37333.
18. Parsons, J., Frank, M., Jackson, P., Subramanian, C., and Rock, C. (2014) Incorporation of extracellular fatty acids by a fatty acid kinase-dependent pathway in Staphylococcus aureus. Mol Microbiol 92: 234-245.
19. Parsons, J.B., Frank, M.W., Subramanian, C., Saenkham, P., and Rock, C.O. (2011) Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors. Proc Natl Acad Sci USA 108: 15378-15383.
20. Parsons, J.B., Frank, M.W., Rosch, J.W., and Rock, C.O. (2013) Staphylococcus aureus fatty acid auxotrophs do not proliferate in mice. Antimicrob Agents Chemother 57: 5729-5732.
21. Polyak, S.W., Abell, A.D., Wilce, M.C., Zhang, L., and Booker, G.W. (2012) Structure, function and selective inhibition of bacterial acetyl-CoA carboxylase. Appl Microbiol Biotechnol 93: 983-992.
22. Projan, S.J. (2002) New (and not so new) antibacterial targets - from where and when will the novel drugs come? Curr Opin Pharmacol 2: 513-522.
23. Wang, J., Soisson, S.M., Young, K., Shoop, W., Kodali, S., Galgoci, A., etal. (2006) Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441: 358-361.
24. Wang, J., Kodali, S., Lee, S.H., Galgoci, A., Painter, R., Dorso, K., etal. (2007) Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc Natl Acad Sci USA 104: 7612-7616.
25. Zhang, Y.M., White, S.W., and Rock, C.O. (2006) Inhibiting bacterial fatty acid synthesis. J Biol Chem 281: 17541-17544.
26. Zhu, L., Bi, H., Ma, J., Hu, Z., Zhang, W., Cronan, J.E., and Wang, H. (2013) The two functional enoyl-acyl carrier protein reductases of Enterococcus faecalis do not mediate triclosan resistance. mBio 4: e00613-00613.