메뉴 건너뛰기




Volumn 221, Issue 1, 2014, Pages 1-13

Diabetic neuropathic pain: A role for testosterone metabolites

Author keywords

Astrocyte immunoreactivity; Cytokines; Diabetic neuropathy; Glutamate; Neuroactive steroids; Streptozotocin; Substance p; Synaptic proteins

Indexed keywords

3ALPHA DIOL; ANDROSTANOLONE; GLUTAMIC ACID; INTERLEUKIN 1BETA; N METHYL DEXTRO ASPARTIC ACID; PROTEIN KINASE C; SUBSTANCE P; SYNAPSIN I; SYNTAXIN 1; TESTOSTERONE; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84897824612     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-13-0541     Document Type: Article
Times cited : (29)

References (70)
  • 1
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • (doi:10.1016/j.cell.2006.02.015)
    • Akira S, Uematsu S & Takeuchi O 2006 Pathogen recognition and innate immunity. Cell 124 783-801. (doi:10.1016/j.cell.2006.02.015)
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 2
    • 6344237140 scopus 로고    scopus 로고
    • Down regulation of interleukin-1β-induced nitric oxide production in lacrimal gland acinar cells by sex steroids
    • (doi:10.1080/02713680490513227)
    • Beauregard C & Brandt P 2004 Down regulation of interleukin-1β-induced nitric oxide production in lacrimal gland acinar cells by sex steroids. Current Eye Research 29 59-66. (doi:10.1080/02713680490513227)
    • (2004) Current Eye Research , vol.29 , pp. 59-66
    • Beauregard, C.1    Brandt, P.2
  • 3
    • 0742324418 scopus 로고    scopus 로고
    • Androgen receptor regulation by physiological concentrations of the isoflavonoid genistein in androgen-dependent LNCaP cells is mediated by estrogen receptor b.
    • discussion 251. (doi:10.1016/ j.eururo.2003.09.001)
    • Bektic J, Berger AP, Pfeil K, Dobler G, Bartsch G & Klocker H 2004 Androgen receptor regulation by physiological concentrations of the isoflavonoid genistein in androgen-dependent LNCaP cells is mediated by estrogen receptor b. European Urology 45 245-251 discussion 251. (doi:10.1016/ j.eururo.2003.09.001)
    • (2004) European Urology , vol.45 , pp. 245-251
    • Bektic, J.1    Berger, A.P.2    Pfeil, K.3    Dobler, G.4    Bartsch, G.5    Klocker, H.6
  • 4
    • 33645104146 scopus 로고    scopus 로고
    • Absence of synapsin I and II is accompanied by decreases in vesicular transport of specific neurotransmitters
    • (doi:10.1111/j.1471-4159.2005.03636.x)
    • Bogen IL, Boulland JL, Mariussen E, Wright MS, Fonnum F, Kao HT & Walaas SI 2006 Absence of synapsin I and II is accompanied by decreases in vesicular transport of specific neurotransmitters. Journal of Neurochemistry 96 1458-1466. (doi:10.1111/j.1471-4159.2005.03636.x)
    • (2006) Journal of Neurochemistry , vol.96 , pp. 1458-1466
    • Bogen, I.L.1    Boulland, J.L.2    Mariussen, E.3    Wright, M.S.4    Fonnum, F.5    Kao, H.T.6    Walaas, S.I.7
  • 5
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • (doi:10.1016/ 0003-2697(76)90527-3)
    • Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 248-254. (doi:10.1016/ 0003-2697(76)90527-3)
    • (1976) Analytical Biochemistry , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 6
    • 0030733297 scopus 로고    scopus 로고
    • Spinal pharmacology of tactile allodynia in diabetic rats
    • (doi:10.1038/sj.bjp.0701538)
