Glial activation in the early stages of brain metastasis: TSPO as a diagnostic biomarker

Journal of Nuclear Medicine

Volumn 55, Issue 2, 2014, Pages 275-280

  O'Brien, Emma R ^a   Kersemans, Veerle ^a   Tredwell, Matthew ^b   Checa, Begona ^b   Serres, Sébastien ^a   Soto, Manuel Sarmiento ^a   Gouverneur, Veronique ^b   Leppert, David ^c   Anthony, Daniel C ^b   Sibson, Nicola R ^a,d  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

Astrocytes; Metastasis; Microglia; Mouse; SPECT imaging; TSPO

Indexed keywords

BENZODIAZEPINE RECEPTOR; DPA 713; GREEN FLUORESCENT PROTEIN; IODINE N,N DIETHYL 2 [2 (4 HYDROXY PHENYL) 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE I 123; RADIOPHARMACEUTICAL AGENT; TRANSLOCATOR PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; ACETAMIDE DERIVATIVE; BZRP PROTEIN, MOUSE; DIAGNOSTIC AGENT; GADOLINIUM; LIGAND; N,N DIETHYL 2 (2 (4 METHOXYPHENYL) 5,7 DIMETHYL PYRAZOLO(1,5 A)PYRIMIDIN 3 YL) ACETAMIDE; N,N-DIETHYL-2-(2-(4-METHOXYPHENYL)-5,7-DIMETHYL-PYRAZOLO(1,5-A)PYRIMIDIN-3-YL)-ACETAMIDE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTORADIOGRAPHY; BRAIN METASTASIS; BREAST CARCINOMA; BREAST METASTASIS; CANCER GROWTH; CANCER STAGING; CARCINOMA CELL; CELL ACTIVATION; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG BINDING; EXPERIMENTAL MODEL; FEMALE; GLIOSIS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; ISOTOPE LABELING; MICROGLIA; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR VOLUME; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BRAIN TUMOR; CANCER TRANSPLANTATION; CHEMISTRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GLIA; METABOLISM; METASTASIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN BINDING; SCINTISCANNING; SPECT IMAGING; TIME; TSPO;

ASTROCYTES; METASTASIS; MICROGLIA; MOUSE; SPECT IMAGING; TSPO;

ACETAMIDES; ANIMALS; ASTROCYTES; BRAIN NEOPLASMS; FEMALE; GADOLINIUM; GENE EXPRESSION REGULATION, NEOPLASTIC; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; LIGANDS; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED BALB C; MICROGLIA; MICROSCOPY, FLUORESCENCE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEUROGLIA; PROTEIN BINDING; PYRAZOLES; PYRIMIDINES; RECEPTORS, GABA; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TUMOR MARKERS, BIOLOGICAL;

EID: 84897938674     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.113.127449     Document Type: Article

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