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Volumn 42, Issue 3, 2014, Pages 192-203.e1

Differential requirement for wild-type Flt3 in leukemia initiation among mouse models of human leukemia

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; INTERLEUKIN 3; INTERLEUKIN 6; STEM CELL FACTOR;

EID: 84897780344     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2013.11.008     Document Type: Article
Times cited : (7)

References (41)
  • 1
    • 72949114887 scopus 로고    scopus 로고
    • Leukaemogenesis: more than mutant genes
    • Chen J., Odenike O., Rowley J.D. Leukaemogenesis: more than mutant genes. Nat Rev Cancer 2010, 10:23-36.
    • (2010) Nat Rev Cancer , vol.10 , pp. 23-36
    • Chen, J.1    Odenike, O.2    Rowley, J.D.3
  • 2
    • 67650351086 scopus 로고    scopus 로고
    • Structural and functional alterations of FLT3 in acute myeloid leukemia
    • Meshinchi S., Appelbaum F.R. Structural and functional alterations of FLT3 in acute myeloid leukemia. Clin Cancer Res 2009, 15:4263-4269.
    • (2009) Clin Cancer Res , vol.15 , pp. 4263-4269
    • Meshinchi, S.1    Appelbaum, F.R.2
  • 3
    • 47249144115 scopus 로고    scopus 로고
    • Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival
    • Kikushige Y., Yoshimoto G., Miyamoto T., et al. Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival. J Immunol 2008, 180:7358-7367.
    • (2008) J Immunol , vol.180 , pp. 7358-7367
    • Kikushige, Y.1    Yoshimoto, G.2    Miyamoto, T.3
  • 4
    • 0029097145 scopus 로고
    • Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
    • Mackarehtschian K., Hardin J.D., Moore K.A., Boast S., Goff S.P., Lemischka I.R. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 1995, 3:147-161.
    • (1995) Immunity , vol.3 , pp. 147-161
    • Mackarehtschian, K.1    Hardin, J.D.2    Moore, K.A.3    Boast, S.4    Goff, S.P.5    Lemischka, I.R.6
  • 5
    • 65349147139 scopus 로고    scopus 로고
    • FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells
    • Buza-Vidas N., Cheng M., Duarte S., Charoudeh H.N., Jacobsen S.E., Sitnicka E. FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells. Blood 2009, 113:3453-3460.
    • (2009) Blood , vol.113 , pp. 3453-3460
    • Buza-Vidas, N.1    Cheng, M.2    Duarte, S.3    Charoudeh, H.N.4    Jacobsen, S.E.5    Sitnicka, E.6
  • 6
    • 78650073854 scopus 로고    scopus 로고
    • FLT3 as a therapeutic target in AML: still challenging after all these years
    • Kindler T., Lipka D.B., Fischer T. FLT3 as a therapeutic target in AML: still challenging after all these years. Blood 2010, 116:5089-5102.
    • (2010) Blood , vol.116 , pp. 5089-5102
    • Kindler, T.1    Lipka, D.B.2    Fischer, T.3
  • 7
    • 79952043438 scopus 로고    scopus 로고
    • FLT3 inhibitors: a story of the old and the new
    • Fathi A., Levis M. FLT3 inhibitors: a story of the old and the new. Curr Opin Hematol 2011, 18:71-76.
    • (2011) Curr Opin Hematol , vol.18 , pp. 71-76
    • Fathi, A.1    Levis, M.2
  • 8
    • 0013312329 scopus 로고    scopus 로고
    • Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification
    • Armstrong S.A., Kung A.L., Mabon M.E., et al. Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer cell 2003, 3:173-183.
    • (2003) Cancer cell , vol.3 , pp. 173-183
    • Armstrong, S.A.1    Kung, A.L.2    Mabon, M.E.3
  • 9
    • 18544375333 scopus 로고    scopus 로고
    • MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
    • Armstrong S.A., Staunton J.E., Silverman L.B., et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 2002, 30:41-47.
    • (2002) Nat Genet , vol.30 , pp. 41-47
    • Armstrong, S.A.1    Staunton, J.E.2    Silverman, L.B.3
  • 10
    • 27144499798 scopus 로고    scopus 로고
    • Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia
    • Stam R.W., den Boer M.L., Schneider P., et al. Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia. Blood 2005, 106:2484-2490.