    • Calcutt NA & Chaplan SR 1997 Spinal pharmacology of tactile allodynia in diabetic rats. British Journal of Pharmacology 122 1478-1482. (doi:10.1038/sj.bjp.0701538)
    • (1997) British Journal of Pharmacology , vol.122 , pp. 1478-1482
    • Calcutt, N.A.1    Chaplan, S.R.2
  • 7
    • 79952449552 scopus 로고    scopus 로고
    • GABAergic disinhibition induced pain hypersensitivity by upregulating NMDA receptor functions in spinal dorsal horn
    • (doi:10.1016/j.neuropharm.2011.01.034)
    • Cao J, Yang X, Liu YN, Suo ZW, Shi L, Zheng CR, Yang HB, Li S & Hu XD 2011 GABAergic disinhibition induced pain hypersensitivity by upregulating NMDA receptor functions in spinal dorsal horn. Neuropharmacology 60 921-929. (doi:10.1016/j.neuropharm.2011.01.034)
    • (2011) Neuropharmacology , vol.60 , pp. 921-929
    • Cao, J.1    Yang, X.2    Liu, Y.N.3    Suo, Z.W.4    Shi, L.5    Zheng, C.R.6    Yang, H.B.7    Li, S.8    Hu, X.D.9
  • 10
    • 0142247455 scopus 로고    scopus 로고
    • Altered temporal pattern of mechanically evoked C-fiber activity in a model of diabetic neuropathy in the rat
    • (doi:10.1016/S0306-4522(03)00486-X)
    • Chen X & Levine JD 2003 Altered temporal pattern of mechanically evoked C-fiber activity in a model of diabetic neuropathy in the rat. Neuroscience 121 1007-1015. (doi:10.1016/S0306-4522(03)00486-X)
    • (2003) Neuroscience , vol.121 , pp. 1007-1015
    • Chen, X.1    Levine, J.D.2
  • 11
    • 0036088744 scopus 로고    scopus 로고
    • Hypersensitivity of spinothalamic tract neurons associated with diabetic neuropathic pain in rats
    • Chen SR & Pan HL 2002 Hypersensitivity of spinothalamic tract neurons associated with diabetic neuropathic pain in rats. Journal of Neurophysiology 87 2726-2733.
    • (2002) Journal of Neurophysiology , vol.87 , pp. 2726-2733
    • Chen, S.R.1    Pan, H.L.2
  • 12
    • 67650167699 scopus 로고    scopus 로고
    • Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain
    • (doi:10.1016/j.neuropharm.2009.04.010)
    • Chen SR, Samoriski G & Pan HL 2009 Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. Neuropharmacology 57 121-126. (doi:10.1016/j.neuropharm.2009.04.010)
    • (2009) Neuropharmacology , vol.57 , pp. 121-126
    • Chen, S.R.1    Samoriski, G.2    Pan, H.L.3
  • 13
    • 84864008967 scopus 로고    scopus 로고
    • Neuron-astrocyte signaling network in spinal cord dorsal horn mediates painful neuropathy of type 2 diabetes
    • (doi:10.1002/glia.22349)
    • Dauch JR, Yanik BM, HsiehW, Oh SS & Cheng HT 2012 Neuron-astrocyte signaling network in spinal cord dorsal horn mediates painful neuropathy of type 2 diabetes. Glia 60 1301-1315. (doi:10.1002/glia.22349)
    • (2012) Glia , vol.60 , pp. 1301-1315
    • Dauch, J.R.1    Yanik, B.M.2    Hsieh, W.3    Oh, S.S.4    Cheng, H.T.5
  • 14
    • 79251597212 scopus 로고    scopus 로고
    • Phosphorylation of spinal N-methyl-D-aspartate receptor NR1 subunits by extracellular signal-regulated kinase in dorsal horn neurons and microglia contributes to diabetesinduced painful neuropathy
    • e1-169.e12(doi:10.1016/j.ejpain.2010.06.003)
