Genistein suppresses tumor necrosis factor α-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor κB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells

Drug Design, Development and Therapy

Volumn 8, Issue , 2014, Pages 315-323

  Li, Jinchao ^a   Li, Jun ^b   Yue, Ye ^a   Hu, Yiping ^a   Cheng, Wenxiang ^a   Liu, Ruoxi ^c   Pan, Xiaohua ^d   Zhang, Peng ^a  

^a SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY   (China)

^b SHAANXI PROVINCIAL PEOPLE S HOSPITAL   (China)

^c SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d JINAN UNIVERSITY   (China)

Author keywords

Cytokine; Genistein; Inflammation; Rheumatoid arthritis; Signal transduction

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CYTOKINE; GENISTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; INFLAMMATION; INTRACELLULAR SIGNALING; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CYTOLOGY; METABOLISM; PHYSIOLOGY; SYNOVIUM;

AMP-ACTIVATED PROTEIN KINASES; GENISTEIN; HUMANS; INFLAMMATION; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84897875780     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S52354     Document Type: Article

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