    • (2005) Blood , vol.106 , pp. 2484-2490
    • Stam, R.W.1    den Boer, M.L.2    Schneider, P.3
  • 11
    • 11244300074 scopus 로고    scopus 로고
    • FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression
    • Brown P., Levis M., Shurtleff S., Campana D., Downing J., Small D. FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression. Blood 2005, 105:812-820.
    • (2005) Blood , vol.105 , pp. 812-820
    • Brown, P.1    Levis, M.2    Shurtleff, S.3    Campana, D.4    Downing, J.5    Small, D.6
  • 12
    • 79951510658 scopus 로고    scopus 로고
    • Leukemia stem cells in 2010: current understanding and future directions
    • Becker M.W., Jordan C.T. Leukemia stem cells in 2010: current understanding and future directions. Blood reviews 2011, 25:75-81.
    • (2011) Blood reviews , vol.25 , pp. 75-81
    • Becker, M.W.1    Jordan, C.T.2
  • 13
    • 44349166602 scopus 로고    scopus 로고
    • PML targeting eradicates quiescent leukaemia-initiating cells
    • Ito K., Bernardi R., Morotti A., et al. PML targeting eradicates quiescent leukaemia-initiating cells. Nature 2008, 453:1072-1078.
    • (2008) Nature , vol.453 , pp. 1072-1078
    • Ito, K.1    Bernardi, R.2    Morotti, A.3
  • 14
    • 78149470597 scopus 로고    scopus 로고
    • Insights into the stem cells of chronic myeloid leukemia
    • Sloma I., Jiang X., Eaves A.C., Eaves C.J. Insights into the stem cells of chronic myeloid leukemia. Leukemia 2010, 24:1823-1833.
    • (2010) Leukemia , vol.24 , pp. 1823-1833
    • Sloma, I.1    Jiang, X.2    Eaves, A.C.3    Eaves, C.J.4
  • 15
    • 33746620006 scopus 로고    scopus 로고
    • The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia
    • Palmqvist L., Argiropoulos B., Pineault N., et al. The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia. Blood 2006, 108:1030-1036.
    • (2006) Blood , vol.108 , pp. 1030-1036
    • Palmqvist, L.1    Argiropoulos, B.2    Pineault, N.3
  • 16
    • 84881599676 scopus 로고    scopus 로고
    • Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes
    • Albouhair S., Morgado E., Lavau C. Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes. PloS One 2013, 8:e72261.
    • (2013) PloS One , vol.8
    • Albouhair, S.1    Morgado, E.2    Lavau, C.3
  • 17
    • 34247329447 scopus 로고    scopus 로고
    • Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation
    • Morgado E., Albouhair S., Lavau C. Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation. Blood 2007, 109:4020-4022.
    • (2007) Blood , vol.109 , pp. 4020-4022
    • Morgado, E.1    Albouhair, S.2    Lavau, C.3
  • 18
    • 9144236224 scopus 로고    scopus 로고
    • Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization
    • Zeisig B.B., Milne T., Garcia-Cuellar M.P., et al. Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Mol Cell Biol 2004, 24:617-628.
    • (2004) Mol Cell Biol , vol.24 , pp. 617-628
    • Zeisig, B.B.1    Milne, T.2    Garcia-Cuellar, M.P.3
  • 19
    • 0032126633 scopus 로고    scopus 로고
    • Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
    • Kroon E., Krosl J., Thorsteinsdottir U., Baban S., Buchberg A.M., Sauvageau G. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J 1998, 17:3714-3725.
    • (1998) EMBO J , vol.17 , pp. 3714-3725
    • Kroon, E.1    Krosl, J.2    Thorsteinsdottir, U.3    Baban, S.4    Buchberg, A.M.5    Sauvageau, G.6
  • 20
    • 35948964020 scopus 로고    scopus 로고
    • Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential
    • Wong P., Iwasaki M., Somervaille T.C., So C.W., Cleary M.L. Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev 2007, 21:2762-2774.