    • Daulhac L, Maffre V, Mallet C, Etienne M, Privat AM, Kowalski-Chauvel A, Seva C, Fialip J & Eschalier A 2011 Phosphorylation of spinal N-methyl-D-aspartate receptor NR1 subunits by extracellular signal-regulated kinase in dorsal horn neurons and microglia contributes to diabetesinduced painful neuropathy. European Journal of Pain 15 169.e1-169.e12. (doi:10.1016/j.ejpain.2010.06.003)
    • (2011) European Journal of Pain , vol.15 , pp. 169
    • Daulhac, L.1    Maffre, V.2    Mallet, C.3    Etienne, M.4    Privat, A.M.5    Kowalski-Chauvel, A.6    Seva, C.7    Fialip, J.8    Eschalier, A.9
  • 16
    • 3142619945 scopus 로고    scopus 로고
    • Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5areduced metabolites in the hippocampus
    • (doi:10.1037/0735-7044.118.6.1352)
    • Edinger KL & Frye CA 2004 Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5areduced metabolites in the hippocampus. Behavioral Neuroscience 118 1352-1364. (doi:10.1037/0735-7044.118.6.1352)
    • (2004) Behavioral Neuroscience , vol.118 , pp. 1352-1364
    • Edinger, K.L.1    Frye, C.A.2
  • 17
    • 33748740924 scopus 로고    scopus 로고
    • Elevated testosterone induces apoptosis in neuronal cells
    • (doi:10.1074/jbc.M603193200)
    • Estrada M, Varshney A & Ehrlich BE 2006 Elevated testosterone induces apoptosis in neuronal cells. Journal of Biological Chemistry 281 25492-25501. (doi:10.1074/jbc.M603193200)
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 25492-25501
    • Estrada, M.1    Varshney, A.2    Ehrlich, B.E.3
  • 18
    • 33748987380 scopus 로고    scopus 로고
    • Steroids and glial cell function
    • (doi:10.1002/glia.20404)
    • Garcia-Segura LM & Melcangi RC 2006 Steroids and glial cell function. Glia 54 485-498. (doi:10.1002/glia.20404)
    • (2006) Glia , vol.54 , pp. 485-498
    • Garcia-Segura, L.M.1    Melcangi, R.C.2
  • 19
    • 0035831431 scopus 로고    scopus 로고
    • Protein kinase C activation modulates a-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex
    • (doi:10.1074/jbc.M009922200)
    • Gardoni F, Bellone C, Cattabeni F & Di Luca M 2001 Protein kinase C activation modulates a-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. Journal of Biological Chemistry 276 7609-7613. (doi:10.1074/jbc.M009922200)
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 7609-7613
    • Gardoni, F.1    Bellone, C.2    Cattabeni, F.3    Di Luca, M.4
  • 20
    • 34249824292 scopus 로고    scopus 로고
    • Activation of a membrane-associated androgen receptor promotes cell death in primary cortical astrocytes
    • (doi:10.1210/en.2006-1443)
    • Gatson JW& SinghM2007 Activation of a membrane-associated androgen receptor promotes cell death in primary cortical astrocytes. Endocrinology 148 2458-2464. (doi:10.1210/en.2006-1443)
    • (2007) Endocrinology , vol.148 , pp. 2458-2464
    • Gatson, J.W.1    Singh, M.2
  • 23
    • 0034306938 scopus 로고    scopus 로고
    • Antinociceptive properties of neurosteroids I. Spinally-mediated antinociceptive effects of watersoluble aminosteroids
    • (doi:10.1016/S0304-3959(00)00301-8)
    • Goodchild CS, Guo Z & Nadeson R 2000 Antinociceptive properties of neurosteroids I. Spinally-mediated antinociceptive effects of watersoluble aminosteroids. Pain 88 23-29. (doi:10.1016/S0304-3959(00)00301-8)
    • (2000) Pain , vol.88 , pp. 23-29
    • Goodchild, C.S.1    Guo, Z.2    Nadeson, R.3
  • 24
    • 0033612565 scopus 로고    scopus 로고
