E1A inhibition of radiation-induced NF-κB activity through suppression of IKK activity and IκB degradation, independent of Akt activation

Cancer Research

Volumn 61, Issue 20, 2001, Pages 7413-7416

  Shao, Ruping ^a   Eing, Mei Tsai ^a   Wei, Kevin ^a   von Lindern, Ryan ^a   Chen, Yun Houng ^a   Makino, Keishi ^a   Hung, Mien Chie ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

E1A PROTEIN; I KAPPA B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADENOVIRUS 5; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION;

ADENOVIRIDAE; ADENOVIRUS E1A PROTEINS; ENZYME ACTIVATION; FEMALE; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; NF-KAPPA B; OVARIAN NEOPLASMS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION TOLERANCE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035887205     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Inhibition of nuclear factor-κB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis
2. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
3. E1A-mediated paclitaxel sensitization in HER-2/neu-overexpressing ovarian cancer SKOV3.ipl through apoptosis involving the caspase-3 pathway
4. E1A sensitizes HER2/neu-overexpressing Ewing's sarcoma cells to topoisomerase II-targeting anticancer drugs
5. Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to ether p300 or p105-Rb and induction of DNA synthesis
6. E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IκB kinase and nuclear factor κB activities
7. Development of clinical trial of E1A gene therapy targeting HER-2/neu-overexpressing breast and ovarian cancer
8. Tumor suppression activity of adenovirus E1a protein: Anoikis and the epithelial phenotype
9. Inhibition of angiogenesis and induction of apoptosis are involved in E1A-mediated bystander effect and tumor suppression
10. E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products
11. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-κB inhibition
12. A 65-kD subunit of active NF-κB is required for inhibition of NF-κB by IκB
13. NF-κB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
14. Cellular survival: A play in three Akts
15. Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
16. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
17. NF-κB activation by tumor necrosis factor requires the Akt serine-threonine kinase
18. Kinase regulation in inflammatory response
19. Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms
20. IkBa degradation is not requirement for the X-ray-induced activation of nuclear factor kB in normal rat astrocyted and human brain tumor cells