    • (2007) Genes Dev , vol.21 , pp. 2762-2774
    • Wong, P.1    Iwasaki, M.2    Somervaille, T.C.3    So, C.W.4    Cleary, M.L.5
  • 21
    • 33746498580 scopus 로고    scopus 로고
    • Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
    • Krivtsov A.V., Twomey D., Feng Z., et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 2006, 442:818-822.
    • (2006) Nature , vol.442 , pp. 818-822
    • Krivtsov, A.V.1    Twomey, D.2    Feng, Z.3
  • 22
    • 0346100567 scopus 로고    scopus 로고
    • Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    • Cozzio A., Passegue E., Ayton P.M., Karsunky H., Cleary M.L., Weissman I.L. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev 2003, 17:3029-3035.
    • (2003) Genes Dev , vol.17 , pp. 3029-3035
    • Cozzio, A.1    Passegue, E.2    Ayton, P.M.3    Karsunky, H.4    Cleary, M.L.5    Weissman, I.L.6
  • 23
    • 76249123883 scopus 로고    scopus 로고
    • Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia
    • Guibal F.C., Alberich-Jorda M., Hirai H., et al. Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia. Blood 2009, 114:5415-5425.
    • (2009) Blood , vol.114 , pp. 5415-5425
    • Guibal, F.C.1    Alberich-Jorda, M.2    Hirai, H.3
  • 24
    • 33749440584 scopus 로고    scopus 로고
    • Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
    • Somervaille T.C., Cleary M.L. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 2006, 10:257-268.
    • (2006) Cancer Cell , vol.10 , pp. 257-268
    • Somervaille, T.C.1    Cleary, M.L.2
  • 25
    • 0032533257 scopus 로고    scopus 로고
    • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
    • Pear W.S., Miller J.P., Xu L., et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood 1998, 92:3780-3792.
    • (1998) Blood , vol.92 , pp. 3780-3792
    • Pear, W.S.1    Miller, J.P.2    Xu, L.3
  • 26
    • 58949102947 scopus 로고    scopus 로고
    • Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells
    • Somervaille T.C., Matheny C.J., Spencer G.J., et al. Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell 2009, 4:129-140.
    • (2009) Cell Stem Cell , vol.4 , pp. 129-140
    • Somervaille, T.C.1    Matheny, C.J.2    Spencer, G.J.3
  • 27
    • 33746843079 scopus 로고    scopus 로고
    • A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis
    • Yan M., Kanbe E., Peterson L.F., et al. A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis. Nat Med 2006, 12:945-949.
    • (2006) Nat Med , vol.12 , pp. 945-949
    • Yan, M.1    Kanbe, E.2    Peterson, L.F.3
  • 28
    • 73949096431 scopus 로고    scopus 로고
    • FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation
    • Yoshimoto G., Miyamoto T., Jabbarzadeh-Tabrizi S., et al. FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. Blood 2009, 114:5034-5043.
    • (2009) Blood , vol.114 , pp. 5034-5043
    • Yoshimoto, G.1    Miyamoto, T.2    Jabbarzadeh-Tabrizi, S.3
  • 29
    • 0037944120 scopus 로고    scopus 로고
    • Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
    • Mizuki M., Schwable J., Steur C., et al. Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Blood 2003, 101:3164-3173.
    • (2003) Blood , vol.101 , pp. 3164-3173
    • Mizuki, M.1    Schwable, J.2    Steur, C.3
  • 30
    • 0028869112 scopus 로고
    • Altered Hox expression and segmental identity in Mll-mutant mice
    • Yu B.D., Hess J.L., Horning S.E., Brown G.A., Korsmeyer S.J. Altered Hox expression and segmental identity in Mll-mutant mice. Nature 1995, 378:505-508.
    • (1995) Nature , vol.378 , pp. 505-508
    • Yu, B.D.1    Hess, J.L.2    Horning, S.E.3    Brown, G.A.4    Korsmeyer, S.J.5
  • 32
    • 77950287628 scopus 로고    scopus 로고
    • The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML
    • Wang Y., Krivtsov A.V., Sinha A.U., et al. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science 2010, 327:1650-1653.