    • Analysis of cell death in the trochlear nucleus of the chick embryo: calibration of the optical disector counting method reveals systematic bias
    • (doi:10.1002/(SICI)1096-9861(19990628) 409:2<169::AID-C>NE1O3.0.CO;2-O)
    • Hatton WJ & von Bartheld CS 1999 Analysis of cell death in the trochlear nucleus of the chick embryo: calibration of the optical disector counting method reveals systematic bias. Journal of Comparative Neurology 409 169-186. (doi:10.1002/(SICI)1096-9861(19990628) 409:2<169::AID-C>NE1O3.0.CO;2-O)
    • (1999) Journal of Comparative Neurology , vol.409 , pp. 169-186
    • Hatton, W.J.1    von Bartheld, C.S.2
  • 26
    • 54249149338 scopus 로고    scopus 로고
    • Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters
    • (doi:10.1016/j.pain.2008.07.005)
    • Jolivalt CG, Lee CA, Ramos KM & Calcutt NA 2008 Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters. Pain 140 48-57. (doi:10.1016/j.pain.2008.07.005)
    • (2008) Pain , vol.140 , pp. 48-57
    • Jolivalt, C.G.1    Lee, C.A.2    Ramos, K.M.3    Calcutt, N.A.4
  • 27
    • 0036731984 scopus 로고    scopus 로고
    • Androgen receptors in human synoviocytes and androgen regulation of interleukin 1β (IL-1β) induced IL-6 production: a link between hypoandrogenicity and rheumatoid arthritis?
    • Khalkhali-Ellis Z, Handa RJ, Price RH Jr, Adams BD, Callaghan JJ & Hendrix MJ 2002 Androgen receptors in human synoviocytes and androgen regulation of interleukin 1β (IL-1β) induced IL-6 production: a link between hypoandrogenicity and rheumatoid arthritis? Journal of Rheumatology 29 1843-1846.
    • (2002) Journal of Rheumatology , vol.29 , pp. 1843-1846
    • Khalkhali-Ellis, Z.1    Handa, R.J.2    Price Jr., R.H.3    Adams, B.D.4    Callaghan, J.J.5    Hendrix, M.J.6
  • 28
    • 38049141503 scopus 로고    scopus 로고
    • Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord
    • (doi:10.1096/fj.07-8930com)
    • Kibaly C, Meyer L, Patte-Mensah C & Mensah-Nyagan AG 2008 Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord. FASEB Journal 22 93-104. (doi:10.1096/fj.07-8930com)
    • (2008) FASEB Journal , vol.22 , pp. 93-104
    • Kibaly, C.1    Meyer, L.2    Patte-Mensah, C.3    Mensah-Nyagan, A.G.4
  • 29
    • 0347506604 scopus 로고    scopus 로고
    • Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression
    • (doi:10.1016/S0028-3908(03)00308-3)
    • Lavezzari G, McCallum J, Lee R & Roche KW 2003 Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression. Neuropharmacology 45 729-737. (doi:10.1016/S0028-3908(03)00308-3)
    • (2003) Neuropharmacology , vol.45 , pp. 729-737
    • Lavezzari, G.1    McCallum, J.2    Lee, R.3    Roche, K.W.4
  • 31
    • 71649094290 scopus 로고    scopus 로고
    • Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain
    • (doi:10.1111/j.1471-4159.2009.06437.x)
    • Li JQ, Chen SR, Chen H, Cai YQ & Pan HL 2010 Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain. Journal of Neurochemistry 112 162-172. (doi:10.1111/j.1471-4159.2009.06437.x)
    • (2010) Journal of Neurochemistry , vol.112 , pp. 162-172
    • Li, J.Q.1    Chen, S.R.2    Chen, H.3    Cai, Y.Q.4    Pan, H.L.5
  • 33
    • 0031775954 scopus 로고    scopus 로고
    • A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats
