γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer

British Journal of Cancer

Volumn 106, Issue 12, 2012, Pages 1953-1959

  Mizugaki, H ^a   Sakakibara Konishi, J ^a   Ikezawa, Y ^a   Kikuchi, J ^a   Kikuchi, E ^a   Oizumi, S ^a   Dang, T P ^b   Nishimura, M ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

apoptosis; g secretase inhibitor; non small cell lung cancer; Notch; radiation

Indexed keywords

GAMMA SECRETASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH RECEPTOR; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASSAY; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RADIOTHERAPY; CLONOGENESIS; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; TUMOR XENOGRAFT; WESTERN BLOTTING;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; FEMALE; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM TRANSPLANTATION; OLIGOPEPTIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION TOLERANCE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 84862024239     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2012.178     Document Type: Article

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