    • (2010) Science , vol.327 , pp. 1650-1653
    • Wang, Y.1    Krivtsov, A.V.2    Sinha, A.U.3
  • 33
    • 64049095814 scopus 로고    scopus 로고
    • HOXA9 is required for survival in human MLL-rearranged acute leukemias
    • Faber J., Krivtsov A.V., Stubbs M.C., et al. HOXA9 is required for survival in human MLL-rearranged acute leukemias. Blood 2009, 113:2375-2385.
    • (2009) Blood , vol.113 , pp. 2375-2385
    • Faber, J.1    Krivtsov, A.V.2    Stubbs, M.C.3
  • 34
    • 0032530734 scopus 로고    scopus 로고
    • Leukemic predisposition of mice transplanted with gene-modified hematopoietic precursors expressing flt3 ligand
    • Hawley T.S., Fong A.Z., Griesser H., Lyman S.D., Hawley R.G. Leukemic predisposition of mice transplanted with gene-modified hematopoietic precursors expressing flt3 ligand. Blood 1998, 92:2003-2011.
    • (1998) Blood , vol.92 , pp. 2003-2011
    • Hawley, T.S.1    Fong, A.Z.2    Griesser, H.3    Lyman, S.D.4    Hawley, R.G.5
  • 35
    • 35548934558 scopus 로고    scopus 로고
    • MLL translocations, histone modifications and leukaemia stem-cell development
    • Krivtsov A.V., Armstrong S.A. MLL translocations, histone modifications and leukaemia stem-cell development. Nature reviews Cancer 2007, 7:823-833.
    • (2007) Nature reviews Cancer , vol.7 , pp. 823-833
    • Krivtsov, A.V.1    Armstrong, S.A.2
  • 36
    • 84867595341 scopus 로고    scopus 로고
    • Blockade of miR-150 maturation by MLL-Fusion/MYC/LIN-28 is required for MLL-associated leukemia
    • Jiang X., Huang H., Li Z., et al. Blockade of miR-150 maturation by MLL-Fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell 2012, 22:524-535.
    • (2012) Cancer Cell , vol.22 , pp. 524-535
    • Jiang, X.1    Huang, H.2    Li, Z.3
  • 37
    • 34347401419 scopus 로고    scopus 로고
    • Activation mechanisms of STAT5 by oncogenic Flt3-ITD
    • Choudhary C., Brandts C., Schwable J., et al. Activation mechanisms of STAT5 by oncogenic Flt3-ITD. Blood 2007, 110:370-374.
    • (2007) Blood , vol.110 , pp. 370-374
    • Choudhary, C.1    Brandts, C.2    Schwable, J.3
  • 38
    • 70350013557 scopus 로고    scopus 로고
    • Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes
    • Choudhary C., Olsen J.V., Brandts C., et al. Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 2009, 36:326-339.
    • (2009) Mol Cell , vol.36 , pp. 326-339
    • Choudhary, C.1    Olsen, J.V.2    Brandts, C.3
  • 39
    • 65349190643 scopus 로고    scopus 로고
    • Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality
    • Schmidt-Arras D., Bohmer S.A., Koch S., et al. Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality. Blood 2009, 113:3568-3576.
    • (2009) Blood , vol.113 , pp. 3568-3576
    • Schmidt-Arras, D.1    Bohmer, S.A.2    Koch, S.3
  • 40
    • 58749108674 scopus 로고    scopus 로고
    • A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF-beta 2 responsiveness
    • Avagyan S., Glouchkova L., Choi J., Snoeck H.W. A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF-beta 2 responsiveness. J Immunol 2008, 181:5904-5911.
    • (2008) J Immunol , vol.181 , pp. 5904-5911
    • Avagyan, S.1    Glouchkova, L.2    Choi, J.3    Snoeck, H.W.4
  • 41
    • 82955207702 scopus 로고    scopus 로고
    • Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-beta2 and FLT3 in hematopoiesis
    • Avagyan S., Aguilo F., Kamezaki K., Snoeck H.W. Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-beta2 and FLT3 in hematopoiesis. Blood 2011, 118:6078-6086.
    • (2011) Blood , vol.118 , pp. 6078-6086
    • Avagyan, S.1    Aguilo, F.2    Kamezaki, K.3    Snoeck, H.W.4


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