    • (doi:10.1016/S0304-3959(98)00037-2)
    • Malcangio M & Tomlinson DR 1998 A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats. Pain 76 151-157. (doi:10.1016/S0304-3959(98)00037-2)
    • (1998) Pain , vol.76 , pp. 151-157
    • Malcangio, M.1    Tomlinson, D.R.2
  • 34
    • 0032421805 scopus 로고    scopus 로고
    • NMDA receptor activation modulates evoked release of substance P from rat spinal cord
    • (doi:10.1038/sj.bjp. 0702260)
    • Malcangio M, Fernandes K & Tomlinson DR 1998 NMDA receptor activation modulates evoked release of substance P from rat spinal cord. British Journal of Pharmacology 125 1625-1626. (doi:10.1038/sj.bjp. 0702260)
    • (1998) British Journal of Pharmacology , vol.125 , pp. 1625-1626
    • Malcangio, M.1    Fernandes, K.2    Tomlinson, D.R.3
  • 38
    • 71249131930 scopus 로고    scopus 로고
    • Evidence for a key role of steroids in the modulation of pain
    • (doi:10.1016/ j.psyneuen.2009.06.004)
    • Mensah-Nyagan AG, Meyer L, Schaeffer V, Kibaly C & Patte-Mensah C 2009 Evidence for a key role of steroids in the modulation of pain. Psychoneuroendocrinology 34(Suppl 1) S169-S177. (doi:10.1016/ j.psyneuen.2009.06.004)
    • (2009) Psychoneuroendocrinology , vol.34 , Issue.SUPPL. 1
    • Mensah-Nyagan, A.G.1    Meyer, L.2    Schaeffer, V.3    Kibaly, C.4    Patte-Mensah, C.5
  • 40
    • 0032890162 scopus 로고    scopus 로고
    • The induction of pain: an integrative review
    • (doi:10.1016/S0301-0082(98)00048-3)
    • Millan MJ 1999 The induction of pain: an integrative review. Progress in Neurobiology 57 1-164. (doi:10.1016/S0301-0082(98)00048-3)
    • (1999) Progress in Neurobiology , vol.57 , pp. 1-164
    • Millan, M.J.1
  • 41
    • 57749200564 scopus 로고    scopus 로고
    • Pathological and protective roles of glia in chronic pain
    • (doi:10.1038/ nrn2533)
    • Milligan ED & Watkins LR 2009 Pathological and protective roles of glia in chronic pain. Nature Reviews. Neuroscience 10 23-36. (doi:10.1038/ nrn2533)
    • (2009) Nature Reviews. Neuroscience , vol.10 , pp. 23-36
    • Milligan, E.D.1    Watkins, L.R.2
  • 42
  • 43
    • 0021711550 scopus 로고
    • The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic andlumbosacral cord
    • (doi:10.1002/cne.902300112)
    • Molander C, XuQ & Grant G 1984 The cytoarchitectonic organization of the spinal cord in the rat. I.The lower thoracic andlumbosacral cord. Journal of Comparative Neurology 30 133-141. (doi:10.1002/cne.902300112)
    • (1984) Journal of Comparative Neurology , vol.30 , pp. 133-141
    • Molander, C.1    Xu, Q.2    Grant, G.3
  • 44
  • 45
    • 73049086234 scopus 로고    scopus 로고
    • Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats
    • (doi:10.1016/j.yhbeh.2009.04.008)
    • Pesaresi M, Maschi O, Giatti S, Garcia-Segura LM, Caruso D & Melcangi RC 2010 Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats. Hormones and Behavior 57 46-55. (doi:10.1016/j.yhbeh.2009.04.008)
    • (2010) Hormones and Behavior , vol.57 , pp. 46-55
    • Pesaresi, M.1    Maschi, O.2    Giatti, S.3    Garcia-Segura, L.M.4    Caruso, D.5    Melcangi, R.C.6
  • 47
    • 24644491679 scopus 로고    scopus 로고
    • The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2
    • (doi:10.1016/j.neuron.2005.08.016)
    • Prybylowski K, Chang K, Sans N, Kan L, Vicini S & Wenthold RJ 2005 The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2. Neuron 47 845-857. (doi:10.1016/j.neuron.2005.08.016)
    • (2005) Neuron , vol.47 , pp. 845-857
    • Prybylowski, K.1    Chang, K.2    Sans, N.3    Kan, L.4    Vicini, S.5    Wenthold, R.J.6
  • 48
    • 80053568271 scopus 로고    scopus 로고
    • Post-translational modification of NMDA receptor GluN2B subunit and its roles in chronic pain and memory
    • (doi:10.1016/ j.semcdb.2011.06.003)
    • Qiu S, Li XY & Zhuo M 2011 Post-translational modification of NMDA receptor GluN2B subunit and its roles in chronic pain and memory. Seminars in Cell & Developmental Biology 22 521-529. (doi:10.1016/ j.semcdb.2011.06.003)
    • (2011) Seminars in Cell & Developmental Biology , vol.22 , pp. 521-529
    • Qiu, S.1    Li, X.Y.2    Zhuo, M.3
  • 49
    • 0033745545 scopus 로고    scopus 로고
    • Neuroanatomical localisation of Substance P in the CNS and sensory neurons
    • (doi:10.1054/npep.2000.0834)
    • Ribeiro-da-Silva A & Hokfelt T 2000 Neuroanatomical localisation of Substance P in the CNS and sensory neurons. Neuropeptides 34 256-271. (doi:10.1054/npep.2000.0834)
    • (2000) Neuropeptides , vol.34 , pp. 256-271
    • Ribeiro-da-Silva, A.1    Hokfelt, T.2
  • 51
    • 49249114754 scopus 로고    scopus 로고
    • Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury
    • (doi:10.1016/ j.neuroscience.2008.06.034)
    • Roglio I, Bianchi R, Gotti S, Scurati S, Giatti S, Pesaresi M, Caruso D, Panzica GC & Melcangi RC 2008 Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury. Neuroscience 155 673-685. (doi:10.1016/ j.neuroscience.2008.06.034)
    • (2008) Neuroscience , vol.155 , pp. 673-685
    • Roglio, I.1    Bianchi, R.2    Gotti, S.3    Scurati, S.4    Giatti, S.5    Pesaresi, M.6    Caruso, D.7    Panzica, G.C.8    Melcangi, R.C.9
  • 53
    • 53349177461 scopus 로고    scopus 로고
    • Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn
    • (doi:10.1016/j.pain.2008.06.018)
    • Schmidtko A, Luo C, Gao W, Geisslinger G, Kuner R & Tegeder I 2008 Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. Pain 139 632-643. (doi:10.1016/j.pain.2008.06.018)
    • (2008) Pain , vol.139 , pp. 632-643
    • Schmidtko, A.1    Luo, C.2    Gao, W.3    Geisslinger, G.4    Kuner, R.5    Tegeder, I.6
  • 54
    • 84862213367 scopus 로고    scopus 로고
    • Progesterone synthesis in the nervous system: implications for myelination and myelin repair
    • (doi:10.3389/fnins.2012.00010)
    • Schumacher M, Hussain R, Gago N, Oudinet JP, Mattern C & Ghoumari AM 2012 Progesterone synthesis in the nervous system: implications for myelination and myelin repair. Frontiers in Neuroscience 6 10. (doi:10.3389/fnins.2012.00010)
    • (2012) Frontiers in Neuroscience , vol.6 , pp. 10
    • Schumacher, M.1    Hussain, R.2    Gago, N.3    Oudinet, J.P.4    Mattern, C.5    Ghoumari, A.M.6
  • 55
    • 79953201580 scopus 로고    scopus 로고
    • Pharmacological treatment of diabetic neuropathic pain
    • (doi:10.2165/11588940-000000000-00000)
    • Smith HS & Argoff CE 2011 Pharmacological treatment of diabetic neuropathic pain. Drugs 71 557-589. (doi:10.2165/11588940-000000000-00000)
    • (2011) Drugs , vol.71 , pp. 557-589
    • Smith, H.S.1    Argoff, C.E.2
  • 56
    • 77954738979 scopus 로고    scopus 로고
    • Glycinergic and GABAergic tonic inhibition fine tune inhibitory control in regionally distinct subpopulations of dorsal horn neurons
    • (doi:10.1113/jphysiol.2010.188292)
    • Takazawa T & MacDermott AB 2010 Glycinergic and GABAergic tonic inhibition fine tune inhibitory control in regionally distinct subpopulations of dorsal horn neurons. Journal of Physiology 588 2571-2587. (doi:10.1113/jphysiol.2010.188292)
    • (2010) Journal of Physiology , vol.588 , pp. 2571-2587
    • Takazawa, T.1    MacDermott, A.B.2
  • 57
    • 79954420259 scopus 로고    scopus 로고
    • Preprotachykinin-A gene deletion regulates hydrogen sulfide-induced toll-like receptor 4 signaling pathway in cerulein-treated pancreatic acinar cells
    • (doi:10.1097/MPA. 0b013e31820720e6)
    • Tamizhselvi R, Shrivastava P, Koh YH, Zhang H & Bhatia M 2011 Preprotachykinin-A gene deletion regulates hydrogen sulfide-induced toll-like receptor 4 signaling pathway in cerulein-treated pancreatic acinar cells. Pancreas 40 444-452. (doi:10.1097/MPA. 0b013e31820720e6)
    • (2011) Pancreas , vol.40 , pp. 444-452
    • Tamizhselvi, R.1    Shrivastava, P.2    Koh, Y.H.3    Zhang, H.4    Bhatia, M.5
  • 58
    • 84856201567 scopus 로고    scopus 로고
    • Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy
    • (doi:10.1002/dmrr.2239)
    • Tesfaye S & Selvarajah D 2012 Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy. Diabetes/Metabolism Research and Reviews 28(Suppl 1) 8-14. (doi:10.1002/dmrr.2239)
    • (2012) Diabetes/Metabolism Research and Reviews , vol.28 , Issue.SUPPL. 1 , pp. 8-14
    • Tesfaye, S.1    Selvarajah, D.2
  • 60
    • 18944407753 scopus 로고    scopus 로고
    • Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus. Brain Research
    • (doi:10.1016/j.molbrainres. 2005.02.003)
    • Tomiyama M, Furusawa K, Kamijo M, Kimura T, Matsunaga M & Baba M 2005 Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus. Brain Research. Molecular Brain Research 136 275-281. (doi:10.1016/j.molbrainres. 2005.02.003)
    • (2005) Molecular Brain Research , vol.136 , pp. 275-281
    • Tomiyama, M.1    Furusawa, K.2    Kamijo, M.3    Kimura, T.4    Matsunaga, M.5    Baba, M.6
  • 61
    • 0027319508 scopus 로고
    • Dissociated secondary hyperalgesia in a subject with a large-fibre sensory neuropathy
    • (doi:10.1016/ 0304-3959(93)90077-3)
    • Treede RD & Cole JD 1993 Dissociated secondary hyperalgesia in a subject with a large-fibre sensory neuropathy. Pain 53 169-174. (doi:10.1016/ 0304-3959(93)90077-3)
    • (1993) Pain , vol.53 , pp. 169-174
    • Treede, R.D.1    Cole, J.D.2
  • 62
    • 0347169249 scopus 로고    scopus 로고
    • Glia: a novel drug discovery target for clinical pain
    • (doi:10.1038/nrd1251)
    • Watkins LR & Maier SF 2003 Glia: a novel drug discovery target for clinical pain. Nature Reviews. Drug Discovery 2 973-985. (doi:10.1038/nrd1251)
    • (2003) Nature Reviews. Drug Discovery , vol.2 , pp. 973-985
    • Watkins, L.R.1    Maier, S.F.2
  • 63
    • 84872694582 scopus 로고    scopus 로고
    • The upregulation of translocator protein (18 kDa) promotes recovery from neuropathic pain in rats
    • (doi:10.1523/JNEUROSCI.0324-12.2013)
    • Wei XH, Wei X, Chen FY, Zang Y, XinWJ, Pang RP, Chen Y, Wang J, Li YY, Shen KF et al. 2013 The upregulation of translocator protein (18 kDa) promotes recovery from neuropathic pain in rats. Journal of Neuroscience 33 1540-1551. (doi:10.1523/JNEUROSCI.0324-12.2013)
    • (2013) Journal of Neuroscience , vol.33 , pp. 1540-1551
    • Wei, X.H.1    Wei, X.2    Chen, F.Y.3    Zang, Y.4    Xin, W.J.5    Pang, R.P.6    Chen, Y.7    Wang, J.8    Li, Y.Y.9    Shen, K.F.10
  • 64
    • 0041828387 scopus 로고    scopus 로고
    • Antinociceptive properties of neurosteroids: a comparison of alphadolone and alphaxalone in potentiation of opioid antinociception
    • (doi:10.1213/01.ANE.0000075835.73967.F3)
    • Winter L, Nadeson R, Tucker AP & Goodchild CS 2003 Antinociceptive properties of neurosteroids: a comparison of alphadolone and alphaxalone in potentiation of opioid antinociception. Anesthesia and Analgesia 97 798-805. (doi:10.1213/01.ANE.0000075835.73967.F3)
    • (2003) Anesthesia and Analgesia , vol.97 , pp. 798-805
    • Winter, L.1    Nadeson, R.2    Tucker, A.P.3    Goodchild, C.S.4
  • 66
    • 84865615523 scopus 로고    scopus 로고
    • Streptozotocin-induced diabetic hyperalgesia in rats is associated with upregulation of Toll-like receptor 4 expression
    • (doi:10.1016/ j.neulet.2012.08.012)
    • Yan JE, Yuan W, Lou X & Zhu T 2012 Streptozotocin-induced diabetic hyperalgesia in rats is associated with upregulation of Toll-like receptor 4 expression. Neuroscience Letters 526 54-58. (doi:10.1016/ j.neulet.2012.08.012)
    • (2012) Neuroscience Letters , vol.526 , pp. 54-58
    • Yan, J.E.1    Yuan, W.2    Lou, X.3    Zhu, T.4
  • 67
    • 0036089716 scopus 로고    scopus 로고
    • Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal model
    • (doi:10.1063/1.1486251)
    • Yang SH, Perez E, Cutright J, Liu R, He Z, Day AL & Simpkins JW 2002 Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal model. Journal of Applied Physiology 92 195-201. (doi:10.1063/1.1486251)
    • (2002) Journal of Applied Physiology , vol.92 , pp. 195-201
    • Yang, S.H.1    Perez, E.2    Cutright, J.3    Liu, R.4    He, Z.5    Day, A.L.6    Simpkins, J.W.7
  • 69
    • 78650136404 scopus 로고    scopus 로고
    • cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain
    • (doi:10.1111/j.1471-4159.2010.07088.x)
    • Yang HB, Yang X, Cao J, Li S, Liu YN, Suo ZW, Cui HB, Guo Z & Hu XD 2011 cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain. Journal of Neurochemistry 116 93-104. (doi:10.1111/j.1471-4159.2010.07088.x)
    • (2011) Journal of Neurochemistry , vol.116 , pp. 93-104
    • Yang, H.B.1    Yang, X.2    Cao, J.3    Li, S.4    Liu, Y.N.5    Suo, Z.W.6    Cui, H.B.7    Guo, Z.8    Hu, X.D.9
  • 70
    • 0031053363 scopus 로고    scopus 로고
    • NMDA channel regulation by channel-associated protein tyrosine kinase Src
    • (doi:10.1126/science.275.5300.674)
    • Yu XM, Askalan R, Keil GJ II & Salter MW 1997 NMDA channel regulation by channel-associated protein tyrosine kinase Src. Science 275 674-678. (doi:10.1126/science.275.5300.674)
    • (1997) Science , vol.275 , pp. 674-678
    • Yu, X.M.1    Askalan, R.2    Keil II, G.J.3    Salter, M.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.